Respiratory Viral Infections in Exacerbation of Chronic Airway Inflammatory Diseases: Novel Mechanisms and Insights From the Upper Airway Epithelium

A Novel Coronavirus from Patients with Pneumonia in China, 2019

(2020) Na Zhu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mouse models of severe asthma for evaluation of therapeutic cytokine targeting

(2019) Ekaterina O. Gubernatorova et al.   IMMUNOLOGY LETTERS

Airway inflammation in COPD- progress to precision medicine

(2019) Christopher Brightling et al.   EUROPEAN RESPIRATORY JOURNAL

Epithelial cell–derived cytokines: more than just signaling the alarm

(2019) Florence Roan et al.   JOURNAL OF CLINICAL INVESTIGATION

Involvement of epigenetic modification in epithelial immune responses during respiratory syncytial virus infection

(2019) Liu Caixia et al.   MICROBIAL PATHOGENESIS

Recent Advances in Allergy Research Using Humanized Mice

(2019) Ryoji Ito et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The nasal methylome as a biomarker of asthma and airway inflammation in children

(2019) Andres Cardenas et al.   Nature Communications

IL-33 Mediated Inflammation in Chronic Respiratory Diseases—Understanding the Role of the Member of IL-1 Superfamily

(2019) Agata Gabryelska et al.   Frontiers in Immunology

Sputum microbiomic clustering in asthma and COPD reveals a Haemophilus ‐predominant subgroup

(2019) Sarah Diver et al.   ALLERGY

Anti-viral immunity is impaired in COPD patients with frequent exacerbations

(2019) Aran Singanayagam et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Microarray Assay Reveals Ciliary Abnormalities of the Allergic Nasal Mucosa

(2019) Yang Peng et al.   American Journal of Rhinology & Allergy

Rhinovirus‐16 induced temporal interferon responses in nasal epithelium links with viral clearance and symptoms

(2019) Abilash Ravi et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Time-course of upper respiratory tract viral infection and COPD exacerbation

(2019) Daiana Stolz et al.   EUROPEAN RESPIRATORY JOURNAL

IL-33 blockade impacts mediators of persistence and exacerbation in a model of chronic airway inflammation

(2019) Jeanne Allinne et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Decreased expression of type I (IFN-β) and type III (IFN-λ) interferons and interferon-stimulated genes in patients with chronic rhinosinusitis with and without nasal polyps

(2019) Jae Woong Hwang et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Animal Models Reflecting Chronic Obstructive Pulmonary Disease and Related Respiratory Disorders: Translating Pre-Clinical Data into Clinical Relevance

(2019) Lloyd Tanner et al.   Journal of Innate Immunity

Inhaled corticosteroid suppression of cathelicidin drives dysbiosis and bacterial infection in chronic obstructive pulmonary disease

(2019) Aran Singanayagam et al.   Science Translational Medicine

RNA Sequencing of H3N2 Influenza Virus-Infected Human Nasal Epithelial Cells from Multiple Subjects Reveals Molecular Pathways Associated with Tissue Injury and Complications

(2019) Kai Sen Tan et al.   Cells

Epigenetics in Asthma

(2019) Jose L. Gomez   CURRENT ALLERGY AND ASTHMA REPORTS

Why are people with asthma more susceptible to influenza?

(2019) Peter A.B. Wark   EUROPEAN RESPIRATORY JOURNAL

The respiratory virome and exacerbations in patients with chronic obstructive pulmonary disease

(2019) Anneloes L. van Rijn et al.   PLoS One

House dust mite impairs antiviral response in asthma exacerbation models through its effects on TLR3

(2018) H. Akbarshahi et al.   ALLERGY

Antiviral drug screening by assessing epithelial functions and innate immune responses in human 3D airway epithelium model

(2018) Bernadett Boda et al.   ANTIVIRAL RESEARCH

Regional, age and respiratory-secretion-specific prevalence of respiratory viruses associated with asthma exacerbation: a literature review

(2018) Xue-yan Zheng et al.   ARCHIVES OF VIROLOGY

Distinction between rhinovirus-induced acute asthma and asthma-augmented influenza infection

(2018) G. V. Guibas et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Enhanced plasmacytoid dendritic cell antiviral responses after omalizumab

(2018) Michelle A. Gill et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Role of airway glucose in bacterial infections in patients with chronic obstructive pulmonary disease

(2018) Patrick Mallia et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Propagation of respiratory viruses in human airway epithelia reveals persistent virus-specific signatures

(2018) Manel Essaidi-Laziosi et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Viral induced overproduction of epithelial TSLP: Role in exacerbations of asthma and COPD?

(2018) Lena Uller et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

RSV vs. rhinovirus bronchiolitis: difference in nasal airway microRNA profiles and NFκB signaling

(2018) Kohei Hasegawa et al.   PEDIATRIC RESEARCH

Oxidative stress and cellular pathways of asthma and inflammation: Therapeutic strategies and pharmacological targets

(2018) Vikas Mishra et al.   PHARMACOLOGY & THERAPEUTICS

Exacerbation induces a microbiota shift in sputa of COPD patients

(2018) Eric Jubinville et al.   PLoS One

Corticosteroid suppression of antiviral immunity increases bacterial loads and mucus production in COPD exacerbations

(2018) Aran Singanayagam et al.   Nature Communications

Transmission routes of respiratory viruses among humans

(2018) Jasmin S Kutter et al.   Current Opinion in Virology

Airway Microbiota Dynamics Uncover a Critical Window for Interplay of Pathogenic Bacteria and Allergy in Childhood Respiratory Disease

(2018) Shu Mei Teo et al.   Cell Host & Microbe

Motile Ciliary Disorders in Chronic Airway Inflammatory Diseases: Critical Target for Interventions

(2018) Wei-jie Guan et al.   CURRENT ALLERGY AND ASTHMA REPORTS

H3N2 influenza virus infection enhances oncostatin M expression in human nasal epithelium

(2018) Tengfei Tian et al.   EXPERIMENTAL CELL RESEARCH

Oxidative stress in chronic lung disease: From mitochondrial dysfunction to dysregulated redox signaling

(2018) Albert van der Vliet et al.   MOLECULAR ASPECTS OF MEDICINE

SARS-Coronavirus Open Reading Frame-3a drives multimodal necrotic cell death

(2018) Yuan Yue et al.   Cell Death & Disease

MicroRNAs: Mediators and Therapeutic Targets to Airway Hyper Reactivity After Respiratory Syncytial Virus Infection

(2018) Shuwen Feng et al.   Frontiers in Microbiology

Interleukin 33 Selectively Augments Rhinovirus-Induced Type 2 Immune Responses in Asthmatic but not Healthy People

(2018) Lisa M. Jurak et al.   Frontiers in Immunology

Human Rhinovirus Impairs the Innate Immune Response to Bacteria in Alveolar Macrophages in COPD

(2018) Lydia J Finney et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

IL-33 drives influenza-induced asthma exacerbations by halting innate and adaptive antiviral immunity

(2018) Lara Ravanetti et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

ROS Is Involved in Disruption of Tight Junctions of Human Nasal Epithelial Cells Induced by HRV16

(2018) Kyeong Ah Kim et al.   LARYNGOSCOPE

Rhinovirus infections change DNA methylation and mRNA expression in children with asthma

(2018) Martin Pech et al.   PLoS One

Comparative Transcriptomic and Metagenomic Analyses of Influenza Virus-Infected Nasal Epithelial Cells From Multiple Individuals Reveal Specific Nasal-Initiated Signatures

(2018) Kai Sen Tan et al.   Frontiers in Microbiology

Annexins in Influenza Virus Replication and Pathogenesis

(2018) Patrick Baah Ampomah et al.   Frontiers in Pharmacology

Resolving Viral-Induced Secondary Bacterial Infection in COPD: A Concise Review

(2018) Hao Wang et al.   Frontiers in Immunology

MicroRNA-146a induction during influenza H3N2 virus infection targets and regulates TRAF6 levels in human nasal epithelial cells (hNECs)

(2017) Yuqin Deng et al.   EXPERIMENTAL CELL RESEARCH

Community-acquired rhinovirus infection is associated with changes in the airway microbiome

(2017) Kirsten M. Kloepfer et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

MicroRNA-21 drives severe, steroid-insensitive experimental asthma by amplifying phosphoinositide 3-kinase–mediated suppression of histone deacetylase 2

(2017) Richard Y. Kim et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Role of viral infections in the development and exacerbation of asthma in children

(2017) Tuomas Jartti et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

In Vitro Model of Fully Differentiated Human Nasal Epithelial Cells Infected With Rhinovirus Reveals Epithelium-Initiated Immune Responses

(2017) Kai Sen Tan et al.   JOURNAL OF INFECTIOUS DISEASES

Absence or mislocalization of DNAH5 is a characteristic marker for motile ciliary abnormality in nasal polyps

(2017) Qianhui Qiu et al.   LARYNGOSCOPE

The role of oxidative stress in influenza virus infection

(2017) Miaomiao Liu et al.   MICROBES AND INFECTION

Worldwide prevalence of viral infection in AECOPD patients: A meta-analysis

(2017) Habib Jafarinejad et al.   MICROBIAL PATHOGENESIS

An innate defense peptide BPIFA1/SPLUNC1 restricts influenza A virus infection

(2017) K M Akram et al.   Mucosal Immunology

Endosomal NOX2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapy

(2017) Eunice E. To et al.   Nature Communications

Global, regional, and national deaths, prevalence, disability-adjusted life years, and years lived with disability for chronic obstructive pulmonary disease and asthma, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015

(2017) Joan B Soriano et al.   Lancet Respiratory Medicine

Dysregulation of Antiviral Function of CD8+T Cells in the Chronic Obstructive Pulmonary Disease Lung. Role of the PD-1–PD-L1 Axis

(2016) Richard T. McKendry et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Impaired Antiviral Stress Granule and IFN-β Enhanceosome Formation Enhances Susceptibility to Influenza Infection in Chronic Obstructive Pulmonary Disease Epithelium

(2016) Alan C.-Y. Hsu et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Human nasal epithelial cells derived from multiple subjects exhibit differential responses to H3N2 influenza virus infection in vitro

(2016) Yan Yan et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Inflammatory triggers associated with exacerbations of COPD orchestrate plasticity of group 2 innate lymphoid cells in the lungs

(2016) Jonathan S Silver et al.   NATURE IMMUNOLOGY

Airway Secretory microRNAome Changes during Rhinovirus Infection in Early Childhood

(2016) Maria J. Gutierrez et al.   PLoS One

Th2 biased upper airway inflammation is associated with an impaired response to viral infection with Herpes simplex virus

(2016) F. Lan et al.   RHINOLOGY

Rhinovirus Infection Induces Interleukin-13 Production from CD11b-Positive, M2-Polarized Exudative Macrophages

(2015) Yutein Chung et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The Role of Viruses in the Clinical Presentation of Chronic Rhinosinusitis

(2015) Nicholas R. Rowan et al.   American Journal of Rhinology & Allergy

Levels of CMV-reactive antibodies correlate with the induction of CD28null T cells and systemic inflammation in chronic obstructive pulmonary disease (COPD)

(2015) Dino B A Tan et al.   Cellular & Molecular Immunology

Rhinovirus and Asthma: a Storied History of Incompatibility

(2015) Catherine Hammond et al.   CURRENT ALLERGY AND ASTHMA REPORTS

Oncostatin M promotes mucosal epithelial barrier dysfunction, and its expression is increased in patients with eosinophilic mucosal disease

(2015) Kathryn L. Pothoven et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Morphogenesis of respiratory syncytial virus in human primary nasal ciliated epithelial cells occurs at surface membrane microdomains that are distinct from cilia

(2015) Muhammad Raihan Jumat et al.   VIROLOGY

Link between chronic inflammation and human papillomavirus-induced carcinogenesis (Review)

(2015) JOSÉ VERÍSSIMO FERNANDES et al.   Oncology Letters

Angiopoietin-like 4 Increases Pulmonary Tissue Leakiness and Damage during Influenza Pneumonia

(2015) Liang Li et al.   Cell Reports

Streptococcus pneumoniae biofilm formation and dispersion during colonization and disease

(2015) Yashuan Chao et al.   Frontiers in Cellular and Infection Microbiology

The role of viral infections in exacerbations of chronic obstructive pulmonary disease and asthma

(2015) Richard Hewitt et al.   Therapeutic Advances in Respiratory Disease

Genomic instability in chronic airway inflammatory diseases

(2015) Huahao Shen et al.   Biomedical Journal

IL-33–Dependent Type 2 Inflammation during Rhinovirus-induced Asthma ExacerbationsIn Vivo

(2014) David J. Jackson et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Micro-RNAs in regenerating lungs: an integrative systems biology analysis of murine influenza pneumonia

(2014) Kai Tan et al.   BMC GENOMICS

Human rhinovirus infection causes different DNA methylation changes in nasal epithelial cells from healthy and asthmatic subjects

(2014) Peter McErlean et al.   BMC Medical Genomics

Influenza Promotes Pneumococcal Growth during Coinfection by Providing Host Sialylated Substrates as a Nutrient Source

(2014) Steven J. Siegel et al.   Cell Host & Microbe

Viral infections and asthma: an inflammatory interface?

(2014) Brian G.G. Oliver et al.   EUROPEAN RESPIRATORY JOURNAL

MicroRNAs and the immune response to respiratory virus infections

(2014) Anna Głobińska et al.   Expert Review of Clinical Immunology

Exacerbation of asthma and airway infection: is the virus the villain?

(2014) Lusmaia D.C. Costa et al.   Jornal de Pediatria

Detection of pathogenic bacteria during rhinovirus infection is associated with increased respiratory symptoms and asthma exacerbations

(2014) Kirsten M. Kloepfer et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

What DNA Viral Genomic Rearrangements Tell Us about Persistence

(2014) Michael J. Imperiale et al.   JOURNAL OF VIROLOGY

Rhinovirus-induced IL-25 in asthma exacerbation drives type 2 immunity and allergic pulmonary inflammation

(2014) J. Beale et al.   Science Translational Medicine

Outgrowth of the Bacterial Airway Microbiome after Rhinovirus Exacerbation of Chronic Obstructive Pulmonary Disease

(2013) Philip L. Molyneaux et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

IL-33–Responsive Innate Lymphoid Cells Are an Important Source of IL-13 in Chronic Rhinosinusitis with Nasal Polyps

(2013) Joanne L. Shaw et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Human parainfluenza type 3 virus impairs the efficacy of glucocorticoids to limit allergy-induced pulmonary inflammation in guinea-pigs

(2013) William R. Ford et al.   CLINICAL SCIENCE

Basic Research on Virus-Induced Asthma Exacerbation: Inhibition of Inflammatory Chemokine Expression by Fluticasone Propionate

(2013) Satoshi Matsukura et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Rhinovirus infection causes steroid resistance in airway epithelium through nuclear factor κB and c-Jun N-terminal kinase activation

(2013) Alberto Papi et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Long-term IL-33–producing epithelial progenitor cells in chronic obstructive lung disease

(2013) Derek E. Byers et al.   JOURNAL OF CLINICAL INVESTIGATION

Bilateral Entry and Release of Middle East Respiratory Syndrome Coronavirus Induces Profound Apoptosis of Human Bronchial Epithelial Cells

(2013) X. Tao et al.   JOURNAL OF VIROLOGY

Viral and bacterial infection in acute asthma and chronic obstructive pulmonary disease increases the risk of readmission

(2013) Peter A.B. Wark et al.   RESPIROLOGY

Interkingdom Signaling Induces Streptococcus pneumoniae Biofilm Dispersion and Transition from Asymptomatic Colonization to Disease

(2013) L. R. Marks et al.   mBio

Virus-induced exacerbations in asthma and COPD

(2013) Daisuke Kurai et al.   Frontiers in Microbiology

Type 2 innate lymphoid cells: new players in asthma and allergy

(2012) Seth T Scanlon et al.   CURRENT OPINION IN IMMUNOLOGY

Local Inflammation in Chronic Upper Airway Disease

(2012) Lien Calus et al.   CURRENT PHARMACEUTICAL DESIGN

Airway epithelial cells activate TH2 cytokine production in mast cells through IL-1 and thymic stromal lymphopoietin

(2012) Deepti R. Nagarkar et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Human Papillomavirus and Diseases of the Upper Airway: Head and Neck Cancer and Respiratory Papillomatosis

(2012) Maura L. Gillison et al.   VACCINE

Treating Clostridium difficile Infection With Fecal Microbiota Transplantation

(2011) Johan S. Bakken et al.   Clinical Gastroenterology and Hepatology

The Airway Epithelium: Soldier in the Fight against Respiratory Viruses

(2011) M. Vareille et al.   CLINICAL MICROBIOLOGY REVIEWS

Upper-Respiratory Viral Infection, Biomarkers, and COPD Exacerbations

(2010) Omar Kherad et al.   CHEST

Childhood asthma and infection: virus-induced exacerbations as determinants and modifiers

(2010) P. Xepapadaki et al.   EUROPEAN RESPIRATORY JOURNAL

Human rhinovirus proteinase 2A induces TH1 and TH2 immunity in patients with chronic obstructive pulmonary disease

(2010) Manisha Singh et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Role of viral respiratory infections in asthma and asthma exacerbations

(2010) William W Busse et al.   LANCET

Persistence of rhinovirus RNA and IP-10 gene expression after acute asthma

(2010) Lisa G. WOOD et al.   RESPIROLOGY

Double-stranded RNA poly(I:C) enhances matrix metalloproteinase mRNA expression in human nasal polyp epithelial cells

(2009) Jiyun Wang et al.   ACTA OTO-LARYNGOLOGICA

Human Rhinovirus Infection Up-Regulates MMP-9 Production in Airway Epithelial Cells via NF-κB

(2009) Claire E. Tacon et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Acute exacerbations of asthma: epidemiology, biology and the exacerbation-prone phenotype

(2009) R. H. Dougherty et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Adenovirus E1A regulates lung epithelial ICAM-1 expression by interacting with transcriptional regulators at its promoter

(2008) Kiyoshi Morimoto et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Rhinovirus Disrupts the Barrier Function of Polarized Airway Epithelial Cells

(2008) Umadevi Sajjan et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Rhinovirus-Induced Major Airway Mucin Production Involves a Novel TLR3-EGFR–Dependent Pathway

(2008) Lingxiang Zhu et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

In Vivo Potential Effects of Adenovirus Type 5 E1A and E1B on Lung Carcinogenesis and Lymphoproliferative Inflammation

(2008) Y. Yang et al.   JOURNAL OF VIROLOGY

Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease

(2008) Edy Y Kim et al.   NATURE MEDICINE

Viral Infection in Asthma

(2008) Shu Hashimoto et al.   ALLERGOLOGY INTERNATIONAL