标题
Targeting ERK-Hippo Interplay in Cancer Therapy
作者
关键词
-
出版物
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 21, Issue 9, Pages 3236
出版商
MDPI AG
发表日期
2020-05-05
DOI
10.3390/ijms21093236
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Nebulin: big protein with big responsibilities
- (2020) Michaela Yuen et al. JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY
- Gossypol inhibits cullin neddylation by targeting SAG-CUL5 and RBX1-CUL1 complexes
- (2020) Qing Yu et al. NEOPLASIA
- The MEK-ERK-MST1 Axis Potentiates the Activation of the Extrinsic Apoptotic Pathway during GDC-0941 Treatment in Jurkat T Cells
- (2019) Jana Nováková et al. Cells
- Targeting Alterations in the RAF–MEK Pathway
- (2019) Rona Yaeger et al. Cancer Discovery
- β-Thujaplicin induces autophagic cell death, apoptosis, and cell cycle arrest through ROS-mediated Akt and p38/ERK MAPK signaling in human hepatocellular carcinoma
- (2019) Guangya Zhang et al. Cell Death & Disease
- Wnt1-inducible signaling protein 1 regulates laryngeal squamous cell carcinoma glycolysis and chemoresistance via the YAP1/TEAD1/GLUT1 pathway
- (2019) Liang Wang et al. JOURNAL OF CELLULAR PHYSIOLOGY
- EGF receptor and PKCδ kinase activate DNA damage–induced pro-survival and pro-apoptotic signaling via biphasic activation of ERK and MSK1 kinases
- (2019) Angela M. Ohm et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- FGFR4 phosphorylates MST1 to confer breast cancer cells resistance to MST1/2-dependent apoptosis
- (2019) S. Pauliina Turunen et al. CELL DEATH AND DIFFERENTIATION
- Targeted inhibition of the dual specificity phosphatases DUSP1 and DUSP6 suppress MPNST growth via JNK
- (2019) Annmarie Ramkissoon et al. CLINICAL CANCER RESEARCH
- Fisetin activates Hippo pathway and JNK/ERK/AP‐1 signaling to inhibit proliferation and induce apoptosis of human osteosarcoma cells via ZAK overexpression
- (2019) Chien‐Yao Fu et al. ENVIRONMENTAL TOXICOLOGY
- PTPN1 promotes the progression of glioma by activating the MAPK/ERK and PI3K/AKT pathways and is associated with poor patient survival
- (2019) Tao Jin et al. ONCOLOGY REPORTS
- Multi-targeted kinase inhibition alleviates mTOR inhibitor resistance in triple-negative breast cancer
- (2019) Jichao He et al. BREAST CANCER RESEARCH AND TREATMENT
- A gain-of-functional screen identifies the Hippo pathway as a central mediator of receptor tyrosine kinases during tumorigenesis
- (2019) Taha Azad et al. ONCOGENE
- MS-Based Approaches Enable the Structural Characterization of Transcription Factor/DNA Response Element Complex
- (2019) Slavata et al. Biomolecules
- YAP1 Mediates Resistance to MEK1/2 Inhibition in Neuroblastomas with Hyperactivated RAS Signaling
- (2019) Grace E. Coggins et al. CANCER RESEARCH
- Myelin-specific CD8+ T cells exacerbate brain inflammation in CNS autoimmunity
- (2019) Catriona A. Wagner et al. JOURNAL OF CLINICAL INVESTIGATION
- Insulin Signaling as a Key Moderator in Myotonic Dystrophy Type 1
- (2019) Sylvia Nieuwenhuis et al. Frontiers in Neurology
- ERK1 indicates good prognosis and inhibits breast cancer progression by suppressing YAP1 signaling
- (2019) Shiyi Yu et al. Aging-US
- YAP/TAZ Activation Drives Uveal Melanoma Initiation and Progression
- (2019) Huapeng Li et al. Cell Reports
- Yes-Associated Protein 1 Plays Major Roles in Pancreatic Stellate Cell Activation and Fibroinflammatory Responses
- (2019) Cheng Hu et al. Frontiers in Physiology
- Notch1 regulates endothelial apoptosis via ERK pathway in chronic obstructive pulmonary disease
- (2018) Dandan Zong et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Hispidulin inhibits hepatocellular carcinoma growth and metastasis through AMPK and ERK signaling mediated activation of PPARγ
- (2018) Mei Han et al. BIOMEDICINE & PHARMACOTHERAPY
- A speculative outlook on embryonic aneuploidy: Can molecular pathways be involved?
