Article
Clinical Neurology
Marco Onofrj, Angelo Di Iorio, Claudia Carrarini, Mirella Russo, Raffaella Franciotti, Alberto J. Espay, Laura S. Boylan, John-Paul Taylor, Massimo Di Giannantonio, Giovanni Martinotti, Enza M. Valente, Astrid Thomas, Laura Bonanni, Stefano Delli Pizzi, Fedele Dono, StefanoL Sensi
Summary: Patients with bipolar spectrum disorders (BSDs) have an increased risk of Parkinson's disease (PD). This study found that patients with BSD-PD have significant differences in family history, impulse control disorders, functional disorders, early occurrence of delusions or mild dementia, and mortality compared to PD patients. The presence of BSDs as a prodrome to PD negatively affects the course of the disease and is associated with detrimental neuropsychiatric features and treatment outcomes.
MOVEMENT DISORDERS
(2021)
Article
Clinical Neurology
Anna Covolo, Gabriele Imbalzano, Carlo Alberto Artusi, Elisa Montanaro, Claudia Ledda, Marco Bozzali, Mario Giorgio Rizzone, Maurizio Zibetti, Tiziana Martone, Leonardo Lopiano, Alberto Romagnolo
Summary: This case report describes the very long-term outcome of a Parkinson's disease patient with PRKN gene mutations after more than 15 years of deep brain stimulation treatment. The patient experienced significant improvement in motor symptoms and fluctuations, although he developed some cognitive impairments. However, his overall quality of life was better compared to before the surgery.
NEUROLOGICAL SCIENCES
(2023)
Letter
Clinical Neurology
Nina Asheim Birkeland, Viel Nyborg Carlsen, Sasha Gulati, Emil K. Gustavsson, Jan O. Aasly
Summary: A patient with Parkinson's disease initially rejected for DBS due to extensive brain calcifications underwent successful surgery after seeking a second opinion. Genetic analysis revealed a mutation in the SLC20A2 gene, known to cause brain calcifications, but no known PD-causing mutation.
PARKINSONISM & RELATED DISORDERS
(2022)
Review
Medicine, General & Internal
Marwan Hariz, Patric Blomstedtl
Summary: Parkinson's disease is a progressive neurodegenerative illness with motor and nonmotor symptoms. Deep brain stimulation is an effective symptomatic treatment that can be tailored to individual patients. DBS has significant effects on tremors, rigidity, and dyskinesias, but less responsive for axial symptoms. Specialized multidisciplinary teams are required for DBS in PD.
JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Clinical Neurology
Martin M. Reich, Joey Hsu, Michael Ferguson, Frederic L. W. V. J. Schaper, Juho Joutsa, Jonas Roothans, Robert C. Nickl, Anneke Frankemolle-Gilbert, Jay Alberts, Jens Volkmann, Michael D. Fox
Summary: The study demonstrates that the decline in cognitive function caused by deep brain stimulation (DBS) is related to the connectivity between the stimulation site and a specific brain network associated with memory impairment. Transforming this network into a heat map can help identify DBS patients at risk of delayed-onset side-effects and guide reprogramming efforts.
Article
Clinical Neurology
Carlo Alberto Artusi, Leonardo Lopiano
Summary: Parkinson's disease (PD) patients with glucosylceramidase beta 1 (GBA1) gene mutations often have an earlier onset and more aggressive disease course, with increased neuropsychological issues. Deep brain stimulation (DBS) is a common therapeutic option for PD patients with disabling motor fluctuations and no dementia, showing good outcomes in terms of daily living activities and quality of life improvement. However, studies suggest that PD patients with GBA1 variants may have a worse DBS outcome due to accelerated cognitive decline. This summary highlights the current literature, identifies knowledge gaps, and proposes suggestions for further research and clinical practice in using DBS for PD patients with GBA1 variants.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Abteen Mostofi, Francesca Morgante, Mark J. Edwards, Peter Brown, Erlick A. C. Pereira
Summary: Pain in Parkinson's disease is often untreated due to lack of understanding of its mechanisms. Deep brain stimulation of the subthalamic nucleus has shown potential in treating pain, but the exact type of pain it benefits and how it interferes with pain processing remain unclear.
Review
Clinical Neurology
Hengameh Zahed, Jose Rafael Pantoja Zuzuarregui, Ro'ee Gilron, Timothy Denison, Philip A. Starr, Simon Little
Summary: Sleep disturbances are common nonmotor complications of Parkinson's disease, potentially contributing to disease progression. Limited options currently exist to modulate sleep disturbances, prompting the need for further research into neurophysiological changes affecting sleep in PD.
MOVEMENT DISORDERS
(2021)
Article
Clinical Neurology
Lais M. Oliveira, Marta Ruiz-Lopez, Alexandre Boutet, Gavin J. B. Elias, Suneil K. Kalia, Mojgan Hodaie, Andres M. Lozano, Renato P. Munhoz, Alfonso Fasano
Summary: The study found that using the advanced functions of the patient programmer delays programming optimization and is associated with a higher number of side effects. Therefore, there is a need for other faster and safer stimulation programming methods.
Review
Psychology, Multidisciplinary
Joshua A. Wilt, Amanda R. Merner, Jaclyn Zeigler, Michelle Montpetite, Cynthia S. Kubu
Summary: Deep Brain Stimulation (DBS) is a safe and effective treatment for Parkinson's Disease (PD) in improving motor symptoms, but concerns about its effects on patients' personality remain. Research shows that while there is little evidence of changes in dispositional traits following DBS, there is some positive progress in characteristic adaptations. Further research is needed in exploring the impact on narrative identity after DBS treatment for PD.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Clinical Neurology
Gian D. Pal, Daniel M. Corcos, Leo Verhagen Metman, Zvi Israel, Hagai Bergman, David Arkadir
Summary: Genetic subtyping of patients with Parkinson's disease may help predict the cognitive and motor outcomes of subthalamic deep brain stimulation. However, there are still controversies and gaps in understanding the effects of STN-DBS on PD patients with pathogenic variants in the GBA1 gene. Further research is needed to determine the clinical significance, risk-to-benefit ratio, and strategies to minimize the negative effects of STN-DBS. Genetic testing for GBA1 may be considered in PD patients considering DBS to properly assess the potential risks and benefits.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Caroline Weill, Akiva Gallant, Halen Baker Erdman, Muneer Abu Snineh, Eduard Linetsky, Hagai Bergman, Zvi Israel, David Arkadir
Summary: This study aimed to investigate the relationship between pathogenic gene variants in Parkinson's disease (PD) patients and electrophysiological activity. The results showed that genetic heterogeneity in PD is not associated with electrophysiological differences, indicating that adaptive deep brain stimulation algorithms would be applicable to genetically heterogeneous patient populations.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Khaled Moussawi, Min Jae Kim, Sydney Baybayan, Myles Wood, Kelly A. Mills
Summary: The study investigated the behavioral responses of Parkinson's disease patients under globus pallidus internus DBS settings, revealing a negative correlation between the volume of tissue activation connected to the right prefrontal cortex and impulsivity, while greater overlap with the non-prefrontally-connected globus pallidus internus was associated with increased impulsivity.
Article
Medicine, General & Internal
Tianqi Hu, Hutao Xie, Yu Diao, Houyou Fan, Delong Wu, Yifei Gan, Fangang Meng, Yutong Bai, Jianguo Zhang
Summary: This study aimed to investigate the effects of STN-DBS on PD patients with different levels of depression and identify predictors of these effects. The results showed that patients with moderate depression had better improvement, and gender (female) and preoperative HAMA scores were predictors of the effects of STN-DBS on PD depression.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Neurosciences
Faisal Alosaimi, Jackson Tyler Boonstra, Sonny Tan, Yasin Temel, Ali Jahanshahi
Summary: DBS is a successful paradigm for treating movement disorders, but its specific mechanisms and effects on neurotransmitter dynamics are still not fully understood. This review discusses the role of neurotransmitter dynamics in mediating DBS effects in Parkinson's disease.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Pharmacology & Pharmacy
Carlo Alberto Artusi, Lidia Sarro, Gabriele Imbalzano, Margherita Fabbri, Leonardo Lopiano
Summary: The literature review provided evidence supporting the safety and efficacy of tolcapone, showing minimal safety concerns when hepatic function monitoring is strictly followed. Tolcapone demonstrates significant improvement in symptoms for Parkinson's disease patients but carries a risk of severe liver injury if monitoring guidelines are not followed.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Clinical Neurology
Elisa Montanaro, Carlo Alberto Artusi, Cristina Rosano, Carlotta Boschetto, Gabriele Imbalzano, Alberto Romagnolo, Marco Bozzali, Mario Giorgio Rizzone, Maurizio Zibetti, Leonardo Lopiano
Summary: During the COVID-19 outbreak, a higher prevalence of anxiety and depression was observed in APD patients and their caregivers, with main worries including infection risk, interruption of treatments, clinic closures, and PD complications related to COVID-19. Specific interventions are necessary to effectively manage these psychological distresses.
NEUROLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Beatrice Benatti, Nicolaja Girone, Dario Conti, Rita Cafaro, Caterina Vigano, Matteo Briguglio, Donatella Marazziti, Federico Mucci, Orsola Gambini, Benedetta Demartini, Antonio Tundo, Roberta Necci, Domenico De Berardis, Roberta Galentino, Sara De Michele, Roberta Balestrino, Umberto Albert, Sylvia Rigardetto, Giuseppe Mania, Giacomo Grassi, Stefano Pallanti, Andrea Amerio, Andrea Aguglia, Davide Prestia, Mario Amore, Alberto Priori, Domenico Servello, Mauro Porta, Bernardo Dell'Osso
Summary: This study found that remission was associated with later onset of TD and OCD, while the treatment-resistant group had higher rates of psychiatric comorbidities, TD, and lifetime suicidal ideation and attempts, along with worsened quality of life and family involvement. These findings suggest that early onset and presence of psychiatric comorbidities and concomitant TD predict a worse treatment response in OCD patients with OCTD.
Editorial Material
Medicine, General & Internal
Gabriella Gruden, Sara Bernardi, Michela Scandella, Francesca Arietti, Giuseppe Gargiulo, Claudia Papa, Guglielmo Beccuti, Mario Giorgio Rizzone, Vincenzo Villari, Paolo Cavallo Perin, Marilena Durazzo
INTERNAL AND EMERGENCY MEDICINE
(2022)
Article
Clinical Neurology
Elisa Montanaro, Alberto Romagnolo, Margherita Fabbri, Carlo Alberto Artusi, Gabriele Imbalzano, Mario Giorgio Rizzone, Leonardo Lopiano, Maurizio Zibetti
Summary: In advanced PD patients, sleep disturbances selectively correlate with specific neuropsychological functions and not with short-term memory and consolidation. It is suggested to consider treatment of sleep disturbances to minimize their potential impact on cognition.
JOURNAL OF NEUROLOGY
(2022)
Review
Clinical Neurology
Giuseppe Cosentino, Micol Avenali, Antonio Schindler, Nicole Pizzorni, Cristina Montomoli, Giovanni Abbruzzese, Angelo Antonini, Filippo Barbiera, Marco Benazzo, Eduardo Elias Benarroch, Giulia Bertino, Emanuele Cereda, Pere Clave, Pietro Cortelli, Roberto Eleopra, Chiara Ferrari, Shaheen Hamdy, Maggie-Lee Huckabee, Leonardo Lopiano, Rosario Marchese Ragona, Stefano Masiero, Emilia Michou, Antonio Occhini, Claudio Pacchetti, Ronald F. Pfeiffer, Domenico A. Restivo, Mariangela Rondanelli, Giovanni Ruoppolo, Giorgio Sandrini, Anthony H. Schapira, Fabrizio Stocchi, Eduardo Tolosa, Francesca Valentino, Mauro Zamboni, Roberta Zangaglia, Mario Zappia, Cristina Tassorelli, Enrico Alfonsi
Summary: Parkinson's disease is a neurodegenerative disorder characterized by motor and non-motor dysfunction, with dysphagia being a common yet often underdiagnosed symptom. A multinational group of experts conducted a systematic review and consensus conference to provide guidance on the screening, diagnosis, and impact of dysphagia on the prognosis and quality of life of PD patients. The consensus statements offer a framework for timely detection and accurate diagnosis of dysphagia in PD.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Alberto Romagnolo, Gabriele Imbalzano, Carlo Alberto Artusi, Roberta Balestrino, Claudia Ledda, Francesco Giuseppe De Rosa, Franco Riccardini, Elisa Montanaro, Marco Bozzali, Mario Giorgio Rizzone, Maurizio Zibetti, Leonardo Lopiano
Summary: This study found that patients with pre-existing neurological diseases, especially neurodegenerative diseases, had a significantly increased case fatality rate after contracting COVID-19, highlighting the importance of viral screening, access to care facilities, and vaccination for these populations.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Article
Clinical Neurology
Michele Tinazzi, Mirta Fiorio, Alfredo Berardelli, Bruno Bonetti, Domenico Marco Bonifati, Alessandro Burlina, Annachiara Cagnin, Francesca Calabria, Maurizio Corbetta, Pietro Cortelli, Bruno Giometto, Silvia Vittoria Guidoni, Leonardo Lopiano, Gianluigi Mancardi, Fabio Marchioretto, Maria Pellegrini, Francesco Teatini, Gioacchino Tedeschi, Lucia Tesolin, Emanuele Turinese, Mario Zappia, Angela Marotta
Summary: The study investigated Italian neurologists' knowledge and clinical experience in managing patients with Functional Neurological Disorders (FND). Results showed that neurologists preferred using the term FND over other psychological or descriptive terms when communicating with patients, and were more inclined to refer patients to psychologists rather than psychiatrists. Some believed in the usefulness of physiotherapy and psychiatric interventions, while others thought patients may simulate their symptoms. Overall, the study suggests that understanding of scientific advances in FND is somewhat lacking, and there is a need for professional education to improve patient management.
JOURNAL OF NEUROLOGY
(2022)
Correction
Clinical Neurology
Roberta Balestrino, Paolo Barone, Massimo Filippi, Roberto Erro
JOURNAL OF NEUROLOGY
(2022)
Meeting Abstract
Clinical Neurology
Gabriele Imbalzano, Alberto Romagnolo, Carlo Alberto Artusi, Roberta Balestrino, Claudia Ledda, Francesco De Rosa, Franco Riccardini, Elisa Montanaro, Marco Bozzali, Mario Rizzone, Maurizio Zibetti, Leonardo Lopiano
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Article
Clinical Neurology
Mario Giorgio Rizzone, Francesca Mancini, Carlo Alberto Artusi, Roberta Balestrino, Salvatore Bonvegna, Margherita Fabbri, Gabriele Imbalzano, Elisa Montanaro, Alberto Romagnolo, Maurizio Zibetti, Leonardo Lopiano
Summary: We evaluated the effect of Safinamide as adjunctive therapy in PD patients still experiencing motor fluctuations and dyskinesias after STN-DBS.
NEUROLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Francesca Palumbo, Barbara Iazzolino, Laura Peotta, Antonio Canosa, Umberto Manera, Maurizio Grassano, Federico Casale, Giorgio Pellegrino, Mario Giorgio Rizzone, Rosario Vasta, Cristina Moglia, Adriano Chio, Andrea Calvo
Summary: This study assessed the differences in facial emotion recognition and theory of mind between ALS patients and controls, and found that ALS patients performed worse in social cognition, including facial emotion recognition and theory of mind. These findings support the importance of routinely assessing social cognition in ALS patients.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Jun-Pyo Hong, Hanim Kwon, Euyhyun Park, Sun-Uk Lee, Chan-Nyoung Lee, Byung-Jo Kim, Ji-Soo Kim, Kun-Woo Park
Summary: In patients with mild-to-moderate PD, vestibular function assessed by video head-impulse tests appears relatively preserved and has minimal impact on the risk of falls. Risk of postural instability is associated with the severity of clinical symptoms in PD.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yaqin Xiang, XiuRong Huang, Qian Xu, Zhenhua Liu, Yase Chen, Qiying Sun, Junling Wang, Hong Jiang, Lu Shen, Xinxiang Yan, Beisha Tang, Jifeng Guo
Summary: Using the novel data-driven method DEBM, this study determined the sequence of several common biomarker changes in Parkinson's disease (PD). The left putamen was found to be the earliest biomarker to become abnormal, followed by the right putamen, CSF alpha-synuclein, right caudate, left caudate, and serum NfL. The estimated disease stages showed significant differences between PD and healthy controls, and achieved a high accuracy for distinguishing PD from HC.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yan Li, David J. McLernon, Carl E. Counsell, Angus D. Macleod
Summary: This study aimed to investigate the incidence and risk factors for institutionalisation in Parkinson's disease (PD) and atypical parkinsonism (AP). The study found that institutionalisation was more frequent in AP compared to PD and controls. Age, poorer cognition, and more-severe parkinsonian impairment were independent predictors of institutionalisation.
PARKINSONISM & RELATED DISORDERS
(2024)
