Inhibitory Network Bistability Explains Increased Interneuronal Activity Prior to Seizure Onset

Generation and On-Demand Initiation of Acute Ictal Activity in Rodent and Human Tissue

(2019) Michael Chang et al.   Jove-Journal of Visualized Experiments

Mathematical model of Na-K-Cl homeostasis in ictal and interictal discharges

(2019) Anton V. Chizhov et al.   PLoS One

Phase response theory explains cluster formation in sparsely but strongly connected inhibitory neural networks and effects of jitter due to sparse connectivity

(2019) Ruben A. Tikidji-Hamburyan et al.   JOURNAL OF NEUROPHYSIOLOGY

Self-propagating, non-synaptic epileptiform activity recruits neurons by endogenous electric fields

(2019) Rajat S. Shivacharan et al.   EXPERIMENTAL NEUROLOGY

Role of inhibitory control in modulating focal seizure spread

(2018) Jyun-you Liou et al.   BRAIN

Effects of Neuromodulation on Excitatory–Inhibitory Neural Network Dynamics Depend on Network Connectivity Structure

(2018) Scott Rich et al.   JOURNAL OF NONLINEAR SCIENCE

Brief activation of GABAergic interneurons initiates the transition to ictal events through post-inhibitory rebound excitation

(2018) Michael Chang et al.   NEUROBIOLOGY OF DISEASE

Low-Voltage Fast Seizures in Humans Begin With Increased Interneuron Firing

(2018) Bahareh Elahian et al.   ANNALS OF NEUROLOGY

Loss of neuronal network resilience precedes seizures and determines the ictogenic nature of interictal synaptic perturbations

(2018) Wei-Chih Chang et al.   NATURE NEUROSCIENCE

Interneuronal Network Activity at the Onset of Seizure-Like Events in Entorhinal Cortex Slices

(2017) Laura Librizzi et al.   JOURNAL OF NEUROSCIENCE

Computational model of interictal discharges triggered by interneurons

(2017) Anton V. Chizhov et al.   PLoS One

Dichotomous Dynamics in E-I Networks with Strongly and Weakly Intra-connected Inhibitory Neurons

(2017) Scott Rich et al.   Frontiers in Neural Circuits

Reliable and Elastic Propagation of Cortical Seizures In Vivo

(2017) Michael Wenzel et al.   Cell Reports

GABAergic networks jump-start focal seizures

(2016) Marco de Curtis et al.   EPILEPSIA

Specific imbalance of excitatory/inhibitory signaling establishes seizure onset pattern in temporal lobe epilepsy

(2016) Massimo Avoli et al.   JOURNAL OF NEUROPHYSIOLOGY

Computational models of epileptiform activity

(2016) Fabrice Wendling et al.   JOURNAL OF NEUROSCIENCE METHODS

Intrinsic Cellular Properties and Connectivity Density Determine Variable Clustering Patterns in Randomly Connected Inhibitory Neural Networks

(2016) Scott Rich et al.   Frontiers in Neural Circuits

GABAergic inhibition shapes interictal dynamics in awake epileptic mice

(2015) Sarah Feldt Muldoon et al.   BRAIN

Reconstruction and Simulation of Neocortical Microcircuitry

(2015) Henry Markram et al.   CELL

Generation of physiological and pathological high frequency oscillations: the role of perisomatic inhibition in sharp-wave ripple and interictal spike generation

(2015) Attila I Gulyás et al.   CURRENT OPINION IN NEUROBIOLOGY

Resonant Interneurons Can Increase Robustness of Gamma Oscillations

(2015) Ruben A. Tikidji-Hamburyan et al.   JOURNAL OF NEUROSCIENCE

Differential modulation of repetitive firing and synchronous network activity in neocortical interneurons by inhibition of A-type K+ channels and Ih

(2015) Sidney B. Williams et al.   Frontiers in Cellular Neuroscience

Mechanisms of Sharp Wave Initiation and Ripple Generation

(2014) D. Schlingloff et al.   JOURNAL OF NEUROSCIENCE

Excitatory Effects of Parvalbumin-Expressing Interneurons Maintain Hippocampal Epileptiform Activity via Synchronous Afterdischarges

(2014) T. J. Ellender et al.   JOURNAL OF NEUROSCIENCE

Network Models Predict that Reduced Excitatory Fluctuations Can Give Rise to Hippocampal Network Hyper-Excitability in MeCP2-Null Mice

(2014) Ernest C. Y. Ho et al.   PLoS One

Modeling oscillatory dynamics in brain microcircuits as a way to help uncover neurological disease mechanisms: A proposal

(2013) F. K. Skinner et al.   CHAOS

Neuronal synchrony and the transition to spontaneous seizures

(2013) Dane W. Grasse et al.   EXPERIMENTAL NEUROLOGY

Experimentally constrained CA1 fast-firing parvalbumin-positive interneuron network models exhibit sharp transitions into coherent high frequency rhythms

(2013) Katie A. Ferguson et al.   Frontiers in Computational Neuroscience

Inhibitory Networks of Fast-Spiking Interneurons Generate Slow Population Activities due to Excitatory Fluctuations and Network Multistability

(2012) E. C. Y. Ho et al.   JOURNAL OF NEUROSCIENCE

Synchronization and desynchronization in epilepsy: controversies and hypotheses

(2012) Premysl Jiruska et al.   JOURNAL OF PHYSIOLOGY-LONDON

Pyramidal cells accumulate chloride at seizure onset

(2012) Kyle P. Lillis et al.   NEUROBIOLOGY OF DISEASE

Evidence of an inhibitory restraint of seizure activity in humans

(2012) Catherine A. Schevon et al.   Nature Communications

Orthogonal wave propagation of epileptiform activity in the planar mouse hippocampus in vitro

(2011) Andrew B. Kibler et al.   EPILEPSIA

GABAergic synchronization in the limbic system and its role in the generation of epileptiform activity

(2011) Massimo Avoli et al.   PROGRESS IN NEUROBIOLOGY

Network Bistability Mediates Spontaneous Transitions between Normal and Pathological Brain States

(2010) F. Frohlich et al.   JOURNAL OF NEUROSCIENCE

Priming of Hippocampal Population Bursts by Individual Perisomatic-Targeting Interneurons

(2010) T. J. Ellender et al.   JOURNAL OF NEUROSCIENCE

Neurophysiological and Computational Principles of Cortical Rhythms in Cognition

(2010) Xiao-Jing Wang   PHYSIOLOGICAL REVIEWS

Synchronization of GABAergic Inputs to CA3 Pyramidal Cells Precedes Seizure-Like Event Onset in Juvenile Rat Hippocampal Slices

(2009) Bálint Lasztóczi et al.   JOURNAL OF NEUROPHYSIOLOGY

Parvalbumin neurons and gamma rhythms enhance cortical circuit performance

(2009) Vikaas S. Sohal et al.   NATURE

Neurons that Fire Together Also Conspire Together: Is Normal Sleep Circuitry Hijacked to Generate Epilepsy?

(2009) Mark P. Beenhakker et al.   NEURON

Cortical Enlightenment: Are Attentional Gamma Oscillations Driven by ING or PING?

(2009) Paul Tiesinga et al.   NEURON

Fast activity at seizure onset is mediated by inhibitory circuits in the entorhinal cortex in vitro

(2008) Vadym Gnatkovsky et al.   ANNALS OF NEUROLOGY

Characterizing synaptic conductance fluctuations in cortical neurons and their influence on spike generation

(2007) Zuzanna Piwkowska et al.   JOURNAL OF NEUROSCIENCE METHODS