Article
Oncology
Yi-Ching Chuang, Ming-Chang Hsieh, Chia-Chieh Lin, Yu-Sheng Lo, Hsin-Yu Ho, Ming-Ju Hsieh, Jen-Tsun Lin
Summary: The study demonstrated that pinosylvin inhibited migration and invasion in nasopharyngeal carcinoma cells, potentially through modulation of multiple signaling pathways.
Article
Pharmacology & Pharmacy
Rujun Jia, Tiegang Li, Nana Wang
Summary: The study revealed that in PQ-induced pulmonary EMT, HOTAIR acts as a ceRNA to regulate MMP2 expression by modulating miR-17-5p. MiR-17-5p negatively regulates HOTAIR and MMP2, while the downregulation of miR-17-5p increases the expression of HOTAIR and MMP2.
Article
Biochemistry & Molecular Biology
On-Yu Hong, Sang Yull Kang, Eun-Mi Noh, Hong-Nu Yu, Hye-Yeon Jang, Seong-Hun Kim, Jingyu Hong, Eun Yong Chung, Jong-Suk Kim
Summary: This study revealed the significant role of Aurora kinase A in colon cancer metastasis, promoting migration and invasion by inducing epithelial-to-mesenchymal transition (EMT). It is the first study to demonstrate that Aurora kinase A is a key molecule in PKC-induced metastasis in colon cancer cells.
Article
Immunology
Xiaofang Xu, Dianhua Qiao, Chenyang Dong, Morgan Mann, Roberto P. Garofalo, Sunduz Keles, Allan R. Brasier
Summary: The SMARCA4 complex is found to play a crucial role in the response of airway epithelial cells to RSV infection, with its depletion leading to cellular state transition and chromatin opening that affect gene expression within cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Sui Chen, Zhimin Shen, Lei Gao, Shaobin Yu, Peipei Zhang, Ziyang Han, Mingqiang Kang
Summary: TPM3 promotes proliferation, migration, and metastatic potential in esophageal cancer cells, as well as the epithelial-mesenchymal transition (EMT) process. This function may be achieved via the regulation of MMP2/9 expression.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Gokhan Bahcecioglu, Xiaoshan Yue, Erin Howe, Ian Guldner, M. Sharon Stack, Harikrishna Nakshatri, Siyuan Zhang, Pinar Zorlutuna
Summary: The study reveals that aging ECM can drive normal mammary epithelial cells to a more invasive and cancer-like phenotype, and enhance motility and invasiveness in breast cancer cells. Different responses of cells to young and aged ECMs may lead to the identification of new targets for cancer treatment and prevention.
Article
Environmental Sciences
Lingju Hong, Mingyuan Chen, Maotuan Huang, Weihong Chen, Xiahenazi Abudukeremu, Feifei She, Yanling Chen
Summary: In this study, FOXA2 expression was found to be downregulated in gallbladder cancer and inversely correlated with tumor metastasis, lymph node metastasis, and poor patient prognosis. FOXA2 inhibits epithelial-mesenchymal transition (EMT) and metastasis of gallbladder cancer cells through positive regulation of serine protein kinase inhibitor B5 (SERPINB5) expression. These findings suggest that FOXA2 may be a potential therapeutic target against gallbladder cancer.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Deguang Kong, Hengbo Zhou, Deepika Neelakantan, Connor J. Hughes, Jessica Y. Hsu, Ramakrishnan Rajaram Srinivasan, Michael T. Lewis, Heide L. Ford
Summary: VEGF-C secreted by EMT breast cancer cells can promote proliferation, migration, and invasion of epithelial breast cancer cells through non-canonical activation of GLI signaling. Inhibiting VEGF-C in EMT cells or knocking down NRP2 in neighboring epithelial cancer cells disrupts the aggressive phenotypes induced by EMT cells, suggesting a novel therapeutic target for metastasis in breast cancer.
Article
Oncology
Wen-Yueh Hung, Wei-Jiunn Lee, Guo-Zhou Cheng, Ching-Han Tsai, Yi-Chieh Yang, Tsung-Ching Lai, Ji-Qing Chen, Chi-Li Chung, Jer-Hwa Chang, Ming-Hsien Chien
Summary: Our study showed that penfluridol can reduce the migration, invasion, and adhesion of LADC cells, potentially by inhibiting MMP-12 expression and reversing MMP-12-induced EMT. MMP-12 may serve as a useful biomarker for predicting LADC progression and as a promising penfluridol target for treating metastatic LADC.
Article
Biochemistry & Molecular Biology
Qiaosi Tang, Ashley Lento, Kensuke Suzuki, Gizem Efe, Tatiana Karakasheva, Apple Long, Veronique Giroux, Mirazul Islam, E. Paul Wileyto, Andres J. Klein-Szanto, Hiroshi Nakagawa, Adam Bass, Anil K. Rustgi
Summary: The study reveals that TP53 mutation is the most common in ESCC, while Rab11-FIP1 gene is significantly downregulated in mutant p53 tumor cells. Genetic knockdown of Rab11-FIP1 results in increased organoid size and promotes tumor cell invasion through mutant p53.
Review
Oncology
Xiaobo Zheng, Fuzhen Dai, Lei Feng, Hong Zou, Li Feng, Mingqing Xu
Summary: The interplay between epithelial-mesenchymal plasticity and cancer stem cells plays a crucial role in cancer progression, affecting the aggressiveness of tumor cells and their response to treatment. Understanding the dynamic nature of EMT as a hybrid state rather than a binary model is important for unraveling the complexities of cancer biology and developing targeted therapeutic interventions.
FRONTIERS IN ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Braxton Noll, Farah Bahrani Mougeot, Michael T. Brennan, Jean-Luc C. Mougeot
Summary: This study found that the degradation of salivary epithelium in primary Sjogren's syndrome (pSS) patients is initially caused by overexpression of MMP9. The expression of MMP9 and its associated transcription factor ETS1 was assessed in primary salivary gland epithelial cells (SGECs) and potential regulatory mechanisms were investigated in immortalized SGECs. It was found that ETS1 and MMP9 were overexpressed in SGECs of pSS patients. Knocking down ETS1 resulted in reduced mRNA and protein levels of MMP9. ETS1 overexpression affected the expression of markers associated with epithelial-mesenchymal transition (EMT) and progenitor cells.
SCIENTIFIC REPORTS
(2022)
Review
Oncology
Yiming Liu, Xinyang Hu, Shiyao Liu, Sining Zhou, Zhi Chen, Hongchuan Jin
Summary: GP73, a glycosylated protein highly expressed in various cancer tissues, has been identified as a novel serum biomarker for cancer diagnosis, especially in hepatocellular carcinoma (HCC). Recent studies have shown that GP73 plays multifunctional roles in cancer progression, especially in promoting EMT and cancer metastasis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Jianhong Zhang, Zeming Hu, Chao Wen, Qicheng Liao, Baoqing He, Jing Peng, Xin Tang, Zhixi Chen, Yuankang Xie
Summary: The study found that miR-182 promotes EMT in GBC cells by targeting FOXN3, which in turn suppresses the Wnt/beta-catenin pathway. Decreased miR-182 expression led to attenuated EMT and reduced activity of beta-catenin and its downstream factors in GBC cells. Overexpression of FOXN3 improved EMT and the beta-catenin pathway.
Article
Biotechnology & Applied Microbiology
Long Yang, Jingwen Li, Guangchao Zang, Sijie Song, Zhengwen Sun, Xinyue Li, Yuanzhu Li, Zhenhong Xie, Guangyuan Zhang, Ni Gui, Shu Zhu, Tingting Chen, Yikui Cai, Yinping Zhao
Summary: High matrix stiffness promotes EMT and migration of cervical cancer cells through the Pin1/YAP pathway.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)