标题
Emerging Role of Sirtuin 2 in Parkinson’s Disease
作者
关键词
-
出版物
Frontiers in Aging Neuroscience
Volume 11, Issue -, Pages -
出版商
Frontiers Media SA
发表日期
2020-01-10
DOI
10.3389/fnagi.2019.00372
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Aging modulates microglia phenotypes in neuroinflammation of MPTP-PD mice
- (2018) Kai Yao et al. EXPERIMENTAL GERONTOLOGY
- Damage to dopaminergic neurons by oxidative stress in Parkinson's disease (Review)
- (2018) Ji‑Dong Guo et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- Pathological histone acetylation in Parkinson’s disease: Neuroprotection and inhibition of microglial activation through SIRT 2 inhibition
- (2018) Ian F. Harrison et al. NEUROSCIENCE LETTERS
- Acetylation as a major determinant to microtubule-dependent autophagy: Relevance to Alzheimer's and Parkinson disease pathology
- (2018) A.R. Esteves et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Peripheral Inflammation Enhances Microglia Response and Nigral Dopaminergic Cell Death in an in vivo MPTP Model of Parkinson’s Disease
- (2018) Irene García-Domínguez et al. Frontiers in Cellular Neuroscience
- MicroRNA-212-5p Prevents Dopaminergic Neuron Death by Inhibiting SIRT2 in MPTP-Induced Mouse Model of Parkinson’s Disease
- (2018) Sifan Sun et al. Frontiers in Molecular Neuroscience
- Alpha-synuclein alters differently gene expression of Sirts, PARPs and other stress response proteins: implications for neurodegenerative disorders
- (2017) J. Motyl et al. MOLECULAR NEUROBIOLOGY
- Mitochondrial Metabolism Regulates Microtubule Acetylome and Autophagy Trough Sirtuin-2: Impact for Parkinson’s Disease
- (2017) Ana R. Esteves et al. MOLECULAR NEUROBIOLOGY
- The mechanism of sirtuin 2–mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease
- (2017) Rita Machado de Oliveira et al. PLOS BIOLOGY
- Sirtuin-2 Protects Neural Cells from Oxidative Stress and Is Elevated in Neurodegeneration
- (2017) Preeti Singh et al. Parkinsons Disease
- PGC-1α/ERRα-Sirt3 Pathway Regulates DAergic Neuronal Death by Directly Deacetylating SOD2 and ATP Synthase β
- (2016) Xuefei Zhang et al. ANTIOXIDANTS & REDOX SIGNALING
- Essential control of mitochondrial morphology and function by chaperone-mediated autophagy through degradation of PARK7
- (2016) Bao Wang et al. Autophagy
- Sirtuins, Cell Senescence, and Vascular Aging
- (2016) Yujiro Kida et al. CANADIAN JOURNAL OF CARDIOLOGY
- Back to the tubule: microtubule dynamics in Parkinson’s disease
- (2016) Laura Pellegrini et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Aging-related 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurochemial and behavioral deficits and redox dysfunction: improvement by AK-7
- (2016) Qiang Guan et al. EXPERIMENTAL GERONTOLOGY
- Sirtuin-2 mediates male specific neuronal injury following experimental cardiac arrest through activation of TRPM2 ion channels
- (2016) Kaori Shimizu et al. EXPERIMENTAL NEUROLOGY
- SIRT2 inactivation reveals a subset of hyperacetylated perinuclear microtubules inaccessible to HDAC6
- (2016) Renate Hvidsten Skoge et al. JOURNAL OF CELL SCIENCE
- 5-((3-Amidobenzyl)oxy)nicotinamides as Sirtuin 2 Inhibitors
- (2016) Teng Ai et al. JOURNAL OF MEDICINAL CHEMISTRY
- Resveratrol alleviates MPTP-induced motor impairments and pathological changes by autophagic degradation of α-synuclein via SIRT1-deacetylated LC3
- (2016) Yan-Jie Guo et al. MOLECULAR NUTRITION & FOOD RESEARCH
- Structural disorder of monomeric α-synuclein persists in mammalian cells
- (2016) Francois-Xavier Theillet et al. NATURE
- Peroxisome proliferator-activated receptor-γ (PPARγ) agonist is neuroprotective and stimulates PGC-1α expression and CREB phosphorylation in human dopaminergic neurons
- (2016) Johanna Mäkelä et al. NEUROPHARMACOLOGY
- Sirtuin regulation in aging and injury
- (2015) Ninu Poulose et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Coordinating Neuronal Actin–Microtubule Dynamics
- (2015) Charlotte H. Coles et al. CURRENT BIOLOGY
- Genes associated with Parkinson's disease: regulation of autophagy and beyond
- (2015) Alexandra Beilina et al. JOURNAL OF NEUROCHEMISTRY
- Rotenone affects p53 transcriptional activity and apoptosis via targeting SIRT1 and H3K9 acetylation in SH-SY5Y cells
- (2015) Ya Feng et al. JOURNAL OF NEUROCHEMISTRY
- Selectivity hot-spots of sirtuin catalytic cores
- (2015) Marco Daniele Parenti et al. Molecular BioSystems
- SIRT3 Attenuates MPTP-Induced Nigrostriatal Degeneration Via Enhancing Mitochondrial Antioxidant Capacity
- (2015) Lei Liu et al. NEUROCHEMICAL RESEARCH
- Building the Neuronal Microtubule Cytoskeleton
- (2015) Lukas C. Kapitein et al. NEURON
- The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease
- (2015) Alicia M. Pickrell et al. NEURON
- SIRT2 is required for lipopolysaccharide-induced activation of BV2 microglia
- (2015) Heyu Chen et al. NEUROREPORT
- Autophagy in neurodegenerative diseases: From pathogenic dysfunction to therapeutic modulation
- (2015) Marta Martinez-Vicente SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Emerging Role of Sirtuin 2 in the Regulation of Mammalian Metabolism
- (2015) Pedro Gomes et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Differential expression of sirtuins in the aging rat brain
- (2015) Nady Braidy et al. Frontiers in Cellular Neuroscience
- Aging-related rotenone-induced neurochemical and behavioral deficits: role of SIRT2 and redox imbalance, and neuroprotection by AK-7
- (2015) Xijin Wang et al. Drug Design Development and Therapy
- Oxidative stress-dependent changes in immune responses and cell death in the substantia nigra after ozone exposure in rat
- (2015) Selva Rivas-Arancibia et al. Frontiers in Aging Neuroscience
- The Sirtuin-2 Inhibitor AK7 Is Neuroprotective in Models of Parkinson’s Disease but Not Amyotrophic Lateral Sclerosis and Cerebral Ischemia
- (2015) Xiqun Chen et al. PLoS One
- Efficient Demyristoylase Activity of SIRT2 Revealed by Kinetic and Structural Studies
- (2015) Yan-Bin Teng et al. Scientific Reports
- The role of melatonin, sirtuin2 and FoXO1 transcription factor in the aging process of colon in male rats
- (2014) Kazime Gonca Akbulut et al. BIOGERONTOLOGY
- Regulation of SIRT2-dependent α-tubulin deacetylation by cellular NAD levels
- (2014) Renate Hvidsten Skoge et al. DNA REPAIR
- Decreased SIRT2 activity leads to altered microtubule dynamics in oxidatively-stressed neuronal cells: Implications for Parkinson's disease
- (2014) Vivek P. Patel et al. EXPERIMENTAL NEUROLOGY
- Reactive Oxygen Species, AMP-activated Protein Kinase, and the Transcription Cofactor p300 Regulate α-Tubulin Acetyltransferase-1 (αTAT-1/MEC-17)-dependent Microtubule Hyperacetylation during Cell Stress
- (2014) Rafah Mackeh et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The tubulin code: Molecular components, readout mechanisms, and functions
- (2014) Carsten Janke JOURNAL OF CELL BIOLOGY
- MicroRNA-7 Protects against 1-Methyl-4-Phenylpyridinium-Induced Cell Death by Targeting RelA
- (2014) D. C. Choi et al. JOURNAL OF NEUROSCIENCE
- The prevalence of Parkinson's disease: A systematic review and meta-analysis
- (2014) Tamara Pringsheim et al. MOVEMENT DISORDERS
- Small-molecule inhibitors at the PSD-95/nNOS interface attenuate MPP+-induced neuronal injury through Sirt3 mediated inhibition of mitochondrial dysfunction
- (2014) Wei Hu et al. NEUROCHEMISTRY INTERNATIONAL
- SIRT2 mediates oxidative stress-induced apoptosis of differentiated PC12 cells
- (2014) Hui Nie et al. NEUROREPORT
- N-Alpha-Acetylation of α-Synuclein Increases Its Helical Folding Propensity, GM1 Binding Specificity and Resistance to Aggregation
- (2014) Tim Bartels et al. PLoS One
- Increasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 Roc-COR domain mutations
- (2014) Vinay K. Godena et al. Nature Communications
- Systemic regulation of mammalian ageing and longevity by brain sirtuins
- (2014) Akiko Satoh et al. Nature Communications
- Microtubule acetylation amplifies p38 kinase signalling and anti-inflammatory IL-10 production
- (2014) Bin Wang et al. Nature Communications
- SIRT2 enhances 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced nigrostriatal damage via apoptotic pathway
- (2014) Lei Liu et al. Frontiers in Aging Neuroscience
- Dietary restriction in cerebral bioenergetics and redox state
- (2014) Ignacio Amigo et al. Redox Biology
- HIV-1 Induces the Formation of Stable Microtubules to Enhance Early Infection
- (2013) Yosef Sabo et al. Cell Host & Microbe
- Recent developments in biomarkers in Parkinson disease
- (2013) Anthony H.V. Schapira CURRENT OPINION IN NEUROLOGY
- The NAD-dependent deacetylase sirtuin 2 is a suppressor of microglial activation and brain inflammation
- (2013) Teresa Faria Pais et al. EMBO JOURNAL
- Oxidative damage to macromolecules in human Parkinson disease and the rotenone model
- (2013) Laurie H. Sanders et al. FREE RADICAL BIOLOGY AND MEDICINE
- Parkinson disease: from pathology to molecular disease mechanisms
- (2013) David T. Dexter et al. FREE RADICAL BIOLOGY AND MEDICINE
- A Direct Interaction between Leucine-rich Repeat Kinase 2 and Specific β-Tubulin Isoforms Regulates Tubulin Acetylation
- (2013) Bernard M. H. Law et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Beyond the mitochondrion: cytosolic PINK1 remodels dendrites through Protein Kinase A
- (2013) Ruben K. Dagda et al. JOURNAL OF NEUROCHEMISTRY
- Modulation of p53 C-Terminal Acetylation by mdm2, p14ARF, and Cytoplasmic SirT2
- (2013) I. M. M. van Leeuwen et al. MOLECULAR CANCER THERAPEUTICS
- Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome
- (2013) Takuma Misawa et al. NATURE IMMUNOLOGY
- Interplay of LRRK2 with chaperone-mediated autophagy
- (2013) Samantha J Orenstein et al. NATURE NEUROSCIENCE
- Poly(ADP-ribose) polymerase mediates both cell death and ATP decreases in SIRT2 inhibitor AGK2-treated microglial BV2 cells
- (2013) Yexin Li et al. NEUROSCIENCE LETTERS
- Antioxidant gene therapy against neuronal cell death
- (2013) Juliana Navarro-Yepes et al. PHARMACOLOGY & THERAPEUTICS
- Toll like receptor 4 mediates cell death in a mouse MPTP model of Parkinson disease
- (2013) Carmen Noelker et al. Scientific Reports
- Programmed Cell Death in Parkinson's Disease
- (2013) K. Venderova et al. Cold Spring Harbor Perspectives in Medicine
- The Role of Autophagy in Parkinson's Disease
- (2013) M. A. Lynch-Day et al. Cold Spring Harbor Perspectives in Medicine
- SNCA (α-synuclein)-induced toxicity in yeast cells is dependent on Sir2-mediated mitophagy
- (2012) Belém Sampaio-Marques et al. Autophagy
- Building Complexity: Insights into Self-Organized Assembly of Microtubule-Based Architectures
- (2012) Radhika Subramanian et al. DEVELOPMENTAL CELL
- SIRT1 Protects against -Synuclein Aggregation by Activating Molecular Chaperones
- (2012) G. Donmez et al. JOURNAL OF NEUROSCIENCE
- Tubulin Acetyltransferase αTAT1 Destabilizes Microtubules Independently of Its Acetylation Activity
- (2012) Nereo Kalebic et al. MOLECULAR AND CELLULAR BIOLOGY
- SIRT2 as a Therapeutic Target for Age-Related Disorders
- (2012) Rita Machado de Oliveira et al. Frontiers in Pharmacology
- Autophagy and Aging
- (2011) David C. Rubinsztein et al. CELL
- Targeting TNF-Alpha to Elucidate and Ameliorate Neuroinflammation in Neurodegenerative Diseases
- (2011) Kathryn A. Frankola et al. CNS & Neurological Disorders-Drug Targets
- Advances in Characterization of Human Sirtuin Isoforms: Chemistries, Targets and Therapeutic Applications
- (2011) Y. Cen et al. CURRENT MEDICINAL CHEMISTRY
- The Sirtuin 2 microtubule deacetylase is an abundant neuronal protein that accumulates in the aging CNS
- (2011) Michele M. Maxwell et al. HUMAN MOLECULAR GENETICS
- Sumoylation inhibits α-synuclein aggregation and toxicity
- (2011) Petranka Krumova et al. JOURNAL OF CELL BIOLOGY
- Cutting Edge: Tubulin Functions as an Adaptor in NFAT-Importin Interaction
- (2011) K. Ishiguro et al. JOURNAL OF IMMUNOLOGY
- Ageing as a primary risk factor for Parkinson's disease: evidence from studies of non-human primates
- (2011) Timothy J. Collier et al. NATURE REVIEWS NEUROSCIENCE
- Neuroinflammation in Parkinson's disease
- (2011) Etienne C. Hirsch et al. PARKINSONISM & RELATED DISORDERS
- Ubiquitin ligase Nedd4 promotes -synuclein degradation by the endosomal-lysosomal pathway
- (2011) G. K. Tofaris et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Anti-neoplastic activity of the cytosolic FoxO1 results from autophagic cell death
- (2010) Ying Zhao et al. Autophagy
- Acetylated microtubules are required for fusion of autophagosomes with lysosomes
- (2010) Rui Xie et al. BMC CELL BIOLOGY
- SIRT2 downregulation confers resistance to microtubule inhibitors by prolonging chronic mitotic arrest
- (2010) Toshiaki Inoue et al. CELL CYCLE
- Calorie Restriction Reduces Oxidative Stress by SIRT3-Mediated SOD2 Activation
- (2010) Xiaolei Qiu et al. Cell Metabolism
- SIRT2 regulates NF- B-dependent gene expression through deacetylation of p65 Lys310
- (2010) K. M. Rothgiesser et al. JOURNAL OF CELL SCIENCE
- MEC-17 is an α-tubulin acetyltransferase
- (2010) Jyothi S. Akella et al. NATURE
- Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity
- (2010) Ying Zhao et al. NATURE CELL BIOLOGY
- A basic smell test is as sensitive as a dopamine transporter scan: comparison of olfaction, taste and DaTSCAN in the diagnosis of Parkinson's disease
- (2010) J. Deeb et al. QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
- The Caenorhabditis elegans Elongator Complex Regulates Neuronal α-tubulin Acetylation
- (2010) Jachen A. Solinger et al. PLoS Genetics
- Sirtuin 1 overexpression mice show a reference memory deficit, but not neuroprotection
- (2009) Kenichi Kakefuda et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Pink1 Forms a Multiprotein Complex with Miro and Milton, Linking Pink1 Function to Mitochondrial Trafficking†
- (2009) Andreas Weihofen et al. BIOCHEMISTRY
- Elongator Controls the Migration and Differentiation of Cortical Neurons through Acetylation of α-Tubulin
- (2009) Catherine Creppe et al. CELL
- SIRT2-mediated protein deacetylation: An emerging key regulator in brain physiology and pathology
- (2009) Kai Harting et al. EUROPEAN JOURNAL OF CELL BIOLOGY
- Does neuroinflammation fan the flame in neurodegenerative diseases?
- (2009) Tamy C Frank-Cannon et al. Molecular Neurodegeneration
- α-Synuclein Protofibrils Inhibit 26 S Proteasome-mediated Protein Degradation
- (2008) Nan-Yan Zhang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Aberrant Interaction between Parkinson Disease-associated Mutant UCH-L1 and the Lysosomal Receptor for Chaperone-mediated Autophagy
- (2008) Tomohiro Kabuta et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Functional Mitochondria Are Required for α-Synuclein Toxicity in Aging Yeast
- (2008) Sabrina Büttner et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The regulation of SIRT2 function by cyclin-dependent kinases affects cell motility
- (2008) Ruwin Pandithage et al. JOURNAL OF CELL BIOLOGY
- Brain SIRT1: Anatomical Distribution and Regulation by Energy Availability
- (2008) G. Ramadori et al. JOURNAL OF NEUROSCIENCE
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started