GABAergic networks jump-start focal seizures

Interneuron activity leads to initiation of low-voltage fast-onset seizures

(2015) Zahra Shiri et al.   ANNALS OF NEUROLOGY

Ictal onset on intracranial EEG: Do we know it when we see it? State of the evidence

(2015) Shaily Singh et al.   EPILEPSIA

Selective activation of parvalbumin- or somatostatin-expressing interneurons triggers epileptic seizurelike activity in mouse medial entorhinal cortex

(2015) Latefa Yekhlef et al.   JOURNAL OF NEUROPHYSIOLOGY

Unit Activity of Hippocampal Interneurons before Spontaneous Seizures in an Animal Model of Temporal Lobe Epilepsy

(2015) I. Toyoda et al.   JOURNAL OF NEUROSCIENCE

Synchronous Inhibitory Potentials Precede Seizure-Like Events in Acute Models of Focal Limbic Seizures

(2015) L. Uva et al.   JOURNAL OF NEUROSCIENCE

KCC2 function modulates in vitro ictogenesis

(2015) Shabnam Hamidi et al.   NEUROBIOLOGY OF DISEASE

Biomarkers of epileptogenic zone defined by quantified stereo-EEG analysis

(2014) Vadym Gnatkovsky et al.   EPILEPSIA

Preictal Activity of Subicular, CA1, and Dentate Gyrus Principal Neurons in the Dorsal Hippocampus before Spontaneous Seizures in a Rat Model of Temporal Lobe Epilepsy

(2014) S. Fujita et al.   JOURNAL OF NEUROSCIENCE

Global Optogenetic Activation of Inhibitory Interneurons during Epileptiform Activity

(2014) M. Ledri et al.   JOURNAL OF NEUROSCIENCE

Excitatory Effects of Parvalbumin-Expressing Interneurons Maintain Hippocampal Epileptiform Activity via Synchronous Afterdischarges

(2014) T. J. Ellender et al.   JOURNAL OF NEUROSCIENCE

Intracranial electroencephalographic seizure-onset patterns: effect of underlying pathology

(2013) Piero Perucca et al.   BRAIN

GABA actions and ionic plasticity in epilepsy

(2013) Kai Kaila et al.   CURRENT OPINION IN NEUROBIOLOGY

Neuronal synchrony and the transition to spontaneous seizures

(2013) Dane W. Grasse et al.   EXPERIMENTAL NEUROLOGY

On-demand optogenetic control of spontaneous seizures in temporal lobe epilepsy

(2013) Esther Krook-Magnuson et al.   Nature Communications

Network Dynamics During the Progression of Seizure-Like Events in the Hippocampal–Parahippocampal Regions

(2012) Davide Boido et al.   CEREBRAL CORTEX

Two Seizure-Onset Types Reveal Specific Patterns of High-Frequency Oscillations in a Model of Temporal Lobe Epilepsy

(2012) M. Levesque et al.   JOURNAL OF NEUROSCIENCE

Cortical inhibition, pH and cell excitability in epilepsy: what are optimal targets for antiepileptic interventions?

(2012) Ivan Pavlov et al.   JOURNAL OF PHYSIOLOGY-LONDON

Fast spiking interneuron control of seizure propagation in a cortical slice model of focal epilepsy

(2012) Mario Cammarota et al.   JOURNAL OF PHYSIOLOGY-LONDON

Pyramidal cells accumulate chloride at seizure onset

(2012) Kyle P. Lillis et al.   NEUROBIOLOGY OF DISEASE

Hub GABA Neurons Mediate Gamma-Frequency Oscillations at Ictal-like Event Onset in the Immature Hippocampus

(2012) Pascale P. Quilichini et al.   NEURON

Evidence of an inhibitory restraint of seizure activity in humans

(2012) Catherine A. Schevon et al.   Nature Communications

Changes in action potential features during focal seizure discharges in the entorhinal cortex of the in vitro isolated guinea pig brain

(2011) Federica Trombin et al.   JOURNAL OF NEUROPHYSIOLOGY

Single-neuron dynamics in human focal epilepsy

(2011) Wilson Truccolo et al.   NATURE NEUROSCIENCE

GABAergic synchronization in the limbic system and its role in the generation of epileptiform activity

(2011) Massimo Avoli et al.   PROGRESS IN NEUROBIOLOGY

Network Dynamics during Development of Pharmacologically Induced Epileptic Seizures in Rats In Vivo

(2010) A. Cymerblit-Sabba et al.   JOURNAL OF NEUROSCIENCE

Prototypic Seizure Activity Driven by Mature Hippocampal Fast-Spiking Interneurons

(2010) Y. Fujiwara-Tsukamoto et al.   JOURNAL OF NEUROSCIENCE

The K+-Cl−cotransporter KCC2 promotes GABAergic excitation in the mature rat hippocampus

(2010) Tero Viitanen et al.   JOURNAL OF PHYSIOLOGY-LONDON

Reevaluating the mechanisms of focal ictogenesis: The role of low-voltage fast activity

(2009) Marco de Curtis et al.   EPILEPSIA

Synchronization of GABAergic Inputs to CA3 Pyramidal Cells Precedes Seizure-Like Event Onset in Juvenile Rat Hippocampal Slices

(2009) Bálint Lasztóczi et al.   JOURNAL OF NEUROPHYSIOLOGY

Fast activity at seizure onset is mediated by inhibitory circuits in the entorhinal cortex in vitro

(2008) Vadym Gnatkovsky et al.   ANNALS OF NEUROLOGY

Three-dimensional hippocampal atrophy maps distinguish two common temporal lobe seizure-onset patterns

(2008) Jennifer A. Ogren et al.   EPILEPSIA

Transition to seizures in the isolated immature mouse hippocampus: a switch from dominant phasic inhibition to dominant phasic excitation

(2007) M. Derchansky et al.   JOURNAL OF PHYSIOLOGY-LONDON