期刊
LEUKEMIA RESEARCH
卷 34, 期 6, 页码 769-776出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.leukres.2009.11.025
关键词
Ezrin; Polarization; MOLT4 cell; Metastasis; CCL25/CCR9; ERM
资金
- National Natural Science Foundation of China [30570780, 30971280]
- National Ministry of Education [200804860039]
- Department of Science and Technology of Hubei Province, China [2006AA301B64]
- Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry
Chemokines and their corresponding receptors participate in transmigration of leukemic cells. ERM (ezrin/radixin/moesin) protein family act as linkers between the plasma membrane and the cytoskeleton and are key component in tumor metastasis. In this study we used the CCR9-expressing acute T lymphocytic cell line MOLT4 as a model and assesssed their morphological and functional changes in response to CCL25. The pseudopodium formed and ERM translocated from the cytoplasm to the cell membrane following treatment with CCL25. Ezrin silencing by miRNA showed that ezrin plays important roles in the polarization and invasive behaviour of MOLT4 cells. (C) 2009 Elsevier Ltd. All rights reserved.
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