Rhinovirus-induced IL-25 in asthma exacerbation drives type 2 immunity and allergic pulmonary inflammation

IL-17E (IL-25) and IL-17RB promote respiratory syncytial virus-induced pulmonary disease

(2014) Bryan C. Petersen et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Toll-like receptor 7 gene deficiency and early-life Pneumovirus infection interact to predispose toward the development of asthma-like pathology in mice

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IL-33 is more potent than IL-25 in provoking IL-13–producing nuocytes (type 2 innate lymphoid cells) and airway contraction

(2013) Jillian L. Barlow et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Proposals for the classification of human rhinovirus species A, B and C into genotypically assigned types

(2013) C. L. McIntyre et al.   JOURNAL OF GENERAL VIROLOGY

TH2, allergy and group 2 innate lymphoid cells

(2013) Paula Licona-Limón et al.   NATURE IMMUNOLOGY

The E3 ubiquitin ligase midline 1 promotes allergen and rhinovirus-induced asthma by inhibiting protein phosphatase 2A activity

(2013) Adam Collison et al.   NATURE MEDICINE

Dupilumab in Persistent Asthma with Elevated Eosinophil Levels

(2013) Sally Wenzel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Human Rhinovirus Species and Season of Infection Determine Illness Severity

(2012) Wai-Ming Lee et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Defining critical roles for NF-κB p65 and type I interferon in innate immunity to rhinovirus

(2012) Nathan W. Bartlett et al.   EMBO Molecular Medicine

Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial

(2012) Ian D Pavord et al.   LANCET

Allergen-induced expression of IL-25 and IL-25 receptor in atopic asthmatic airways and late-phase cutaneous responses

(2011) Chris J. Corrigan et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Innate IL-13–producing nuocytes arise during allergic lung inflammation and contribute to airways hyperreactivity

(2011) Jillian L. Barlow et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Preventing asthma exacerbations: What are the targets?

(2011) Karine Botturi et al.   PHARMACOLOGY & THERAPEUTICS

The Role of IL-15 Deficiency in the Pathogenesis of Virus-Induced Asthma Exacerbations

(2011) Vasile Laza-Stanca et al.   PLoS Pathogens

Experimental Rhinovirus Infection as a Human Model of Chronic Obstructive Pulmonary Disease Exacerbation

(2010) Patrick Mallia et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Rhinovirus induces MUC5AC in a human infection model and in vitro via NF- B and EGFR pathways

(2010) C. A. Hewson et al.   EUROPEAN RESPIRATORY JOURNAL

NK Cell Deficiency Predisposes to Viral-Induced Th2-Type Allergic Inflammation via Epithelial-Derived IL-25

(2010) G. E. Kaiko et al.   JOURNAL OF IMMUNOLOGY

IL-25 in Atopic Dermatitis: A Possible Link between Inflammation and Skin Barrier Dysfunction?

(2010) Malene Hvid et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity

(2010) Daniel R. Neill et al.   NATURE

T-helper Type 2–driven Inflammation Defines Major Subphenotypes of Asthma

(2009) Prescott G. Woodruff et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells

(2009) Hamida Hammad et al.   NATURE MEDICINE

Global strategy for asthma management and prevention: GINA executive summary

(2008) E. D. Bateman et al.   EUROPEAN RESPIRATORY JOURNAL

Increased sputum and bronchial biopsy IL-13 expression in severe asthma

(2008) Shironjit K. Saha et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Mouse models of rhinovirus-induced disease and exacerbation of allergic airway inflammation

(2008) Nathan W Bartlett et al.   NATURE MEDICINE

Rhinovirus-induced lower respiratory illness is increased in asthma and related to virus load and Th1/2 cytokine and IL-10 production

(2008) S. D. Message et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA