标题
Anticancer Activity of Natural Flavonoids: Inhibition of HIF-1α Signaling Pathway
作者
关键词
-
出版物
CURRENT ORGANIC CHEMISTRY
Volume 23, Issue 26, Pages 2945-2959
出版商
Bentham Science Publishers Ltd.
发表日期
2019-12-03
DOI
10.2174/1385272823666191203122030
参考文献
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- HIF-1α/VEGF signaling-mediated epithelial-mesenchymal transition and angiogenesis is critically involved in anti-metastasis effect of luteolin in melanoma cells
- (2019) Chunyu Li et al. PHYTOTHERAPY RESEARCH
- A flavonoid compound library screen revealed potent antiviral activity of plant-derived flavonoids on human enterovirus A71 replication
- (2018) Nyo Min et al. ANTIVIRAL RESEARCH
- Anti-inflammatory effects of flavonoids in neurodegenerative disorders
- (2018) Carmela Spagnuolo et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis and biological evaluation of carbamates derived from aminocombretastatin A-4 as vascular disrupting agents
- (2018) Laura Conesa-Milián et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Polymeric micelles for potentiated antiulcer and anticancer activities of naringin
- (2018) Elham Mohamed et al. International Journal of Nanomedicine
- Luteolin inhibits angiogenesis of the M2‑like TAMs via the downregulation of hypoxia inducible factor‑1α and the STAT3 signalling pathway under hypoxia
- (2018) Binbo Fang et al. Molecular Medicine Reports
- Design, synthesis and biological evaluation of 3′,4′,5′-trimethoxy flavonoid benzimidazole derivatives as potential anti-tumor agents
- (2018) Zhe Wang et al. MedChemComm
- Wogonin attenuates nasal polyp formation by inducing eosinophil apoptosis through HIF-1α and survivin suppression
- (2018) Roza Khalmuratova et al. Scientific Reports
- Recent discoveries of anticancer flavonoids
- (2017) Demetrio Raffa et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Antiproliferative activity of vitexin-2-O-xyloside and avenanthramides on CaCo-2 and HepG2 cancer cells occurs through apoptosis induction and reduction of pro-survival mechanisms
- (2017) Emanuele Salvatore Scarpa et al. EUROPEAN JOURNAL OF NUTRITION
- Flavonoids and platelet aggregation: A brief review
- (2017) Caterina Faggio et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Three new flavonoid glycosides from Smilax glabra and their anti-inflammatory activity
- (2017) Jicheng Shu et al. NATURAL PRODUCT RESEARCH
- Design, synthesis and biological evaluation of flavonoid salicylate derivatives as potential anti-tumor agents
- (2017) Xiangping Deng et al. RSC Advances
- Flavonoids with Therapeutic Potential in Prostate Cancer
- (2016) Bao Vue et al. Anti-Cancer Agents in Medicinal Chemistry
- Isorhamnetin Inhibits Reactive Oxygen Species-Dependent Hypoxia Inducible Factor (HIF)-1α Accumulation
- (2016) Suho Seo et al. BIOLOGICAL & PHARMACEUTICAL BULLETIN
- Anthocyanins from roselle extract arrest cell cycle G2/M phase transition via ATM/Chk pathway in p53-deficient leukemia HL-60 cells
- (2016) Tsung-Chang Tsai et al. ENVIRONMENTAL TOXICOLOGY
- Blocking Blood Flow to Solid Tumors by Destabilizing Tubulin: An Approach to Targeting Tumor Growth
- (2016) María-Jesús Pérez-Pérez et al. JOURNAL OF MEDICINAL CHEMISTRY
- Myricetin arrests human telomeric G-quadruplex structure: a new mechanistic approach as an anticancer agent
- (2016) Soma Mondal et al. Molecular BioSystems
- Delphinidin inhibits angiogenesis through the suppression of HIF-1α and VEGF expression in A549 lung cancer cells
- (2016) Mun-Hyeon Kim et al. ONCOLOGY REPORTS
- Biochanin A inhibits endothelial cell functions and proangiogenic pathways
- (2015) Aditi Jain et al. ANTI-CANCER DRUGS
- First trimester human placental factors induce breast cancer cell autophagy
- (2015) G. Epstein Shochet et al. BREAST CANCER RESEARCH AND TREATMENT
- Anti-inflammatory Glycosylated Flavonoids as Therapeutic Agents for Treatment of Diabetes-Impaired Wounds
- (2015) Marilena Antunes-Ricardo et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
- Theaflavin-3, 3′-digallate decreases human ovarian carcinoma OVCAR-3 cell-induced angiogenesis via Akt and Notch-1 pathways, not via MAPK pathways
- (2015) YING GAO et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Baicalein Inhibits MCF-7 Cell Proliferation In Vitro, Induces Radiosensitivity, and Inhibits Hypoxia Inducible Factor
- (2015) Shruti Gade et al. JOURNAL OF ENVIRONMENTAL PATHOLOGY TOXICOLOGY AND ONCOLOGY
- Effect of treatment with baicalein on the intracerebral tumor growth and survival of orthotopic glioma models
- (2015) Fu-Rong Wang et al. JOURNAL OF NEURO-ONCOLOGY
- Molecular mechanisms underlying anticancer effects of myricetin
- (2015) Kasi Pandima Devi et al. LIFE SCIENCES
- Recent Advances in Developing Inhibitors for Hypoxia-Inducible Factor Prolyl Hydroxylases and Their Therapeutic Implications
- (2015) So Kim et al. MOLECULES
- Naringin suppresses the metabolism of A375 cells by inhibiting the phosphorylation of c-Src
- (2015) Bingyu Guo et al. TUMOR BIOLOGY
- Dietary compounds galangin and myricetin suppress ovarian cancer cell angiogenesis
- (2015) Haizhi Huang et al. Journal of Functional Foods
- Wogonin inhibits multiple myeloma-stimulated angiogenesis via c-Myc/VHL/HIF-1α signaling axis
- (2015) Rong Fu et al. Oncotarget
- Antibacterial Activities of Flavonoids: Structure-Activity Relationship and Mechanism
- (2014) Yixi Xie et al. CURRENT MEDICINAL CHEMISTRY
- Quercetin attenuates cell apoptosis of oxidant-stressed SK-N-MC cells while suppressing up-regulation of the defensive element, HIF-1α
- (2014) F. Roshanzamir et al. NEUROSCIENCE
- Cancer Chemopreventive Effects of the Flavonoid-Rich Fraction Isolated from Papaya Seeds
- (2014) Neelam Pathak et al. NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
- Baicalein reverses hypoxia-induced 5-FU resistance in gastric cancer AGS cells through suppression of glycolysis and the PTEN/Akt/HIF-1α signaling pathway
- (2014) FENGLIN CHEN et al. ONCOLOGY REPORTS
- Preclinical Evidence for the Pharmacological Actions of Naringin: A Review
- (2014) Saurabh Bharti et al. PLANTA MEDICA
- The Effect of Quercetin on Doxorubicin Cytotoxicity in Human Breast Cancer Cells
- (2013) Shi-zheng Li et al. Anti-Cancer Agents in Medicinal Chemistry
- (−)-Epigallocatechin-3-gallate inhibits human papillomavirus (HPV)-16 oncoprotein-induced angiogenesis in non-small cell lung cancer cells by targeting HIF-1α
- (2013) Li He et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Vascular-disrupting agents in oncology
- (2013) Monica M Mita et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Inhibitory Effect of Baicalin and Baicalein on Ovarian Cancer Cells
- (2013) Jianchu Chen et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Epigallocatechin-3-Gallate Inhibits IGF-I-Stimulated Lung Cancer Angiogenesis through Downregulation of HIF-1a and VEGF Expression
- (2013) Xiangyong Li et al. Journal of Nutrigenetics and Nutrigenomics
- Wogonin reverses hypoxia resistance of human colon cancer HCT116 cells via downregulation of HIF-1α and glycolysis, by inhibiting PI3K/Akt signaling pathway
- (2013) Hu Wang et al. MOLECULAR CARCINOGENESIS
- Bioactivity-Guided Identification and Cell Signaling Technology to Delineate the Lactate Dehydrogenase A Inhibition Effects of Spatholobus suberectus on Breast Cancer
- (2013) Zhiyu Wang et al. PLoS One
- Dietary Compound Isoliquiritigenin Inhibits Breast Cancer Neoangiogenesis via VEGF/VEGFR-2 Signaling Pathway
- (2013) Zhiyu Wang et al. PLoS One
- Delphinidin Reduces Cell Proliferation and Induces Apoptosis of Non-Small-Cell Lung Cancer Cells by Targeting EGFR/VEGFR2 Signaling Pathways
- (2013) Harish Chandra Pal et al. PLoS One
- Quercetin enhances hypoxia-mediated apoptosis via direct inhibition of AMPK activity in HCT116 colon cancer
- (2012) Hak-Su Kim et al. APOPTOSIS
- Insights into dietary flavonoids as molecular templates for the design of anti-platelet drugs
- (2012) Bernice Wright et al. CARDIOVASCULAR RESEARCH
- Recent advances in hypoxia-inducible factor (HIF)-1 inhibitors
- (2012) Yan Xia et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Recent agents targeting HIF-1α for cancer therapy
- (2012) Yaozhong Hu et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Inhibitory effects of epigallocatechin-3-gallate on cell proliferation and the expression of HIF-1α and P-gp in the human pancreatic carcinoma cell line PANC-1
- (2012) Qiu Zhao ONCOLOGY REPORTS
- Flavonoids as antioxidants in plants: Location and functional significance
- (2012) Giovanni Agati et al. PLANT SCIENCE
- Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy
- (2012) Gregg L. Semenza TRENDS IN PHARMACOLOGICAL SCIENCES
- Acacetin inhibits VEGF expression, tumor angiogenesis and growth through AKT/HIF-1α pathway
- (2011) Ling-Zhi Liu et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- Cancer Therapeutic Agents Targeting Hypoxia-Inducible Factor-1
- (2011) R. Wang et al. CURRENT MEDICINAL CHEMISTRY
- Recent advances in understanding the antibacterial properties of flavonoids
- (2011) T.P. Tim Cushnie et al. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
- Liquiritigenin Inhibits Serum-induced HIF-1α and VEGF Expression via the AKT/mTOR-p70S6K Signalling Pathway in HeLa Cells
- (2011) Si-Rou Xie et al. PHYTOTHERAPY RESEARCH
- The dietary flavonoid kaempferol effectively inhibits HIF-1 activity and hepatoma cancer cell viability under hypoxic conditions
- (2010) Ilias Mylonis et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Development of novel inhibitors targeting HIF-1α towards anticancer drug discovery
- (2010) Nilambari Yewalkar et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Apigenin Down-Regulates the Hypoxia Response Genes: HIF-1α, GLUT-1, and VEGF in Human Pancreatic Cancer Cells
- (2010) Laleh G. Melstrom et al. JOURNAL OF SURGICAL RESEARCH
- Significance of p27kip1as potential biomarker for intracellular oxidative status
- (2010) Lesley Quintos et al. Nutrition Research and Practice
- Daidzein Effect on Hormone Refractory Prostate Cancer In Vitro and In Vivo Compared to Genistein and Soy Extract: Potentiation of Radiotherapy
- (2010) Vinita Singh-Gupta et al. PHARMACEUTICAL RESEARCH
- Natural compounds and the hypoxia-inducible factor (HIF) signalling pathway
- (2009) Bogdan Manolescu et al. BIOCHIMIE
- Quercetin greatly improved therapeutic index of doxorubicin against 4T1 breast cancer by its opposing effects on HIF-1α in tumor and normal cells
- (2009) Gangjun Du et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Targeting Heat Shock Protein 90 Overrides the Resistance of Lung Cancer Cells by Blocking Radiation-Induced Stabilization of Hypoxia-Inducible Factor-1α
- (2009) Woo-Young Kim et al. CANCER RESEARCH
- Grape seed extract inhibits VEGF expression via reducing HIF-1 protein expression
- (2009) J. Lu et al. CARCINOGENESIS
- Myricetin inhibits UVB-induced angiogenesis by regulating PI-3 kinase in vivo
- (2009) S. K. Jung et al. CARCINOGENESIS
- Hypoxia-inducible factor in cancer angiogenesis: Structure, regulation and clinical perspectives
- (2009) Zaher K. Otrock et al. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
- Flavonoids, Vascular Function and Cardiovascular Protection
- (2009) Davide Grassi et al. CURRENT PHARMACEUTICAL DESIGN
- Baicalin suppresses lung carcinoma and lung metastasis by SOD mimic and HIF-1α inhibition
- (2009) Gangjun Du et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Kaempferol Inhibits Angiogenesis and VEGF Expression Through Both HIF Dependent and Independent Pathways in Human Ovarian Cancer Cells
- (2009) Haitao Luo et al. NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
- Radiation-induced HIF-1α cell survival pathway is inhibited by soy isoflavones in prostate cancer cells
- (2008) Vinita Singh-Gupta et al. INTERNATIONAL JOURNAL OF CANCER
- Update on Uses and Properties of Citrus Flavonoids: New Findings in Anticancer, Cardiovascular, and Anti-inflammatory Activity
- (2008) O. Benavente-García et al. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
- Methylalpinumisoflavone Inhibits Hypoxia-inducible Factor-1 (HIF-1) Activation by Simultaneously Targeting Multiple Pathways
- (2008) Yang Liu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Quercetin suppresses hypoxia-induced accumulation of hypoxia-inducible factor-1α (HIF-1α) through inhibiting protein synthesis
- (2008) Dae-Hee Lee et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Inhibition of HIF-1 alpha and VEGF expression by the chemopreventive bioflavonoid apigenin is accompanied by Akt inhibition in human prostate carcinoma PC3-M cells
- (2008) Salida Mirzoeva et al. MOLECULAR CARCINOGENESIS
- Baicalin inhibits macrophage activation by lipopolysaccharide and protects mice from endotoxin shock
- (2007) Lin-lin Liu et al. BIOCHEMICAL PHARMACOLOGY
- Flavonoids induce HIF-1α but impair its nuclear accumulation and activity
- (2007) Anastasia Triantafyllou et al. FREE RADICAL BIOLOGY AND MEDICINE
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