标题
Sonic Hedgehog Signaling in Organogenesis, Tumors, and Tumor Microenvironments
作者
关键词
-
出版物
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 21, Issue 3, Pages 758
出版商
MDPI AG
发表日期
2020-01-23
DOI
10.3390/ijms21030758
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Role of Protein Kinases in Hedgehog Pathway Control and Implications for Cancer Therapy
- (2019) Valentina Montagnani et al. Cancers
- Nuclear localization and Overexpression of Smoothened in Pancreatic and Colorectal Cancers
- (2019) Madiha Niyaz et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- State of the art of Smo antagonists for cancer therapy: advances in the target receptor and new ligand structures
- (2019) Christian Espinosa-Bustos et al. Future Medicinal Chemistry
- Roles of Primary Cilia in the Developing Brain
- (2019) Sang Min Park et al. Frontiers in Cellular Neuroscience
- Next-Generation Hedgehog/GLI Pathway Inhibitors for Cancer Therapy
- (2019) Elisabeth Peer et al. Cancers
- Sonic Hedgehog Ligand: A Role in Formation of a Mesenchymal Niche in Human Pancreatic Ductal Adenocarcinoma
- (2019) Saini et al. Cells
- Role of Hedgehog Signaling in Breast Cancer: Pathogenesis and Therapeutics
- (2019) Natalia A. Riobo-Del Galdo et al. Cells
- HERC4 exerts an anti-tumor role through destabilizing the oncoprotein Smo
- (2019) Xiaohan Sun et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Tumour-associated macrophages exhibit anti-tumoural properties in Sonic Hedgehog medulloblastoma
- (2019) Victor Maximov et al. Nature Communications
- Phase I and phase II sonidegib and vismodegib clinical trials for the treatment of paediatric and adult MB patients: a systemic review and meta-analysis
- (2019) Yuchen Li et al. Acta Neuropathologica Communications
- Context-Dependent Role of NF-κB Signaling in Primary Liver Cancer—from Tumor Development to Therapeutic Implications
- (2019) Carolin Czauderna et al. Cancers
- Hedgehog signaling promotes tumor-associated macrophage polarization to suppress intratumoral CD8+ T cell recruitment
- (2019) Amy J. Petty et al. JOURNAL OF CLINICAL INVESTIGATION
- SHH signaling mediated by a prechordal and brain enhancer controls forebrain organization
- (2019) Tomoko Sagai et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Involvement of hedgehog pathway in early onset, aggressive molecular subtypes and metastatic potential of breast cancer
- (2018) Syeda Kiran Riaz et al. Cell Communication and Signaling
- A phase Ib study of sonidegib (LDE225), an oral small molecule inhibitor of smoothened or Hedgehog pathway, in combination with docetaxel in triple negative advanced breast cancer patients: GEICAM/2012–12 (EDALINE) study
- (2018) Manuel Ruiz-Borrego et al. INVESTIGATIONAL NEW DRUGS
- Strategies to target the Hedgehog signaling pathway for cancer therapy
- (2018) Minhang Xin et al. MEDICINAL RESEARCH REVIEWS
- SMO Inhibition Modulates Cellular Plasticity and Invasiveness in Colorectal Cancer
- (2018) Paolo Magistri et al. Frontiers in Pharmacology
- Inhibition of smoothened in breast cancer cells reduces CAXII expression and cell migration
- (2018) Giuditta Guerrini et al. JOURNAL OF CELLULAR PHYSIOLOGY
- The role of stromal cancer-associated fibroblasts in pancreatic cancer
- (2017) Dagny von Ahrens et al. Journal of Hematology & Oncology
- The role of canonical and non-canonical Hedgehog signaling in tumor progression in a mouse model of small cell lung cancer
- (2017) A Szczepny et al. ONCOGENE
- Inhibition of hedgehog pathway reveals the regulatory role of SMO in gastric cancer cells
- (2017) Zixin Yang et al. TUMOR BIOLOGY
- Smoothened antagonist GDC-0449 (Vismodegib) inhibits proliferation and triggers apoptosis in colon cancer cell lines
- (2017) Chuanqing Wu et al. Experimental and Therapeutic Medicine
- Non-Canonical Hedgehog Signaling Is a Positive Regulator of the WNT Pathway and Is Required for the Survival of Colon Cancer Stem Cells
- (2017) Joseph L. Regan et al. Cell Reports
- Targeting Smoothened Sensitizes Gastric Cancer to Chemotherapy in Experimental Models
- (2017) Huifa Ma et al. MEDICAL SCIENCE MONITOR
- Design, Synthesis and Biological Evaluation of novel Hedgehog Inhibitors for treating Pancreatic Cancer
- (2017) Vinod Kumar et al. Scientific Reports
- GDC-0449 improves the antitumor activity of nano-doxorubicin in pancreatic cancer in a fibroblast-enriched microenvironment
- (2017) Quan Zhou et al. Scientific Reports
- Heterogeneous Stromal Signaling within the Tumor Microenvironment Controls the Metastasis of Pancreatic Cancer
- (2016) Agnieszka A. Rucki et al. CANCER RESEARCH
- Primary Cilia in the Murine Cerebellum and in Mutant Models of Medulloblastoma
- (2016) Chiara Di Pietro et al. CELLULAR AND MOLECULAR NEUROBIOLOGY
- Hedgehog signaling in the stomach
- (2016) Daniel Konstantinou et al. CURRENT OPINION IN PHARMACOLOGY
- Genetic ablation of Smoothened in pancreatic fibroblasts increases acinar–ductal metaplasia
- (2016) Xin Liu et al. GENES & DEVELOPMENT
- Hedgehog regulates yes-associated protein 1 in regenerating mouse liver
- (2016) Marzena Swiderska-Syn et al. HEPATOLOGY
- Hedgehog signaling: modulation of cancer properies and tumor mircroenvironment
- (2016) Ann Hanna et al. Molecular Cancer
- Sonic hedgehog signaling pathway mediates development of hepatocellular carcinoma
- (2016) Heng Cai et al. TUMOR BIOLOGY
- Liver regeneration microenvironment of hepatocellular carcinoma for prevention and therapy
- (2016) Hanmin Li et al. Oncotarget
- In vitro and in vivo inhibition of breast cancer cell growth by targeting the Hedgehog/GLI pathway with SMO (GDC-0449) or GLI (GANT-61) inhibitors
- (2016) Monica Benvenuto et al. Oncotarget
- Galectin-1 induces invasion and the epithelial-mesenchymal transition in human gastric cancer cells via non-canonical activation of the hedgehog signaling pathway
- (2016) Yang Chong et al. Oncotarget
- Hedgehog Signaling Regulates Epithelial-Mesenchymal Transition in Pancreatic Cancer Stem-Like Cells
- (2016) Feng Wang et al. Journal of Cancer
- Hedgehog Signaling Non-Canonical Activated by Pro-Inflammatory Cytokines in Pancreatic Ductal Adenocarcinoma
- (2016) Yuqiong Wang et al. Journal of Cancer
- Sonic Hedgehog Signaling in the Lung. From Development to Disease
- (2015) Matthias C. Kugler et al. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
- Sonic hedgehog patterning during cerebellar development
- (2015) Annarita De Luca et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Consensus Paper: Cerebellar Development
- (2015) Ketty Leto et al. CEREBELLUM
- Hedgehog Acyltransferase as a target in estrogen receptor positive, HER2 amplified, and tamoxifen resistant breast cancer cells
- (2015) Armine Matevossian et al. Molecular Cancer
- Reduced proliferation and increased apoptosis of the SGC-7901 gastric cancer cell line on exposure to GDC-0449
- (2015) CHUANQING WU et al. Molecular Medicine Reports
- Association between donor and recipient smoothened gene polymorphisms and the risk of hepatocellular carcinoma recurrence following orthotopic liver transplantation in a Han Chinese population
- (2015) Pusen Wang et al. TUMOR BIOLOGY
- Chemotherapy induces the cancer-associated fibroblast phenotype, activating paracrine Hedgehog-GLI signalling in breast cancer cells
- (2015) Maria Peiris-Pagès et al. Oncotarget
- FOXC1 Activates Smoothened-Independent Hedgehog Signaling in Basal-like Breast Cancer
- (2015) Bingchen Han et al. Cell Reports
- SMO Expression in Colorectal Cancer: Associations with Clinical, Pathological, and Molecular Features
- (2014) Tingting Li et al. ANNALS OF SURGICAL ONCOLOGY
- Primary cilia in pancreatic development and disease
- (2014) Sukanya Lodh et al. BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS
- Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma
- (2014) Andrew D. Rhim et al. CANCER CELL
- Hedgehog signaling pathway is a potential therapeutic target for gallbladder cancer
- (2014) Shojiro Matsushita et al. CANCER SCIENCE
- Tumor-Associated Macrophages in SHH Subgroup of Medulloblastomas
- (2014) A. S. Margol et al. CLINICAL CANCER RESEARCH
- Oestrogen receptor-alpha regulates non-canonical Hedgehog-signalling in the mammary gland
- (2014) Nadia Okolowsky et al. DEVELOPMENTAL BIOLOGY
- Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012
- (2014) Jacques Ferlay et al. INTERNATIONAL JOURNAL OF CANCER
- Distinct Effects of themesenchymal dysplasiaGene Variant of Murine Patched-1 Protein on Canonical and Non-canonical Hedgehog Signaling Pathways
- (2014) Malcolm C. Harvey et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Estrogen promotes stemness and invasiveness of ER-positive breast cancer cells through Gli1 activation
- (2014) Ying Sun et al. Molecular Cancer
- Targeted treatment for sonic hedgehog-dependent medulloblastoma
- (2014) M. W. Kieran NEURO-ONCOLOGY
- Hedgehog acyltransferase as a target in pancreatic ductal adenocarcinoma
- (2014) E Petrova et al. ONCOGENE
- Tumor Microenvironment and Metabolic Synergy in Breast Cancers: Critical Importance of Mitochondrial Fuels and Function
- (2014) Ubaldo Martinez-Outschoorn et al. SEMINARS IN ONCOLOGY
- New targeted therapies for breast cancer: A focus on tumor microenvironmental signals and chemoresistant breast cancers
- (2014) Armel Hervé Nwabo Kamdje World Journal of Clinical Cases
- Expression of Smoothened Protein in Colon Cancer and its Prognostic Value for Postoperative Liver Metastasis
- (2013) Yin-Lu Ding et al. Asian Pacific Journal of Cancer Prevention
- Hypoxia Triggers Hedgehog-Mediated Tumor-Stromal Interactions in Pancreatic Cancer
- (2013) T. R. Spivak-Kroizman et al. CANCER RESEARCH
- GLI1 regulates a novel neuropilin-2/α6β1 integrin based autocrine pathway that contributes to breast cancer initiation
- (2013) Hira Lal Goel et al. EMBO Molecular Medicine
- Aberrant activation of Sonic hedgehog signaling in chronic cholecystitis and gallbladder carcinoma
- (2013) Fang Xie et al. HUMAN PATHOLOGY
- Nonclassical Activation of Hedgehog Signaling Enhances Multidrug Resistance and Makes Cancer Cells Refractory to Smoothened-targeting Hedgehog Inhibition
- (2013) Shamik Das et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Non-canonical Hedgehog signaling contributes to chemotaxis in cholangiocarcinoma
- (2013) Nataliya Razumilava et al. JOURNAL OF HEPATOLOGY
- High Expression of Patched Homolog-1 Messenger RNA and Glioma-Associated Oncogene-1 Messenger RNA of Sonic Hedgehog Signaling Pathway Indicates a Risk of Postresection Recurrence of Hepatocellular Carcinoma
- (2012) Kuo-Shyang Jeng et al. ANNALS OF SURGICAL ONCOLOGY
- Canonical TGF-β Pathway Activity Is a Predictor of SHH-Driven Medulloblastoma Survival and Delineates Putative Precursors in Cerebellar Development
- (2012) Donya Aref et al. BRAIN PATHOLOGY
- Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment
- (2012) Douglas Hanahan et al. CANCER CELL
- Hedgehog Signaling Blockade Delays Hepatocarcinogenesis Induced by Hepatitis B Virus X Protein
- (2012) A. Arzumanyan et al. CANCER RESEARCH
- Hedgehog Signaling Is a Novel Therapeutic Target in Tamoxifen-Resistant Breast Cancer Aberrantly Activated by PI3K/AKT Pathway
- (2012) B. Ramaswamy et al. CANCER RESEARCH
- Sonic hedgehog signaling pathway induces cell migration and invasion through focal adhesion kinase/AKT signaling-mediated activation of matrix metalloproteinase (MMP)-2 and MMP-9 in liver cancer
- (2012) Jing-Song Chen et al. CARCINOGENESIS
- Paracrine Sonic Hedgehog Signaling Derived from Tumor Epithelial Cells: A Key Regulator in the Pancreatic Tumor Microenvironment
- (2012) Xuqi Li et al. CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION
- Mammary epithelial-restricted expression of activated c-src rescues the block to mammary gland morphogenesis due to the deletion of the C-terminus of Patched-1
- (2012) Hong Chang et al. DEVELOPMENTAL BIOLOGY
- Inhibition of hedgehog signaling attenuates carcinogenesisin vitroand increases necrosis of cholangiocellular carcinoma
- (2012) Mona El Khatib et al. HEPATOLOGY
- Sonic Hedgehog contributes to gastric mucosal restitution after injury
- (2012) Chang Xiao et al. LABORATORY INVESTIGATION
- Sulforaphane regulates self-renewal of pancreatic cancer stem cells through the modulation of Sonic hedgehog–GLI pathway
- (2012) Shih-Hui Li et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- Subgroup-specific structural variation across 1,000 medulloblastoma genomes
- (2012) Paul A. Northcott et al. NATURE
- Stromal control of cystine metabolism promotes cancer cell survival in chronic lymphocytic leukaemia
- (2012) Wan Zhang et al. NATURE CELL BIOLOGY
- Immunohistochemical evidence of the prognostic value of hedgehog pathway components in primary gallbladder carcinoma
- (2012) Jinmao Li et al. SURGERY TODAY
- Pediatric and adult sonic hedgehog medulloblastomas are clinically and molecularly distinct
- (2011) Paul A. Northcott et al. ACTA NEUROPATHOLOGICA
- Molecular subgroups of medulloblastoma: the current consensus
- (2011) Michael D. Taylor et al. ACTA NEUROPATHOLOGICA
- Targeting GLI1 expression in human inflammatory breast cancer cells enhances apoptosis and attenuates migration
- (2011) Z I Thomas et al. BRITISH JOURNAL OF CANCER
- Hedgehog Overexpression Is Associated with Stromal Interactions and Predicts for Poor Outcome in Breast Cancer
- (2011) S. A. O'Toole et al. CANCER RESEARCH
- Understanding the metabolic basis of drug resistance
- (2011) Ubaldo E. Martinez-Outschoorn et al. CELL CYCLE
- Gli1 enhances migration and invasion via up-regulation of MMP-11 and promotes metastasis in ERα negative breast cancer cell lines
- (2011) Yeon-Jin Kwon et al. CLINICAL & EXPERIMENTAL METASTASIS
- Altered differentiation and paracrine stimulation of mammary epithelial cell proliferation by conditionally activated Smoothened
- (2011) Adriana P. Visbal et al. DEVELOPMENTAL BIOLOGY
- Mechanisms of Hedgehog signalling in cancer
- (2011) Kieren D. Marini et al. GROWTH FACTORS
- Myofibroblast-derived PDGF-BB promotes hedgehog survival signaling in cholangiocarcinoma cells
- (2011) Christian D. Fingas et al. HEPATOLOGY
- Hedgehog signalling in gut development, physiology and cancer
- (2011) Juanita L. Merchant JOURNAL OF PHYSIOLOGY-LONDON
- Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth
- (2011) Kristin M Nieman et al. NATURE MEDICINE
- Upregulation of VEGF-A and CD24 gene expression by the tGLI1 transcription factor contributes to the aggressive behavior of breast cancer cells
- (2011) X Cao et al. ONCOGENE
- Increased vascularity and spontaneous metastasis of breast cancer by hedgehog signaling mediated upregulation of cyr61
- (2011) L G Harris et al. ONCOGENE
- Breast Cancer Stem Cells and Their Role in Resistance to Endocrine Therapy
- (2011) Ciara S. O’Brien et al. Hormones & Cancer
- Expression of Sonic Hedgehog Signaling Components in Hepatocellular Carcinoma and Cyclopamine-induced Apoptosis Through Bcl-2 Downregulation In Vitro
- (2010) Xi-lin Chen et al. ARCHIVES OF MEDICAL RESEARCH
- Hedgehog signaling and gastrointestinal cancer
- (2010) Milena Saqui-Salces et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Differential impact of fibroblasts on the efficient cell death of lung cancer cells induced by paclitaxel and cisplatin
- (2010) Babett Bartling et al. CANCER BIOLOGY & THERAPY
- TGF- Promotion of Gli2-Induced Expression of Parathyroid Hormone-Related Protein, an Important Osteolytic Factor in Bone Metastasis, Is Independent of Canonical Hedgehog Signaling
- (2010) R. W. Johnson et al. CANCER RESEARCH
- Hedgehog signaling pathway mediates the progression of non-invasive breast cancer to invasive breast cancer
- (2010) Masae Souzaki et al. CANCER SCIENCE
- Primary Cilia Regulate Branching Morphogenesis during Mammary Gland Development
- (2010) Kimberly M. McDermott et al. CURRENT BIOLOGY
- Medulloblastoma Comprises Four Distinct Molecular Variants
- (2010) Paul A. Northcott et al. JOURNAL OF CLINICAL ONCOLOGY
- Paracrine Hedgehog Signaling in Cancer
- (2009) J.-W. Theunissen et al. CANCER RESEARCH
- Hedgehog signalling: Emerging evidence for non-canonical pathways
- (2009) Dagan Jenkins CELLULAR SIGNALLING
- The Patched dependence receptor triggers apoptosis through a DRAL–caspase-9 complex
- (2009) Frédéric Mille et al. NATURE CELL BIOLOGY
- Sonic hedgehog paracrine signaling regulates metastasis and lymphangiogenesis in pancreatic cancer
- (2009) J M Bailey et al. ONCOGENE
- Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis
- (2009) H. Tian et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer
- (2009) K. P. Olive et al. SCIENCE
- The Smo/Smo Model: Hedgehog-Induced Medulloblastoma with 90% Incidence and Leptomeningeal Spread
- (2008) B. A. Hatton et al. CANCER RESEARCH
- Characterization of primary cilia and Hedgehog signaling during development of the human pancreas and in human pancreatic duct cancer cell lines
- (2008) Sonja K. Nielsen et al. DEVELOPMENTAL DYNAMICS
- A paracrine requirement for hedgehog signalling in cancer
- (2008) Robert L. Yauch et al. NATURE
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now