- (2018) Olga Tšuiko et al. DEVELOPMENTAL BIOLOGY
- Disruption of MEK/ERK/c-Myc signaling radiosensitizes prostate cancer cells in vitro and in vivo
- (2018) Carmela Ciccarelli et al. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
- The mTOR Targets 4E-BP1/2 Restrain Tumor Growth and Promote Hypoxia Tolerance in PTEN-driven Prostate Cancer
- (2018) Mei Ding et al. MOLECULAR CANCER RESEARCH
- Dynamics and control of the ERK signaling pathway: Sensitivity, bistability, and oscillations
- (2018) Yaman Arkun et al. PLoS One
- Honokiol induces apoptosis and autophagy via the ROS/ERK1/2 signaling pathway in human osteosarcoma cells in vitro and in vivo
- (2018) Kangmao Huang et al. Cell Death & Disease
- EGFR-PI3K-PDK1 pathway regulates YAP signaling in hepatocellular carcinoma: the mechanism and its implications in targeted therapy
- (2018) Hongwei Xia et al. Cell Death & Disease
- A LATS biosensor screen identifies VEGFR as a regulator of the Hippo pathway in angiogenesis
- (2018) T. Azad et al. Nature Communications
- Targeting ERK, an Achilles' Heel of the MAPK pathway, in cancer therapy
- (2018) Feifei Liu et al. Acta Pharmaceutica Sinica B
- Translational and HIF-1α-Dependent Metabolic Reprogramming Underpin Metabolic Plasticity and Responses to Kinase Inhibitors and Biguanides
- (2018) Laura Hulea et al. Cell Metabolism
- Decursin inhibits the growth of HepG2 hepatocellular carcinoma cells via Hippo/YAP signaling pathway
- (2018) Jianchun Li et al. PHYTOTHERAPY RESEARCH
- CCL19 suppresses angiogenesis through promoting miR-206 and inhibiting Met/ERK/Elk-1/HIF-1α/VEGF-A pathway in colorectal cancer
- (2018) Zhuoqing Xu et al. Cell Death & Disease
- BH3 mimetics induce apoptosis independent of DRP-1 in melanoma
- (2018) Nabanita Mukherjee et al. Cell Death & Disease
- Novel 2-phenyloxypyrimidine derivative induces apoptosis and autophagy via inhibiting PI3K pathway and activating MAPK/ERK signaling in hepatocellular carcinoma cells
- (2018) Jing Wang et al. Scientific Reports
- The BioGRID interaction database: 2019 update
- (2018) Rose Oughtred et al. NUCLEIC ACIDS RESEARCH
- Hyperactivation of ERK by multiple mechanisms is toxic to RTK-RAS mutation-driven lung adenocarcinoma cells
- (2018) Arun M Unni et al. eLife
- Cucurbitacin B Inhibits the Hippo-YAP Signaling Pathway and Exerts Anticancer Activity in Colorectal Cancer Cells
- (2018) Yanting Chai et al. MEDICAL SCIENCE MONITOR
- Effect of the BH3 Mimetic Polyphenol (–)-Gossypol (AT-101) on the in vitro and in vivo Growth of Malignant Mesothelioma
- (2018) Monica Benvenuto et al. Frontiers in Pharmacology
- PHD3 is a transcriptional coactivator of HIF-1α in nucleus pulposus cells independent of the PKM2-JMJD5 axis
- (2017) Zachary R. Schoepflin et al. FASEB JOURNAL
- Identification of ACA-28, a 1′-acetoxychavicol acetate analogue compound, as a novel modulator of ERK MAPK signaling, which preferentially kills human melanoma cells
- (2017) Ryosuke Satoh et al. GENES TO CELLS
- Platelet-derived growth factor regulates YAP transcriptional activity via Src family kinase dependent tyrosine phosphorylation
- (2017) Rory L. Smoot et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Pan-mTOR inhibitor MLN0128 is effective against intrahepatic cholangiocarcinoma in mice
- (2017) Shanshan Zhang et al. JOURNAL OF HEPATOLOGY
