Article
Medicine, Research & Experimental
Akanksha Behl, Parul Sarwalia, Sushil Kumar, Chittaranjan Behera, Mubashir Javed Mintoo, Tirtha Kumar Datta, Prem N. Gupta, Anil K. Chhillar
Summary: The synergistic potential of MUC1 inhibitors and Gemcitabine-loaded nanoparticles was discussed in this study, aiming to enhance the therapeutic efficacy. Gemcitabine and MUC1 inhibitors were loaded into polymeric nanoparticles using the double emulsion solvent evaporation method. The results showed that the twin-loaded nanoparticles exhibited better anticancer effects.
MOLECULAR PHARMACEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Yu Chen, Ping Li, Yueting Peng, Xiaoxue Xie, Yixi Zhang, Ying Jiang, Tingting Li, Xiang Qin, Shun Li, Hong Yang, Chunhui Wu, Chuan Zheng, Jie Zhu, Fengming You, Yiyao Liu
Summary: The study demonstrates that the soft substrate-induced ROS/JNK signaling increases cell apoptosis and protective autophagy by promoting the interaction of Bcl-2 and Beclin-1 and suppressing the interaction of Bcl-2 and Beclin-1, respectively, in human breast cancer cells.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Chemistry, Applied
Yuanxiao Zhang, Yu Hai, Yuqing Miao, Xiao Qi, Weiming Xue, Yane Luo, Haiming Fan, Tianli Yue
Summary: The toxicity mechanism of superparamagnetic iron oxide nanoparticles (SPIONs) was investigated to reduce risks, with higher dosage and suitable sizes of SPIONs enhancing uptake into cells and leading to increased reactive oxygen species (ROS) formation. Smaller SPIONs tended to produce more ROS in mitochondria, damaging them, while larger SPIONs promoted ROS production in plasma to destroy cytomembrane. Different size SPIONs activated distinct cell death pathways, with ferroptosis playing a significant role in mitochondrial and cytomembrane damage. ROS levels correlated with gene expression, suggesting RNA-seq as a new method to assess oxidative stress and toxicity of nanomaterials.
Article
Biochemistry & Molecular Biology
Shuyi Chen, Yabiao Gao, Ping Zhu, Xue Wang, Linzi Zeng, Youping Jin, Xiuling Zhi, Huanjun Yang, Ping Zhou
Summary: In this study, it was found that anlotinib could inhibit breast cancer cell growth by inducing cell autophagy and promoting cell apoptosis. Furthermore, the Akt/GSK-3a pathway was inactivated by anlotinib treatment. These findings suggest that anlotinib may be an effective new drug for breast cancer treatment.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2022)
Article
Medicine, General & Internal
Yu-Chih Hsu, Wen-Che Hsieh, Shu-Hsin Chen, Yi-Zhen Li, Mei-Yi Lin, Hui-Fen Liao, Shew-Meei Sheu
Summary: 180-GA can modulate autophagy and inhibit proliferation of luminal A subtype breast cancer cells through apoptosis promotion and JNK activation.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Subashani Maniam, Sandra Maniam
Summary: Targeted chemotherapy has become the forefront of cancer treatment, offering more effective treatment with reduced side effects through selective and specific features; Research targeting the compensatory mechanisms in tumor cells is progressing in order to overcome drug resistance; Promising small molecules that target autophagy and apoptosis are being developed for the difficult-to-treat TNBC, showing potential in preclinical data.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Jieqing Li
Summary: This study aimed to confirm the possibility of using CHI combined with DOX to prevent chemotherapeutic BC resistance. The results showed that CHI could inhibit cell proliferation, tumor growth, and cell invasion in BC. It also promoted apoptosis and autophagy, and increased cell sensitivity to DOX, leading to decreased tumor growth.
Article
Oncology
Yichao Wang, Hongsheng Lu, Zhongrong Wang, Yueguo Li, Xiaoying Chen
Summary: This study successfully constructed a prognostic risk model for breast cancer and identified an autophagy-related prognostic gene, TP63. The study also demonstrated that TGF-beta 1 promotes autophagy and inhibits apoptosis in breast cancer cells by inhibiting the expression of TP63.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Yongqi Zhen, Zhaoxin Yuan, Jiahui Zhang, Yao Chen, Yuning Fu, Yi Liu, Leilei Fu, Lan Zhang, Xian-Li Zhou
Summary: This study found that flubendazole could inhibit the proliferation and migration of breast cancer cells by impairing mitochondrial function. Moreover, excessive DRP1-mediated mitophagy plays a critical role in the anticancer effects of EVA1A.
CELL DEATH & DISEASE
(2022)
Article
Plant Sciences
Jiazhe Liu, Yongzhi Liu, Hongchang Li, Chuangchao Wei, Anwei Mao, Weiyan Liu, Gaofeng Pan
Summary: The study found that Polyphyllin D (PD) can induce autophagy in breast cancer cells through activation of the JNK1/Bcl-2 pathway, and increase PD-induced cell apoptosis by inhibiting autophagy, thus achieving anti-tumor effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Fengchao Chen, Siya Zhang, Tongtong Yan, Hongquan Wang, Jie Li, Qiang Wang, Subhan Danish, Kun Li
Summary: This study evaluated the potential photodynamic effect of tanshinone I (TanI), an extract from Danshen herb, in photodynamic therapy. The results showed that TanI could be photoexcited and induce cytotoxic effects in breast cancer cells, including inhibition of cell survival and migration, as well as induction of apoptosis and necrosis. This indicates that TanI may serve as a natural photosensitizer.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Jingnan Zhang, Fan Yang, Xiyu Mei, Rui Yang, Bin Lu, Zhengtao Wang, Lili Ji
Summary: Toosendanin (TSN) and isotoosendanin (ITSN) are natural triterpenoids that inhibit the growth of triple-negative breast cancer (TNBC) by inducing necrosis, apoptosis, and autophagy in tumor cells.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Pharmacology & Pharmacy
Lin Guo, Yupei Liang, Shiwen Wang, Lihui Li, Lili Cai, Yongqing Heng, Jing Yang, Xing Jin, Junqian Zhang, Shuying Yuan, Tong Xu, Lijun Jia
Summary: JB induces apoptosis and autophagy in human breast cancer cell lines, mediated by NOXA and AMPK signaling pathway. In vivo study confirms JB's anti-breast cancer effect by suppressing tumor growth. Autophagy plays a pro-survival role in attenuating apoptosis induced by JB.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Dahae Lee, Sanghee Shim, Kisung Kang
Summary: This study found that SSF2-2 can inhibit the viability of MCF-7 breast cancer cells, increase the levels of cleaved caspase-9, cleaved caspase-7, PARP, and LC3B, as well as promote the conversion of LC3-I to LC3II and the formation of LC3-positive puncta in MCF-7 cells.
