Selective Loss of Responsiveness to Exogenous but Not Endogenous Cyclic-Dinucleotides in Mice Expressing STING-R231H

Structural basis of STING binding with and phosphorylation by TBK1

(2019) Conggang Zhang et al.   NATURE

Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP–AMP

(2019) Guijun Shang et al.   NATURE

Autophagy induction via STING trafficking is a primordial function of the cGAS pathway

(2019) Xiang Gui et al.   NATURE

cGAS facilitates sensing of extracellular cyclic dinucleotides to activate innate immunity

(2019) Haipeng Liu et al.   EMBO REPORTS

A STING to inflammation and autoimmunity

(2019) Vijay Kumar   JOURNAL OF LEUKOCYTE BIOLOGY

TMEM173 variants and potential importance to human biology and disease

(2018) Seema Patel et al.   GENES AND IMMUNITY

The cGAS–cGAMP–STING pathway connects DNA damage to inflammation, senescence, and cancer

(2018) Tuo Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Multiple Homozygous Variants in the STING-EncodingTMEM173Gene in HIV Long-Term Nonprogressors

(2018) Sara K. Nissen et al.   JOURNAL OF IMMUNOLOGY

Suppression of STING signaling through epigenetic silencing and missense mutation impedes DNA damage mediated cytokine production

(2018) Hiroyasu Konno et al.   ONCOGENE

Analysis of Drosophila STING Reveals an Evolutionarily Conserved Antimicrobial Function

(2018) Marina Martin et al.   Cell Reports

The common HAQ STING variant impairs cGAS-dependent antibacterial responses and is associated with susceptibility to Legionnaires’ disease in humans

(2018) Juan S. Ruiz-Moreno et al.   PLoS Pathogens

Streptococcal M protein promotes IL-10 production by cGAS-independent activation of the STING signaling pathway

(2018) Elin Movert et al.   PLoS Pathogens

Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage

(2018) Gillian Dunphy et al.   MOLECULAR CELL

STING directly activates autophagy to tune the innate immune response

(2018) Dong Liu et al.   CELL DEATH AND DIFFERENTIATION

B Cell–Intrinsic STING Signaling Triggers Cell Activation, Synergizes with B Cell Receptor Signals, and Promotes Antibody Responses

(2018) Melissa M. Walker et al.   JOURNAL OF IMMUNOLOGY

Immature lung TNFR2− conventional DC 2 subpopulation activates moDCs to promote cyclic di-GMP mucosal adjuvant responses in vivo

(2018) Samira Mansouri et al.   Mucosal Immunology

Comment on “The Common R71H-G230A-R293Q HumanTMEM173Is a Null Allele”

(2017) Kelsey E. Sivick et al.   JOURNAL OF IMMUNOLOGY

Brucella abortusTriggers a cGAS-Independent STING Pathway To Induce Host Protection That Involves Guanylate-Binding Proteins and Inflammasome Activation

(2017) Miriam M. Costa Franco et al.   JOURNAL OF IMMUNOLOGY

cGAS is essential for cellular senescence

(2017) Hui Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Detection of a microbial metabolite by STING regulates inflammasome activation in response to Chlamydia trachomatis infection

(2017) Steve J. Webster et al.   PLoS Pathogens

The Common R71H-G230A-R293Q HumanTMEM173Is a Null Allele

(2016) Seema Patel et al.   JOURNAL OF IMMUNOLOGY

The Cytosolic Sensor cGAS Detects Mycobacterium tuberculosis DNA to Induce Type I Interferons and Activate Autophagy

(2015) Robert O. Watson et al.   Cell Host & Microbe

A bacterial cyclic dinucleotide activates the cytosolic surveillance pathway and mediates innate resistance to tuberculosis

(2015) Bappaditya Dey et al.   NATURE MEDICINE

Molecular basis for the specific recognition of the metazoan cyclic GMP-AMP by the innate immune adaptor protein STING

(2015) Heping Shi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

STING agonist formulated cancer vaccines can cure established tumors resistant to PD-1 blockade

(2015) Juan Fu et al.   Science Translational Medicine

Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity

(2015) Leticia Corrales et al.   Cell Reports

The mucosal adjuvant cyclic di-GMP enhances antigen uptake and selectively activates pinocytosis-efficient cells in vivo

(2015) Steven M Blaauboer et al.   eLife

STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors

(2014) Seng-Ryong Woo et al.   IMMUNITY

MPYS/STING-Mediated TNF- , Not Type I IFN, Is Essential for the Mucosal Adjuvant Activity of (3'-5')-Cyclic-Di-Guanosine-Monophosphate In Vivo

(2013) S. M. Blaauboer et al.   JOURNAL OF IMMUNOLOGY

Single Nucleotide Polymorphisms of Human STING Can Affect Innate Immune Response to Cyclic Dinucleotides

(2013) Guanghui Yi et al.   PLoS One

STING-Dependent Recognition of Cyclic di-AMP Mediates Type I Interferon Responses during Chlamydia trachomatis Infection

(2013) J. R. Barker et al.   mBio

The Innate Immune DNA Sensor cGAS Produces a Noncanonical Cyclic Dinucleotide that Activates Human STING

(2013) Elie J. Diner et al.   Cell Reports

Extracellular M. tuberculosis DNA Targets Bacteria for Autophagy by Activating the Host DNA-Sensing Pathway

(2012) Robert O. Watson et al.   CELL

Autoimmunity Initiates in Nonhematopoietic Cells and Progresses via Lymphocytes in an Interferon-Dependent Autoimmune Disease

(2012) Alevtina Gall et al.   IMMUNITY

STING manifests self DNA-dependent inflammatory disease

(2012) J. Ahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA

(2012) J. Wu et al.   SCIENCE

Identification and characterization of a loss-of-function human MPYS variant

(2011) L Jin et al.   GENES AND IMMUNITY

MPYS Is Required for IFN Response Factor 3 Activation and Type I IFN Production in the Response of Cultured Phagocytes to Bacterial Second Messengers Cyclic-di-AMP and Cyclic-di-GMP

(2011) L. Jin et al.   JOURNAL OF IMMUNOLOGY

STING is a direct innate immune sensor of cyclic di-GMP

(2011) Dara L. Burdette et al.   NATURE

Bis-(3′,5′)-cyclic dimeric adenosine monophosphate: Strong Th1/Th2/Th17 promoting mucosal adjuvant

(2011) Thomas Ebensen et al.   VACCINE

TheN-Ethyl-N-Nitrosourea-InducedGoldenticketMouse Mutant Reveals an Essential Function ofStingin theIn VivoInterferon Response toListeria monocytogenesand Cyclic Dinucleotides

(2010) John-Demian Sauer et al.   INFECTION AND IMMUNITY

STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

(2009) Hiroki Ishikawa et al.   NATURE

Intramuscular Matrix-M-adjuvanted virosomal H5N1 vaccine induces high frequencies of multifunctional Th1 CD4+ cells and strong antibody responses in mice

(2009) Abdullah S. Madhun et al.   VACCINE

c-di-GMP as a vaccine adjuvant enhances protection against systemic methicillin-resistant Staphylococcus aureus (MRSA) infection

(2009) Dong-Liang Hu et al.   VACCINE

The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3 Transcription Factor Activation

(2008) Bo Zhong et al.   IMMUNITY

MPYS, a Novel Membrane Tetraspanner, Is Associated with Major Histocompatibility Complex Class II and Mediates Transduction of Apoptotic Signals

(2008) L. Jin et al.   MOLECULAR AND CELLULAR BIOLOGY

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

(2008) Hiroki Ishikawa et al.   NATURE