HIV-1 blocks the signaling adaptor MAVS to evade antiviral host defense after sensing of abortive HIV-1 RNA by the host helicase DDX3

TREX1 Knockdown Induces an Interferon Response to HIV that Delays Viral Infection in Humanized Mice

(2016) Lee Adam Wheeler et al.   Cell Reports

SAMHD1 Degradation Enhances Active Suppression of Dendritic Cell Maturation by HIV-1

(2015) Nina Hertoghs et al.   JOURNAL OF IMMUNOLOGY

Genetic variation in Trex1 affects HIV-1 disease progression

(2014) Thijs Booiman et al.   AIDS

Measles Virus Suppresses RIG-I-like Receptor Activation in Dendritic Cells via DC-SIGN-Mediated Inhibition of PP1 Phosphatases

(2014) Annelies W. Mesman et al.   Cell Host & Microbe

Gut Epithelial Barrier Dysfunction and Innate Immune Activation Predict Mortality in Treated HIV Infection

(2014) Peter W. Hunt et al.   JOURNAL OF INFECTIOUS DISEASES

Type I interferon responses in rhesus macaques prevent SIV infection and slow disease progression

(2014) Netanya G. Sandler et al.   NATURE

Human immature Langerhans cells restrict CXCR4-using HIV-1 transmission

(2014) Ramin Sarrami-Forooshani et al.   Retrovirology

Cytosolic Sensing of Viruses

(2013) Delphine Goubau et al.   IMMUNITY

Dendritic cell dysregulation during HIV-1 infection

(2013) Elizabeth Miller et al.   IMMUNOLOGICAL REVIEWS

Developments of Polo-like Kinase 1 (Plk1) Inhibitors as Anti-Cancer Agents

(2013) Shanshan Li et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Human MX2 is an interferon-induced post-entry inhibitor of HIV-1 infection

(2013) Caroline Goujon et al.   NATURE

MX2 is an interferon-induced inhibitor of HIV-1 infection

(2013) Melissa Kane et al.   NATURE

The DEAD-box helicase DDX3 substitutes for the cap-binding protein eIF4E to promote compartmentalized translation initiation of the HIV-1 genomic RNA

(2013) Ricardo Soto-Rifo et al.   NUCLEIC ACIDS RESEARCH

Cyclic GMP-AMP Synthase Is an Innate Immune Sensor of HIV and Other Retroviruses

(2013) D. Gao et al.   SCIENCE

Type I Interferon Upregulates Bak and Contributes to T Cell Loss during Human Immunodeficiency Virus (HIV) Infection

(2013) Joseph A. Fraietta et al.   PLoS Pathogens

Decisions About Dendritic Cells: Past, Present, and Future

(2012) Ralph M. Steinman   Annual Review of Immunology

Innate Immune Sensing of HIV-1 by Dendritic Cells

(2012) Jeremy Luban   Cell Host & Microbe

DEAD-box protein DDX3 associates with eIF4F to promote translation of selected mRNAs

(2012) Ricardo Soto-Rifo et al.   EMBO JOURNAL

Type I IFN Drives a Distinctive Dendritic Cell Maturation Phenotype That Allows Continued Class II MHC Synthesis and Antigen Processing

(2012) D. P. Simmons et al.   JOURNAL OF IMMUNOLOGY

Intrinsic antiviral immunity

(2012) Nan Yan et al.   NATURE IMMUNOLOGY

SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates

(2012) Hichem Lahouassa et al.   NATURE IMMUNOLOGY

MAVS Forms Functional Prion-like Aggregates to Activate and Propagate Antiviral Innate Immune Response

(2011) Fajian Hou et al.   CELL

A loss-of-function variant of the antiviral molecule MAVS is associated with a subset of systemic lupus patients

(2011) Julien Pothlichet et al.   EMBO Molecular Medicine

CD4+ T-Cell Deficiency in HIV Patients Responding to Antiretroviral Therapy Is Associated With Increased Expression of Interferon-Stimulated Genes in CD4+ T Cells

(2011) Sonia Fernandez et al.   JOURNAL OF INFECTIOUS DISEASES

Genital Tract Inflammation During Early HIV-1 Infection Predicts Higher Plasma Viral Load Set Point in Women

(2011) Lindi Roberts et al.   JOURNAL OF INFECTIOUS DISEASES

Host Cell Interactome of HIV-1 Rev Includes RNA Helicases Involved in Multiple Facets of Virus Production

(2011) Souad Naji et al.   MOLECULAR & CELLULAR PROTEOMICS

Vpx rescues HIV-1 transduction of dendritic cells from the antiviral state established by type 1 interferon

(2011) Thomas Pertel et al.   Retrovirology

Purification and proteomic identification of putative upstream regulators of polo-like kinase-1 from mitotic cell extracts

(2010) Jae-Hoon Ji et al.   FEBS LETTERS

RIG-I-Mediated Antiviral Signaling Is Inhibited in HIV-1 Infection by a Protease-Mediated Sequestration of RIG-I

(2010) M. Solis et al.   JOURNAL OF VIROLOGY

A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells

(2010) Nicolas Manel et al.   NATURE

HIV-1 exploits innate signaling by TLR8 and DC-SIGN for productive infection of dendritic cells

(2010) Sonja I Gringhuis et al.   NATURE IMMUNOLOGY

The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1

(2010) Nan Yan et al.   NATURE IMMUNOLOGY

Polo-like Kinase 1 (PLK1) Regulates Interferon (IFN) Induction by MAVS

(2009) Damien Vitour et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Use of the Pharmacological Inhibitor BX795 to Study the Regulation and Physiological Roles of TBK1 and IκB Kinase ϵ

(2009) Kristopher Clark et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Carbohydrate-specific signaling through the DC-SIGN signalosome tailors immunity to Mycobacterium tuberculosis, HIV-1 and Helicobacter pylori

(2009) Sonja I Gringhuis et al.   NATURE IMMUNOLOGY

Polo-like kinases: conservation and divergence in their functions and regulation

(2009) Vincent Archambault et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY