Review
Immunology
Rebecca L. Watkinson, Kevin Looi, Ingrid A. Laing, Antonella Cianferoni, Anthony Kicic
Summary: The epithelium plays a crucial role in protecting biological systems and maintaining biochemical homeostasis. Certain children may have epithelial vulnerabilities leading to disease pathogenesis. Allergic-type epithelial diseases in children likely share common disease processes related to inflammation and immune response dysregulation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Virology
Cihan Papan, Alberto Argentiero, Ortwin Adams, Marian Porwoll, Ummaya Hakim, Edoardo Farinelli, Ilaria Testa, Maria B. Pasticci, Daniele Mezzetti, Katia Perruccio, Arne Simon, Johannes G. Liese, Markus Knuf, Michal Stein, Renata Yacobov, Ellen Bamberger, Sven Schneider, Susanna Esposito, Tobias Tenenbaum
Summary: This study found that viral load is associated with biomarkers and may serve as a complementary tool for assessing disease severity.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Immunology
Anthony Bosco
Summary: Respiratory syncytial virus (RSV) and Rhinovirus (RV) infections are major triggers of severe lower respiratory illnesses (sLRI) in infants and children and are strongly associated with the subsequent development of asthma. Recent findings highlight novel aspects of the interferon response in sLRI pathogenesis and provide new directions for mechanistic studies and drug development.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Teresa C. Williams, David J. Jackson, Steven Maltby, Ross P. Walton, Yee-Mann Ching, Nicholas Glanville, Aran Singanayagam, Jennifer J. Brewins, Deborah Clarke, Aurica G. Hirsman, Su-Ling Loo, Lan Wei, Janine E. Beale, Paolo Casolari, Gaetano Caramori, Alberto Papi, Maria Belvisi, Peter A. B. Wark, Sebastian L. Johnston, Michael R. Edwards, Nathan W. Bartlett
Summary: The study revealed that in asthma patients, RV infection can lead to increased expression of CCL17 and CCL22, which correlates differentially with clinical and immunological parameters. Type-2 cytokines and STAT6 activation have different effects on chemokine expression, with NF-kappa B promoting the expression of both chemokines in asthma airway epithelial cells.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2021)
Article
Virology
Erwan Sallard, Frank Schult, Carolin Baehren, Eleni Buedding, Olivier Mboma, Parviz Ahmad-Nejad, Beniam Ghebremedhin, Anja Ehrhardt, Stefan Wirth, Malik Aydin
Summary: Respiratory viruses play a significant role in exacerbating asthma, and human rhinovirus (HRV) infection is a strong biomarker for exacerbation.
Article
Biochemistry & Molecular Biology
Eric B. Gebski, Vishal Parikh, Hong Lam, Nicholas Kim, Yury A. Bochkov, Gaoyuan Cao, Reynold A. Panettieri, Richard Kurten, James Gern, Steven S. An, Cynthia J. Koziol-White
Summary: Rhinovirus C15 attenuates agonist-induced bronchodilation, decreases efficacy of current therapeutics, and modulates components of relaxation pathways in airway smooth muscle.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2023)
Article
Allergy
Yu Kawakami, Ikuo Takazawa, Merritt L. Fajt, Kazumi Kasakura, Joseph Lin, Julienne Ferrer, David B. Kantor, Wanda Phipatanakul, Peter W. Heymann, Chris A. Benedict, Yuko Kawakami, Toshiaki Kawakami
Summary: This study investigates the role of histamine-releasing factor (HRF) in asthma severity and virus-induced asthma exacerbations. The results show that HRF-reactive IgE is higher in severe asthmatic patients and that respiratory epithelial cells secrete HRF in response to RV infection. This suggests that HRF may contribute to the pathogenesis of asthma and RV-induced asthma exacerbation.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Review
Allergy
Niek B. Achten, Annemarie M. C. van Rossum, Leonard B. Bacharier, Anne M. Fitzpatrick, Tina Hartert
Summary: This article examines the impact of early-life viral infections on the lung and immune systems and focuses on the causal relationship between early-life viral infections and asthma. The article calls for a shift in research focus towards improving patient outcomes in the spectrum of respiratory diseases.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2022)
Article
Virology
Erwan Sallard, Katarzyna Niespodziana, Maja Bajic, Thomas Schlederer, Peter Errhalt, Ann-Kathrin Behrendt, Stefan Wirth, Almut Meyer-Bahlburg, Anja Ehrhardt, Rudolf Valenta, Malik Aydin
Summary: Rhinoviruses (RV) are found to contribute significantly to asthma exacerbations, especially RV species C, which may cause severe development in vulnerable patient groups. Patients with atopic wheezing have higher levels of RV-specific IgG for species A and species C. This study adds important observations to the existing data on pediatric and adolescent exacerbation, highlighting the relevance of RV species in susceptible pediatric patients.
