Specific imbalance of excitatory/inhibitory signaling establishes seizure onset pattern in temporal lobe epilepsy

Activation of specific neuronal networks leads to different seizure onset types

(2016) Zahra Shiri et al.   ANNALS OF NEUROLOGY

Models of drug-induced epileptiform synchronization in vitro

(2016) Massimo Avoli et al.   JOURNAL OF NEUROSCIENCE METHODS

The in vitro isolated whole guinea pig brain as a model to study epileptiform activity patterns

(2016) Marco de Curtis et al.   JOURNAL OF NEUROSCIENCE METHODS

Hypersynchronous ictal onset in the perirhinal cortex results from dynamic weakening in inhibition

(2016) Rüdiger Köhling et al.   NEUROBIOLOGY OF DISEASE

Interneurons spark seizure-like activity in the entorhinal cortex

(2016) Maxime Lévesque et al.   NEUROBIOLOGY OF DISEASE

Interneuron activity leads to initiation of low-voltage fast-onset seizures

(2015) Zahra Shiri et al.   ANNALS OF NEUROLOGY

Ictal onset on intracranial EEG: Do we know it when we see it? State of the evidence

(2015) Shaily Singh et al.   EPILEPSIA

Hippocampal sharp wave-ripple: A cognitive biomarker for episodic memory and planning

(2015) György Buzsáki   HIPPOCAMPUS

Distinct EEG seizure patterns reflect different seizure generation mechanisms

(2015) Pariya Salami et al.   JOURNAL OF NEUROPHYSIOLOGY

Selective activation of parvalbumin- or somatostatin-expressing interneurons triggers epileptic seizurelike activity in mouse medial entorhinal cortex

(2015) Latefa Yekhlef et al.   JOURNAL OF NEUROPHYSIOLOGY

Unit Activity of Hippocampal Interneurons before Spontaneous Seizures in an Animal Model of Temporal Lobe Epilepsy

(2015) I. Toyoda et al.   JOURNAL OF NEUROSCIENCE

Synchronous Inhibitory Potentials Precede Seizure-Like Events in Acute Models of Focal Limbic Seizures

(2015) L. Uva et al.   JOURNAL OF NEUROSCIENCE

KCC2 function modulates in vitro ictogenesis

(2015) Shabnam Hamidi et al.   NEUROBIOLOGY OF DISEASE

Role of ictal baseline shifts and ictal high-frequency oscillations in stereo-electroencephalography analysis of mesial temporal lobe seizures

(2014) Shasha Wu et al.   EPILEPSIA

Intracranial electroencephalographic seizure-onset patterns: effect of underlying pathology

(2013) Piero Perucca et al.   BRAIN

GABA actions and ionic plasticity in epilepsy

(2013) Kai Kaila et al.   CURRENT OPINION IN NEUROBIOLOGY

Neuronal synchrony and the transition to spontaneous seizures

(2013) Dane W. Grasse et al.   EXPERIMENTAL NEUROLOGY

Perirhinal cortex and temporal lobe epilepsy

(2013) Giuseppe Biagini et al.   Frontiers in Cellular Neuroscience

Two Seizure-Onset Types Reveal Specific Patterns of High-Frequency Oscillations in a Model of Temporal Lobe Epilepsy

(2012) M. Levesque et al.   JOURNAL OF NEUROSCIENCE

Transition to Seizure: Ictal Discharge Is Preceded by Exhausted Presynaptic GABA Release in the Hippocampal CA3 Region

(2012) Z. J. Zhang et al.   JOURNAL OF NEUROSCIENCE

Two different interictal spike patterns anticipate ictal activity in vitro

(2012) Massimo Avoli et al.   NEUROBIOLOGY OF DISEASE

Does interictal synchronization influence ictogenesis?

(2012) Massimo Avoli et al.   NEUROPHARMACOLOGY

Mechanisms of physiological and epileptic HFO generation

(2012) John G.R. Jefferys et al.   PROGRESS IN NEUROBIOLOGY

High-frequency oscillations (HFOs) in clinical epilepsy

(2012) J. Jacobs et al.   PROGRESS IN NEUROBIOLOGY

Evidence of an inhibitory restraint of seizure activity in humans

(2012) Catherine A. Schevon et al.   Nature Communications

Further evidence that pathologic high-frequency oscillations are bursts of population spikes derived from recordings of identified cells in dentate gyrus

(2011) Anatol Bragin et al.   EPILEPSIA

Identification of reproducible ictal patterns based on quantified frequency analysis of intracranial EEG signals

(2011) Vadym Gnatkovsky et al.   EPILEPSIA

Changes in action potential features during focal seizure discharges in the entorhinal cortex of the in vitro isolated guinea pig brain

(2011) Federica Trombin et al.   JOURNAL OF NEUROPHYSIOLOGY

Single-neuron dynamics in human focal epilepsy

(2011) Wilson Truccolo et al.   NATURE NEUROSCIENCE

GABAergic synchronization in the limbic system and its role in the generation of epileptiform activity

(2011) Massimo Avoli et al.   PROGRESS IN NEUROBIOLOGY

The K+-Cl−cotransporter KCC2 promotes GABAergic excitation in the mature rat hippocampus

(2010) Tero Viitanen et al.   JOURNAL OF PHYSIOLOGY-LONDON

High-frequency electroencephalographic oscillations correlate with outcome of epilepsy surgery

(2009) Julia Jacobs et al.   ANNALS OF NEUROLOGY

Reevaluating the mechanisms of focal ictogenesis: The role of low-voltage fast activity

(2009) Marco de Curtis et al.   EPILEPSIA

Synchronous GABAA-receptor-dependent potentials in limbic areas of thein-vitroisolated adult guinea pig brain

(2009) Laura Uva et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Fast activity at seizure onset is mediated by inhibitory circuits in the entorhinal cortex in vitro

(2008) Vadym Gnatkovsky et al.   ANNALS OF NEUROLOGY

Interictal high-frequency oscillations (80-500 Hz) are an indicator of seizure onset areas independent of spikes in the human epileptic brain

(2008) Julia Jacobs et al.   EPILEPSIA

Three-dimensional hippocampal atrophy maps distinguish two common temporal lobe seizure-onset patterns

(2008) Jennifer A. Ogren et al.   EPILEPSIA

Transition to seizures in the isolated immature mouse hippocampus: a switch from dominant phasic inhibition to dominant phasic excitation

(2007) M. Derchansky et al.   JOURNAL OF PHYSIOLOGY-LONDON