The common HAQ STING variant impairs cGAS-dependent antibacterial responses and is associated with susceptibility to Legionnaires’ disease in humans

The Common R71H-G230A-R293Q HumanTMEM173Is a Null Allele

(2016) Seema Patel et al.   JOURNAL OF IMMUNOLOGY

Cooperation between Monocyte-Derived Cells and Lymphoid Cells in the Acute Response to a Bacterial Lung Pathogen

(2016) Andrew S. Brown et al.   PLoS Pathogens

IFNs Modify the Proteome of Legionella-Containing Vacuoles and Restrict Infection Via IRG1-Derived Itaconic Acid

(2016) Jan Naujoks et al.   PLoS Pathogens

The Cytosolic Sensor cGAS Detects Mycobacterium tuberculosis DNA to Induce Type I Interferons and Activate Autophagy

(2015) Robert O. Watson et al.   Cell Host & Microbe

Mycobacterium tuberculosis Differentially Activates cGAS- and Inflammasome-Dependent Intracellular Immune Responses through ESX-1

(2015) Ruth Wassermann et al.   Cell Host & Microbe

Cyclic GMP-AMP Synthase Is an Innate Immune DNA Sensor for Mycobacterium tuberculosis

(2015) Angela C. Collins et al.   Cell Host & Microbe

IL-1R signaling enables bystander cells to overcome bacterial blockade of host protein synthesis

(2015) Alan M. Copenhaver et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytosolic RNA:DNA hybrids activate the cGAS–STING axis

(2014) Arun K Mankan et al.   EMBO JOURNAL

The DNA Sensor, Cyclic GMP–AMP Synthase, Is Essential for Induction of IFN-β duringChlamydia trachomatisInfection

(2014) Yugen Zhang et al.   JOURNAL OF IMMUNOLOGY

Cytosolic-DNA-Mediated, STING-Dependent Proinflammatory Gene Induction Necessitates Canonical NF- B Activation through TBK1

(2014) T. Abe et al.   JOURNAL OF VIROLOGY

Epidemiology and clinical management of Legionnaires' disease

(2014) Nick Phin et al.   LANCET INFECTIOUS DISEASES

Activated STING in a Vascular and Pulmonary Syndrome

(2014) Yin Liu et al.   NEW ENGLAND JOURNAL OF MEDICINE

A TLR6 polymorphism is associated with increased risk of Legionnaires’ disease

(2013) E A Misch et al.   GENES AND IMMUNITY

The Dot/Icm Effector SdhA Is Necessary for Virulence of Legionella pneumophila in Galleria mellonella and A/J Mice

(2013) Clare R. Harding et al.   INFECTION AND IMMUNITY

Single Nucleotide Polymorphisms of Human STING Can Affect Innate Immune Response to Cyclic Dinucleotides

(2013) Guanghui Yi et al.   PLoS One

The Innate Immune DNA Sensor cGAS Produces a Noncanonical Cyclic Dinucleotide that Activates Human STING

(2013) Elie J. Diner et al.   Cell Reports

Mycobacterium Tuberculosis Activates the DNA-Dependent Cytosolic Surveillance Pathway within Macrophages

(2012) Paolo S. Manzanillo et al.   Cell Host & Microbe

Genetic variation in Toll-like receptors and disease susceptibility

(2012) Mihai G Netea et al.   NATURE IMMUNOLOGY

The protein SdhA maintains the integrity of the Legionella-containing vacuole

(2012) E. A. Creasey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA

(2012) J. Wu et al.   SCIENCE

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

Dissection of a type I interferon pathway in controlling bacterial intracellular infection in mice

(2011) Juliane Lippmann et al.   CELLULAR MICROBIOLOGY

Racial Differences in Tuberculosis Infection in United States Communities: The Coronary Artery Risk Development in Young Adults Study

(2011) P. Nahid et al.   CLINICAL INFECTIOUS DISEASES

Medical, psychological and socioeconomic aspects of aging in Poland

(2011) Piotr Bledowski et al.   EXPERIMENTAL GERONTOLOGY

Identification and characterization of a loss-of-function human MPYS variant

(2011) L Jin et al.   GENES AND IMMUNITY

Innate Immune Recognition of an AT-Rich Stem-Loop DNA Motif in the Plasmodium falciparum Genome

(2011) Shruti Sharma et al.   IMMUNITY

The Atypical Two-component Sensor Kinase Lpl0330 fromLegionella pneumophilaControls the Bifunctional Diguanylate Cyclase-Phosphodiesterase Lpl0329 to Modulate Bis-(3′-5′)-cyclic Dimeric GMP Synthesis

(2011) Mélanie Levet-Paulo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nonhematopoietic Cells Are Key Players in Innate Control of Bacterial Airway Infection

(2011) S. LeibundGut-Landmann et al.   JOURNAL OF IMMUNOLOGY

MPYS Is Required for IFN Response Factor 3 Activation and Type I IFN Production in the Response of Cultured Phagocytes to Bacterial Second Messengers Cyclic-di-AMP and Cyclic-di-GMP

(2011) L. Jin et al.   JOURNAL OF IMMUNOLOGY

The overlapping host responses to bacterial cyclic dinucleotides

(2011) Ali A. Abdul-Sater et al.   MICROBES AND INFECTION

STING is a direct innate immune sensor of cyclic di-GMP

(2011) Dara L. Burdette et al.   NATURE

Cyclic Diguanylate Signaling Proteins Control Intracellular Growth of Legionella pneumophila

(2011) A. Levi et al.   mBio

The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1

(2010) Nan Yan et al.   NATURE IMMUNOLOGY

Interferons Direct an Effective Innate Response toLegionella pneumophilaInfection

(2009) Courtney R. Plumlee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

(2009) Hiroki Ishikawa et al.   NATURE

Identification of Host Cytosolic Sensors and Bacterial Factors Regulating the Type I Interferon Response to Legionella pneumophila

(2009) Kathryn M. Monroe et al.   PLoS Pathogens

IFNβ responses induced by intracellular bacteria or cytosolic DNA in different human cells do not require ZBP1 (DLM-1/DAI)

(2008) Juliane Lippmann et al.   CELLULAR MICROBIOLOGY

Community‐AcquiredLegionellaPneumonia: New Insights from the German Competence Network for Community Acquired Pneumonia

(2008) Heike von Baum et al.   CLINICAL INFECTIOUS DISEASES

TNF receptor 1 and 2 contribute in different ways to resistance to Legionella pneumophila-induced mortality in mice

(2008) Masaki Fujita et al.   CYTOKINE

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

(2008) Hiroki Ishikawa et al.   NATURE

The Legionella pneumophila replication vacuole: making a cosy niche inside host cells

(2008) Ralph R. Isberg et al.   NATURE REVIEWS MICROBIOLOGY

The Effect of Toll-Like Receptors and Toll-Like Receptor Genetics in Human Disease

(2007) Stavros Garantziotis et al.   Annual Review of Medicine