A heterodimer formed by bone morphogenetic protein 9 (BMP9) and BMP10 provides most BMP biological activity in plasma

BMP-9 interferes with liver regeneration and promotes liver fibrosis

(2017) Katja Breitkopf-Heinlein et al.   GUT

Prodomain–growth factor swapping in the structure of pro-TGF-β1

(2017) Bo Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TGF-β Family Signaling in Early Vertebrate Development

(2017) Joseph Zinski et al.   Cold Spring Harbor Perspectives in Biology

BMP signaling in vascular biology and dysfunction

(2016) Amaya García de Vinuesa et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Extracellular Regulation of Bone Morphogenetic Protein Activity by the Microfibril Component Fibrillin-1

(2016) Alexander P. Wohl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Biology and Evolution of the TGF-β Family

(2016) Andrew P. Hinck et al.   Cold Spring Harbor Perspectives in Biology

Rapid Activation of Bone Morphogenic Protein 9 by Receptor-mediated Displacement of Pro-domains

(2015) Yvonne Kienast et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Prodomain-bound Form of Bone Morphogenetic Protein 10 Is Biologically Active on Endothelial Cells

(2015) He Jiang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cumulin, an Oocyte-secreted Heterodimer of the Transforming Growth Factor-β Family, Is a Potent Activator of Granulosa Cells and Improves Oocyte Quality

(2015) David G. Mottershead et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BMP9 and BMP10 are necessary for proper closure of the ductus arteriosus

(2015) Sandrine Levet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of bone morphogenetic protein 9 procomplex

(2015) Li-Zhi Mi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nodal·Gdf1 Heterodimers with Bound Prodomains Enable Serum-independent Nodal Signaling and Endoderm Differentiation

(2014) Christophe Fuerer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of TGFβ and related signals by precursor processing

(2014) Daniel B. Constam   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Bone morphogenetic protein 9 (BMP9) controls lymphatic vessel maturation and valve formation

(2013) S. Levet et al.   BLOOD

Circulating Bmp10 acts through endothelial Alk1 to mediate flow-dependent arterial quiescence

(2013) D. W. Laux et al.   DEVELOPMENT

Context-dependent signaling defines roles of BMP9 and BMP10 in embryonic and postnatal development

(2013) H. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Growth differentiation factor 9:bone morphogenetic protein 15 heterodimers are potent regulators of ovarian functions

(2013) J. Peng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the Alk1 Extracellular Domain and Characterization of Its Bone Morphogenetic Protein (BMP) Binding Properties

(2012) Pardeep Mahlawat et al.   BIOCHEMISTRY

BMP9 and BMP10 are critical for postnatal retinal vascular remodeling

(2012) N. Ricard et al.   BLOOD

The signaling and functions of heterodimeric bone morphogenetic proteins

(2012) Jing Guo et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Promiscuity and specificity in BMP receptor activation

(2012) Thomas D. Mueller et al.   FEBS LETTERS

Specificity and Structure of a High Affinity Activin Receptor-like Kinase 1 (ALK1) Signaling Complex

(2012) Sharon A. Townson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BMP9 is produced by hepatocytes and circulates mainly in an active mature form complexed to its prodomain

(2011) Marie Bidart et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Latent TGF-β structure and activation

(2011) Minlong Shi et al.   NATURE

Prodomains of Transforming Growth Factor β (TGFβ) Superfamily Members Specify Different Functions

(2010) Gerhard Sengle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TGFβ/BMP Type I Receptors ALK1 and ALK2 Are Essential for BMP9-induced Osteogenic Signaling in Mesenchymal Stem Cells

(2010) Jinyong Luo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bone Morphogenetic Protein-2 and -6 Heterodimer Illustrates the Nature of Ligand-Receptor Assembly

(2010) Michael J. Isaacs et al.   MOLECULAR ENDOCRINOLOGY

BMP-2/6 Heterodimer Is More Effective than BMP-2 or BMP-6 Homodimers as Inductor of Differentiation of Human Embryonic Stem Cells

(2010) Elvira Valera et al.   PLoS One

Autocrine Bone Morphogenetic Protein-9 Signals through Activin Receptor-like Kinase-2/Smad1/Smad4 to Promote Ovarian Cancer Cell Proliferation

(2009) B. Herrera et al.   CANCER RESEARCH

Extracellular microfibrils: contextual platforms for TGFβ and BMP signaling

(2009) Francesco Ramirez et al.   CURRENT OPINION IN CELL BIOLOGY

Bone morphogenetic protein receptors and signal transduction

(2009) K. Miyazono et al.   JOURNAL OF BIOCHEMISTRY

Bone morphogenetic protein heterodimers assemble heteromeric type I receptor complexes to pattern the dorsoventral axis

(2009) Shawn C. Little et al.   NATURE CELL BIOLOGY

Bone Morphogenetic Protein-9 Is a Circulating Vascular Quiescence Factor

(2008) Laurent David et al.   CIRCULATION RESEARCH

Targeting of Bone Morphogenetic Protein Growth Factor Complexes to Fibrillin

(2008) Gerhard Sengle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY