Article
Biology
Hueng-Chuen Fan, Fung-Wei Chang, Jeng-Dau Tsai, Kao-Min Lin, Chuan-Mu Chen, Shinn-Zong Lin, Ching-Ann Liu, Horng-Jyh Harn
Summary: Telomeres cap the ends of eukaryotic chromosomes and are essential for genome protection and replication. The maintenance of telomere length is regulated by various factors and dysfunctions in telomere maintenance and telomerase activation are associated with diseases, particularly cancer. Understanding the molecular mechanisms behind telomere length regulation and protection is crucial for future therapeutic opportunities.
Review
Biochemistry & Molecular Biology
Tsung-Jang Yeh, Chi-Wen Luo, Jeng-Shiun Du, Chien-Tzu Huang, Min-Hung Wang, Tzer-Ming Chuang, Yuh-Ching Gau, Shih-Feng Cho, Yi-Chang Liu, Hui-Hua Hsiao, Li-Tzong Chen, Mei-Ren Pan, Hui-Ching Wang, Sin-Hua Moi
Summary: Head and neck cancers (HNCs) are a major global malignancy. Telomerase reactivation through TERT promoter mutations has been linked to carcinogenesis. These mutations have high frequencies in HNCs and are associated with poor survival. Therapies targeting telomerase have been developed, but few have reached clinical trials. This review summarizes the current understanding and evidence of TERT promoter mutations in HNC patients.
Article
Oncology
Tongjian Zhao, Chang Zhao, Yuanhua Lu, Jian Lin, Yafei Tian, Yongjun Ma, Jialin Li, Hugang Zhang, Weiqun Yan, Ping Jiao, Jie Ma
Summary: Liver cancer is a common and deadly disease. The study found that Noxa and Puma proteins can suppress liver cancer by regulating cell proliferation, apoptosis, invasion, and metastasis. In vivo experiments showed that injecting Noxa and Puma genes effectively inhibited tumor growth and activated T lymphocytes to exert anti-tumor effects.
Review
Cell Biology
Ruozhu Yang, Yi Han, Xinyu Guan, Yue Hong, Jiahao Meng, Shirong Ding, Qian Long, Wenjun Yi
Summary: TERT is an essential enzyme responsible for telomere maintenance and genome stability. In breast cancer, the overactivation of hTERT plays a critical role in tumor initiation and progression. Understanding the mechanisms of hTERT activation in cancer could lead to improved understanding of the disease and the development of more effective treatment strategies.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Oncology
Theodore Vougiouklakis, Kelsey Zhu, Varshini Vasudevaraja, Jonathan Serrano, Guomiao Shen, Rebecca L. Linn, Xiaojun Feng, Sarah Chiang, Julieta E. Barroeta, Kristen M. Thomas, Lauren E. Schwartz, Pratibha S. Shukla, Anais Malpica, Esther Oliva, Paolo Cotzia, Deborah F. DeLair, Matija Snuderl, George Jour
Summary: This study is the largest comprehensive molecular study of juvenile granulosa cell tumors, revealing putative oncogenic drivers and TERT rearrangements, offering insights into possible targeted therapies for this rare entity.
CLINICAL CANCER RESEARCH
(2022)
Article
Oncology
Jianping Yang, Chunjun Li, Yong Tang, Fang Guo, Yu Chen, Wenqi Luo, Xiaoyu Chen, Yun Ma, Lixia Zeng
Summary: The markers MI and Ki-67 are important indicators of histopathology and cell proliferation, and can be easily measured with good reproducibility. These markers may play a meaningful role in assigning the pathological grade of UBC.
Article
Multidisciplinary Sciences
Gavin R. Oliver, Sofia Marcano-Bonilla, Jonathan Quist, Ezequiel J. Tolosa, Eriko Iguchi, Amy A. Swanson, Nicole L. Hoppman, Tanya Schwab, Ashley Sigafoos, Naresh Prodduturi, Jesse S. Voss, Shannon M. Knight, Jin Zhang, Numrah Fadra, Raul Urrutia, Michael Zimmerman, Jan B. Egan, Anthony G. Bilyeu, Jin Jen, Ema Veras, Rema'a Al-Safi, Matthew Block, Sarah Kerr, Martin E. Fernandez-Zapico, John K. Schoolmeester, Eric W. Klee
Summary: Gestational trophoblastic disease (GTD) is a group of lesions derived from placental tissue. Epithelioid trophoblastic tumor (ETT) is the rarest form of GTD and its molecular characterization is lacking. This study identified LPCAT1-TERT fusion transcripts in ETTs, which can positively modulate cell proliferation, potentially serving as future treatment targets. TERT upregulation, even in the absence of fusions, and its association with copy number gains of chromosome 5, appear to be characteristic of ETTs and may serve as novel markers for improving diagnosis and treatment outcomes.
Article
Genetics & Heredity
Paula Martinez, Raul Sanchez-Vazquez, Iole Ferrara-Romeo, Rosa Serrano, Juana M. Flores, Maria A. Blasco
Summary: By generating a mouse model for the human POT1(R117C) mutation, this study found that the mutation leads to longer telomeres and exerts dominant-negative effects at telomeres. Heterozygous mice with this mutation also develop angiosarcomas, including cardiac angiosarcomas. This research provides important insights into human cancers initiated by POT1 mutations.
Review
Biochemistry & Molecular Biology
Tsimur N. Hasanau, Eduard P. Pisarev, Olga V. Kisil, Maria E. Zvereva
Summary: The review discusses the role of telomeres and telomerase in tumor progression, as well as the different mechanisms of telomerase reverse transcriptase (TERT) activation in CNS tumors and other cancers. The main mechanism involves somatic mutations in the TERT gene promoter (TERTp). The article presents information on the structure of TERTp and the transcription factors that interact with it and regulate its transcription. The potential use of TERTp mutational status as a prognostic marker for CNS malignancies and other tumors with common TERTp mutations is also discussed.
BIOCHEMISTRY-MOSCOW
(2023)
Review
Oncology
Sara Gandini, Ines Zanna, Simone De Angelis, Domenico Palli, Sara Raimondi, Simone Ribero, Giovanna Masala, Mariano Suppa, Federica Bellerba, Federica Corso, Luigi Nezi, Eduardo Nagore, Saverio Caini
Summary: Somatic mutations of the TERT gene promoter are associated with worse overall survival in melanoma patients, especially in non-acral cutaneous melanomas. Limited evidence suggests a detrimental effect of TERT mutations on various survival measures.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Li Tao, Wei Zhang, Yaxin Zhang, Mei Zhang, Yueying Zhang, Xing Niu, Qing Zhao, Zhenxing Liu, Yuyin Li, Aipo Diao
Summary: The study showed that caffeine can promote the expression of TERT to extend telomere length and prevent cellular senescence. In animal studies, caffeine also reversed the decline in organ index and improved tissue structure in aging mice. These results suggest that caffeine-containing foods can delay cellular senescence and aging through the expression of TERT.
Article
Multidisciplinary Sciences
Walaa R. Seif Eldin, Entsar A. Saad, Ahmed Monier, Rami M. Elshazli
Summary: This study evaluated the correlation between specific variants within the TERT gene and the risk of HCC using computational bioinformatics tools. The results showed a significant association between TERT (rs2736098*A and rs2736100*T) alleles and an increased risk of HCC progression and telomere shortening.
SCIENTIFIC REPORTS
(2023)
Article
Infectious Diseases
Mijael Rozenszajn, Solange Arazi-Caillaud, Moira Taicz, Rosa Bologna, Andrea Mangano, Paula C. Aulicino
Summary: Baseline genotyping for HIV-1 in vertically infected children is crucial for personalized medicine. Children with PDR require closer monitoring of their first-line ART regimens to prevent early virological failure and resistance accumulation.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Oncology
Chao Zhou, Jie Ma, Yuanhua Lu, Wan Zhao, Bingxue Xu, Jian Lin, Yongjun Ma, Yafei Tian, Qi Zhang, Wei Wang, Weiqun Yan, Ping Jiao
Summary: Esophageal squamous cell carcinoma is a major cause of cancer-related deaths, and melittin from bee venom has shown potential anti-cancer properties. A study constructed a recombinant plasmid containing human TERT promoter and melittin coding sequence, which induced apoptosis in esophageal carcinoma cells and inhibited tumor metastasis.
Article
Oncology
Julie Delyon, Anais Vallet, Melanie Bernard-Cacciarella, Isabelle Kuzniak, Coralie Reger de Moura, Baptiste Louveau, Fanelie Jouenne, Samia Mourah, Celeste Lebbe, Nicolas Dumaz
Summary: TERT promoter mutations are frequently found in melanoma and are associated with a poorer prognosis. Our data suggest that TERT mRNA level is a reliable marker for prognosis and is associated with resistance to targeted therapy in melanoma. We showed that TERT overexpression drives resistance to BRAF and MEK inhibitors, and inhibition of TERT can be a therapeutic option for melanoma with acquired resistance to BRAF inhibition.
Article
Gastroenterology & Hepatology
Jihyun An, Deokhoon Kim, Bora Oh, Yoo-Jin Oh, Jihyun Song, Naomi Park, Ha Il Kim, Hyo Jeong Kang, Ji-Hye Oh, Wonkyung Kim, Eunjung Lee, Chang Ohk Sung, Gi-Won Song, Dae-Ghon Kim, Eunsil Yu, Eric Letouze, Jessica Zucman-Rossi, Han Chu Lee, Ju Hyun Shim
Summary: This study identified the landscape and mechanisms of HBV integration in iCCA tumors, revealing recurrent viral integration breakpoints at multiple sites including TERT and FAT2, and oncogenic effects through intergenic insertions activating the mTOR pathway. The mutational profiles of HBV-iCCA were found to be more similar to nonviral conventional iCCA, rather than HBV-related liver cancers like HBV-HCC and HBV-cHCC/CCA.
Article
Gastroenterology & Hepatology
Maria Conticchio, Antonella Delvecchio, Francesca Ratti, Maximiliano Gelli, Ferdinando M. Anelli, Alexis Laurent, Giulio C. Vitali, Paolo Magistri, Giacomo Assirati, Emanuele Felli, Taiga Wakabayashi, Patrick Pessaux, Tullio Piardi, Fabrizio Di Benedetto, Nicola de'Angelis, Delgado F. Javier Briceno, Antonio G. Rampoldi, Rene Adam, Daniel Cherqui, Luca Aldrighetti, Riccardo Memeo
Summary: This study compared the effectiveness of LLR and RFA in elderly patients with single HCC smaller than 3 cm. The results showed that despite the longer length of hospital stay and operative time, LLR had a comparable postoperative course and better overall and disease-free survival in patients with HCC located in the anterolateral segments.
Article
Oncology
Cong Trung Nguyen, Stefano Caruso, Pascale Maille, Aurelie Beaufrere, Jeremy Augustin, Loetitia Favre, Anais Pujals, Camille Boulagnon-Rombi, Rami Rhaiem, Giuliana Amaddeo, Luca di Tommaso, Alain Luciani, Helene Regnault, Raffaele Brustia, Olivier Scatton, Frederic Charlotte, Isabelle Brocheriou, Daniele Sommacale, Patrick Soussan, Vincent Leroy, Alexis Laurent, Van Ky Le, Van To Ta, Hong Son Trinh, Thi Lan Tran, David Gentien, Audrey Rapinat, Jean Charles Nault, Manon Allaire, Sebastien Mule, Jessica Zucman-Rossi, Jean-Michel Pawlotsky, Christophe Tournigand, Fouad Lafdil, Valerie Paradis, Julien Calderaro
Summary: This study identified two immune subtypes of combined hepatocellular-cholangiocarcinoma (cHCC-CCA): an immune-high subtype characterized by higher densities of immune cells and activation of gene signatures related to immune response and immunotherapy in hepatocellular carcinoma (HCC), and an immune-low subtype. The immune-high subtype was associated with improved overall survival. These findings suggest that a subset of cHCC-CCA patients may benefit from immunomodulating therapeutic approaches.
CLINICAL CANCER RESEARCH
(2022)
Article
Gastroenterology & Hepatology
Aurelie Beaufrere, Stefano Caruso, Julien Calderaro, Nicolas Pote, Jean-Charles Bijot, Gabielle Couchy, Francois Cauchy, Valerie Vilgrain, Jessica Zucman-Rossi, Valerie Paradis
Summary: With the use of transcriptomic signature, we identified a 6-gene expression signature that is associated with microvascular invasion in hepatocellular carcinoma (HCC). This signature can be applied to routine tumor biopsies and is also associated with overall survival.
JOURNAL OF HEPATOLOGY
(2022)
Article
Oncology
Eric Trepo, Stefano Caruso, Jie Yang, Sandrine Imbeaud, Gabrielle Couchy, Quentin Bayard, Eric Letouze, Nathalie Ganne-Carrie, Christophe Moreno, Abderrahim Oussalah, Cyrille Feray, Jean Frederic Blanc, Bruno Clement, Patrick Hillon, Jerome Boursier, Valerie Paradis, Julien Calderaro, Viviane Gnemmi, Jean-Charles Nault, Jean-Louis Gueant, Jacques Deviere, Isabelle Archambeaud, Carole Vitellius, Bruno Turlin, Jean-Pierre Bronowicki, Thierry Gustot, Angela Sutton, Marianne Ziol, Pierre Nahon, Jessica Zucman-Rossi
Summary: This study identified genetic variants associated with alcohol-related hepatocellular carcinoma through a genome-wide association analysis. The researchers found that WNT3A-WNT9A is a susceptibility locus for alcohol-related hepatocellular carcinoma and discovered several other genetic variants associated with the risk of liver cancer.
Article
Gastroenterology & Hepatology
Alix Demory, Jean-Marie Peron, Julien Calderaro, Janick Selves, Fatima-Zohra Mokrane, Giuliana Amaddeo, Valerie Paradis, Marianne Ziol, Olivier Sutter, Lorraine Blaise, Nathalie Ganne-Carrie, Valerie Vilgrain, Francois Cauchy, Jessica Zucman-Rossi, Maxime Ronot, Jean-Charles Nault
Summary: This study aims to describe the natural history of hepatocellular adenomas (HCAs) and identify predictive factors for HCA evolution after discontinuation of estrogen-based contraception. The results show that weight variation is strongly associated with the radiological evolution of HCAs, and an estrogen exposure score can predict the regression of HCAs.
Article
Gastroenterology & Hepatology
Emanuele Felli, Emmanuel Boleslawski, Daniele Sommacale, Olivier Scatton, Raffaele Brustia, Lilian Schwarz, Daniel Cherqui, Thomas Zacharias, Alexis Laurent, Jean-Yves Mabrut, Catherine Schuster, Benoit Gallix, Patrick Pessaux
Summary: This study analyzed the role of preoperative 3D reconstruction models in selecting the surgical approach and modifying the established plan for hepatocellular carcinoma patients. The results showed that 3D imaging had a better prediction of the actual surgical procedure compared to conventional 2D imaging.
Meeting Abstract
Oncology
Jessica Zucman-Rossi
CLINICAL CANCER RESEARCH
(2022)
Meeting Abstract
Oncology
Jessica Zucman-Rossi
CLINICAL CANCER RESEARCH
(2022)
Meeting Abstract
Oncology
Jessica Zucman-Rossi
CLINICAL CANCER RESEARCH
(2022)
Meeting Abstract
Oncology
Jessica Zucman-Rossi
CLINICAL CANCER RESEARCH
(2022)
Meeting Abstract
Oncology
Jessica Zucman-Rossi
CLINICAL CANCER RESEARCH
(2022)
Meeting Abstract
Oncology
Jessica Zucman-Rossi
CLINICAL CANCER RESEARCH
(2022)
Meeting Abstract
Oncology
Jessica Zucman-Rossi
CLINICAL CANCER RESEARCH
(2022)
Meeting Abstract
Oncology
Jessica Zucman-Rossi
CLINICAL CANCER RESEARCH
(2022)
