Loss of Endothelial Endoglin Promotes High-Output Heart Failure Through Peripheral Arteriovenous Shunting Driven by VEGF Signaling

Role of soluble endoglin in BMP9 signaling

(2019) Aleksandra Lawera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Somatic Mutations in Vascular Malformations of Hereditary Hemorrhagic Telangiectasia Result in Bi-allelic Loss of ENG or ACVRL1

(2019) Daniel A. Snellings et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Vascular deficiency of Smad4 causes arteriovenous malformations: a mouse model of Hereditary Hemorrhagic Telangiectasia

(2018) Angela M. Crist et al.   ANGIOGENESIS

ALK1 Loss Results in Vascular Hyperplasia in Mice and Humans Through PI3K ActivationHighlights

(2018) Elisenda Alsina-Sanchís et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

A heterodimer formed by bone morphogenetic protein 9 (BMP9) and BMP10 provides most BMP biological activity in plasma

(2018) Emmanuelle Tillet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Somatic Activating KRAS Mutations in Arteriovenous Malformations of the Brain

(2018) Sergey I. Nikolaev et al.   NEW ENGLAND JOURNAL OF MEDICINE

Decreased Expression of Vascular Endothelial Growth Factor Receptor 1 Contributes to the Pathogenesis of Hereditary Hemorrhagic Telangiectasia Type 2

(2018) Jérémy H. Thalgott et al.   CIRCULATION

Long-term cardiovascular changes following creation of arteriovenous fistula in patients with end stage renal disease

(2017) Yogesh N. V. Reddy et al.   EUROPEAN HEART JOURNAL

Conditional knockout of activin like kinase-1 (ALK-1) leads to heart failure without maladaptive remodeling

(2017) Kevin J. Morine et al.   HEART AND VESSELS

Endoglin prevents vascular malformation by regulating flow-induced cell migration and specification through VEGFR2 signalling

(2017) Yi Jin et al.   NATURE CELL BIOLOGY

Endoglin controls blood vessel diameter through endothelial cell shape changes in response to haemodynamic cues

(2017) Wade W. Sugden et al.   NATURE CELL BIOLOGY

Structural Basis of the Human Endoglin-BMP9 Interaction: Insights into BMP Signaling and HHT1

(2017) Takako Saito et al.   Cell Reports

Cardiosphere-Derived Cells Require Endoglin for Paracrine-Mediated Angiogenesis

(2017) Rachael E. Redgrave et al.   Stem Cell Reports

Defective fluid shear stress mechanotransduction mediates hereditary hemorrhagic telangiectasia

(2016) Nicolas Baeyens et al.   JOURNAL OF CELL BIOLOGY

High-Output Heart Failure

(2016) Yogesh N.V. Reddy et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

PI3 kinase inhibition improves vascular malformations in mouse models of hereditary haemorrhagic telangiectasia

(2016) Roxana Ola et al.   Nature Communications

Mouse models of hereditary hemorrhagic telangiectasia: recent advances and future challenges

(2015) Simon Tual-Chalot et al.   Frontiers in Genetics

Common and Distinctive Pathogenetic Features of Arteriovenous Malformations in Hereditary Hemorrhagic Telangiectasia 1 and Hereditary Hemorrhagic Telangiectasia 2 Animal Models—Brief Report

(2014) Eva M. Garrido-Martin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Anatomy of hepatic arteriolo-portal venular shunts evaluated by 3D micro-CT imaging

(2014) Timothy L. Kline et al.   JOURNAL OF ANATOMY

Novel Brain Arteriovenous Malformation Mouse Models for Type 1 Hereditary Hemorrhagic Telangiectasia

(2014) Eun-Jung Choi et al.   PLoS One

Endothelial Depletion of Acvrl1 in Mice Leads to Arteriovenous Malformations Associated with Reduced Endoglin Expression

(2014) Simon Tual-Chalot et al.   PLoS One

Deficiency for endoglin in tumor vasculature weakens the endothelial barrier to metastatic dissemination

(2013) Charlotte Anderberg et al.   JOURNAL OF EXPERIMENTAL MEDICINE

LRG1 promotes angiogenesis by modulating endothelial TGF-β signalling

(2013) Xiaomeng Wang et al.   NATURE

A Phase I First-in-Human Study of TRC105 (Anti-Endoglin Antibody) in Patients with Advanced Cancer

(2012) L. S. Rosen et al.   CLINICAL CANCER RESEARCH

Rodent models of heart failure: an updated review

(2012) A. C. Gomes et al.   HEART FAILURE REVIEWS

Bevacizumab in Patients With Hereditary Hemorrhagic Telangiectasia and Severe Hepatic Vascular Malformations and High Cardiac Output

(2012) Sophie Dupuis-Girod et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Increased plasma soluble endoglin levels as an indicator of cardiovascular alterations in hypertensive and diabetic patients

(2011) Ana M Blázquez-Medela et al.   BMC Medicine

BMP9 is produced by hepatocytes and circulates mainly in an active mature form complexed to its prodomain

(2011) Marie Bidart et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Soluble Endoglin Specifically Binds Bone Morphogenetic Proteins 9 and 10 via Its Orphan Domain, Inhibits Blood Vessel Formation, and Suppresses Tumor Growth

(2011) Roselyne Castonguay et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Usefulness of Soluble Endoglin as a Noninvasive Measure of Left Ventricular Filling Pressure in Heart Failure

(2010) Navin K. Kapur et al.   AMERICAN JOURNAL OF CARDIOLOGY

High-Output Heart Failure Secondary to Large Pelvic Arteriovenous Malformation

(2010) Martina Mookadam et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Hereditary haemorrhagic telangiectasia: Pathophysiology, diagnosis and treatment

(2010) Claire L. Shovlin   BLOOD REVIEWS

Pathogenesis of Arteriovenous Malformations in the Absence of Endoglin

(2010) Marwa Mahmoud et al.   CIRCULATION RESEARCH

HIF-mediated articular chondrocyte function: prospects for cartilage repair

(2009) Christopher L Murphy et al.   ARTHRITIS RESEARCH & THERAPY

Bone Morphogenetic Protein-9 Is a Circulating Vascular Quiescence Factor

(2008) Laurent David et al.   CIRCULATION RESEARCH

Endoglin and activin receptor-like-kinase 1 are co-expressed in the distal vessels of the lung: implications for two familial vascular dysplasias, HHT and PAH

(2008) Marwa Mahmoud et al.   LABORATORY INVESTIGATION

Bevacizumab reverses need for liver transplantation in hereditary hemorrhagic telangiectasia

(2008) Andrew Mitchell et al.   LIVER TRANSPLANTATION

Elevated serum soluble endoglin (sCD105) decreased during extracorporeal elimination therapy for familial hypercholesterolemia

(2007) Milan Blaha et al.   ATHEROSCLEROSIS