NLRP3 inhibitor glibenclamide attenuates high-fat diet and streptozotocin-induced non-alcoholic fatty liver disease in rat: studies on oxidative stress, inflammation, DNA damage and insulin signalling pathway

Glibenclamide ameliorates the disrupted blood-brain barrier in experimental intracerebral hemorrhage by inhibiting the activation of NLRP3 inflammasome

(2019) Fulin Xu et al.   Brain and Behavior

THU-074-Anti-fibrotic effect of dimethyl fumarate on rat liver fibrosis induced by thioacetamide: Role of NF-kappa B, NLRP3, Nrf2 and autophagy

(2019) Durgesh Dwivedi et al.   JOURNAL OF HEPATOLOGY

NLRP3 inhibitors stoke anti-inflammatory ambitions

(2019) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

Hepatoprotective potential of 7,8-Dihydroxyflavone against Alcohol and High-Fat Diet induced Liver Toxicity via attenuation of oxido-nitrosative stress and NF-ҡB activation

(2019) Dinesh Kumar et al.   Pharmacological Reports

To die or not to die: death signaling in nonalcoholic fatty liver disease

(2018) Yuko Akazawa et al.   JOURNAL OF GASTROENTEROLOGY

Suppression of NF-κB activation by PDLIM2 restrains hepatic lipogenesis and inflammation in high fat diet induced mice

(2018) Ya-Rong Hao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Glibenclamide protects against thioacetamide-induced hepatic damage in Wistar rat: investigation on NLRP3, MMP-2, and stellate cell activation

(2018) Durgesh Kumar Dwivedi et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Voluntary alcohol consumption exacerbated high fat diet-induced cognitive deficits by NF-κB-calpain dependent apoptotic cell death in rat hippocampus: Ameliorative effect of melatonin

(2018) Durgesh Kumar Dwivedi et al.   BIOMEDICINE & PHARMACOTHERAPY

Non-alcoholic fatty liver disease – A global public health perspective

(2018) Zobair M. Younossi   JOURNAL OF HEPATOLOGY

Ameliorative effect of fisetin against lipopolysaccharide and restraint stress-induced behavioral deficits via modulation of NF-κB and IDO-1

(2018) Priyansha Choubey et al.   PSYCHOPHARMACOLOGY

NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice

(2017) Auvro R. Mridha et al.   JOURNAL OF HEPATOLOGY

A vicious circle between insulin resistance and inflammation in nonalcoholic fatty liver disease

(2017) Zhonge Chen et al.   Lipids in Health and Disease

A Protective Role of Glibenclamide in Inflammation-Associated Injury

(2017) Gensheng Zhang et al.   MEDIATORS OF INFLAMMATION

Animal Models of Nonalcoholic Fatty Liver Disease—A Starter’s Guide

(2017) Mikhaïl Van Herck et al.   Nutrients

Inhibition of NLRP3 inflammasome by thioredoxin-interacting protein in mouse Kupffer cells as a regulatory mechanism for non-alcoholic fatty liver disease development

(2017) Kun He et al.   Oncotarget

NLRP3 Inflammasome Expression and Signaling in Human Diabetic Wounds and in High Glucose Induced Macrophages

(2017) Xiaotian Zhang et al.   Journal of Diabetes Research

Edaravone alleviates cisplatin-induced neurobehavioral deficits via modulation of oxidative stress and inflammatory mediators in the rat hippocampus

(2016) Ashok Jangra et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)

(2016) Elena Buzzetti et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Role of NLRP3 Inflammasome in the Progression of NAFLD to NASH

(2016) Xingyong Wan et al.   Canadian Journal of Gastroenterology and Hepatology

A pharmacological inhibitor of NLRP3 inflammasome prevents non-alcoholic fatty liver disease in a mouse model induced by high fat diet

(2016) Gabsik Yang et al.   Scientific Reports

NLRP3 deficiency protects from type 1 diabetes through the regulation of chemotaxis into the pancreatic islets

(2015) Changyun Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Inflammasome in Liver Injury and Non-Alcoholic Fatty Liver Disease

(2014) Wajahat Zafar Mehal   DIGESTIVE DISEASES

Drug metabolism enzymes in a steatotic model of rat treated with a high fat diet and a low dose of streptozotocin

(2014) A. Vornoli et al.   FOOD AND CHEMICAL TOXICOLOGY

The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes

(2014) Rachel J. Perry et al.   NATURE

Establishment of a General NAFLD Scoring System for Rodent Models and Comparison to Human Liver Pathology

(2014) Wen Liang et al.   PLoS One

Caspase-1 as a Central Regulator of High Fat Diet-Induced Non-Alcoholic Steatohepatitis

(2013) Laura J. Dixon et al.   PLoS One

Glibenclamide reduces pro-inflammatory cytokine production by neutrophils of diabetes patients in response to bacterial infection

(2013) Chidchamai Kewcharoenwong et al.   Scientific Reports

Glyburide Reduces Bacterial Dissemination in a Mouse Model of Melioidosis

(2013) Gavin C. K. W. Koh et al.   PLoS Neglected Tropical Diseases

Upregulated NLRP3 Inflammasome Activation in Patients With Type 2 Diabetes

(2012) Hye-Mi Lee et al.   DIABETES

Liver and diabetes. A vicious circle

(2012) Paola Loria et al.   HEPATOLOGY RESEARCH

Animal models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis

(2012) Yoshihisa Takahashi   WORLD JOURNAL OF GASTROENTEROLOGY

Glibenclamide ameliorates ischemia–reperfusion injury via modulating oxidative stress and inflammatory mediators in the rat hippocampus

(2011) Dalaal M. Abdallah et al.   BRAIN RESEARCH

Glibenclamide reduces proinflammatory cytokines in an ex vivo model of human endotoxinaemia under hypoxaemic conditions

(2011) Diethart Schmid et al.   LIFE SCIENCES

Central Role of Fatty Liver in the Pathogenesis of Insulin Resistance in Obese Adolescents

(2010) E. D'Adamo et al.   DIABETES CARE

Diet-induced obesity increases NF-κB signaling in reporter mice

(2009) Harald Carlsen et al.   Genes and Nutrition

Glyburide inhibits the Cryopyrin/Nalp3 inflammasome

(2009) Mohamed Lamkanfi et al.   JOURNAL OF CELL BIOLOGY

The effects of sulfonylurea glyburide on superoxide dismutase, catalase, and glutathione peroxidase activities in the brain tissue of streptozotocin-induced diabetic rat

(2008) Namık K. Nazaroglu et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS