Article
Biochemistry & Molecular Biology
Deyu Zhang, Qiwei Jiang, Xiangwei Ge, Yanzhu Shi, Tianxing Ye, Yue Mi, Tian Xie, Qihong Li, Qinong Ye
Summary: The study revealed a critical role of RHOV in LUAD metastasis, suggesting it as a potential biomarker for patient prognosis and a therapeutic target.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Medicine, Research & Experimental
Yuliu Zhang, Jianping Du, Xiaofan Duan, Wei Peng, Lei Lv, Zhiyu Chen, Yumei Zhang
Summary: In this study, RIPK1 expression was found to significantly contribute to cisplatin-induced apoptosis in human ESCC cells. Reduced RIPK1 expression promoted cell proliferation, while overexpressed RIPK1 facilitated apoptosis. Mechanistic investigations revealed that inhibition of RIPK1 proliferation in ESCC cells was regulated through activation of the c-Jun NH2-terminal kinase signaling pathway, leading to mitochondrial damage, ATP depletion, and increased reactive oxygen species generation.
Article
Oncology
Jia Sun, Jin-Rui Hu, Chao-Feng Liu, Yuan Li, Wei Wang, Rong Fu, Min Guo, Hai-Long Wang, Min Pang
Summary: ANKRD49 accelerates invasion and metastasis of NSCLC cells through JNK-mediated transcription activation of c-Jun and ATF2, which regulates the expression of MMP-2/MMP-9.
Article
Biochemistry & Molecular Biology
Thomas Gabriel Mhone, Ming-Cheng Chen, Chia-Hua Kuo, Tzu-Ching Shih, Chung-Min Yeh, Tso-Fu Wang, Ray-Jade Chen, Yu-Chun Chang, Wei-Wen Kuo, Chih-Yang Huang
Summary: This study aimed to explore a tumor suppressive compound that can enhance the efficacy of Gefitinib treatment in lung cancer. Through in vitro and in vivo experiments, it was found that the combination of Daidzein and Gefitinib synergistically induced apoptosis and cell cycle arrest, effectively inhibiting lung cancer growth.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Chemistry, Medicinal
Haoshen Feng, Dan Zhang, Yan Yin, Jian Kang, Rui Zheng
Summary: This study aimed to explore the effects and mechanisms of salidroside on macrophage polarization induced by cigarette smoke (CS). The results showed that salidroside could alleviate pulmonary inflammation and M1 polarization of alveolar macrophages (AMs) induced by CS, and the mechanism might be related to the inhibition of the JNK/c-Jun signaling pathway.
PHYTOTHERAPY RESEARCH
(2023)
Article
Integrative & Complementary Medicine
Hongling Zhou, Tangjia Yang, Zibin Lu, Xuemei He, Jingyu Quan, Shanhong Liu, Yuyao Chen, Kangtai Wu, Huihui Cao, Junshan Liu, Linzhong Yu
Summary: The main bioactive compound in licorice, liquiritin (LQ), has significant anti-inflammatory effects against acute lung injury (ALI) induced by lipopolysaccharide (LPS). It inhibits the activation of the JNK/Nur77/c-Jun signaling pathway, suggesting that LQ may be a potential therapeutic candidate for ALI and inflammatory disorders.