- Autocrine parathyroid hormone-like hormone promotes intrahepatic cholangiocarcinoma cell proliferation via increased ERK/JNK-ATF2-cyclinD1 signaling
- (2017) Jing Tang et al. Journal of Translational Medicine
- Regulation of glucose uptake in lymphoma cell lines by c-MYC- and PI3K-dependent signaling pathways and impact of glycolytic pathways on cell viability
- (2017) Martina Broecker-Preuss et al. Journal of Translational Medicine
- Anti-lung cancer effect of glucosamine by suppressing the phosphorylation of FOXO
- (2017) Zhanwu Yu et al. Molecular Medicine Reports
- Activation of tumor suppressor LKB1 by honokiol abrogates cancer stem-like phenotype in breast cancer via inhibition of oncogenic Stat3
- (2017) S Sengupta et al. ONCOGENE
- MAPK and Hippo signaling pathways crosstalk via the RAF-1/MST-2 interaction in malignant melanoma
- (2017) Ruizheng Feng et al. ONCOLOGY REPORTS
- Reprogramming of leukemic cell metabolism through the naphthoquinonic compound Quambalarine B
- (2017) Karel Vališ et al. Oncotarget
- The N-terminal tail coordinates with carbohydrate recognition domain to mediate galectin-3 induced apoptosis in T cells
- (2017) Huiting Xue et al. Oncotarget
- Restoration of the prolyl-hydroxylase domain protein-3 oxygen-sensing mechanism is responsible for regulation of HIF2α expression and induction of sensitivity of myeloma cells to hypoxia-mediated apoptosis
- (2017) Gilberto Gastelum et al. PLoS One
- Human histone deacetylase 6 shows strong preference for tubulin dimers over assembled microtubules
- (2017) Lubica Skultetyova et al. Scientific Reports
- YAP/TAZ at the Roots of Cancer
- (2016) Francesca Zanconato et al. CANCER CELL
- Long-Term ERK Inhibition in KRAS-Mutant Pancreatic Cancer Is Associated with MYC Degradation and Senescence-like Growth Suppression
- (2016) Tikvah K. Hayes et al. CANCER CELL
- Action mechanisms of histone deacetylase inhibitors in the treatment of hematological malignancies
- (2016) Yoichi Imai et al. CANCER SCIENCE
- Sustained ERK activation-mediated proliferation inhibition of farrerol on human gastric carcinoma cell line by G0/G1-phase cell-cycle arrest
- (2016) Enli Liu et al. EUROPEAN JOURNAL OF CANCER PREVENTION
- Shikonin regulates C-MYC and GLUT1 expression through the MST1-YAP1-TEAD1 axis
- (2016) Karel Vališ et al. EXPERIMENTAL CELL RESEARCH
- Cell cycle arrest caused by MEK/ERK signaling is a mechanism for suppressing growth of antigen-hyperstimulated effector T cells
- (2016) Shizuka Ohtsuka et al. INTERNATIONAL IMMUNOLOGY
- The complexities and versatility of the RAS-to-ERK signalling system in normal and cancer cells
- (2016) Dirk Fey et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- New insights into posttranslational modifications of Hippo pathway in carcinogenesis and therapeutics
- (2016) Mingjing He et al. Cell Division
- Suppression of B-Raf(V600E) cancers by MAPK hyper-activation
- (2016) Rawan Atiq et al. Oncotarget
- Antitumor activity of curcumin is involved in down-regulation of YAP/TAZ expression in pancreatic cancer cells
- (2016) Xiuxia Zhou et al. Oncotarget
- Effects of RAF inhibitors on PI3K/AKT signalling depend on mutational status of the RAS/RAF signalling axis
- (2016) Raphaela Fritsche-Guenther et al. Oncotarget
- Unveiling Hidden Dynamics of Hippo Signalling: A Systems Analysis
- (2016) Sung-Young Shin et al. Genes
- Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging
- (2016) Linda S. Steelman et al. Aging-US
- Crosstalk Between MAPK/ERK and PI3K/AKT Signal Pathways During Brain Ischemia/Reperfusion
- (2015) Jing Zhou et al. ASN Neuro
- Active ERK2 is sufficient to mediate growth arrest and differentiation signaling
- (2015) Pui-Kei Wu et al. FEBS Journal
- The Steroid Hormone 20-Hydroxyecdysone Up-regulates Ste-20 Family Serine/Threonine KinaseHippoto Induce Programmed Cell Death
- (2015) Du-Juan Dong et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Adhesion to fibronectin regulates Hippo signaling via the FAK–Src–PI3K pathway
- (2015) Nam-Gyun Kim et al. JOURNAL OF CELL BIOLOGY
- Discovery of 1-(3,3-Dimethylbutyl)-3-(2-fluoro-4-methyl-5-(7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl)phenyl)urea (LY3009120) as a Pan-RAF Inhibitor with Minimal Paradoxical Activation and Activity against BRAF or RAS Mutant Tumor Cells
- (2015) James R. Henry et al. JOURNAL OF MEDICINAL CHEMISTRY
- Lithium chloride antileukemic activity in acute promyelocytic leukemia is GSK-3 and MEK/ERK dependent
- (2015) F Zassadowski et al. LEUKEMIA
- Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth
- (2015) Francesca Zanconato et al. NATURE CELL BIOLOGY
- Clinical Acquired Resistance to RAF Inhibitor Combinations in BRAF-Mutant Colorectal Cancer through MAPK Pathway Alterations
- (2015) L. G. Ahronian et al. Cancer Discovery
- Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Inhibitors: Rationale and Importance to Inhibiting These Pathways in Human Health
- (2015) William H. Chappell et al. Oncotarget
- Regulation of YAP by mTOR and autophagy reveals a therapeutic target of tuberous sclerosis complex
- (2014) Ning Liang et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Mst1 Promotes Cardiac Myocyte Apoptosis through Phosphorylation and Inhibition of Bcl-xL
- (2014) Dominic P. Del Re et al. MOLECULAR CELL
- CUL9 Mediates the Functions of the 3M Complex and Ubiquitylates Survivin to Maintain Genome Integrity
- (2014) Zhijun Li et al. MOLECULAR CELL
- MST1 is a key regulator of beta cell apoptosis and dysfunction in diabetes
- (2014) Amin Ardestani et al. NATURE MEDICINE
- Effect of Proline Analogues on Activity of Human Prolyl Hydroxylase and the Regulation of HIF Signal Transduction Pathway
- (2014) Xiaoyan Ma et al. PLoS One
- The Synthetic Tryptanthrin Analogue Suppresses STAT3 Signaling and Induces Caspase Dependent Apoptosis via ERK Up Regulation in Human Leukemia HL-60 Cells
- (2014) Anup S. Pathania et al. PLoS One
- MST1 activation by curcumin mediates JNK activation, Foxo3a nuclear translocation and apoptosis in melanoma cells
- (2013) Teng Yu et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Resistance to BH3 mimetic S1 in SCLC cells that up-regulate and phosphorylate Bcl-2 through ERK1/2
- (2013) Yubo Liu et al. BRITISH JOURNAL OF PHARMACOLOGY
- Tumor suppressor activity of the ERK/MAPK pathway by promoting selective protein degradation
- (2013) X. Deschenes-Simard et al. GENES & DEVELOPMENT
- Bengalin initiates autophagic cell death through ERK–MAPK pathway following suppression of apoptosis in human leukemic U937 cells
- (2013) Shubho Das Gupta et al. LIFE SCIENCES
