Tau oligomers mediate α-synuclein toxicity and can be targeted by immunotherapy

Alzheimer's disease pathology in synucleinopathies

(2017) Johannes Attems   LANCET NEUROLOGY

Drugs in Clinical Trials for Alzheimer's Disease: The Major Trends

(2017) Sergey O. Bachurin et al.   MEDICINAL RESEARCH REVIEWS

Differential effects of immunotherapy with antibodies targeting α-synuclein oligomers and fibrils in a transgenic model of synucleinopathy

(2017) Omar El-Agnaf et al.   NEUROBIOLOGY OF DISEASE

The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

(2016) Jeff Sevigny et al.   NATURE

Caspase-2 cleavage of tau reversibly impairs memory

(2016) Xiaohui Zhao et al.   NATURE MEDICINE

Specific Targeting of Tau Oligomers in Htau Mice Prevents Cognitive Impairment and Tau Toxicity Following Injection with Brain-Derived Tau Oligomeric Seeds

(2016) Diana L. Castillo-Carranza et al.   JOURNAL OF ALZHEIMERS DISEASE

Pathological Interface Between Oligomeric Alpha-Synuclein and Tau in Synucleinopathies

(2015) Urmi Sengupta et al.   BIOLOGICAL PSYCHIATRY

Direct visualization of alpha-synuclein oligomers reveals previously undetected pathology in Parkinson’s disease brain

(2015) Rosalind F. Roberts et al.   BRAIN

Tau Immunotherapy Modulates Both Pathological Tau and Upstream Amyloid Pathology in an Alzheimer's Disease Mouse Model

(2015) D. L. Castillo-Carranza et al.   JOURNAL OF NEUROSCIENCE

Passive Immunization with Tau Oligomer Monoclonal Antibody Reverses Tauopathy Phenotypes without Affecting Hyperphosphorylated Neurofibrillary Tangles

(2014) D. L. Castillo-Carranza et al.   JOURNAL OF NEUROSCIENCE

Amyloid-β and Tau

(2014) George S. Bloom   JAMA Neurology

Distinct α-Synuclein Strains Differentially Promote Tau Inclusions in Neurons

(2013) Jing L. Guo et al.   CELL

Alpha-synuclein interferes with cAMP/PKA-dependent upregulation of dopamine β-hydroxylase and is associated with abnormal adaptive responses to immobilization stress

(2013) Sasuk Kim et al.   EXPERIMENTAL NEUROLOGY

Non-motor parkinsonian pathology in aging A53T α-Synuclein mice is associated with progressive synucleinopathy and altered enzymatic function

(2013) Kaitlin F. Farrell et al.   JOURNAL OF NEUROCHEMISTRY

Age-Dependent Effects of A53T Alpha-Synuclein on Behavior and Dopaminergic Function

(2013) Adam W. Oaks et al.   PLoS One

Behavioral Characterization of A53T Mice Reveals Early and Late Stage Deficits Related to Parkinson’s Disease

(2013) Katrina L. Paumier et al.   PLoS One

What is the pathological significance of tau oligomers?

(2012) Catherine M. Cowan et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Exosomal cell-to-cell transmission of alpha synuclein oligomers

(2012) Karin M Danzer et al.   Molecular Neurodegeneration

Synergistic influence of phosphorylation and metal ions on tau oligomer formation and coaggregation with α-synuclein at the single molecule level

(2012) Georg Nübling et al.   Molecular Neurodegeneration

Tau acts as an independent genetic risk factor in pathologically proven PD

(2012) Gavin Charlesworth et al.   NEUROBIOLOGY OF AGING

MAPT H1 haplotype is associated with enhanced α-synuclein deposition in dementia with Lewy bodies

(2012) Martí Colom-Cadena et al.   NEUROBIOLOGY OF AGING

Tau Accumulation Causes Mitochondrial Distribution Deficits in Neurons in a Mouse Model of Tauopathy and in Human Alzheimer's Disease Brain

(2011) Katherine J. Kopeikina et al.   AMERICAN JOURNAL OF PATHOLOGY

Region-specific tauopathy and synucleinopathy in brain of the alpha-synuclein overexpressing mouse model of Parkinson's disease

(2011) Tiffany Kaul et al.   BMC NEUROSCIENCE

Hyperphosphorylated Tau in an α-synuclein-overexpressing transgenic model of Parkinson’s disease

(2011) Thomas Haggerty et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

E46K Human α-Synuclein Transgenic Mice Develop Lewy-like and Tau Pathology Associated with Age-dependent, Detrimental Motor Impairment

(2011) Kristel L. Emmer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

 -Syn Suppression Reverses Synaptic and Memory Defects in a Mouse Model of Dementia with Lewy Bodies

(2011) Y. Lim et al.   JOURNAL OF NEUROSCIENCE

Induction of Intracellular Tau Aggregation Is Promoted by  -Synuclein Seeds and Provides Novel Insights into the Hyperphosphorylation of Tau

(2011) E. A. Waxman et al.   JOURNAL OF NEUROSCIENCE

Tauopathic Changes in the Striatum of A53T α-Synuclein Mutant Mouse Model of Parkinson's Disease

(2011) Jonathan Wills et al.   PLoS One

Interaction between -Synuclein and Other Proteins in Neurodegenerative Disorders

(2011) Kurt A. Jellinger   TheScientificWorldJOURNAL

Preparation and Characterization of Neurotoxic Tau Oligomers

(2010) Cristian A. Lasagna-Reeves et al.   BIOCHEMISTRY

Elevated tauopathy and alpha-synuclein pathology in postmortem Parkinson's disease brains with and without dementia

(2010) Jonathan Wills et al.   EXPERIMENTAL NEUROLOGY

Distinct Region-Specific  -Synuclein Oligomers in A53T Transgenic Mice: Implications for Neurodegeneration

(2010) E. Tsika et al.   JOURNAL OF NEUROSCIENCE

Staging of α-synuclein in the olfactory bulb in a model of Parkinson's disease: Cell types involved

(2010) Isabel Ubeda-Bañon et al.   MOVEMENT DISORDERS

α-Synuclein contributes to GSK-3β-catalyzed Tau phosphorylation in Parkinson’s disease models

(2009) Tetyana Duka et al.   FASEB JOURNAL

Genome-wide association study reveals genetic risk underlying Parkinson's disease

(2009) Javier Simón-Sánchez et al.   NATURE GENETICS

Selective noradrenergic vulnerability in alpha-synuclein transgenic mice

(2009) Evangelos Sotiriou et al.   NEUROBIOLOGY OF AGING

A critical reappraisal of current staging of Lewy-related pathology in human brain

(2008) Kurt A. Jellinger   ACTA NEUROPATHOLOGICA

Applicability of current staging/categorization of α-synuclein pathology and their clinical relevance

(2008) Laura Parkkinen et al.   ACTA NEUROPATHOLOGICA

Phosphorylation of tau and α-synuclein in synaptic-enriched fractions of the frontal cortex in Alzheimer’s disease, and in Parkinson’s disease and related α-synucleinopathies

(2008) G. Muntané et al.   NEUROSCIENCE