Article
Biochemistry & Molecular Biology
Jun Yang, Juan Wang, Yu Zhang, Wenjing Huang, Shaoqing Zhang, Peihao Yin, Wenfu Tan
Summary: In colorectal cancer, PGE2-JNK can activate the Hh signaling pathway non-canonically. This study demonstrates that c-Jun prevents Gli2 protein from degradation by protease through phosphorylation by PGE2. Suppression of c-Jun decreases Gli2 expression and ubiquitination, and restricts PGE2-induced Hh activity and colorectal cancer cell proliferation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2023)
Article
Immunology
Chandrakanth Reddy Edamakanti, Vishwa Mohan, Puneet Opal
Summary: Using human SCA autopsy samples, researchers discovered inflammatory JNK-dependent c-Jun phosphorylation in Bergmann glia, and inhibiting the JNK pathway reduced Bergmann glia inflammation and improved the SCA1 phenotype both behaviorally and pathologically, suggesting a causal role for Bergmann glia inflammation in SCA1 and a potential therapeutic strategy.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Pharmacology & Pharmacy
Pei Xie, Li-Jun Yan, Hong-Ling Zhou, Hui-Hui Cao, Yuan-Ru Zheng, Zi-Bin Lu, Hua-Yi Yang, Jia-Mei Ma, Yu-Yao Chen, Chuying Huo, Chunyang Tian, Jun-Shan Liu, Lin-Zhong Yu
Summary: This study found that emodin protects against LPS-induced acute lung injury (ALI) by regulating the JNK/Nur77/c-Jun signaling pathway. The results of this study indicate the potential of emodin in the treatment of ALI.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Rajvir Singh, Ravinder K. Kaundal, Baoyin Zhao, Rihab Bouchareb, Djamel Lebeche
Summary: This study reveals the role of resistin in cardiac fibrosis, promoting fibroblast-to-myofibroblast differentiation through JAK/STAT3 and JNK/c-Jun pathways, independent of TGF beta 1. Resistin-null mice showed improvements in cardiac function and reduction in tissue fibrosis, indicating the potential stimulation of cardiac fibrosis by resistin.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Oncology
Milad Soleimani, Alexander Somma, Tamer Kaoud, Ria Goyal, Jorge Bustamante, Dennis C. Wylie, Nisha Holay, Agnieszka Looney, Uma Giri, Todd Triplett, Kevin Dalby, Jeanne Kowalski, S. Gail Eckhardt, Carla Van Den Berg
Summary: JNK-IN-8, a covalent JNK inhibitor, suppresses the growth of triple-negative breast cancer (TNBC) by activating TFEB/TFE3 and inducing lysosome biogenesis and autophagy via mTOR inhibition independently of JNK.
MOLECULAR CANCER THERAPEUTICS
(2022)
Article
Multidisciplinary Sciences
Jiao Luo, Xiujun Tan, Ling Ye, Chenglin Wang
Summary: The study reveals that the JNK signaling pathway plays a positive role in the formation of dental papilla cell polarity, as indicated by the up-regulation of polarity-related genes and rescue effects of RhoA Q63L mutant. JNK activation is linked to polarization, migration, and differentiation of dental papilla cells, highlighting its importance in tooth development.
Article
Pharmacology & Pharmacy
Fang Liu, Yan Liu, Qifeng Peng, Guodong Wang, Qing Tan, Zhongyue Ou, Qishan Xu, Chixiang Liu, Daming Zuo, Jianbo Zhao
Summary: This study revealed that creatinine is closely related to drug-induced liver injury and exacerbates APAP-induced hepatocyte death by promoting the production and activation of reactive oxygen species and c-Jun N-terminal kinase.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zhelong Nie, Xiaoli Xia, Yang Zhao, Sheng Zhang, Yanwei Zhang, Junhui Wang
Summary: The study demonstrated that IQ-1S significantly reduced mortality and lung inflammation in sepsis mice by inhibiting inflammatory cytokine levels and suppressing M1 macrophage polarization. Furthermore, IQ-1S effectively inhibited the activation of the JNK signaling pathway and reduced the phosphorylation level of JNK2 in sepsis mice, ultimately protecting the mice against LPS-induced sepsis.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Huihui Wang, Chuangyu Wen, Siyu Chen, Weiqian Li, Qiyuan Qin, Lu He, Fang Wang, Junxiong Chen, Weibiao Ye, Wende Li, Junsheng Peng, Xiangling Yang, Huanliang Liu
Summary: The study demonstrates that chaetocin induces apoptosis in CRC cells by causing ROS accumulation and activating the JNK/c-Jun pathway, while also down-regulating CD47 expression and enhancing macrophages phagocytosis of CRC cells. Additionally, chaetocin inhibits tumor growth in CRC xenograft models, suggesting its potential as a candidate for CRC chemotherapy.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Gastroenterology & Hepatology
Junya Arai, Tomonori Aoki, Yoku Hayakawa, Ryota Niikura, Rei Ishibashi, Nobumi Suzuki, Yosuke Tsuji, Atsuo Yamada, Tetsuo Ushiku, Mitsuhiro Fujishiro
Summary: The incidence of early-onset colorectal neoplasms is increasing, and the risk factors differ between early-onset and late-onset neoplasms. For young male patients, especially those with a family history of colorectal cancer, colonoscopy is recommended.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Gastroenterology & Hepatology
Akiko Eguchi, Motoh Iwasa, Hayato Nakagawa
Summary: Non-alcoholic fatty liver disease (NAFLD) and alcohol-associated liver disease (ALD) both involve lipid deposition in hepatocytes, with NAFLD occurring without excessive alcohol consumption and ALD occurring with excessive alcohol consumption. These conditions range from simple steatosis to more severe forms of liver disease. The term metabolic associated fatty liver disease (MAFLD) has been proposed to better reflect the risk factors and progression of the disease. Extracellular vesicles (EVs) released by cells contain cellular cargo and can serve as biomarkers for identifying the degree and type of liver disease. Mesenchymal stem cell (MSC)-derived EVs (MSC-EVs) have shown promise in regulating the immune response and are being investigated as a treatment for liver disease.
LIVER INTERNATIONAL
(2023)
Article
Oncology
Yuta Sekino, Ryosuke Tateishi, Nobuyoshi Fukumitsu, Toshiyuki Okumura, Kazushi Maruo, Takashi Iizumi, Haruko Numajiri, Masashi Mizumoto, Tatsuya Minami, Ryo Nakagomi, Masaya Sato, Yoshinari Asaoka, Hayato Nakagawa, Yuki Hayata, Naoto Fujiwara, Shuichiro Shiina, Kazuhiko Koike, Hideyuki Sakurai
Summary: This study compared the survival outcomes of proton beam therapy (PBT) with radiofrequency ablation (RFA) in treatment-naive solitary hepatocellular carcinoma (HCC). The results showed that after propensity score matching, there was no significant difference in recurrence-free survival (RFS) and overall survival (OS) between PBT and RFA. PBT can be considered as an alternative treatment for patients with solitary treatment-naive HCC.
Article
Gastroenterology & Hepatology
Yasuhiko Hamada, Kyosuke Tanaka, Katsumi Mukai, Youichirou Baba, Makoto Kobayashi, Shintaro Tominaga, Hiroyuki Kawabata, Shoma Sawai, Masabumi Kaneko, Shinya Sugimoto, Hidekazu Inoue, Maya Mimuro, Satoshi Tamaru, Hayato Nakagawa
Summary: For patients with rectal neuroendocrine tumors (NETs) < 15 mm without risk factors for metastasis, local resection, including endoscopic resection, is recommended, although the short- and long-term outcomes are unclear.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Editorial Material
Gastroenterology & Hepatology
Kyosuke Tanaka, Hirofumi Okuda, Yuhei Umeda, Tsuyoshi Beppu, Misaki Nakamura, Yasuhiko Hamada, Hayato Nakagawa
Editorial Material
Gastroenterology & Hepatology
Shoma Sawai, Kyosuke Tanaka, Tsuyoshi Beppu, Yuhei Umeda, Misaki Nakamura, Yasuhiko Hamada, Hayato Nakagawa
Article
Gastroenterology & Hepatology
Issei Saeki, Yutaka Suehiro, Yurika Yamauchi, Tomomi Hoshida, Norikazu Tanabe, Takashi Oono, Daiki Kawamoto, Tatsuro Nishimura, Toshihiko Matsumoto, Tsuyoshi Ishikawa, Mototsugu Shimokawa, Akihiro Tamori, Norifumi Kawada, Yasuyuki Tamai, Motoh Iwasa, Hayato Nakagawa, Hiroaki Nagano, Taro Takami, Takahiro Yamasaki
Summary: The potential of methylated SEPT9 gene as a biomarker for the treatment efficacy of molecular targeted agents (MTAs) in hepatocellular carcinoma (HCC) was investigated. The study analyzed 157 patients receiving sorafenib or lenvatinib as a first-line therapy and found that AFP level, methylated SEPT9 (m-SEPT9) level, and Eastern Cooperative Oncology Group (ECOG) performance status were significant predictors of overall survival (OS) in HCC patients. A predictive score called the MTA score was developed based on these predictors, and it showed that patients with MTA scores >= 2 had a significantly poor prognosis compared to those with MTA scores >= 1.
HEPATOLOGY INTERNATIONAL
(2023)
Article
Gastroenterology & Hepatology
Taijiro Wake, Ryosuke Tateishi, Makoto Moriyama, Tsuyoshi Fukumoto, Tomoharu Yamada, Ryo Nakagomi, Takuma Nakatsuka, Masaya Sato, Tatsuya Minami, Koji Uchino, Hayato Nakagawa, Shuichiro Shiina, Kazuhiko Koike, Mitsuhiro Fujishiro
Summary: The aim of this study was to evaluate the effects of steroids on ischemic complications after radiofrequency ablation. A total of 58 patients with ischemic complications were divided into two groups according to corticosteroid use or non-use. The results showed that patients who were administered steroids had a shorter duration of fever than those who were not administered steroids, and steroid administration was associated with a reduction in the duration of fever.
HEPATOLOGY RESEARCH
(2023)
Article
Medicine, General & Internal
Ryosuke Sugimoto, Motoh Iwasa, Akiko Eguchi, Yasuyuki Tamai, Ryuta Shigefuku, Naoto Fujiwara, Hideaki Tanaka, Yoshinao Kobayashi, Jiro Ikoma, Masahiko Kaito, Hayato Nakagawa
Summary: This study retrospectively evaluated the efficacy of Pemafibrate in patients with non-alcoholic fatty liver disease (NAFLD). The results showed that Pemafibrate significantly improved liver function, serum lipid levels, and liver stiffness in NAFLD patients. This suggests that Pemafibrate may be a promising therapeutic agent for NAFLD patients.
FRONTIERS IN MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Reiko Yamada, Junya Tsuboi, Yumi Murashima, Takamitsu Tanaka, Kenji Nose, Hayato Nakagawa
Summary: Pancreatic cancer is often diagnosed at late stages, making treatment difficult. Early diagnosis is crucial, but it can be challenging due to nonspecific symptoms. Recent studies suggest that selective screening and biomarkers can improve early detection. This review discusses advancements in imaging, biomarkers, biopsies, surveillance, and machine learning for identifying high-risk individuals. These new methods and techniques have the potential to improve overall survival in pancreatic cancer patients.
Article
Gastroenterology & Hepatology
Masaya Sato, Makoto Moriyama, Tsuyoshi Fukumoto, Tomoharu Yamada, Taijiro Wake, Ryo Nakagomi, Takuma Nakatsuka, Tatsuya Minami, Koji Uchino, Kenichiro Enooku, Hayato Nakagawa, Shuichiro Shiina, Kazuhiko Koike, Mitsuhiro Fujishiro, Ryosuke Tateishi
Summary: This study developed a transformer model to predict overall survival in HCC patients treated with RFA and compared its performance with a deep learning model. The transformer-based model showed better discrimination performance and the ability to stratify patients into different risk groups. It also provided personalized cumulative recurrence prediction for each patient.
HEPATOLOGY INTERNATIONAL
(2023)
Article
Gastroenterology & Hepatology
Takuma Nakatsuka, Hayato Nakagawa, Koji Uchino, Hirofumi Rokutan, Mariko Tanaka, Makoto Moriyama, Tsuyoshi Fukumoto, Tomoharu Yamada, Taijiro Wake, Ryo Nakagomi, Masaya Sato, Tatsuya Minami, Yotaro Kudo, Tetsuo Ushiku, Mitsuhiro Fujishiro, Ryosuke Tateishi
Summary: Biopsy of liver tumor after radiofrequency ablation (RFA) can reduce the risk of neoplastic seeding and provide tumor samples for gene mutation analysis and pathological assessment.
HEPATOLOGY RESEARCH
(2023)
Review
Oncology
Yasuyuki Tamai, Naoto Fujiwara, Takamitsu Tanaka, Shugo Mizuno, Hayato Nakagawa
Summary: Hepatocellular carcinoma is the fourth leading cause of cancer-related deaths worldwide. Immune checkpoint inhibitors have improved the therapeutic efficacy for advanced HCC, but their response rates are still unsatisfactory. Researchers are actively exploring combination therapies of ICIs with locoregional therapy to overcome this limitation.
Article
Gastroenterology & Hepatology
Tomoharu Yamada, Naoto Fujiwara, Naoto Kubota, Yuki Matsushita, Takuma Nakatsuka, Shigeyuki Kurosaki, Tatsuya Minami, Ryosuke Tateishi, Akihiko Ichida, Junichi Arita, Kiyoshi Hasegawa, Kazuhiko Koike, Mitsuhiro Fujishiro, Hayato Nakagawa
Summary: The combination therapy of Lenvatinib and immune checkpoint inhibitors (ICIs) did not show synergy in treating unresectable HCC, as revealed by a phase III clinical trial. It was found that Lenvatinib induced the "excluded condition" in HCC, which reduced the efficacy of ICIs.
HEPATOLOGY COMMUNICATIONS
(2023)
Article
Gastroenterology & Hepatology
Hirono Owa, Kazushi Sugimoto, Masahiko Tameda, Suguru Ogura, Masashi Kishiwada, Hiroto Yuasa, Yuji Kozuka, Hayato Nakagawa
Summary: We report a case of steatohepatitis that occurred after pancreaticoduodenectomy (PD) and led to decompensated liver cirrhosis and hepatocellular carcinoma (HCC). Our findings indicate that progression to liver cirrhosis and HCC may become a severe problem in long-term post-PD survival, highlighting the need for further research on the mechanism of steatohepatitis after PD and the development of appropriate therapeutic strategies.
CLINICAL JOURNAL OF GASTROENTEROLOGY
(2023)
