Article
Pharmacology & Pharmacy
Hang Su, Yu Mei, Shuangxue Luo, Haixia Wu, Yan He, Yasunaga Shiraishi, Pingping Hu, Richard A. Cohen, Xiaoyong Tong
Summary: The substitution of SERCA2 C674 thiol accelerates the development of atherosclerosis by inducing ER stress and inflammation. This study highlights the importance of SERCA2 C674 redox state in the context of atherosclerosis and proposes a novel therapeutic strategy to combat atherosclerosis.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Hematology
Enyong Su, Peng Yu, Baoli Zhang, Anjing Zhang, Shiyao Xie, Chunyu Zhang, Su Li, Yunzeng Zou, Ming Liu, Hong Jiang, Junbo Ge
Summary: This study discovered that ANG exerts a protective effect against atherosclerosis by regulating ER stress through ST3GAL5. Deficiency of endothelial ANG aggravates ER stress and adhesion molecule expression, leading to exacerbation of atherosclerotic lesions.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Na Zhang, Lili Zhu, Xianxian Wu, Ru Yan, Shaobing Yang, Xiaoliang Jiang, Xing Liu, Xue Liu, Ning Yan, Guangzhi Cong, Zhiwei Yang, Shaobin Jia
Summary: Hyperhomocysteinemia aggravates atherosclerosis and plaque vulnerability through endoplasmic reticulum oxidoreductase 1 alpha, which is critical in ER stress-induced macrophage apoptosis and plaque stability.
Article
Biochemistry & Molecular Biology
Weimin Yu, Siqi Li, Haixia Wu, Pingping Hu, Lili Chen, Chunyu Zeng, Xiaoyong Tong
Summary: The study showed that inhibiting sEH can alleviate atherosclerosis caused by endothelial Nox4 dysfunction, potentially through suppression of ER stress. Endothelial Nox4 dysfunction can lead to inflammation, and inhibiting sEH and ER stress is beneficial for alleviating atherosclerosis.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Zhiwen Zhang, Quan Guo, Zhenzhou Zhao, Ming Nie, Qingbo Shi, En Li, Kaiyuan Liu, Haosen Yu, Lixin Rao, Muwei Li
Summary: This study investigated the role and regulatory mechanism of DNMT3B in ER stress during AS progression. The results showed that DNMT3B could activate FGFR3-mediated ER stress by decreasing PTPN2 expression and increasing FGFR2 expression, thus promoting AS progression.
Article
Biochemistry & Molecular Biology
Zhiwen Zhang, Quan Guo, Zhenzhou Zhao, Ming Nie, Qingbo Shi, En Li, Kaiyuan Liu, Haosen Yu, Lixin Rao, Muwei Li
Summary: In this study, the role and regulatory mechanism of DNA methyltransferase 3 beta (DNMT3B) in endoplasmic reticulum (ER) stress during atherosclerosis (AS) progression was investigated. Results showed that DNMT3B and FGFR3 were upregulated in AS patient tissues, while PTPN2 was downregulated. PTPN2 overexpression attenuated ER stress, inflammation, and apoptosis in endothelial cells and improved AS symptoms in vivo. DNMT3B negatively regulated PTPN2 expression, positively regulated FGFR2 expression, and activated FGFR3-mediated ER stress by increasing PTPN2 promoter methylation.
Review
Pharmacology & Pharmacy
Qiao Jiang, Li Wang, Xu Si, Jin-Long Tian, Ye Zhang, Hai-Long Gui, Bin Li, De-Hong Tan
Summary: Hyperhomocysteinemia is an independent risk factor for cardiovascular diseases, and natural polyphenols can reduce homocysteine levels by acting on oxidative stress and endoplasmic reticulum stress-related signaling pathways, thus improving vascular injury caused by high homocysteine levels.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Immunology
Jana Messias Sandes, Regina Celia Bressan Queiroz de Figueiredo
Summary: The endoplasmic reticulum (ER) is an important organelle in higher eukaryotic cells responsible for protein folding and assembly. It undergoes strict quality control to ensure proper processing of proteins, with unfolded proteins being targeted for degradation through the ER-associated degradation (ERAD) complex. Additionally, the ER responds to stress through the unfolded protein response (UPR) to restore homeostasis or induce cell death. Protozoan parasites such as Trypanosoma cruzi, Trypanosoma brucei, and Leishmania spp. also have similar ER structures and stress response mechanisms, making them attractive targets for chemotherapy.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Cell Biology
Ruiyuan Xu, Jianlu Song, Rexiati Ruze, Yuan Chen, Xinpeng Yin, Chengcheng Wang, Yupei Zhao
Summary: This study reveals squalene epoxidase (SQLE) as a novel oncogene that promotes pancreatic cancer (PC) growth by mitigating endoplasmic reticulum stress and activating lipid raft-regulated Src/PI3K/Akt signaling pathway. SQLE facilitates cell proliferation, induces cell cycle progression, and inhibits apoptosis in vitro, while promoting tumor growth in vivo. SQLE inhibitors effectively suppress PC cell proliferation and xenograft tumor growth, highlighting the potential of SQLE as a therapeutic target for PC.
CELL DEATH & DISEASE
(2023)
Article
Multidisciplinary Sciences
Gunes Parlakgul, Ana Paula Arruda, Song Pang, Erika Cagampan, Nina Min, Ekin Guney, Grace Yankun Lee, Karen Inouye, Harald F. Hess, C. Shan Xu, Gokhan S. Hotamisligil
Summary: This study reveals the complex structural organization of organelles in liver tissue and highlights the significant alterations in obese mice. The functional importance of these structural changes on cellular and systemic metabolism is also demonstrated.
Review
Cardiac & Cardiovascular Systems
BingYu Wang, Jun Qiu, JiangFang Lian, Xi Yang, JianQing Zhou
Summary: Atherosclerosis is an inflammatory disease linked to substances like trimethylamine-N-oxide (TMAO) in the gut flora. TMAO is considered an independent risk factor for malignant cardiovascular events, but its impact on patients with cardiovascular diseases remains controversial.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cell Biology
Zhen Tang, Xinghui Wei, Tian Li, Wei Wang, Hao Wu, Hui Dong, Yichao Liu, Feilong Wei, Lei Shi, Xiaokang Li, Zheng Guo, Xin Xiao
Summary: The study elucidates the potential role of Sestrin2 in regulating the sensitivity of osteosarcoma to chemotherapy, demonstrating that Sestrin2 activates autophagy by inhibiting the mTOR pathway and decreases apoptosis via Bcl-2, ultimately slowing down tumor progression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biophysics
Lijuan Gui, Jun Yan, Junyuan Zhao, Shiya Wang, Yingying Ji, Ji Liu, Jinsheng Wu, Kang Yuan, Heng Liu, Dawei Deng, Zhenwei Yuan
Summary: This study developed a novel ratiometric probe Rx-NCE to detect hypochlorite levels in foam cells and outline the boundaries of atherosclerotic plaques. The innovative application of this probe in distinguishing atherosclerotic blood vessels is also demonstrated. This research has significant value in studying ER stress and atherosclerosis.
BIOSENSORS & BIOELECTRONICS
(2023)
Review
Geriatrics & Gerontology
Tao Wang, Jia Zhou, Xiao Zhang, Yujie Wu, Kehan Jin, Yilin Wang, Ran Xu, Ge Yang, Wenjing Li, Liqun Jiao
Summary: Atherosclerosis is closely related to aging and is a primary cause of heart disease and stroke. Disrupted metabolic homeostasis leads to endoplasmic reticulum stress, which plays a dual role in the development of atherosclerosis. The IRE1α/XBP1 axis is a potential therapeutic target for treating atherosclerosis.
Article
Biotechnology & Applied Microbiology
Peipei Ge, Mingxiao Gao, Juan Du, Jingbin Yu, Lei Zhang
Summary: miR-512-3p regulates the survival and migration of ox-LDL-treated endothelial cells by modulating XBP-1, playing a role in preventing and alleviating atherosclerosis.