Article
Allergy
Chloe I. Bloom, Courtney Franklin, Andrew Bush, Sejal Saglani, Jennifer K. Quint
Summary: The study found that preschool wheeze in the United Kingdom causes a significant healthcare burden, affecting around 7.7% of preschool children. Wheeze events were least common in August and most common in late-autumn/early-winter. Various factors such as wheeze frequency and severity, atopy, maternal asthma, were associated with progression to asthma in preschool children.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Allergy
Alexis Celle, Pauline Esteves, Guillaume Cardouat, Fabien Beaufils, Edmee Eyraud, Isabelle Dupin, Elise Maurat, Sabrina Lacomme, Olga Ousova, Hugues Begueret, Matthieu Thumerel, Roger Marthan, Pierre-Olivier Girodet, Patrick Berger, Thomas Trian
Summary: This study demonstrates a novel mechanism of bronchial smooth muscle (BSM) remodeling in patients with severe asthma following rhinovirus (RV) exacerbation. The specific migration of BSM cells towards RV-infected bronchial epithelium (BE) is driven by the chemokine ligand C-X-C motif chemokine ligand 10. Decreased expression and activation of the CXCR3-B-specific isoform in BSM cells from patients with severe asthma contribute to this mechanism. These findings highlight the potential therapeutic target of the C-X-C motif chemokine ligand 10/CXCR3-A axis in severe asthma.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Review
Medicine, General & Internal
Sergio de Jesus Romero-Tapia, Crystell Guadalupe Guzman Priego, Blanca E. Del-Rio-Navarro, Manuel Sanchez-Solis
Summary: This review summarizes the close association between viral infection and the onset, progression, and exacerbation of asthma, discussing related protective and risk factors, as well as treatment options. It also presents recent research on the innate immunological pathways and changes in the epithelial barrier. The review emphasizes the importance of genetics and epigenetics in asthma and virus susceptibility, and describes the involvement of viral etiology in bronchiolitis, childhood wheezing, and asthma. The most frequently related respiratory viruses and their mechanisms of action are mentioned.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Allergy
Tuomas Jartti, Unna Liimatainen, Paraskevi Xepapadaki, Tero Vahlberg, Claus Bachert, Susetta Finotto, Marek L. Kowalski, Anna Sobanska, Heikki Lukkarinen, Maria Pasioti, Tytti Vuorinen, Nan Zhang, Theodor Zimmermann, Nikolaos G. Papadopoulos
Summary: The study suggests that vitamin D supplementation may have a beneficial effect in combating rhinovirus infection, and that RV infection is closely linked to the severity of preschool asthma and disease progression.
Article
Biochemistry & Molecular Biology
Joanna Wieczfinska, Rafal Pawliczak
Summary: Fibrosis is an important characteristic of lung tissue remodeling in asthma. This study aimed to investigate the potential of relaxin, a natural fibrosis suppressor, in inhibiting airway remodeling. The results showed that relaxin decreased collagen I and TGF-beta expression and increased MMP-9 expression. Relaxin also reduced HRV-induced expression of collagen I and alpha-SMA. Furthermore, the transcription factors NF-kappa B, c-Myc, and STAT3 were found to be involved in the pathways associated with relaxin action.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Katarzyna Niespodziana, Clarissa R. Cabauatan, Petra Pazderova, Phyllis C. Vacal, Judith Wortmann, Walter Keller, Peter Errhalt, Rudolf Valenta
Summary: Rhinoviruses are major causes of the common cold and can trigger exacerbations of asthma. Different strains of the virus, even when reacting with different receptors, seem to engage similar parts of their capsid in the infection process. These findings are important for the development of vaccines and immunization strategies against rhinoviruses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Allergy
Hajar Ali, Collin Brooks, Yu-Chieh Tzeng, Julian Crane, Richard Beasley, Peter Gibson, Philip Pattemore, Thorsten Stanley, Neil Pearce, Jeroen Douwes
Summary: This study found that autonomic nervous system activity is not associated with pathophysiology or inflammatory phenotype in young asthmatics with generally well-controlled asthma. However, enhanced sympathetic nervous system activity can be detected in asthmatics with airway hyperreactivity or who use beta-agonist medication.
Article
Allergy
Vanessa E. Murphy, Annelies L. Robijn, Tommy B. Metcalfe, Thomas K. Wright, Peter G. Gibson, Kirsten McCaffery, Megan E. Jensen
Summary: This study investigated beliefs about medicines in pregnant women with asthma and their association with adherence to inhaled corticosteroids (ICS). The findings showed that ICS users were more likely to perceive that the benefits of medication use outweighed any risks, while non-adherence was not associated with having relatively more concerns about asthma medicines.
Editorial Material
Respiratory System
Peter G. Gibson
Article
Allergy
Lei Liu, Ying Liu, Xin Zhang, Yu Lai Yuan, Zhi Hong Chen, Alan Chen-Yu Hsu, Brian G. Oliver, Min Xie, Ling Qin, Wei Min Li, Dan Liu, Gang Wang, Lisa G. Wood
Summary: This study investigated the relationships between dyslipidemia, asthma phenotypes, and future asthma exacerbations. The results showed that dyslipidemia was associated with airway obstruction, asthma phenotypes, and asthma exacerbations.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Review
Respiratory System
Hayley A. Scott, Shawn H. M. Ng, Rebecca F. McLoughlin, Sarah R. Valkenborghs, Parameswaran Nair, Alexandra C. Brown, Olivia R. Carroll, Jay C. Horvat, Lisa G. Wood
Summary: This review examined the association between obesity and airway/systemic inflammation and adipokine levels in adults with asthma. The results showed that obese asthmatics have a different pattern of inflammation compared to non-obese asthmatics. Further mechanistic studies and investigations into the clinical relevance of this altered inflammatory response are warranted.
Article
Nutrition & Dietetics
Lily M. Williams, Bronwyn S. Berthon, Isobel L. Stoodley, Evan J. Williams, Lisa G. Wood
Summary: Medicinal mushroom extracts (MMEs) have immunomodulatory effects on innate immunity. This study examined the influence of MMEs on immune cell responses to inflammatory stimuli in older adults. The extracts showed differential effects on the release of inflammatory and antiviral mediators in vitro.
Article
Nutrition & Dietetics
Erin D. Clarke, Jordan Stanford, Jessica J. A. Ferguson, Lisa G. Wood, Clare E. Collins
Summary: This study investigates the relationship between fatty acids, diet quality scores, and inflammatory markers. The results indicate a positive association between saturated fat and inflammation, while monounsaturated fatty acids, polyunsaturated fatty acids, and the Mediterranean diet are inversely associated with inflammation.
Article
Nutrition & Dietetics
Natalie Gray, Isobel G. Stoodley, Lisa E. Wood, Clare J. Collins, Leanne M. Brown, Kym G. Rae, Kirsty L. Pringle, Tracy Schumacher
Summary: Higher intakes of Omega-3 long-chain polyunsaturated fatty acids are associated with lower rates of preterm birth and preeclampsia. This study analyzed the dietary intake and fractions of LC-PUFAs in Indigenous Australian women during pregnancy. Results showed that a majority of the women met national recommendations for n-3 LC-PUFA intake, but had low levels of ALA in their RBC membranes. Further research is needed to understand the role of fatty acids in preterm birth and preeclampsia.
Article
Respiratory System
Vanessa M. Mcdonald, Gregory Archbold, Tesfalidet Beyene, Bronwyn K. Brew, Peter Franklin, Peter G. Gibson, John Harrington, Philip M. Hansbro, Fay H. Johnston, Paul D. Robinson, Michael Sutherland, Deborah Yates, Graeme R. Zosky, Michael J. Abramson
Summary: Landscape fires are becoming more frequent and severe worldwide, causing a significant health and socioeconomic burden, especially in Australia. People with asthma are especially susceptible to the effects of landscape fire smoke (LFS) exposure. This position statement highlights the impact of LFS on individuals with asthma, particularly vulnerable groups, and provides guidance on asthma management, smoke mitigation strategies, and access to air quality information during periods of LFS.
Review
Respiratory System
Peter G. Gibson, Vanessa M. McDonald, Dennis Thomas
Summary: The landscape of asthma has changed significantly in the last decade with the development of effective medications and inhaler devices. However, the proportion of uncontrolled patients remains high, primarily due to factors such as inappropriate use of medications, disease heterogeneity, and other contributing factors. Inhaled corticosteroids (ICS) with or without long-acting beta agonists (LABA) are currently the mainstay of asthma management. The future of asthma treatment will involve personalized medications and smart inhalers to improve adherence, inhaler technique, and polypharmacy. Precision medicine approaches, such as treatable traits (TTs), aim to identify and manage specific clinically important factors to optimize treatment. Research and validation of TTs in different clinical settings and populations are ongoing. Combination inhaler therapy and the TTs approach are complementary treatment strategies.
Review
Respiratory System
Hayley Lewthwaite, Anthony Byrne, Bruce Brew, Peter G. Gibson
Summary: Long COVID is a new and complex chronic health condition experienced by one in eight adults following acute COVID-19. 'Treatable Traits' is a personalized medicine approach that can address the complexity and heterogeneity of this condition, by identifying and targeting the most prevalent treatable traits associated with long COVID. Current evidence supports exercise training or respiratory muscle training for long COVID treatable traits in the chest and functional limitation clusters, but further high-quality research is needed for other treatable traits.
Editorial Material
Respiratory System
Peter G. Gibson
Review
Nutrition & Dietetics
Isobel L. Stoodley, Lily M. Williams, Lisa G. Wood
Summary: Maintaining muscle mass, strength, and function is crucial for the elderly population. Exercise and dietary protein intake are recommended strategies, with animal proteins being the most studied. However, plant-based proteins have been found to have lower digestibility and incomplete amino acid profiles. This systematic review evaluated the effects of plant-based protein interventions compared to placebo on body composition, strength, and physical function in older adults. The review found that plant-based protein interventions improved muscle mass over time and were comparable to other interventions in terms of effectiveness.
Editorial Material
Allergy
Paola D. Urroz Guerrero, Peter G. Gibson
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Meeting Abstract
Nutrition & Dietetics
B. S. Berthon, C. A. Thompson, H. A. Scott, P. G. Gibson, L. G. Wood
PROCEEDINGS OF THE NUTRITION SOCIETY
(2023)