- A genetic screen identifies an LKB1–MARK signalling axis controlling the Hippo–YAP pathway
- (2013) Morvarid Mohseni et al. NATURE CELL BIOLOGY
- Ursolic Acid Simultaneously Targets Multiple Signaling Pathways to Suppress Proliferation and Induce Apoptosis in Colon Cancer Cells
- (2013) Jingshu Wang et al. PLoS One
- Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast cancer cell motility
- (2013) Z. Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Regulation of Hippo pathway by mitogenic growth factors via phosphoinositide 3-kinase and phosphoinositide-dependent kinase-1
- (2013) R. Fan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Discovery of Dabrafenib: A Selective Inhibitor of Raf Kinases with Antitumor Activity against B-Raf-Driven Tumors
- (2013) Tara R. Rheault et al. ACS Medicinal Chemistry Letters
- MYC on the Path to Cancer
- (2012) Chi V. Dang CELL
- Threonine-120 Phosphorylation Regulated by Phosphoinositide-3-Kinase/Akt and Mammalian Target of Rapamycin Pathway Signaling Limits the Antitumor Activity of Mammalian Sterile 20-Like Kinase 1
- (2012) Filiz Kisaayak Collak et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- 3,3'-Diindolylmethane suppresses growth of human esophageal squamous cancer cells by G1 cell cycle arrest
- (2012) Soo Kim ONCOLOGY REPORTS
- Hippo/Mst1 Stimulates Transcription of the Proapoptotic Mediator NOXA in a FoxO1-Dependent Manner
- (2011) K. Valis et al. CANCER RESEARCH
- Oncogenic Ras-Induced Expression of Noxa and Beclin-1 Promotes Autophagic Cell Death and Limits Clonogenic Survival
- (2011) Mohamed Elgendy et al. MOLECULAR CELL
- Prolyl Hydroxylase PHD3 Enhances the Hypoxic Survival and G1 to S Transition of Carcinoma Cells
- (2011) Heidi Högel et al. PLoS One
- PHD3 regulates differentiation, tumour growth and angiogenesis in pancreatic cancer
- (2010) Y Su et al. BRITISH JOURNAL OF CANCER
- An ERK-dependent pathway to Noxa expression regulates apoptosis by platinum-based chemotherapeutic drugs
- (2010) C Sheridan et al. ONCOGENE
- MEK–ERK-dependent multiple caspase activation by mitochondrial proapoptotic Bcl-2 family proteins is essential for heavy ion irradiation-induced glioma cell death
- (2010) A Tomiyama et al. Cell Death & Disease
- Mst1 and Mst2 Maintain Hepatocyte Quiescence and Suppress Hepatocellular Carcinoma Development through Inactivation of the Yap1 Oncogene
- (2009) Dawang Zhou et al. CANCER CELL
- Critical Role for Caspase-8 in Epidermal Growth Factor Signaling
- (2009) D. Finlay et al. CANCER RESEARCH
- ERK and cell death: Mechanisms of ERK-induced cell death - apoptosis, autophagy and senescence
- (2009) Sebastien Cagnol et al. FEBS Journal
- A Non-canonical MEK/ERK Signaling Pathway Regulates Autophagy via Regulating Beclin 1
- (2009) Jianrong Wang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- MAPK, Phosphatidylinositol 3-Kinase, and Mammalian Target of Rapamycin Pathways Converge at the Level of Ribosomal Protein S6 Phosphorylation to Control Metabolic Signaling in CD8 T Cells
- (2009) R. J. Salmond et al. JOURNAL OF IMMUNOLOGY
- Dislocation of HMG-CoA Reductase and Insig-1, Two Polytopic Endoplasmic Reticulum Proteins, En Route to Proteasomal Degradation
- (2009) Gil S. Leichner et al. MOLECULAR BIOLOGY OF THE CELL
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started