The Impact of Hypoxia on Neutrophil Degranulation and Consequences for the Host

IL4Rα Signaling Abrogates Hypoxic Neutrophil Survival and Limits Acute Lung Injury Responses In Vivo.

(2019) Alison J Harris et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Biological Roles of Neutrophil-Derived Granule Proteins and Cytokines

(2019) Marco Antonio Cassatella et al.   TRENDS IN IMMUNOLOGY

The counter-intuitive role of the neutrophil in the acute respiratory distress syndrome

(2019) Arlette Vassallo et al.   BRITISH MEDICAL BULLETIN

Prolonged exposure to hypoxia induces an autophagy‐like cell survival program in human neutrophils

(2019) Usharani Talla et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The Impact of Hypoxia on the Host-Pathogen Interaction between Neutrophils and Staphylococcus aureus

(2019) Natalia H Hajdamowicz et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Extracellular Neutrophil Proteases Are Efficient Regulators of IL-1, IL-33, and IL-36 Cytokine Activity but Poor Effectors of Microbial Killing

(2018) Danielle M. Clancy et al.   Cell Reports

CEBPE-Mutant Specific Granule Deficiency Correlates With Aberrant Granule Organization and Substantial Proteome Alterations in Neutrophils

(2018) Nina K. Serwas et al.   Frontiers in Immunology

Hypoxia increases neutrophil-driven matrix destruction after exposure to Mycobacterium tuberculosis

(2018) Catherine W. M. Ong et al.   Scientific Reports

Organ-Specific Mechanisms of Transendothelial Neutrophil Migration in the Lung, Liver, Kidney, and Aorta

(2018) Sanne L. Maas et al.   Frontiers in Immunology

Human neutrophil elastase induces endothelial cell apoptosis by activating the PERK-CHOP branch of the unfolded protein response

(2017) Irina Grechowa et al.   FASEB JOURNAL

Weibel−Palade bodies at a glance

(2017) Jessica J. McCormack et al.   JOURNAL OF CELL SCIENCE

Prolyl hydroxylase 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses

(2017) Pranvera Sadiku et al.   JOURNAL OF CLINICAL INVESTIGATION

Hypoxia Modulates the Response of Mast Cells to Staphylococcus aureus Infection

(2017) Helene Möllerherm et al.   Frontiers in Immunology

Oxidant Mechanisms in Renal Injury and Disease

(2016) Brian B. Ratliff et al.   ANTIOXIDANTS & REDOX SIGNALING

Iron-chelating agent desferrioxamine stimulates formation of neutrophil extracellular traps (NETs) in human blood-derived neutrophils

(2016) L. Vollger et al.   BIOSCIENCE REPORTS

Molecular mechanisms regulating secretory organelles and endosomes in neutrophils and their implications for inflammation

(2016) Mahalakshmi Ramadass et al.   IMMUNOLOGICAL REVIEWS

Neutrophil azurophilic granule exocytosis is primed by TNF-α and partially regulated by NADPH oxidase

(2016) Renee M Potera et al.   Innate Immunity

Hypoxia upregulates neutrophil degranulation and potential for tissue injury

(2016) Kim Hoenderdos et al.   THORAX

Hypoxia and tissue destruction in pulmonary TB

(2016) Moerida Belton et al.   THORAX

Formation of Neutrophil Extracellular Traps under Low Oxygen Level

(2016) Katja Branitzki-Heinemann et al.   Frontiers in Immunology

Physiologic hypoxia and oxygen homeostasis in the healthy intestine. A Review in the Theme: Cellular Responses to Hypoxia

(2015) Leon Zheng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Neutrophil Elastase Promotes Interleukin-1β Secretion from Human Coronary Endothelium

(2015) Mabruka Alfaidi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Store-operated calcium signaling in neutrophils

(2015) R. A. Clemens et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Genetic Deletion and Pharmacological Inhibition of PI3KγReduces Neutrophilic Airway Inflammation and Lung Damage in Mice with Cystic Fibrosis-Like Lung Disease

(2015) Maria Galluzzo et al.   MEDIATORS OF INFLAMMATION

Autophagy Is Required for Neutrophil-Mediated Inflammation

(2015) Abhisek Bhattacharya et al.   Cell Reports

Classical ROS-dependent and early/rapid ROS-independent release of Neutrophil Extracellular Traps triggered by Leishmania parasites

(2015) Natalia C. Rochael et al.   Scientific Reports

A neutrophil intrinsic impairment affecting Rab27a and degranulation in cystic fibrosis is corrected by CFTR potentiator therapy

(2014) K. Pohl et al.   BLOOD

Increased expression of vascular endothelial growth factor and hypoxia inducible factor-1α in lung tissue of patients with chronic bronchitis

(2014) Seung Hyeun Lee et al.   CLINICAL BIOCHEMISTRY

Transmigrating Neutrophils Shape the Mucosal Microenvironment through Localized Oxygen Depletion to Influence Resolution of Inflammation

(2014) Eric L. Campbell et al.   IMMUNITY

Hypoxia in Leishmania major Skin Lesions Impairs the NO-Dependent Leishmanicidal Activity of Macrophages

(2014) Alexander Mahnke et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The multifactorial role of neutrophils in rheumatoid arthritis

(2014) Helen L. Wright et al.   Nature Reviews Rheumatology

Oxygen levels determine the ability of glucocorticoids to influence neutrophil survival in inflammatory environments

(2013) John A. Marwick et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Proteome profiling of human neutrophil granule subsets, secretory vesicles, and cell membrane: correlation with transcriptome profiling of neutrophil precursors

(2013) Sara Rørvig et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Methods for defining distinct bioenergetic profiles in platelets, lymphocytes, monocytes and neutrophils and the oxidative burst from human blood

(2013) Balu K Chacko et al.   LABORATORY INVESTIGATION

Hypoxia Inducible Factor Signaling Modulates Susceptibility to Mycobacterial Infection via a Nitric Oxide Dependent Mechanism

(2013) Philip M. Elks et al.   PLoS Pathogens

HIF-1α Is Essential for Effective PMN Bacterial Killing, Antimicrobial Peptide Production and Apoptosis in Pseudomonas aeruginosa Keratitis

(2013) Elizabeth A. Berger et al.   PLoS Pathogens

Extracellular Chromatin Is an Important Mediator of Ischemic Stroke in Mice

(2012) Simon F. De Meyer et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

VEGF-A recruits a proangiogenic MMP-9-delivering neutrophil subset that induces angiogenesis in transplanted hypoxic tissue

(2012) G. Christoffersson et al.   BLOOD

Mammalian target of rapamycin regulates neutrophil extracellular trap formation via induction of hypoxia-inducible factor 1  

(2012) A. M. McInturff et al.   BLOOD

Store-operated Ca2+Entry (SOCE) Plays a Role in the Polarization of Neutrophil-like HL-60 Cells by Regulating the Activation of Akt, Src, and Rho Family GTPases

(2012) Wenying Zou et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

MUNC13-4 Protein Regulates the Oxidative Response and Is Essential for Phagosomal Maturation and Bacterial Killing in Neutrophils

(2012) Jlenia Monfregola et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Munc13-4 reconstitutes calcium-dependent SNARE-mediated membrane fusion

(2012) Kristin L. Boswell et al.   JOURNAL OF CELL BIOLOGY

Vesicular trafficking through cortical actin during exocytosis is regulated by the Rab27a effector JFC1/Slp1 and the RhoA-GTPase–activating protein Gem-interacting protein

(2012) Jennifer L. Johnson et al.   MOLECULAR BIOLOGY OF THE CELL

Functional Redundancy of Class I Phosphoinositide 3-Kinase (PI3K) Isoforms in Signaling Growth Factor-Mediated Human Neutrophil Survival

(2012) Jatinder K. Juss et al.   PLoS One

Autocrine stimulation of clear-cell renal carcinoma cell migration in hypoxia via HIF-independent suppression of thrombospondin-1

(2012) Raquel Bienes-Martínez et al.   Scientific Reports

Cathepsin G and Neutrophil Elastase Play Critical and Nonredundant Roles in Lung-Protective Immunity against Streptococcus pneumoniae in Mice

(2011) Ines Hahn et al.   INFECTION AND IMMUNITY

Ischemia and reperfusion—from mechanism to translation

(2011) Holger K Eltzschig et al.   NATURE MEDICINE

Hypoxia and Inflammation

(2011) Holger K. Eltzschig et al.   NEW ENGLAND JOURNAL OF MEDICINE

Synovial tissue hypoxia and inflammation in vivo

(2010) C. T. Ng et al.   ANNALS OF THE RHEUMATIC DISEASES

Akt isoforms differentially regulate neutrophil functions

(2010) J. Chen et al.   BLOOD

Regulation of the autophagic machinery in human neutrophils

(2010) Ioannis Mitroulis et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Calcium-dependent Regulation of SNARE-mediated Membrane Fusion by Calmodulin

(2010) Jerome Di Giovanni et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pyk2 Is Required for Neutrophil Degranulation and Host Defense Responses to Bacterial Infection

(2010) L. A. Kamen et al.   JOURNAL OF IMMUNOLOGY

Hypoxia Selectively Inhibits Respiratory Burst Activity and Killing of Staphylococcus aureus in Human Neutrophils

(2010) N. N. McGovern et al.   JOURNAL OF IMMUNOLOGY

Neutrophil elastase–mediated degradation of IRS-1 accelerates lung tumor growth

(2010) A McGarry Houghton et al.   NATURE MEDICINE

Activation of Hypoxia Inducible Factor 1 Is a General Phenomenon in Infections with Human Pathogens

(2010) Nadine Werth et al.   PLoS One

Mast Cell Survival and Mediator Secretion in Response to Hypoxia

(2010) Magdalena Gulliksson et al.   PLoS One

Neutrophil spontaneous death is mediated by down-regulation of autocrine signaling through GPCR, PI3K , ROS, and actin

(2010) Y. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of autophagy by ROS: physiology and pathology

(2010) Ruth Scherz-Shouval et al.   TRENDS IN BIOCHEMICAL SCIENCES

The Systemic Inflammation of Alveolar Hypoxia Is Initiated by Alveolar Macrophage–Borne Mediator(s)

(2009) Jie Chao et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN

(2009) Zvi G. Fridlender et al.   CANCER CELL

Neutrophils Are the Predominant Infected Phagocytic Cells in the Airways of Patients With Active Pulmonary TB

(2009) Seok-Yong Eum et al.   CHEST

Critical role of phospholipase Cγ2 in integrin and Fc receptor-mediated neutrophil functions and the effector phase of autoimmune arthritis

(2009) Zoltán Jakus et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Human Neutrophils Kill Streptococcus pneumoniae via Serine Proteases

(2009) A. J. Standish et al.   JOURNAL OF IMMUNOLOGY

Activation of antibacterial autophagy by NADPH oxidases

(2009) J. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neutrophil Elastase Is Needed for Neutrophil Emigration into Lungs in Ventilator-Induced Lung Injury

(2008) A. Murat Kaynar et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Neutrophil secretion products pave the way for inflammatory monocytes

(2008) O. Soehnlein et al.   BLOOD

Systemic hypoxia enhances bactericidal activities of human polymorphonuclear leuocytes

(2008) Jong-Shyan Wang et al.   CLINICAL SCIENCE

Hypoxia-Independent Activation of HIF-1 by Enterobacteriaceae and Their Siderophores

(2008) Hanna Hartmann et al.   GASTROENTEROLOGY

Tuberculous Granulomas Are Hypoxic in Guinea Pigs, Rabbits, and Nonhuman Primates

(2008) L. E. Via et al.   INFECTION AND IMMUNITY

Pharmacologic Augmentation of Hypoxia‐Inducible Factor–1α with Mimosine Boosts the Bactericidal Capacity of Phagocytes

(2008) Annelies S. Zinkernagel et al.   JOURNAL OF INFECTIOUS DISEASES

Development of Chronic Bronchitis and Emphysema in β-Epithelial Na+Channel–Overexpressing Mice

(2007) Marcus A. Mall et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The HIF/VHL Pathway

(2007) Sarah R. Walmsley et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Phosphoinositide 3-Kinase γ Gene Knockout Impairs Postischemic Neovascularization and Endothelial Progenitor Cell Functions

(2007) Paolo Madeddu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Oxygen sensors in context

(2007) Jeremy P.T. Ward   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS