Inhibitor-induced HER2-HER3 heterodimerisation promotes proliferation through a novel dimer interface
出版年份 2018 全文链接
标题
Inhibitor-induced HER2-HER3 heterodimerisation promotes proliferation through a novel dimer interface
作者
关键词
-
出版物
eLife
Volume 7, Issue -, Pages -
出版商
eLife Sciences Organisation, Ltd.
发表日期
2018-05-01
DOI
10.7554/elife.32271
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- 11 years' follow-up of trastuzumab after adjuvant chemotherapy in HER2-positive early breast cancer: final analysis of the HERceptin Adjuvant (HERA) trial
- (2017) David Cameron et al. LANCET
- Trastuzumab emtansine versus capecitabine plus lapatinib in patients with previously treated HER2-positive advanced breast cancer (EMILIA): a descriptive analysis of final overall survival results from a randomised, open-label, phase 3 trial
- (2017) Véronique Diéras et al. LANCET ONCOLOGY
- Trastuzumab emtansine versus treatment of physician's choice in patients with previously treated HER2-positive metastatic breast cancer (TH3RESA): final overall survival results from a randomised open-label phase 3 trial
- (2017) Ian E Krop et al. LANCET ONCOLOGY
- Computational insights into HER3 gatekeeper T768I resistance mutation to bosutinib in HER3-related breast cancer
- (2017) Chun-Ling Dong et al. MEDICINAL CHEMISTRY RESEARCH
- EGF and NRG induce phosphorylation of HER3/ERBB3 by EGFR using distinct oligomeric mechanisms
- (2017) Bettina van Lengerich et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structure of Fam20A reveals a pseudokinase featuring a unique disulfide pattern and inverted ATP-binding
- (2017) Jixin Cui et al. eLife
- MET-EGFR dimerization in lung adenocarcinoma is dependent on EGFR mtations and altered by MET kinase inhibition
- (2017) Elena Ortiz-Zapater et al. PLoS One
- Probing the Heterogeneity of Protein Kinase Activation in Cells by Super-resolution Microscopy
- (2016) Ruobing Zhang et al. ACS Nano
- Adjuvant Lapatinib and Trastuzumab for Early Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer: Results From the Randomized Phase III Adjuvant Lapatinib and/or Trastuzumab Treatment Optimization Trial
- (2016) Martine Piccart-Gebhart et al. JOURNAL OF CLINICAL ONCOLOGY
- Overcoming resistance to HER2 inhibitors through state-specific kinase binding
- (2016) Chris J Novotny et al. Nature Chemical Biology
- EGFR oligomerization organizes kinase-active dimers into competent signalling platforms
- (2016) Sarah R. Needham et al. Nature Communications
- Molecular basis for multimerization in the activation of the epidermal growth factor receptor
- (2016) Yongjian Huang et al. eLife
- Effect of Phosphorylation on EGFR Dimer Stability Probed by Single-Molecule Dynamics and FRET/FLIM
- (2015) Oana Coban et al. BIOPHYSICAL JOURNAL
- Bayesian cluster identification in single-molecule localization microscopy data
- (2015) Patrick Rubin-Delanchy et al. NATURE METHODS
- Thermal proteome profiling monitors ligand interactions with cellular membrane proteins
- (2015) Friedrich B M Reinhard et al. NATURE METHODS
- Pertuzumab, Trastuzumab, and Docetaxel in HER2-Positive Metastatic Breast Cancer
- (2015) Sandra M. Swain et al. NEW ENGLAND JOURNAL OF MEDICINE
- ATP binding to the pseudokinase domain of JAK2 is critical for pathogenic activation
- (2015) Henrik M. Hammarén et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A secretory kinase complex regulates extracellular protein phosphorylation
- (2015) Jixin Cui et al. eLife
- A role for the pseudokinase HER3 in the acquired resistance against EGFR- and HER2-directed targeted therapy
- (2014) Jeroen Claus et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Hematogenous Metastasis of Ovarian Cancer: Rethinking Mode of Spread
- (2014) Sunila Pradeep et al. CANCER CELL
- Pharmacological targeting of the pseudokinase Her3
- (2014) Ting Xie et al. Nature Chemical Biology
- The cellular thermal shift assay for evaluating drug target interactions in cells
- (2014) Rozbeh Jafari et al. Nature Protocols
- Crystal structure of a BRAF kinase domain monomer explains basis for allosteric regulation
- (2014) Neroshan Thevakumaran et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death
- (2014) Joanne M. Hildebrand et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structural analysis of the EGFR/HER3 heterodimer reveals the molecular basis for activating HER3 mutations
- (2014) P. Littlefield et al. Science Signaling
- The EGFR Family: Not So Prototypical Receptor Tyrosine Kinases
- (2014) M. A. Lemmon et al. Cold Spring Harbor Perspectives in Biology
- A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties
- (2013) James M. Murphy et al. BIOCHEMICAL JOURNAL
- Pseudokinase drug intervention: a potentially poisoned chalice
- (2013) Jeroen Claus et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Oncogenic ERBB3 Mutations in Human Cancers
- (2013) Bijay S. Jaiswal et al. CANCER CELL
- The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism
- (2013) James M. Murphy et al. IMMUNITY
- A conserved water-mediated hydrogen bond network defines bosutinib's kinase selectivity
- (2013) Nicholas M Levinson et al. Nature Chemical Biology
- Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors
- (2012) Timothy R. Wilson et al. NATURE
- Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors
- (2012) Likun Wang et al. Nature Chemical Biology
- Trastuzumab Emtansine for HER2-Positive Advanced Breast Cancer
- (2012) Sunil Verma et al. NEW ENGLAND JOURNAL OF MEDICINE
- A single ligand is sufficient to activate EGFR dimers
- (2012) P. Liu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- RAF Inhibitor-Induced KSR1/B-RAF Binding and Its Effects on ERK Cascade Signaling
- (2011) Melissa M. McKay et al. CURRENT BIOLOGY
- Comprehensive analysis of kinase inhibitor selectivity
- (2011) Mindy I Davis et al. NATURE BIOTECHNOLOGY
- Simultaneous visualization of the extracellular and cytoplasmic domains of the epidermal growth factor receptor
- (2011) Li-Zhi Mi et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Kinase-mediated quasi-dimers of EGFR
- (2010) Erez M. Bublil et al. FASEB JOURNAL
- Randomized Study of Lapatinib Alone or in Combination With Trastuzumab in Women With ErbB2-Positive, Trastuzumab-Refractory Metastatic Breast Cancer
- (2010) Kimberly L. Blackwell et al. JOURNAL OF CLINICAL ONCOLOGY
- RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF
- (2010) Poulikos I. Poulikakos et al. NATURE
- RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth
- (2010) Georgia Hatzivassiliou et al. NATURE
- ErbB3/HER3 intracellular domain is competent to bind ATP and catalyze autophosphorylation
- (2010) Fumin Shi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Distribution of resting and ligand-bound ErbB1 and ErbB2 receptor tyrosine kinases in living cells using number and brightness analysis
- (2010) P. Nagy et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Resiliency and Vulnerability in the HER2-HER3 Tumorigenic Driver
- (2010) D. N. Amin et al. Science Translational Medicine
- Mechanism for Activation of the EGF Receptor Catalytic Domain by the Juxtamembrane Segment
- (2009) Natalia Jura et al. CELL
- Inhibitor hijacking of Akt activation
- (2009) Tatsuya Okuzumi et al. Nature Chemical Biology
- PKC maturation is promoted by nucleotide pocket occupation independently of intrinsic kinase activity
- (2009) Angus J M Cameron et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Structural analysis of the catalytically inactive kinase domain of the human EGF receptor 3
- (2009) N. Jura et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structure of the LKB1-STRAD-MO25 Complex Reveals an Allosteric Mechanism of Kinase Activation
- (2009) E. Zeqiraj et al. SCIENCE
- Structure of the Pseudokinase VRK3 Reveals a Degraded Catalytic Site, a Highly Conserved Kinase Fold, and a Putative Regulatory Binding Site
- (2009) Eric D. Scheeff et al. STRUCTURE
- ATP and MO25α Regulate the Conformational State of the STRADα Pseudokinase and Activation of the LKB1 Tumour Suppressor
- (2009) Elton Zeqiraj et al. PLOS BIOLOGY
- Multiphoton time-domain fluorescence lifetime imaging microscopy: practical application to protein-protein interactions using global analysis
- (2008) P.R Barber et al. Journal of the Royal Society Interface
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started