Article
Medicine, Research & Experimental
Zhilin Hu, Xiaoyan Yu, Rui Ding, Ben Liu, Chuanjia Gu, Xiu-Wu Pan, Qiaoqiao Han, Yuerong Zhang, Jie Wan, Xin-Gang Cui, Jiayuan Sun, Qiang Zou
Summary: Activation of STING signaling in DCs is enhanced by glycolysis, leading to increased antitumor immunity. Tumor-infiltrating DCs exhibit elevated glycolytic activity, and blocking glycolysis impairs antitumor immunity. Mechanistically, glycolysis enhances ATP production, boosting STING activation and DC-mediated antitumor functions. Additionally, DC-intrinsic STING activation accelerates HIF-1 alpha-mediated glycolysis, establishing a positive feedback loop. Importantly, glycolysis facilitates STING-dependent DC activity in tissue samples from patients with non-small cell lung cancer. These findings provide insights into the crosstalk between glycolytic metabolism and STING signaling, offering potential for improving cancer therapies.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Biochemistry & Molecular Biology
Jun Lu, Yi Zhang, Huiyue Dong, Jingjing Sun, Ling Zhu, Pengyang Liu, Fuli Wen, Rong Lin
Summary: Triptolide activates the cGAS-STING signaling pathway in kidney tubular cells, leading to renal injury. Inhibiting over-activation of the cGAS-STING pathway may be a new strategy to alleviate triptolide-induced nephrotoxicity.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Cell Biology
Qiang Guo, Ximiao Chen, Jiaoxiang Chen, Gang Zheng, Chenglong Xie, Hongqiang Wu, Zhimin Miao, Yan Lin, Xiangyang Wang, Weiyang Gao, Xiangtao Zheng, Zongyou Pan, Yifei Zhou, Yaosen Wu, Xiaolei Zhang
Summary: The study investigated the role of STING in osteoarthritis progression, revealing its involvement in ECM metabolism, apoptosis, and senescence in chondrocytes. STING activation of NF-kappa B signaling cascade was found to contribute to OA development, with suppression of STING showing potential as a therapeutic approach.
CELL DEATH & DISEASE
(2021)
Review
Immunology
Yuchen Yang, Li Wang, Ivonne Peugnet-Gonzalez, Daniela Parada-Venegas, Gerard Dijkstra, Klaas Nico Faber
Summary: The intestinal mucosa serves as a barrier and is involved in nutrient absorption. Genetic susceptibility and environmental factors play a critical role in the development of intestinal diseases. The innate immune system recognizes potential threats through pattern recognition receptors (PRRs), including the cGAS-STING pathway. However, the role of the cGAS-STING pathway in intestinal diseases is still debated.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Cell Biology
Yuting Yang, Yiming Huang, Zhenguo Zeng
Summary: Pathogens can produce conserved pathogen-associated molecular patterns (PAMPs) that are recognized by host pattern recognition receptors (PRRs). Recent studies have shown that cytoplasmic DNA receptors can specifically recognize exogenous DNA and activate interferon 1 (IFN1), which is a significant advancement in various research fields. The cGAS-STING signaling pathway is a critical natural immune pathway in cells and plays a crucial role in pathogen infection, tumors, and various autoimmune diseases in humans.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Cell Biology
Kunli Zhang, Sutian Wang, Hongchao Gou, Jianfeng Zhang, Chunling Li
Summary: Innate immunity serves as the initial defense against infectious microorganisms, with the cGAS-STING pathway and autophagy playing crucial roles in regulating the production of type I interferons and combating pathogenic microbial infections.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Xinxin Ke, Tao Hu, Mizu Jiang
Summary: The cGAS-STING signaling pathway plays a crucial role in GI inflammatory diseases and cancers. Understanding the function and mechanism of this pathway is helpful for developing therapeutic strategies.
Article
Immunology
Shaobin Luo, Rongkun Luo, Huanyuan Lu, Rui Zhang, Gang Deng, Hongwu Luo, Xiao Yu, Changfa Wang, Hui Zhang, Yuping Zhang, Wei Huang, Jichun Sun, Yinghong Liu, Feizhou Huang, Zhao Lei
Summary: This study investigated the role of the cGAS-STING signaling pathway in the development of liver fibrosis. The results showed that upregulation of this pathway exacerbated liver fibrosis and inflammation, and increased the contribution of hepatic sinusoidal microthrombosis to liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Virology
Rongzhao Zhang, Wenxian Yang, Huifang Zhu, Jingbo Zhai, Mengzhou Xue, Chunfu Zheng
Summary: TBK1 activation is crucial for antiviral innate immunity. NLRC4 has been identified as a positive regulator of TBK1, enhancing the activity of the cGAS-STING signaling pathway and promoting antiviral immune response.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Multidisciplinary Sciences
Qian Shen, Lei Yang, Chengguo Li, Tao Wang, Jianbo Lv, Weizhen Liu, Yao Lin, Yuping Yin, Kaixiong Tao
Summary: In this study, we found that metformin activates the cGAS/STING signaling pathway in gastric cancer by suppressing SOX2/AKT, suggesting its potential in gastric cancer immunotherapy.
Article
Virology
Huifang Zhu, Rongzhao Zhang, Li Yi, Yan-Dong Tang, Chunfu Zheng
Summary: This study demonstrates that UNC93B1 acts as a crucial regulator of STING, attenuating its signaling pathway through autophagy-lysosome degradation, and provides novel insights into UNC93B1's function in antiviral innate immunity.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Immunology
Wanglong Zheng, Nengwen Xia, Jiajia Zhang, Qi Cao, Sen Jiang, Jia Luo, Hui Wang, Nanhua Chen, Quan Zhang, Francois Meurens, Jianzhong Zhu
Summary: The structural protein p17 of African swine fever virus interacts with STING to inhibit the cGAS-STING pathway, thus evading the host immune response.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Neurosciences
Guo-Liang Jiang, Xing-Long Yang, Hou-Jun Zhou, Jiang Long, Bin Liu, Lin-Ming Zhang, Di Lu
Summary: Inflammation plays a crucial role in the pathophysiology of ischemic stroke, with the cGAS-STING pathway being identified as a key player in neuroinflammation. Inhibiting the cGAS-STING pathway can reduce cell apoptosis, decrease the extent of cerebral infarction, and improve nerve function during ischemic stroke.
BRAIN RESEARCH BULLETIN
(2021)
Review
Immunology
Lishuang Deng, Zhiwen Xu, Fengqin Li, Jun Zhao, Zhijie Jian, Huidan Deng, Siyuan Lai, Xiangang Sun, Yi Geng, Ling Zhu
Summary: Herpesviruses are large DNA viruses that can establish lifelong infection in hosts, posing a burden on human and animal health. The cGAS-STING signaling pathway plays an important role in the innate immunity against herpesvirus infections.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Sen Jiang, Mengjia Lv, Desheng Zhang, Qi Cao, Nengwen Xia, Jia Luo, Wanglong Zheng, Nanhua Chen, Francois Meurens, Jianzhong Zhu
Summary: It has been recently discovered that chicken STING (chSTING) exhibits an antiviral activity independent of IFN production, and this function is likely achieved through apoptosis. In addition, chSTING's antiviral function is dependent on the presence of IRF7. Overall, this study highlights the IFN-independent antiviral function of chSTING and its involvement in apoptosis.
Article
Cell Biology
Julia Lienard, Elin Movert, Christine Valfridsson, Erik Sturegard, Fredric Carlsson
CELLULAR MICROBIOLOGY
(2016)
Article
Immunology
Therese Nordstrom, Manisha Pandey, Ainslie Calcutt, Jessica Powell, Zachary N. Phillips, Grace Yeung, Ashwini K. Giddam, Yun Shi, Thomas Haselhorst, Mark von Itzstein, Michael R. Batzloff, Michael F. Good
JOURNAL OF IMMUNOLOGY
(2017)
Article
Microbiology
Brigida Rusconi, Julia Lienard, Sebastien Aeby, Antony Croxatto, Claire Bertelli, Gilbert Greub
ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY
(2013)
Article
Immunology
Susanne M. Ohlsson, Carl Petrus Linge, Birgitta Gullstrand, Christian Lood, Asa Johansson, Sophie Ohlsson, Andrea Lundqvist, Anders A. Bengtsson, Fredric Carlsson, Thomas Hellmark
CLINICAL IMMUNOLOGY
(2014)
Article
Multidisciplinary Sciences
Nicolas Jacquier, Sebastien Aeby, Julia Lienard, Gilbert Greub
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2013)
Article
Multidisciplinary Sciences
Julia Lienard, Esther Nobs, Victoria Lovins, Elin Movert, Christine Valfridsson, Fredric Carlsson
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Microbiology
Julia Lienard, Kristina Munke, Line Wulff, Clement Da Silva, Julien Vandamme, Katie Laschanzky, Thorsten Joeris, William Agace, Fredric Carlsson
Summary: The ESX-1 type VII secretion system is essential for the virulence of pathogenic mycobacteria. It interacts with infected macrophages but its role in regulating other host cells and immunopathology is not well understood.