NO1, a New Sigma 2 Receptor/TMEM97 Fluorescent Ligand, Downregulates SOCE and Promotes Apoptosis in the Triple Negative Breast Cancer Cell Lines

STIM1 phosphorylation at Y316 modulates its interaction with SARAF and the activation of SOCE and ICRAC

(2019) Esther Lopez et al.   JOURNAL OF CELL SCIENCE

HIIT changes the expression of MuRF1 and MAFBx proteins and proteins involved in the mTOR pathway and autophagy in rat skeletal muscle

(2019) Xinwen Cui et al.   EXPERIMENTAL PHYSIOLOGY

Fine-tuning of store-operated calcium entry by fast and slow Ca 2+ -dependent inactivation: Involvement of SARAF

(2018) Isaac Jardín et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Betulinic acid chemosensitizes breast cancer by triggering ER stress-mediated apoptosis by directly targeting GRP78

(2018) Youli Cai et al.   Cell Death & Disease

Overexpression of sigma‑1 receptor in MCF‑7 cells enhances proliferation via the classic protein kinase C subtype signaling pathway

(2018) Yuqi Wu et al.   Oncology Letters

TRPC6 Channels Are Required for Proliferation, Migration and Invasion of Breast Cancer Cell Lines by Modulation of Orai1 and Orai3 Surface Exposure

(2018) Isaac Jardin et al.   Cancers

Sigma-2 Receptor/TMEM97 and PGRMC-1 Increase the Rate of Internalization of LDL by LDL Receptor through the Formation of a Ternary Complex

(2018) Aladdin Riad et al.   Scientific Reports

Transcriptomic Analysis of Calcium Remodeling in Colorectal Cancer

(2017) Enrique Pérez-Riesgo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Expression of STIM1 is associated with tumor aggressiveness and poor prognosis in breast cancer

(2017) Yanfang Yang et al.   PATHOLOGY RESEARCH AND PRACTICE

The σ 1 receptor agonist (+)-pentazocine increases store-operated Ca 2+ entry in MCF7σ 1 and SK-N-SH cell lines

(2017) Giuseppe Gasparre et al.   Pharmacological Reports

Identification of the gene that codes for the σ2receptor

(2017) Assaf Alon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhanced Stim1 expression is associated with acquired chemo-resistance of cisplatin in osteosarcoma cells

(2017) Xilong Sun et al.   Human Cell

Mitochondria sustain store-operated currents in colon cancer cells but not in normal colonic cells: reversal by non-steroidal anti-inflammatory drugs

(2017) Miriam Hernández-Morales et al.   Oncotarget

Sigma-1 and Sigma-2 receptor ligands induce apoptosis and autophagy but have opposite effect on cell proliferation in uveal melanoma

(2017) Lucia Longhitano et al.   Oncotarget

SZC015, a synthetic oleanolic acid derivative, induces both apoptosis and autophagy in MCF-7 breast cancer cells

(2016) Jingjun Wu et al.   CHEMICO-BIOLOGICAL INTERACTIONS

High Expression of Orai1 Enhances Cell Proliferation and is Associated with Poor Prognosis in Human Colorectal Cancer

(2016) Lin Gui et al.   Clinical Laboratory

Reduction of TMEM97 increases NPC1 protein levels and restores cholesterol trafficking in Niemann-pick type C1 disease cells

(2016) Darius Ebrahimi-Fakhari et al.   HUMAN MOLECULAR GENETICS

Sigma1 receptors inhibit store-operated Ca 2+ entry by attenuating coupling of STIM1 to Orai1

(2016) Shyam Srivats et al.   JOURNAL OF CELL BIOLOGY

Antiangiogenic Effect of (±)-Haloperidol Metabolite II Valproate Ester [(±)-MRJF22] in Human Microvascular Retinal Endothelial Cells

(2016) Melania Olivieri et al.   JOURNAL OF MEDICINAL CHEMISTRY

Stromal Interaction Molecule 1 rescues store-operated calcium entry and protects NG115-401L cells against cell death induced by endoplasmic reticulum and mitochondrial oxidative stress

(2016) Changfeng Zhang et al.   NEUROCHEMISTRY INTERNATIONAL

Dynamic interaction of SARAF with STIM1 and Orai1 to modulate store-operated calcium entry

(2016) Letizia Albarran et al.   Scientific Reports

The sigma-2 receptor as a therapeutic target for drug delivery in triple negative breast cancer

(2015) Mehran Makvandi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Potential applications for sigma receptor ligands in cancer diagnosis and therapy

(2015) Aren van Waarde et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Novel and Selective Fluorescent σ2-Receptor Ligand with a 3,4-Dihydroisoquinolin-1-one Scaffold: A Tool to Study σ2Receptors in Living Cells

(2015) Mauro Niso et al.   CHEMBIOCHEM

The Evolutionarily Conserved C-terminal Domains in the Mammalian Retinoblastoma Tumor Suppressor Family Serve as Dual Regulators of Protein Stability and Transcriptional Potency

(2015) Satyaki Sengupta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct Spatial Ca2+ Signatures Selectively Activate Different NFAT Transcription Factor Isoforms

(2015) Pulak Kar et al.   MOLECULAR CELL

Ca2+signals regulate mitochondrial metabolism by stimulating CREB-mediated expression of the mitochondrial Ca2+uniporter geneMCU

(2015) Santhanam Shanmughapriya et al.   Science Signaling

Ca2+signals regulate mitochondrial metabolism by stimulating CREB-mediated expression of the mitochondrial Ca2+uniporter geneMCU

(2015) Santhanam Shanmughapriya et al.   Science Signaling

The Sigma-2 Receptor and Progesterone Receptor Membrane Component 1 are Different Binding Sites Derived From Independent Genes

(2015) Uyen B. Chu et al.   EBioMedicine

The proto-oncogene KRAS is targeted by miR-200c

(2015) Florian Kopp et al.   Oncotarget

Blockade of SOCE protects HT22 cells from hydrogen peroxide-induced apoptosis

(2013) Wei Rao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Sigma-2 Receptor Agonists as Possible Antitumor Agents in Resistant Tumors: Hints for Collateral Sensitivity

(2013) Mauro Niso et al.   ChemMedChem

Progesterone Antagonism of Neurite Outgrowth Depends on Microglial Activation via Pgrmc1/S2R

(2013) N Bali et al.   ENDOCRINOLOGY

Sigma-1 Receptor Chaperone at the ER-Mitochondrion Interface Mediates the Mitochondrion-ER-Nucleus Signaling for Cellular Survival

(2013) Tomohisa Mori et al.   PLoS One

Inhibition of Store-Operated Calcium Entry Attenuates MPP+-Induced Oxidative Stress via Preservation of Mitochondrial Function in PC12 Cells: Involvement of Homer1a

(2013) Xia Li et al.   PLoS One

Orai3 is an estrogen receptor α-regulated Ca2+ channel that promotes tumorigenesis

(2012) Rajender K. Motiani et al.   FASEB JOURNAL

Analogues of σ Receptor Ligand 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with Added Polar Functionality and Reduced Lipophilicity for Potential Use as Positron Emission Tomography Radiotracers

(2011) Carmen Abate et al.   JOURNAL OF MEDICINAL CHEMISTRY

ORAI1-Mediated Calcium Influx in Lactation and in Breast Cancer

(2011) D. McAndrew et al.   MOLECULAR CANCER THERAPEUTICS

SV119-gold nanocage conjugates: a new platform for targeting cancer cellsvia sigma-2 receptors

(2011) Yucai Wang et al.   Nanoscale

1-Cyclohexyl-4-(4-arylcyclohexyl)piperazines: Mixed σ and Human Δ8-Δ7 Sterol Isomerase Ligands with Antiproliferative and P-Glycoprotein Inhibitory Activity

(2010) Carmen Abate et al.   ChemMedChem

A Novel Native Store-operated Calcium Channel Encoded by Orai3

(2010) Rajender K. Motiani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Down-regulation of Orai3 arrests cell-cycle progression and induces apoptosis in breast cancer cells but not in normal breast epithelial cells

(2010) Malika Faouzi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Homocysteine induces caspase activation by endoplasmic reticulum stress in platelets from type 2 diabetics and healthy donors

(2010) Hanene Zbidi et al.   THROMBOSIS AND HAEMOSTASIS

Orai1 and STIM1 Are Critical for Breast Tumor Cell Migration and Metastasis

(2009) Shengyu Yang et al.   CANCER CELL

F281, synthetic agonist of the sigma-2 receptor, induces Ca2+ efflux from the endoplasmic reticulum and mitochondria in SK-N-SH cells

(2009) Giuseppe Cassano et al.   CELL CALCIUM

Identification of Cholesterol-Regulating Genes by Targeted RNAi Screening

(2009) Fabian Bartz et al.   Cell Metabolism

N,N,N′,N′-tetrakis(2-pyridylmethyl)ethylenediamine induces apoptosis through the activation of caspases-3 and -8 in human platelets. A role for endoplasmic reticulum stress

(2009) J. J. LÓPEZ et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Caspase-3 and -9 are activated in human myeloid HL-60 cells by calcium signal

(2009) D. González et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY