Muscle mitohormesis promotes cellular survival via serine/glycine pathway flux

Transcriptomic profiling of TK2 deficient human skeletal muscle suggests a role for the p53 signalling pathway and identifies growth and differentiation factor-15 as a potential novel biomarker for mitochondrial myopathies

(2014) Susana Kalko et al.   BMC GENOMICS

Tissue-Specific Loss of DARS2 Activates Stress Responses Independently of Respiratory Chain Deficiency in the Heart

(2014) Sukru Anil Dogan et al.   Cell Metabolism

Molecular Basis of the ‘Anti-Aging' Effect of Spermidine and Other Natural Polyamines - A Mini-Review

(2014) Nadège Minois   GERONTOLOGY

Methylene blue upregulates Nrf2/ARE genes and prevents tau-related neurotoxicity

(2014) Cliona Stack et al.   HUMAN MOLECULAR GENETICS

Quantitative flux analysis reveals folate-dependent NADPH production

(2014) Jing Fan et al.   NATURE

Activation of AMPKα2 Is Not Crucial for Mitochondrial Uncoupling-Induced Metabolic Effects but Required to Maintain Skeletal Muscle Integrity

(2014) Mario Ost et al.   PLoS One

Spermidine Feeding Decreases Age-Related Locomotor Activity Loss and Induces Changes in Lipid Composition

(2014) Nadège Minois et al.   PLoS One

D-Glucosamine supplementation extends life span of nematodes and of ageing mice

(2014) Sandra Weimer et al.   Nature Communications

Mitochondrial uncoupling in skeletal muscle by UCP1 augments energy expenditure and glutathione content while mitigating ROS production

(2013) Cyril Nii-Klu Adjeitey et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Skeletal muscle uncoupling-induced longevity in mice is linked to increased substrate metabolism and induction of the endogenous antioxidant defense system

(2013) S. Keipert et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Skeletal muscle mitochondrial uncoupling drives endocrine cross-talk through the induction of FGF21 as a myokine

(2013) Susanne Keipert et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Reduced mitochondrial ROS, enhanced antioxidant defense, and distinct age-related changes in oxidative damage in muscles of long-lived Peromyscus leucopus

(2013) Yun Shi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Muscle Mitohormesis Promotes Longevity via Systemic Repression of Insulin Signaling

(2013) Edward Owusu-Ansah et al.   CELL

Glycine administration attenuates skeletal muscle wasting in a mouse model of cancer cachexia

(2013) Daniel J. Ham et al.   CLINICAL NUTRITION

Dysregulation of Mitochondrial Quality Control Processes Contribute to Sarcopenia in a Mouse Model of Premature Aging

(2013) Anna-Maria Joseph et al.   PLoS One

Skeletal muscle aging and the mitochondrion

(2013) Matthew L. Johnson et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Contribution of serine, folate and glycine metabolism to the ATP, NADPH and purine requirements of cancer cells

(2013) P M Tedeschi et al.   Cell Death & Disease

Mitochondrial signaling contributes to disuse muscle atrophy

(2012) Scott K. Powers et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

BIOCLAIMS standard diet (BIOsd): a reference diet for nutritional physiology

(2012) Femke P. M. Hoevenaars et al.   Genes and Nutrition

Stress-induced Skeletal Muscle Gadd45a Expression Reprograms Myonuclei and Causes Muscle Atrophy

(2012) Scott M. Ebert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Resurgence of Serine: An Often Neglected but Indispensable Amino Acid

(2012) Satish C. Kalhan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine

(2012) Kook Hwan Kim et al.   NATURE MEDICINE

Metabolite Profiling Identifies a Key Role for Glycine in Rapid Cancer Cell Proliferation

(2012) M. Jain et al.   SCIENCE

Spermidine promotes stress resistance in Drosophila melanogaster through autophagy-dependent and -independent pathways

(2012) N Minois et al.   Cell Death & Disease

The Cell-Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity

(2011) Jenni Durieux et al.   CELL

Role of aminotransferases in glutamate metabolism of human erythrocytes

(2011) James J. Ellinger et al.   JOURNAL OF BIOMOLECULAR NMR

Myogenin regulates denervation-dependent muscle atrophy in mouse soleus muscle

(2011) Peter C. D. Macpherson et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Dietary restriction of mice on a high-fat diet induces substrate efficiency and improves metabolic health

(2011) Loes P M Duivenvoorde et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Definition and classification of cancer cachexia: an international consensus

(2011) Kenneth Fearon et al.   LANCET ONCOLOGY

Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

(2011) Richard Possemato et al.   NATURE

Serine Biosynthesis with One Carbon Catabolism and the Glycine Cleavage System Represents a Novel Pathway for ATP Generation

(2011) Alexei Vazquez et al.   PLoS One

Dietary effects on body composition, glucose metabolism, and longevity are modulated by skeletal muscle mitochondrial uncoupling in mice

(2010) Susanne Keipert et al.   AGING CELL

The cathepsin L gene is a direct target of FOXO1 in skeletal muscle

(2010) Yoshihiro Yamazaki et al.   BIOCHEMICAL JOURNAL

Knockout of the Bcmo1 gene results in an inflammatory response in female lung, which is suppressed by dietary beta-carotene

(2010) Yvonne G. J. van Helden et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis)

(2010) Michael Ristow et al.   EXPERIMENTAL GERONTOLOGY

Mitochondrial myopathy induces a starvation-like response

(2010) Henna Tyynismaa et al.   HUMAN MOLECULAR GENETICS

Estrogen-related Receptor γ Is a Key Regulator of Muscle Mitochondrial Activity and Oxidative Capacity

(2010) Shamina M. Rangwala et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

UCP1 ectopically expressed in murine muscle displays native function and mitigates mitochondrial superoxide production

(2009) Susanne Keipert et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Autophagy Is Required to Maintain Muscle Mass

(2009) Eva Masiero et al.   Cell Metabolism

Metabolic Remodeling Induced by Mitochondrial Aldehyde Stress Stimulates Tolerance to Oxidative Stress in the Heart

(2009) Jin Endo et al.   CIRCULATION RESEARCH

The MIQE Guidelines: Minimum Information for Publication of Quantitative Real-Time PCR Experiments

(2009) S. A. Bustin et al.   CLINICAL CHEMISTRY

Inhibition of mitochondrial function induces an integrated stress response in oligodendroglia

(2009) Jillian M. Silva et al.   NEUROBIOLOGY OF DISEASE

Antioxidants prevent health-promoting effects of physical exercise in humans

(2009) M. Ristow et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolomic analysis of the cerebrospinal fluid reveals changes in phospholipase expression in the CNS of SIV-infected macaques

(2008) William R. Wikoff et al.   JOURNAL OF CLINICAL INVESTIGATION

Uncoupling protein 1 expression in murine skeletal muscle increases AMPK activation, glucose turnover, and insulin sensitivity in vivo

(2008) Susanne Neschen et al.   PHYSIOLOGICAL GENOMICS