Neuronal Activity and Its Role in Controlling Antioxidant Genes

The mitochondrial calcium uniporter is crucial for the generation of fast cortical network rhythms

(2019) Carlos Bas-Orth et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Adaptive regulation of the brain’s antioxidant defences by neurons and astrocytes

(2016) Paul S. Baxter et al.   FREE RADICAL BIOLOGY AND MEDICINE

Evidence for evolutionary divergence of activity-dependent gene expression in developing neurons

(2016) Jing Qiu et al.   eLife

Selective dendritic susceptibility to bioenergetic, excitotoxic and redox perturbations in cortical neurons

(2015) Philip Hasel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Astrocyte NMDA receptors' activity sustains neuronal survival through a Cdk5–Nrf2 pathway

(2015) D Jimenez-Blasco et al.   CELL DEATH AND DIFFERENTIATION

Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease

(2015) Lauren E. Tebay et al.   FREE RADICAL BIOLOGY AND MEDICINE

Synaptic NMDA receptor activity is coupled to the transcriptional control of the glutathione system

(2015) Paul S. Baxter et al.   Nature Communications

Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2

(2015) Karen F.S. Bell et al.   Nature Communications

Maturation of AMPAR Composition and the GABAAR Reversal Potential in hPSC-Derived Cortical Neurons

(2014) M. R. Livesey et al.   JOURNAL OF NEUROSCIENCE

Glutathione Transferase-M2-2 Secreted from Glioblastoma Cell Protects SH-SY5Y Cells from Aminochrome Neurotoxicity

(2014) Carlos Cuevas et al.   NEUROTOXICITY RESEARCH

Physiological Normoxia and Absence of EGF Is Required for the Long-Term Propagation of Anterior Neural Precursors from Human Pluripotent Cells

(2014) Bilada Bilican et al.   PLoS One

Nrf2 target genes can be controlled by neuronal activity in the absence of Nrf2 and astrocytes

(2014) R. F. Deighton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Nrf2 regulatory network provides an interface between redox and intermediary metabolism

(2014) John D. Hayes et al.   TRENDS IN BIOCHEMICAL SCIENCES

Role of Nrf2 in Oxidative Stress and Toxicity

(2013) Qiang Ma   Annual Review of Pharmacology and Toxicology

Phosphoinositide 3-Kinases Upregulate System xc− via Eukaryotic Initiation Factor 2α and Activating Transcription Factor 4 – A Pathway Active in Glioblastomas and Epilepsy

(2013) Jan Lewerenz et al.   ANTIOXIDANTS & REDOX SIGNALING

The control of brain mitochondrial energization by cytosolic calcium: The mitochondrial gas pedal

(2013) Frank Norbert Gellerich et al.   IUBMB LIFE

Calcium Entry and  -Synuclein Inclusions Elevate Dendritic Mitochondrial Oxidant Stress in Dopaminergic Neurons

(2013) D. I. Dryanovski et al.   JOURNAL OF NEUROSCIENCE

Calcium-Regulation of Mitochondrial Respiration Maintains ATP Homeostasis and Requires ARALAR/AGC1-Malate Aspartate Shuttle in Intact Cortical Neurons

(2013) I. Llorente-Folch et al.   JOURNAL OF NEUROSCIENCE

NMDA receptor-dependent glutamate excitotoxicity in human embryonic stem cell-derived neurons

(2013) Kunal Gupta et al.   NEUROSCIENCE LETTERS

Antioxidant and bioenergetic coupling between neurons and astrocytes

(2012) Seila Fernandez-Fernandez et al.   BIOCHEMICAL JOURNAL

Role of Mitochondrial Ca2+ in the Regulation of Cellular Energetics

(2012) Brian Glancy et al.   BIOCHEMISTRY

PGC-1  Negatively Regulates Extrasynaptic NMDAR Activity and Excitotoxicity

(2012) C. Puddifoot et al.   JOURNAL OF NEUROSCIENCE

Oxidative Phosphorylation, Not Glycolysis, Powers Presynaptic and Postsynaptic Mechanisms Underlying Brain Information Processing

(2012) C. N. Hall et al.   JOURNAL OF NEUROSCIENCE

Excitotoxicity Downregulates TrkB.FL Signaling and Upregulates the Neuroprotective Truncated TrkB Receptors in Cultured Hippocampal and Striatal Neurons

(2012) J. R. Gomes et al.   JOURNAL OF NEUROSCIENCE

Synaptic Energy Use and Supply

(2012) Julia J. Harris et al.   NEURON

Human embryonic stem cell derived astrocytes mediate non-cell-autonomous neuroprotection through endogenous and drug-induced mechanisms

(2011) K Gupta et al.   CELL DEATH AND DIFFERENTIATION

The influence of synaptic activity on neuronal health

(2011) Karen FS Bell et al.   CURRENT OPINION IN NEUROBIOLOGY

Pituitary adenylate cyclase-activating peptide induces long-lasting neuroprotection through the induction of activity-dependent signaling via the cyclic AMP response element-binding protein-regulated transcription co-activator 1

(2011) Paul S. Baxter et al.   JOURNAL OF NEUROCHEMISTRY

Activation of Nrf2-Regulated Glutathione Pathway Genes by Ischemic Preconditioning

(2011) Karen F. S. Bell et al.   Oxidative Medicine and Cellular Longevity

Homeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function

(2011) G. Turrigiano   Cold Spring Harbor Perspectives in Biology

Cancer Chemoprevention Mechanisms Mediated Through the Keap1–Nrf2 Pathway

(2010) John D. Hayes et al.   ANTIOXIDANTS & REDOX SIGNALING

Neuronal Activity Controls the Antagonistic Balance Between Peroxisome Proliferator-Activated Receptor-γ Coactivator-1α and Silencing Mediator of Retinoic Acid and Thyroid Hormone Receptors in Regulating Antioxidant Defenses

(2010) Francesc X. Soriano et al.   ANTIOXIDANTS & REDOX SIGNALING

Control of Redox State and Redox Signaling by Neural Antioxidant Systems

(2010) Jan Lewerenz et al.   ANTIOXIDANTS & REDOX SIGNALING

CNS Peroxiredoxins and Their Regulation in Health and Disease

(2010) Karen F.S. Bell et al.   ANTIOXIDANTS & REDOX SIGNALING

Regulation of Neuronal Oxidative and Nitrosative Stress by Endogenous Protective Pathways and Disease Processes

(2010) Giles E. Hardingham et al.   ANTIOXIDANTS & REDOX SIGNALING

Synaptic NMDAR activity suppresses FOXO1 expression via a cis-acting FOXO binding site: FOXO1 is a FOXO target gene

(2010) Bashayer Mubarak et al.   Channels

Quantal Analysis Reveals a Functional Correlation between Presynaptic and Postsynaptic Efficacy in Excitatory Connections from Rat Neocortex

(2010) N. R. Hardingham et al.   JOURNAL OF NEUROSCIENCE

Mild oxidative stress activates Nrf2 in astrocytes, which contributes to neuroprotective ischemic preconditioning

(2010) K. F. Bell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals

(2010) M. McMahon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nrf2-dependent upregulation of antioxidative enzymes: a novel pathway for proteasome inhibitor-mediated cardioprotection

(2009) H. Dreger et al.   CARDIOVASCULAR RESEARCH

The Nrf2–ARE cytoprotective pathway in astrocytes

(2009) Marcelo R. Vargas et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Transcriptional regulation of the AP-1 and Nrf2 target gene sulfiredoxin

(2009) Francesc X. Soriano et al.   MOLECULES AND CELLS

NADPH oxidase is the primary source of superoxide induced by NMDA receptor activation

(2009) Angela M Brennan et al.   NATURE NEUROSCIENCE

Transcription factor Nrf2 mediates an adaptive response to sulforaphane that protects fibroblasts in vitro against the cytotoxic effects of electrophiles, peroxides and redox-cycling agents

(2009) Larry G. Higgins et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Mitochondrial generation of free radicals and hypoxic signaling

(2009) Robert O. Poyton et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Nuclear Calcium Signaling Controls Expression of a Large Gene Pool: Identification of a Gene Program for Acquired Neuroprotection Induced by Synaptic Activity

(2009) Sheng-Jia Zhang et al.   PLoS Genetics

Antioxidants and Phase 2 Enzymes in Macrophages: Regulation by Nrf2 Signaling and Protection Against Oxidative and Electrophilic Stress

(2008) Hong Zhu et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Nrf2 Activation in Astrocytes Protects against Neurodegeneration in Mouse Models of Familial Amyotrophic Lateral Sclerosis

(2008) M. R. Vargas et al.   JOURNAL OF NEUROSCIENCE

Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses

(2008) Sofia Papadia et al.   NATURE NEUROSCIENCE

Hypoxic/ischemic conditions induce expression of the putative pro-death gene Clca1 via activation of extrasynaptic N-methyl-d-aspartate receptors

(2008) A.-S. Wahl et al.   NEUROSCIENCE