Article
Environmental Sciences
Sheng-Yuan Chen, Chien-Chih Chiu, Chun-Tzu Hung, Wen-Hsiung Pan, Yen-Chun Chen, Yung-Ding Bow, Wan-Ju Li, Sheng-Kai Hsu, I-Ling Lin, Zhi-Hong Wen, Chang-Yi Wu
Summary: Breast cancer is a major cause of cancer-related deaths globally, and chemotherapy resistance often leads to poor patient outcomes. The study investigated the anticancer activity of synthetic diphenyl disulfide (DPDS) in breast cancer cell lines. DPDS inhibited cell proliferation and viability in a dose-dependent manner, reduced colony formation, and induced apoptosis and autophagy in breast cancer cells. These findings suggest that DPDS has potential as a candidate for breast cancer treatment and further modifications are needed.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Sotirios P. Fortis, Anthimia Batrinou, Hara T. Georgatzakou, Ioannis Tsamesidis, Grigorios Alvanidis, Effie G. Papageorgiou, Kontantinos Stamoulis, Dimitrios Gkiliopoulos, Georgia K. Pouroutzidou, Anna Theocharidou, Eleana Kontonasaki, Anastasios G. Kriebardis
Summary: This study evaluated the compatibility of human blood cells with silica-based mesoporous nanomaterials (MSNs) manufactured using the solgel method, with Ca and Ce as doping elements. The results showed that these nanomaterials had no impact on the viability of lymphocytes and monocytes, but reduced the viability of granulocytes. Additionally, the expression of Pselectin in platelets and the level of internal reactive oxygen species increased when exposed to MSNs. The presence of Ce in the MSNs improved their hemocompatibility to some extent. Further research is needed to understand how MSNs may affect different blood components and design safe and effective MSNs for biomedical applications.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Retraction
Biochemistry & Molecular Biology
Tiechao Jiang, Dongli Jiang, Dong You, Lirong Zhang, Long Liu, Qini Zhao
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Yuting Chen, Lin Chen, Shiheng Zhu, Hui Yang, Zhongming Ye, Huanhuan Wang, Haipeng Wu, Yao Wu, Qian Sun, Xiaoshan Liu, Hairong Liang, Huanwen Tang
Summary: This study investigates the impact of exosomal derived miR-1246 from HQ-transformed cells on cell-to-cell communication in recipient TK6 cells. The results show that exosomal miR-1246 targets CCNG2, regulating TK6 cell cycle arrest, highlighting its potential as a biomarker for HQ-induced malignant transformation.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuping Yu, Yaming Mu, Kai Wang, Ling Wang, Chunying Wang, Zexin Yang, Yu Liu, Shuxian Li, Meihua Zhang
Summary: Fetal growth restriction (FGR) is a common complication in obstetrics, and its exact cause is unknown. In this study, we constructed 1-NP exposed pregnant mice models and found that 1-NP induced FGR. Additionally, we observed significant ferroptosis in placental trophoblasts from 1-NP exposed mice and human FGR patients. Using in vitro cell models, we demonstrated that 1-NP impaired trophoblast biological function and induced cellular ferroptosis. We also identified the ERK signaling pathway and CYP1B1 as key regulators of 1-NP-induced ferroptosis. This study provides new insights into the aetiology of FGR and the reproductive toxicity of environmental pollutants.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Lei Hou, Yingying Zhao, Shiyu Zhao, Xuexia Zhang, Xia Yao, Jianjun Yang, Ziteng Wang, Shuaibing Liu
Summary: This study systematically characterized the UGTs enzymes involved in the formation of M4 and the inhibitory effects of ciprofol and its metabolite M4 on P450s enzymes. In vitro-in vivo extrapolation and PBPK simulations were performed to predict potential drug-drug interactions caused by ciprofol.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Disheng Liu, Lu Wang, Wuhua Ha, Kan Li, Rong Shen, Degui Wang
Summary: Renal fibrosis is a common outcome of renal injuries, characterized by structural destruction and functional decline of the kidneys. Hypoxia induces the activation of HIF-1 alpha, which regulates cellular metabolism, proliferation, apoptosis, and inflammation, contributing to the development of renal fibrosis. Understanding the regulation and cascade reactions mediated by HIF-1 alpha can provide new insights for studying the mechanism of renal fibrosis.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Zhao-Bo Luo, Liu-Hui Yang, Sheng-Zhong Han, Shuang-Yan Chang, Hongye Liu, Zhi-Yong An, Xiu-Li Zhang, Biao-Hu Quan, Xi-Jun Yin, Jin-Dan Kang
Summary: This study demonstrates that cyclophosphamide (CTX) treatment has detrimental effects on oocytes and embryos, leading to DNA damage, apoptosis, and abnormal histone modification. Supplementation with LBH589 can effectively restore the developmental potential of embryos by increasing histone modification levels and restoring protein expression of NF-kappa B, a key regulator of early embryo development.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Sheng Chen, Hanqing Xu, Yi He, Chen Meng, Yunhui Fan, Yunkun Qu, Yingguang Wang, Wei Zhou, Xiaojian Huang, Hongbo You
Summary: Osteoarthritis is a heterogeneous disease that affects the entire joint. This study found that Carveol can reverse the inflammatory state of macrophages, promote their anti-inflammatory effects, and protect cartilage by activating the NRF2/HO-1/NQO1 pathway and reducing ROS clearance. The results also showed that Carveol can alleviate the pathological changes of osteoarthritis in mice, suggesting its potential therapeutic efficacy.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Liyi Wei, Tingting Wang, Mingcui Luo, Shuai Zhang, Mengxi Lu, Xinli Zhou, Xuelei Cheng, Hui Wang, Dan Xu
Summary: This study found that azithromycin during pregnancy may have toxic effects on fetal hippocampal development, especially in the late pregnancy, high dose, and multi-course situation. The results also suggest that the SOX2/Wnt signaling pathway may be involved in this toxicity.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Di Wu, Faheem Ahmed Khan, Kejia Zhang, Nuruliarizki Shinta Pandupuspitasari, Windu Negara, Kaifeng Guan, Fei Sun, Chunjie Huang
Summary: Retinoic acid (RA) is a signaling molecule derived from vitamin A/retinol, with implications in various aspects of health and disease. It regulates cell functioning through both transcriptional and non-genomic mechanisms, influencing cell-fate determination, neurogenesis, visual function, inflammatory responses, and gametogenesis commitment.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Bilal Murtaza, Lili Wang, Xiaoyu Li, Muhammad Yasir Nawaz, Muhammad Kashif Saleemi, Aisha Khatoon, Xu Yongping
Summary: Mycotoxins in food pose significant concerns for food safety and public health, potentially causing a range of adverse symptoms and cancer development. Deoxynivalenol (DON) is particularly worrisome due to its harm to vital organs. Altered mycotoxins present possible risks to the environment and well-being, necessitating further research into their adverse consequences. Accurately assessing the risk posed by modified mycotoxins remains challenging.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Emine Toraman, Buesra Budak, Cemil Bayram, Selma Sezen, Behzad Mokhtare, Ahmet Hacimueftueoglu
Summary: The study suggests that parthenolide (PTL) may have therapeutic effects in treating testicular toxicity caused by paclitaxel (PTX) through reducing oxidative stress and increasing glutathione levels. PTL also promotes the expression of genes involved in reproduction and sperm production.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Correction
Biochemistry & Molecular Biology
Cuicui Zhuang, Hui Huo, Wanfa Fu, Wanyue Huang, Lulu Han, Miao Song, Yanfei Li
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Taotao Zhao, Jia Lv, Mingyuan Peng, Jiahui Mi, Shaosan Zhang, Jie Liu, Tong Chen, Zilong Sun, Ruiyan Niu
Summary: This study explores the protective effects of fecal microbiota transplantation (FMT) and short-chain fatty acids (SCFAs) supplementation on learning and memory impairment caused by fluoride exposure in mice. The results show that FMT and SCFAs can improve memory deficits and alleviate pathological damages caused by fluoride, possibly by activating the BDNF-PI3K/AKT pathway. Furthermore, the disordered gut microbiome caused by fluoride can be restored through frequent FMT.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Yong Liu, Zhaofei Pang, Yadong Wang, Jichang Liu, Guanghui Wang, Jiajun Du
Summary: This study reveals that silencing PKD2 promotes ferroptosis in LUAD by increasing reactive oxygen species, malondialdehyde accumulation, intracellular iron content and cell death. Overexpression of PKD2 prevents autophagic degradation of ferritin and promotes proliferation, migration and invasion of LUAD cells. Moreover, targeting PKD2 enhances the efficacy of carboplatin through ferroptosis and apoptosis in LUAD.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)