Mitochondrial Interactome: A Focus on Antiviral Signaling Pathways

Mitochondria: the indispensable players in innate immunity and guardians of the inflammatory response

(2019) Abhishek Mohanty et al.   Journal of Cell Communication and Signaling

NLRP12 Regulates Anti-viral RIG-I Activation via Interaction with TRIM25

(2019) Szu-Ting Chen et al.   Cell Host & Microbe

LRRC59 modulates type I interferon signaling by restraining the SQSTM1/p62-mediated autophagic degradation of pattern recognition receptor DDX58/RIG-I

(2019) Huifang Xian et al.   Autophagy

The Immunobiology of the Interleukin-12 Family: Room for Discovery

(2019) Elia D. Tait Wojno et al.   IMMUNITY

Shared and Distinct Functions of Type I and Type III Interferons

(2019) Helen M. Lazear et al.   IMMUNITY

The Otubain YOD1 Suppresses Aggregation and Activation of the Signaling Adaptor MAVS through Lys63-Linked Deubiquitination

(2019) Chang Liu et al.   JOURNAL OF IMMUNOLOGY

Lactate Is a Natural Suppressor of RLR Signaling by Targeting MAVS

(2019) Weina Zhang et al.   CELL

RNF34 functions in immunity and selective mitophagy by targeting MAVS for autophagic degradation

(2019) Xiang He et al.   EMBO JOURNAL

DNA sensing by the cGAS–STING pathway in health and disease

(2019) Mona Motwani et al.   NATURE REVIEWS GENETICS

Phosphorylation of MAVS/VISA by Nemo-like kinase (NLK) for degradation regulates the antiviral innate immune response

(2019) Shang-Ze Li et al.   Nature Communications

Comparative Structure and Function Analysis of the RIG-I-Like Receptors: RIG-I and MDA5

(2019) Morgan Brisse et al.   Frontiers in Immunology

SNX8 modulates the innate immune response to RNA viruses by regulating the aggregation of VISA

(2019) Wei Guo et al.   Cellular & Molecular Immunology

MAVS O-GlcNAcylation Is Essential for Host Antiviral Immunity against Lethal RNA Viruses

(2019) Nan Song et al.   Cell Reports

Zika Virus NS3 Mimics a Cellular 14-3-3-Binding Motif to Antagonize RIG-I- and MDA5-Mediated Innate Immunity

(2019) William Riedl et al.   Cell Host & Microbe

Stimulation of Innate Immunity by Host and Viral RNAs

(2019) Felix Streicher et al.   TRENDS IN IMMUNOLOGY

RNA sensor LGP2 inhibits TRAF ubiquitin ligase to negatively regulate innate immune signaling

(2018) Jean‐Patrick Parisien et al.   EMBO REPORTS

TRIM29 Negatively Regulates the Type I IFN Production in Response to RNA Virus

(2018) Junji Xing et al.   JOURNAL OF IMMUNOLOGY

TRIM21 Promotes Innate Immune Response to RNA Viral Infection through Lys27-Linked Polyubiquitination of MAVS

(2018) Binbin Xue et al.   JOURNAL OF VIROLOGY

HAUS8 regulates RLR‑VISA antiviral signaling positively by targeting VISA

(2018) Tian‑Sheng He et al.   Molecular Medicine Reports

MLL5 suppresses antiviral innate immune response by facilitating STUB1-mediated RIG-I degradation

(2018) Peipei Zhou et al.   Nature Communications

Human cytomegalovirus-encoded US9 targets MAVS and STING signaling to evade type I interferon immune responses

(2018) Hyun jin Choi et al.   Nature Communications

Zika Virus Non-structural Protein 4A Blocks the RLR-MAVS Signaling

(2018) Jinzhu Ma et al.   Frontiers in Microbiology

Regulation of RIG-I Activation by K63-Linked Polyubiquitination

(2018) Masaaki Okamoto et al.   Frontiers in Immunology

Detection of Microbial Infections Through Innate Immune Sensing of Nucleic Acids

(2018) Xiaojun Tan et al.   Annual Review of Microbiology

Positive regulatory role of c-Src-mediated TRIM25 tyrosine phosphorylation on RIG-I ubiquitination and RIG-I-mediated antiviral signaling pathway

(2018) Na-Rae Lee et al.   CELLULAR IMMUNOLOGY

Negative regulation of MAVS-mediated antiviral signaling by the mitochondrial protein LRPPRC during HCV infection

(2018) Giulia Refolo et al.   HEPATOLOGY

FAF1 Regulates Antiviral Immunity by Inhibiting MAVS but Is Antagonized by Phosphorylation upon Viral Infection

(2018) Tong Dai et al.   Cell Host & Microbe

O-GlcNAc Transferase Links Glucose Metabolism to MAVS-Mediated Antiviral Innate Immunity

(2018) Tianliang Li et al.   Cell Host & Microbe

Induction of OTUD4 by viral infection promotes antiviral responses through deubiquitinating and stabilizing MAVS

(2018) Tianzi Liuyu et al.   CELL RESEARCH

Innate immunity to RNA virus is regulated by temporal and reversible sumoylation of RIG-I and MDA5

(2017) Ming-Ming Hu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Interferon-Stimulated Genes as Enhancers of Antiviral Innate Immune Signaling

(2017) Keaton M. Crosse et al.   Journal of Innate Immunity

NLRX1 Mediates MAVS Degradation To Attenuate the Hepatitis C Virus-Induced Innate Immune Response through PCBP2

(2017) Yuwen Qin et al.   JOURNAL OF VIROLOGY

Tetherin Suppresses Type I Interferon Signaling by Targeting MAVS for NDP52-Mediated Selective Autophagic Degradation in Human Cells

(2017) Shouheng Jin et al.   MOLECULAR CELL

Phosphorylation-Dependent Feedback Inhibition of RIG-I by DAPK1 Identified by Kinome-wide siRNA Screening

(2017) Joschka Willemsen et al.   MOLECULAR CELL

Assembly of the WHIP-TRIM14-PPP6C Mitochondrial Complex Promotes RIG-I-Mediated Antiviral Signaling

(2017) Peng Tan et al.   MOLECULAR CELL

Crosstalk between Cytoplasmic RIG-I and STING Sensing Pathways

(2017) Alessandra Zevini et al.   TRENDS IN IMMUNOLOGY

ARRDC4 regulates enterovirus 71-induced innate immune response by promoting K63 polyubiquitination of MDA5 through TRIM65

(2017) Jun Meng et al.   Cell Death & Disease

Multiple truncated isoforms of MAVS prevent its spontaneous aggregation in antiviral innate immune signalling

(2017) Nan Qi et al.   Nature Communications

Ube2D3 and Ube2N are essential for RIG-I-mediated MAVS aggregation in antiviral innate immunity

(2017) Yuheng Shi et al.   Nature Communications

The E3 Ubiquitin Ligase TRIM40 Attenuates Antiviral Immune Responses by Targeting MDA5 and RIG-I

(2017) Chunyuan Zhao et al.   Cell Reports

Systems-based analysis of RIG-I-dependent signalling identifies KHSRP as an inhibitor of RIG-I receptor activation

(2017) Stephen Soonthornvacharin et al.   Nature Microbiology

RLR-mediated antiviral innate immunity requires oxidative phosphorylation activity

(2017) Takuma Yoshizumi et al.   Scientific Reports

Autophagy regulates MAVS signaling activation in a phosphorylation-dependent manner in microglia

(2016) Jinbo Cheng et al.   CELL DEATH AND DIFFERENTIATION

HDAC6 regulates cellular viral RNA sensing by deacetylation of RIG-I

(2016) S. J. Choi et al.   EMBO JOURNAL

The cell biology of inflammasomes: Mechanisms of inflammasome activation and regulation

(2016) Deepika Sharma et al.   JOURNAL OF CELL BIOLOGY

TRIM65-catalized ubiquitination is essential for MDA5-mediated antiviral innate immunity

(2016) Xueting Lang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TAX1BP1 Restrains Virus-Induced Apoptosis by Facilitating Itch-Mediated Degradation of the Mitochondrial Adaptor MAVS

(2016) Young Bong Choi et al.   MOLECULAR AND CELLULAR BIOLOGY

HIV-1 blocks the signaling adaptor MAVS to evade antiviral host defense after sensing of abortive HIV-1 RNA by the host helicase DDX3

(2016) Sonja I Gringhuis et al.   NATURE IMMUNOLOGY

The ubiquitin E3 ligase TRIM31 promotes aggregation and activation of the signaling adaptor MAVS through Lys63-linked polyubiquitination

(2016) Bingyu Liu et al.   NATURE IMMUNOLOGY

RNF122 suppresses antiviral type I interferon production by targeting RIG-I CARDs to mediate RIG-I degradation

(2016) Wendie Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Syndecan-4 negatively regulates antiviral signalling by mediating RIG-I deubiquitination via CYLD

(2016) Wei Lin et al.   Nature Communications

Accessory Factors of Cytoplasmic Viral RNA Sensors Required for Antiviral Innate Immune Response

(2016) Hiroyuki Oshiumi et al.   Frontiers in Immunology

PPM1A silences cytosolic RNA sensing and antiviral defense through direct dephosphorylation of MAVS and TBK1

(2016) W. Xiang et al.   Science Advances

Regulation of Retinoic Acid Inducible Gene-I (RIG-I) Activation by the Histone Deacetylase 6

(2016) Helene Minyi Liu et al.   EBioMedicine

MAVS maintains mitochondrial homeostasis via autophagy

(2016) Xiaofeng Sun et al.   Cell Discovery

Innate Immune Pattern Recognition: A Cell Biological Perspective

(2015) Sky W. Brubaker et al.   Annual Review of Immunology

A Src-family-tyrosine kinase, Lyn, is required for efficient IFN-β expression in pattern recognition receptor, RIG-I, signal pathway by interacting with IPS-1

(2015) Young Ju Lim et al.   CYTOKINE

LGP2 synergy with MDA5 in RLR-mediated RNA recognition and antiviral signaling

(2015) Annie M. Bruns et al.   CYTOKINE

A non‐canonical role of the p97 complex in RIG‐I antiviral signaling

(2015) Qian Hao et al.   EMBO JOURNAL

pVHL Negatively Regulates Antiviral Signaling by Targeting MAVS for Proteasomal Degradation

(2015) Juan Du et al.   JOURNAL OF IMMUNOLOGY

Cytoplasmic STAT4 Promotes Antiviral Type I IFN Production by Blocking CHIP-Mediated Degradation of RIG-I

(2015) Kai Zhao et al.   JOURNAL OF IMMUNOLOGY

MAVS Coordination of Antiviral Innate Immunity

(2015) Christine Vazquez et al.   JOURNAL OF VIROLOGY

Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation

(2015) S. Liu et al.   SCIENCE

The mitochondrial ubiquitin ligase MARCH5 resolves MAVS aggregates during antiviral signalling

(2015) Young-Suk Yoo et al.   Nature Communications

RIOK3-Mediated Phosphorylation of MDA5 Interferes with Its Assembly and Attenuates the Innate Immune Response

(2015) Ken Takashima et al.   Cell Reports

Proteomic Analysis of Mitochondrial-Associated ER Membranes (MAM) during RNA Virus Infection Reveals Dynamic Changes in Protein and Organelle Trafficking

(2015) Stacy M. Horner et al.   PLoS One

A Bicistronic MAVS Transcript Highlights a Class of Truncated Variants in Antiviral Immunity

(2014) Sky W. Brubaker et al.   CELL

TAK1-ECSIT-TRAF6 Complex Plays a Key Role in the TLR4 Signal to Activate NF-κB

(2014) Sae Mi Wi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

USP21 negatively regulates antiviral response by acting as a RIG-I deubiquitinase

(2014) Yihui Fan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Smurf2 Negatively Modulates RIG-I-Dependent Antiviral Response by Targeting VISA/MAVS for Ubiquitination and Degradation

(2014) Y. Pan et al.   JOURNAL OF IMMUNOLOGY

TRIM13 Is a Negative Regulator of MDA5-Mediated Type I Interferon Production

(2014) K. Narayan et al.   JOURNAL OF VIROLOGY

Diverse intracellular pathogens activate type III interferon expression from peroxisomes

(2014) Charlotte Odendall et al.   NATURE IMMUNOLOGY

The Adaptor MAVS Promotes NLRP3 Mitochondrial Localization and Inflammasome Activation

(2013) Naeha Subramanian et al.   CELL

Induction of Siglec-G by RNA Viruses Inhibits the Innate Immune Response by Promoting RIG-I Degradation

(2013) Weilin Chen et al.   CELL

USP3 inhibits type I interferon signaling by deubiquitinating RIG-I-like receptors

(2013) Jun Cui et al.   CELL RESEARCH

Dephosphorylation of the RNA Sensors RIG-I and MDA5 by the Phosphatase PP1 Is Essential for Innate Immune Signaling

(2013) Effi Wies et al.   IMMUNITY

Regulation of Mitochondrial Antiviral Signaling (MAVS) Expression and Signaling by the Mitochondria-associated Endoplasmic Reticulum Membrane (MAM) Protein Gp78

(2013) Jana L. Jacobs et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

USP4 Positively Regulates RIG-I-Mediated Antiviral Response through Deubiquitination and Stabilization of RIG-I

(2013) L. Wang et al.   JOURNAL OF VIROLOGY

GEF-H1 controls microtubule-dependent sensing of nucleic acids for antiviral host defenses

(2013) Hao-Sen Chiang et al.   NATURE IMMUNOLOGY

TRIM14 is a mitochondrial adaptor that facilitates retinoic acid-inducible gene-I-like receptor-mediated innate immune response

(2013) Z. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

UBXN1 Interferes with Rig-I-like Receptor-Mediated Antiviral Immune Response by Targeting MAVS

(2013) Penghua Wang et al.   Cell Reports

COX5B Regulates MAVS-mediated Antiviral Signaling through Interaction with ATG5 and Repressing ROS Production

(2013) Yuanyuan Zhao et al.   PLoS Pathogens

Enterovirus 71 Protease 2Apro Targets MAVS to Inhibit Anti-Viral Type I Interferon Responses

(2013) Bei Wang et al.   PLoS Pathogens

MAVS recruits multiple ubiquitin E3 ligases to activate antiviral signaling cascades

(2013) Siqi Liu et al.   eLife

MAVS ubiquitination by the E3 ligase TRIM25 and degradation by the proteasome is involved in type I interferon production after activation of the antiviral RIG-I-like receptors

(2012) Céline Castanier et al.   BMC BIOLOGY

The Mitochondrial Targeting Chaperone 14-3-3ε Regulates a RIG-I Translocon that Mediates Membrane Association and Innate Antiviral Immunity

(2012) Helene Minyi Liu et al.   Cell Host & Microbe

Focal Adhesion Kinase Is a Component of Antiviral RIG-I-like Receptor Signaling

(2012) Rebecca A. Bozym et al.   Cell Host & Microbe

Ubiquitin-Induced Oligomerization of the RNA Sensors RIG-I and MDA5 Activates Antiviral Innate Immune Response

(2012) Xiaomo Jiang et al.   IMMUNITY

NLRX1 does not inhibit MAVS-dependent antiviral signalling

(2012) Fraser Soares et al.   Innate Immunity

Ndfip1 Negatively Regulates RIG-I-Dependent Immune Signaling by Enhancing E3 Ligase Smurf1-Mediated MAVS Degradation

(2012) Y. Wang et al.   JOURNAL OF IMMUNOLOGY

Influenza Virus Protein PB1-F2 Inhibits the Induction of Type I Interferon by Binding to MAVS and Decreasing Mitochondrial Membrane Potential

(2012) Zsuzsanna T. Varga et al.   JOURNAL OF VIROLOGY

Proteomic Analyses Reveal Divergent Ubiquitylation Site Patterns in Murine Tissues

(2012) Sebastian A. Wagner et al.   MOLECULAR & CELLULAR PROTEOMICS

Sensing and reacting to microbes through the inflammasomes

(2012) Luigi Franchi et al.   NATURE IMMUNOLOGY

Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA

(2012) J. Wu et al.   SCIENCE

Structural Basis for the Activation of Innate Immune Pattern-Recognition Receptor RIG-I by Viral RNA

(2011) Eva Kowalinski et al.   CELL

MAVS Forms Functional Prion-like Aggregates to Activate and Propagate Antiviral Innate Immune Response

(2011) Fajian Hou et al.   CELL

NLRX1/NOD5 deficiency does not affect MAVS signalling

(2011) M Rebsamen et al.   CELL DEATH AND DIFFERENTIATION

NLRX1 Protein Attenuates Inflammatory Responses to Infection by Interfering with the RIG-I-MAVS and TRAF6-NF-κB Signaling Pathways

(2011) Irving C. Allen et al.   IMMUNITY

Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity

(2011) Taro Kawai et al.   IMMUNITY

IFN-Induced TPR Protein IFIT3 Potentiates Antiviral Signaling by Bridging MAVS and TBK1

(2011) X.-Y. Liu et al.   JOURNAL OF IMMUNOLOGY

Conventional Protein Kinase C-  (PKC- ) and PKC-  Negatively Regulate RIG-I Antiviral Signal Transduction

(2011) N. P. Maharaj et al.   JOURNAL OF VIROLOGY

DDX60, a DEXD/H Box Helicase, Is a Novel Antiviral Factor Promoting RIG-I-Like Receptor-Mediated Signaling

(2011) M. Miyashita et al.   MOLECULAR AND CELLULAR BIOLOGY

TLR signalling augments macrophage bactericidal activity through mitochondrial ROS

(2011) A. Phillip West et al.   NATURE

Mitochondrial-associated endoplasmic reticulum membranes (MAM) form innate immune synapses and are targeted by hepatitis C virus

(2011) S. M. Horner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial Membrane Potential Is Required for MAVS-Mediated Antiviral Signaling

(2011) T. Koshiba et al.   Science Signaling

The Coxsackievirus B 3Cpro Protease Cleaves MAVS and TRIF to Attenuate Host Type I Interferon and Apoptotic Signaling

(2011) Amitava Mukherjee et al.   PLoS Pathogens

Peroxisomes Are Signaling Platforms for Antiviral Innate Immunity

(2010) Evelyn Dixit et al.   CELL

Tom70 mediates activation of interferon regulatory factor 3 on mitochondria

(2010) Xin-Yi Liu et al.   CELL RESEARCH

Negative Role of RIG-I Serine 8 Phosphorylation in the Regulation of Interferon-β Production

(2010) Estanislao Nistal-Villán et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The E3 Ubiquitin Ligase RNF5 Targets Virus-Induced Signaling Adaptor for Ubiquitination and Degradation

(2010) B. Zhong et al.   JOURNAL OF IMMUNOLOGY

Phosphorylation of RIG-I by Casein Kinase II Inhibits Its Antiviral Response

(2010) Z. Sun et al.   JOURNAL OF VIROLOGY

Phosphorylation-Mediated Negative Regulation of RIG-I Antiviral Activity

(2010) M. U. Gack et al.   JOURNAL OF VIROLOGY

ZAPS is a potent stimulator of signaling mediated by the RNA helicase RIG-I during antiviral responses

(2010) Sumio Hayakawa et al.   NATURE IMMUNOLOGY

LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses

(2010) T. Satoh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Virus-Infection or 5′ppp-RNA Activates Antiviral Signal through Redistribution of IPS-1 Mediated by MFN1

(2010) Kazuhide Onoguchi et al.   PLoS Pathogens

Autophagic control of RLR signaling

(2009) Michal Caspi Tal et al.   Autophagy

c-Abl tyrosine kinase interacts with MAVS and regulates innate immune response

(2009) Ting Song et al.   FEBS LETTERS

Polo-like Kinase 1 (PLK1) Regulates Interferon (IFN) Induction by MAVS

(2009) Damien Vitour et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An N-terminal addressing sequence targets NLRX1 to the mitochondrial matrix

(2009) D. Arnoult et al.   JOURNAL OF CELL SCIENCE

PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4

(2009) Fuping You et al.   NATURE IMMUNOLOGY

Inhibition of RIG-I and MDA5-dependent antiviral response by gC1qR at mitochondria

(2009) L. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitofusin 2 Inhibits Mitochondrial Antiviral Signaling

(2009) K. Yasukawa et al.   Science Signaling

MAM: more than just a housekeeper

(2009) Teruo Hayashi et al.   TRENDS IN CELL BIOLOGY

Riplet/RNF135, a RING Finger Protein, Ubiquitinates RIG-I to Promote Interferon-β Induction during the Early Phase of Viral Infection

(2008) Hiroyuki Oshiumi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY