Life, death and autophagy

Recessive mutations in >VPS13D cause childhood onset movement disorders

(2018) Julie Gauthier et al.   ANNALS OF NEUROLOGY

Mutations in VPS13D lead to a new recessive ataxia with spasticity and mitochondrial defects

(2018) Eunju Seong et al.   ANNALS OF NEUROLOGY

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Vps13D Encodes a Ubiquitin-Binding Protein that Is Required for the Regulation of Mitochondrial Size and Clearance

(2018) Allyson L. Anding et al.   CURRENT BIOLOGY

The CCR4-NOT deadenylase complex controls Atg7-dependent cell death and heart function

(2018) Tomokazu Yamaguchi et al.   Science Signaling

The CCR4-NOT deadenylase complex controls Atg7-dependent cell death and heart function

(2018) Tomokazu Yamaguchi et al.   Science Signaling

Beyond self-eating: The control of nonautophagic functions and signaling pathways by autophagy-related proteins

(2017) Ken Cadwell et al.   JOURNAL OF CELL BIOLOGY

Entosis Is Induced by Glucose Starvation

(2017) Jens C. Hamann et al.   Cell Reports

Anti-inflammatory Mechanisms Triggered by Apoptotic Cells during Their Clearance

(2017) Zsuzsa Szondy et al.   Frontiers in Immunology

Neuroprotection by selective neuronal deletion of Atg7 in neonatal brain injury

(2016) Cuicui Xie et al.   Autophagy

Autophagy promotes ferroptosis by degradation of ferritin

(2016) Wen Hou et al.   Autophagy

The clearance of dying cells: table for two

(2016) D R Green et al.   CELL DEATH AND DIFFERENTIATION

Autophagy Determines the Path on the TRAIL to Death

(2016) Jun-ichi Sakamaki et al.   DEVELOPMENTAL CELL

The Autophagy Machinery Controls Cell Death Switching between Apoptosis and Necroptosis

(2016) Megan L. Goodall et al.   DEVELOPMENTAL CELL

The lipolysis pathway sustains normal and transformed stem cells in adult Drosophila

(2016) Shree Ram Singh et al.   NATURE

Vital staining for cell death identifies Atg9a-dependent necrosis in developmental bone formation in mouse

(2016) Yusuke Imagawa et al.   Nature Communications

Autophagy drives epidermal deterioration in a Drosophila model of tissue aging

(2016) Christoph Scherfer et al.   Aging-US

Distinct requirements of Autophagy-related genes in programmed cell death

(2015) T Xu et al.   CELL DEATH AND DIFFERENTIATION

Translational Control of Autophagy by Orb in the Drosophila Germline

(2015) Patricia Rojas-Ríos et al.   DEVELOPMENTAL CELL

Ral GTPase and the exocyst regulate autophagy in a tissue-specific manner

(2015) K. Tracy et al.   EMBO REPORTS

Molecular characterization of LC3-associated phagocytosis reveals distinct roles for Rubicon, NOX2 and autophagy proteins

(2015) Jennifer Martinez et al.   NATURE CELL BIOLOGY

TM9SF4 is a novel V-ATPase-interacting protein that modulates tumor pH alterations associated with drug resistance and invasiveness of colon cancer cells

(2015) F Lozupone et al.   ONCOGENE

Cell death by autophagy: emerging molecular mechanisms and implications for cancer therapy

(2015) S Fulda et al.   ONCOGENE

Eaten alive: novel insights into autophagy from multicellular model systems

(2015) Hong Zhang et al.   TRENDS IN CELL BIOLOGY

Cell Death Signaling

(2015) Douglas R. Green et al.   Cold Spring Harbor Perspectives in Biology

Non-canonical autophagy: An exception or an underestimated form of autophagy?

(2014) Francesca Scarlatti et al.   Autophagy

Eating on the fly: Function and regulation of autophagy during cell growth, survival and death in Drosophila

(2014) Thomas P. Neufeld et al.   Autophagy

The autophagy geneATG5plays an essential role in B lymphocyte development

(2014) Brian C. Miller et al.   Autophagy

Hypoxia induces autophagic cell death in apoptosis-competent cells through a mechanism involving BNIP3

(2014) Meghan B. Azad et al.   Autophagy

Induction of entosis by epithelial cadherin expression

(2014) Qiang Sun et al.   CELL RESEARCH

Ecdysone-Induced Receptor Tyrosine Phosphatase PTP52F Regulates Drosophila Midgut Histolysis by Enhancement of Autophagy and Apoptosis

(2014) A. Santhanam et al.   MOLECULAR AND CELLULAR BIOLOGY

miR-14 Regulates Autophagy during Developmental Cell Death by Targeting ip3-kinase 2

(2014) Charles Nelson et al.   MOLECULAR CELL

Autophagy Controls the Kinetics and Extent of Mitochondrial Apoptosis by Regulating PUMA Levels

(2014) Jacqueline Thorburn et al.   Cell Reports

Autophagy in Development, Cell Differentiation, and Homeodynamics: From Molecular Mechanisms to Diseases and Pathophysiology

(2014) Ioannis P. Nezis et al.   Biomed Research International

Autophagy inhibition radiosensitizes in vitro, yet reduces radioresponses in vivo due to deficient immunogenic signalling

(2013) A Ko et al.   CELL DEATH AND DIFFERENTIATION

Obatoclax (GX15-070) triggers necroptosis by promoting the assembly of the necrosome on autophagosomal membranes

(2013) F Basit et al.   CELL DEATH AND DIFFERENTIATION

Non-autophagic roles of autophagy-related proteins

(2013) Suresh Subramani et al.   EMBO REPORTS

Autophagy proteins stabilize pathogen-containing phagosomes for prolonged MHC II antigen processing

(2013) Susana Romao et al.   JOURNAL OF CELL BIOLOGY

Autophagy variation within a cell population determines cell fate through selective degradation of Fap-1

(2013) Jacob M. Gump et al.   NATURE CELL BIOLOGY

Uba1 functions in Atg7- and Atg3-independent autophagy

(2013) Tsun-Kai Chang et al.   NATURE CELL BIOLOGY

ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase

(2013) Ryan C. Russell et al.   NATURE CELL BIOLOGY

Autosis is a Na+,K+-ATPase-regulated form of cell death triggered by autophagy-inducing peptides, starvation, and hypoxia-ischemia

(2013) Y. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy proteins regulate cell engulfment mechanisms that participate in cancer

(2013) Sung Eun Kim et al.   SEMINARS IN CANCER BIOLOGY

UTX coordinates steroid hormone-mediated autophagy and cell death

(2013) Donna Denton et al.   Nature Communications

Autophagy genes function in apoptotic cell corpse clearance duringC. elegansembryonic development

(2012) Shuyi Huang et al.   Autophagy

Identification of factors that function in Drosophila salivary gland cell death during development using proteomics

(2012) C K McPhee et al.   CELL DEATH AND DIFFERENTIATION

Dectin-1-triggered Recruitment of Light Chain 3 Protein to Phagosomes Facilitates Major Histocompatibility Complex Class II Presentation of Fungal-derived Antigens

(2012) Jun Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Involvement of Beclin 1 in Engulfment of Apoptotic Cells

(2012) Akimitsu Konishi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagosomal Membrane Serves as Platform for Intracellular Death-inducing Signaling Complex (iDISC)-mediated Caspase-8 Activation and Apoptosis

(2012) Megan M. Young et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy genes function sequentially to promote apoptotic cell corpse degradation in the engulfing cell

(2012) Wei Li et al.   JOURNAL OF CELL BIOLOGY

The Atg6/Vps30/Beclin 1 ortholog BEC-1 mediates endocytic retrograde transport in addition to autophagy inC. elegans

(2011) Alexander Ruck et al.   Autophagy

Programmed Cell Death in Animal Development and Disease

(2011) Yaron Fuchs et al.   CELL

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

Cell death by autophagy: facts and apparent artefacts

(2011) D Denton et al.   CELL DEATH AND DIFFERENTIATION

Oncogenic Ras-Induced Expression of Noxa and Beclin-1 Promotes Autophagic Cell Death and Limits Clonogenic Survival

(2011) Mohamed Elgendy et al.   MOLECULAR CELL

Autophagy machinery mediates macroendocytic processing and entotic cell death by targeting single membranes

(2011) Oliver Florey et al.   NATURE CELL BIOLOGY

Canonical and non-canonical autophagy: variations on a common theme of self-eating?

(2011) Patrice Codogno et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Microtubule-associated protein 1 light chain 3 alpha (LC3)-associated phagocytosis is required for the efficient clearance of dead cells

(2011) J. Martinez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy-Dependent Anticancer Immune Responses Induced by Chemotherapeutic Agents in Mice

(2011) M. Michaud et al.   SCIENCE

The engulfment receptor Draper is required for autophagy during cell death

(2010) Christina K. McPhee et al.   Autophagy

ATG12 Conjugation to ATG3 Regulates Mitochondrial Homeostasis and Cell Death

(2010) Lilliana Radoshevich et al.   CELL

Autophagic degradation of dBruce controls DNA fragmentation in nurse cells during lateDrosophila melanogasteroogenesis

(2010) Ioannis P. Nezis et al.   JOURNAL OF CELL BIOLOGY

Autophagy: cellular and molecular mechanisms

(2010) Danielle Glick et al.   JOURNAL OF PATHOLOGY

Activation of autophagy during cell death requires the engulfment receptor Draper

(2010) Christina K. McPhee et al.   NATURE

Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria

(2010) E Wirawan et al.   Cell Death & Disease

Beclin 1 cleavage by caspase-3 inactivates autophagy and promotes apoptosis

(2010) Yushan Zhu et al.   Protein & Cell

Autophagy in Drosophila melanogaster

(2009) Christina K. McPhee et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The Rac1/MKK7/JNK pathway signals upregulation of Atg5 and subsequent autophagic cell death in response to oncogenic Ras

(2009) Joo-Yun Byun et al.   CARCINOGENESIS

Autophagy, Not Apoptosis, Is Essential for Midgut Cell Death in Drosophila

(2009) Donna Denton et al.   CURRENT BIOLOGY

The human homologue of Dictyostelium discoideum phg1A is expressed by human metastatic melanoma cells

(2009) Francesco Lozupone et al.   EMBO REPORTS

Caspase cleavage of Atg4D stimulates GABARAP-L1 processing and triggers mitochondrial targeting and apoptosis

(2009) V. M. S. Betin et al.   JOURNAL OF CELL SCIENCE

Oncogenic Ras Signals through Activation of Both Phosphoinositide 3-Kinase and Rac1 to Induce c-Jun NH2-Terminal Kinase-Mediated, Caspase-Independent Cell Death

(2009) J.-Y. Byun et al.   MOLECULAR CANCER RESEARCH

Dynein light chain 1 is required for autophagy, protein clearance, and cell death in Drosophila

(2009) Y. Batlevi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of antibacterial autophagy by NADPH oxidases

(2009) J. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The autophagic machinery is necessary for removal of cell corpses from the developing retinal neuroepithelium

(2008) M A Mellén et al.   CELL DEATH AND DIFFERENTIATION

Autophagosome-Independent Essential Function for the Autophagy Protein Atg5 in Cellular Immunity to Intracellular Pathogens

(2008) Zijiang Zhao et al.   Cell Host & Microbe

Warts Is Required for PI3K-Regulated Growth Arrest, Autophagy, and Autophagic Cell Death in Drosophila

(2008) Sudeshna Dutta et al.   CURRENT BIOLOGY

Toll-like receptor signaling in the lysosomal pathways

(2008) Miguel A. Sanjuan et al.   IMMUNOLOGICAL REVIEWS

Effector caspase Dcp-1 and IAP protein Bruce regulate starvation-induced autophagy duringDrosophila melanogasteroogenesis

(2008) Ying-Chen Claire Hou et al.   JOURNAL OF CELL BIOLOGY

TM9SF4 is required for Drosophila cellular immunity via cell adhesion and phagocytosis

(2008) E. Bergeret et al.   JOURNAL OF CELL SCIENCE

Autophagic cell death: the story of a misnomer

(2008) Guido Kroemer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Autophagic Death of Adult Hippocampal Neural Stem Cells Following Insulin Withdrawal

(2008) Seong-Woon Yu et al.   STEM CELLS