Article
Cell Biology
Balaji T. Moorthy, Chunhua Jiang, Devang M. Patel, Yuguang Ban, Corin R. O'Shea, Akhilesh Kumar, Tan Yuan, Michael D. Birnbaum, Aldrin Gomes, Xi Chen, Flavia Fontanesi, Theodore J. Lampidis, Antoni Barrientos, Fangliang Zhang
Summary: This study identifies an alternative oxygen-sensing pathway regulated by ATE1, which controls the hypoxic response and glycolysis in mammalian cells by arginylating HIF1α. This pathway plays an important regulatory role in human tumors.
DEVELOPMENTAL CELL
(2022)
Article
Biochemistry & Molecular Biology
Je Lin Sieow, Hweixian Leong Penny, Sin Yee Gun, Ling Qiao Tan, Kaibo Duan, Joe Poh Sheng Yeong, Angela Pang, Diana Lim, Han Chong Toh, Tony Kiat Hon Lim, Edgar Engleman, Olaf Rotzschke, Lai Guan Ng, Jinmao Chen, Suet Mien Tan, Siew Cheng Wong
Summary: A large number of neutrophils infiltrate tumors and contribute to the inflammatory tumor microenvironment. The metabolic status of these neutrophils and their role in tumor progression were investigated in a mouse model of pancreatic ductal adenocarcinoma (PDAC). Tumor-infiltrating neutrophils showed enhanced glycolytic activity compared to neutrophils from the bone marrow and blood of the same mouse. Deletion of hypoxia-inducible factor 1-alpha (HIF-1 alpha) in neutrophils reduced tumor burden and improved survival in the mouse model, indicating a potential target for metabolic modulation in cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Takahiro Shimizu, Norihito Takahashi, Vincent J. Huber, Yasunobu Asawa, Hiroki Ueda, Atsushi Yoshimori, Yukiko Muramatsu, Hiroyuki Seimiya, Hiroyuki Kouji, Hiroyuki Nakamura, Hiroki Oguri
Summary: This study utilized a novel synthetic approach to generate modulators of protein-protein interactions by exploiting alkaloidal macrocyclic scaffolds, mimicking hot-spot residues in alpha-helices responsible for transcriptional regulation. Experimental results demonstrated the effectiveness of this synthesis approach in inhibiting the activity of relevant proteins and impacting cell proliferation.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Ji Young Kim, Eun Jung Lee, Yuri Ahn, Sujin Park, Yu Jeong Bae, Tae Gyun Kim, Sang Ho Oh
Summary: The study demonstrates that CTSL is a novel target gene of HIF-1 alpha and plays a role in melanosome degradation in melanocytes through lysosomal activity during autophagosome-lysosome fusion. Under autophagy-inducing starvation conditions, the expression of HIF-1 alpha and CTSL is upregulated in melan-a cells. Inhibition of conversion of pro-CTSL to mature CTSL leads to accumulation of certain proteins due to decreased lysosomal activity in the autophagic pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Niya L. Morris, David N. Michael, Kathryn M. Crotty, Sarah S. Chang, Samantha M. Yeligar
Summary: This study investigated the effects of alcohol on the metabolism of alveolar macrophages, revealing that chronic alcohol exposure leads to a shift towards glycolysis in alveolar macrophages, resulting in reduced phagocytic capacity.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Sara da Silva-Ferreira, Claudio Duarte-Oliveira, Daniela Antunes, Catarina Barbosa-Matos, Ana Mendes-Frias, Egidio Torrado, Sandra Costa, Ricardo Silvestre, Cristina Cunha, Agostinho Carvalho
Summary: Chronic pulmonary aspergillosis is a devastating disease with increasing prevalence worldwide. The characteristic inflammation limits the effectiveness of antifungal therapies. The study shows that hypoxia-inducible factor 1 alpha (HIF-1 alpha) plays a central role in regulating neutrophil function and fungal infection.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biology
Milica Mandic, Kaitlyn Flear, Pearl Qiu, Yihang K. Pan, Steve F. Perry, Kathleen M. Gilmour
Summary: HIF-1α is important for hypoxic survival in zebrafish, particularly in relation to their ability to perform aquatic surface respiration (ASR). When zebrafish are prevented from accessing the surface during severe hypoxia, their survival is significantly compromised. However, when they are allowed to access the surface, there is no difference in survival between wild-type and HIF-1α knockout fish. ASR mitigates the negative effects of HIF-1α loss, with knockouts initiating ASR at a higher oxygen concentration and performing ASR for longer than wild-types.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Wenpeng Cao, Shan Lei, Zhirui Zeng, Chaolun Xiao, Baofei Sun, Peng Xie, Yumei Li, Daopeng Luo, Wenfeng Yu
Summary: This study identified TRAA2A as an important hypoxia-associated gene in pancreatic cancer, which is associated with tumor progression and metastasis. TRAA2A is regulated by hypoxia-inducible factor HIF1 alpha and promotes the proliferation and motility of pancreatic cancer cells via activation of the AKT pathway. Therefore, TRAA2A may serve as a novel molecular target for investigating the hypoxic response of pancreatic cancer cells.
Review
Oncology
Liyun Yong, Shasha Tang, Haixin Yu, Hongyi Zhang, Yi Zhang, Yuan Wan, Fengfeng Cai
Summary: Breast cancer is the most common cancer in women, and drug resistance is a persistent clinical challenge. Hypoxia-inducible Factor-1 Alpha (HIF-1α) plays a crucial role in regulating cellular response to hypoxia and is closely associated with multidrug resistance in breast cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Isai Martinez-Torres, Araceli Tepale-Segura, Octavio Castro-Escamilla, Juan Carlos Cancino-Diaz, Sandra Rodriguez-Martinez, Sonia Mayra Perez-Tapia, Laura C. Bonifaz, Mario Eugenio Cancino-Diaz
Summary: Psoriasis is a chronic inflammatory skin disease characterized by excessive activation of immune cells and inflammatory cytokines. HIF-1α and pVHL play important roles in regulating angiogenesis and glycolysis, affecting the severity of psoriatic lesions. Restoring pVHL expression can prevent and alleviate psoriasis lesions by inhibiting inflammation and immune cell infiltration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Zirong Pan, Guodong Ma, Linglei Kong, Guanhua Du
Summary: Stroke is an acute cerebrovascular disease caused by sudden rupture or blockage of blood vessels in the brain, and HIF-1 plays an important role in regulating various pathways in the pathological process. The roles of HIF-1 in stroke are controversial, involving factors such as ischemic time and degree, and its regulatory mechanisms include inflammation, autophagy, oxidative stress, and apoptosis.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Cell Biology
Gulnihal Ozcan
Summary: HIF-1 alpha plays a crucial role in gastric cancer, contributing to stemness and chemoresistance. Despite the lack of complete understanding of its mechanisms in gastric cancer, efforts are being made to identify critical molecular targets and overcome the action of HIF-1 alpha.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yi-hui Wang, Dong-yuan Chang, Ming-hui Zhao, Min Chen
Summary: This study revealed that SGLT2i played a renoprotective role in diabetic kidney disease (DKD), at least in part, through alleviating HIF1a/HO1-mediated ferroptosis.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Article
Biochemistry & Molecular Biology
Marina Sakai, Nobuaki Takahashi, Hiroaki Ikeda, Yutaka Furutani, Shoko Higuchi, Takehiro Suzuki, Naoshi Dohmae, Sayaka Kobayashi, Hiroshi Harada, Soichi Kojima, Tomokazu Matsuura, Akira Hattori, Hideaki Kakeya
Summary: HIF-1 is a promising drug target for cancer chemotherapy, with KUSC-5037 identified as an effective inhibitor under hypoxic conditions. KUSC-5037 suppresses HIF-1 signaling and reduces the expression of HIF-1 target genes, showing potential as a lead molecule for cancer treatment.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Jin-Woo Kim, Neunghan Jeon, Dong-Eun Shin, So-Young Lee, Myongwhan Kim, Dong Hun Han, Jae Yeon Shin, Soonchul Lee
Summary: The intervertebral disc is a complex joint structure with nucleus pulposus, annulus fibrosus, and cartilaginous endplate. Degeneration of the intervertebral disc involves cellular, compositional, and structural changes, with significant alterations in the extracellular matrix composition with age. The hypoxia-inducible factor HIF-1 alpha is crucial in regulating various processes of intervertebral disc degeneration and may serve as a diagnostic tool and therapeutic target for inhibiting this degeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Young Dong Yoo, Dae-Hee Lee, Hyunjoo Cha-Molstad, Hyungsin Kim, Su Ran Mun, Changhoon Ji, Seong Hye Park, Ki Sa Sung, Seung Ah Choi, Joonsung Hwang, Deric M. Park, Seung-Ki Kim, Kyung-Jae Park, Shin-Hyuk Kang, Sang Cheul Oh, Aaron Ciechanover, Yong J. Lee, Bo Yeon Kim, Yong Tae Kwon
Article
Oncology
Ashok K. Dilly, Brendon D. Honick, Yong J. Lee, Zong S. Guo, Herbert J. Zeh, David L. Bartlett, Haroon A. Choudry
Meeting Abstract
Oncology
Young-Sun Lee, Se Hoon Hong, Dae-Hee Lee, Min J. Jo, Yoo A. Jeong, William T. Kwon, Haroon A. Choudry, David L. Bartlett, Yong J. Lee
Article
Biochemistry & Molecular Biology
Young-Sun Lee, Dae-Hee Lee, So Yeon Jeong, Seong Hye Park, Sang Cheul Oh, Yong Seok Park, Jian Yu, Haroon A. Choudry, David L. Bartlett, Yong J. Lee
JOURNAL OF CELLULAR BIOCHEMISTRY
(2019)
Article
Cell Biology
Young-Sun Lee, Kalishwaralal Kalimuthu, Yong Seok Park, Hima Makala, Simon C. Watkins, M. Haroon A. Choudry, David L. Bartlett, Yong Tae Kwon, Yong J. Lee
JOURNAL OF CELLULAR PHYSIOLOGY
(2020)
Article
Oncology
Ashokkumar Dilly, Brendon D. Honick, Yong J. Lee, David L. Bartlett, Haroon A. Choudry
Article
Biochemistry & Molecular Biology
Young-Sun Lee, Kalishwaralal Kalimuthu, Yong Seok Park, Xu Luo, M. Haroon A. Choudry, David L. Bartlett, Yong J. Lee
Article
Genetics & Heredity
Ashok K. Dilly, Brendon D. Honick, Yong J. Lee, David L. Bartlett, Haroon A. Choudry
ORPHANET JOURNAL OF RARE DISEASES
(2020)
Article
Medical Laboratory Technology
Ashok K. Dilly, Brendon D. Honick, Robin Frederick, Anulekha Elapavaluru, Sachin Velankar, Hima Makala, T. Kevin Hitchens, Lesley M. Foley, Jianxia Guo, Jan H. Beumer, Lora Heather Rigatti, Yong J. Lee, David L. Bartlett, Haroon A. Choudry
Summary: In patients with appendiceal mucinous carcinoma peritonei, abundant intraperitoneal accumulation of extracellular mucus causes organ dysfunction and hampers chemotherapeutic drug delivery. Combination of bromelain and N-acetylcysteine efficiently lyses extracellular mucus, reduces tumor-related symptoms, and enhances the efficacy of chemotherapy.
TRANSLATIONAL RESEARCH
(2021)
Article
Cell Biology
Kalishwaralal Kalimuthu, Jin Hong Kim, Yong Seok Park, Xu Luo, Lin Zhang, Ja-Lok Ku, M. Haroon A. Choudry, Yong J. Lee
Summary: The combination treatment of glucose deprivation and TRAIL can induce apoptosis in tumor cells through the activation of various caspases, involving the ER stress response pathway and the mitochondria-dependent pathway.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Yue Xi, Yanping Li, Pengfei Xu, Sihan Li, Zhengsheng Liu, Hung-Chun Tung, Xinran Cai, Jingyuan Wang, Haozhe Huang, Menglin Wang, Meishu Xu, Songrong Ren, Song Li, Min Zhang, Yong J. Lee, Leaf Huang, Da Yang, Jinhan He, Zhiying Huang, Wen Xie
Summary: The study demonstrates that GLRX reverses PSSG by liberating GSH, inhibiting activation of hepatic stellate cells and liver fibrosis. GLRX depletion exacerbates liver fibrosis, while overexpression of GLRX inhibits PSSG and liver fibrosis development.
Review
Biochemistry & Molecular Biology
Kalishwaralal Kalimuthu, Chenicheri K. Keerthana, Manikandan Mohan, Jaison Arivalagan, Johnson Retnaraj Samuel Selvan Christyraj, Michael A. Firer, Mohammad Haroon Asif Choudry, Ruby John Anto, Yong J. Lee
Summary: This review critically analyzes the molecular mechanisms of selenium metabolism and its potential as a therapeutic target for cancer, highlighting SECISBP2 as a novel prognostic predictor and an alternative target for cancer. Strategies to develop a novel selenium metabolism-based approach for cancer therapy are emphasized, with expectations for extensive clinical use of SECISBP2 as a specific biomarker in cancer therapy. Scientists face additional challenges, including research on anticancer peptides targeting the intracellular protein SECISBP2.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Weilin Liu, Hongqi Chen, Zhi Zhu, Zuqiang Liu, Congrong Ma, Yong J. Lee, David L. Bartlett, Zong-Sheng Guo
Summary: The study found that the combination of the ferroptosis activator Erastin with the oncolytic vaccinia virus could effectively inhibit tumor growth, prolong host survival, and enhance antitumoral immunity in hepatocellular carcinoma and colon cancer models.
Article
Cell Biology
Jin Hong Kim, Abdo J. Najy, Jian Li, Xu Luo, Hyeong-Reh C. Kim, Mohammad Haroon Asif Choudry, Yong J. Lee
Summary: This study investigated the crosstalk between the ferroptotic agent-induced endoplasmic reticulum (ER) stress response and TRAIL-induced apoptosis, and found that Bid plays a critical role in this process.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Letter
Biochemistry & Molecular Biology
Yong J. Lee