Vascular deficiency of Smad4 causes arteriovenous malformations: a mouse model of Hereditary Hemorrhagic Telangiectasia

Characterization of arteriovenous identity in the developing neonate mouse retina

(2017) Angela M. Crist et al.   GENE EXPRESSION PATTERNS

Endoglin prevents vascular malformation by regulating flow-induced cell migration and specification through VEGFR2 signalling

(2017) Yi Jin et al.   NATURE CELL BIOLOGY

Endoglin controls blood vessel diameter through endothelial cell shape changes in response to haemodynamic cues

(2017) Wade W. Sugden et al.   NATURE CELL BIOLOGY

Interaction Between ALK1 Signaling and Connexin40 in the Development of Arteriovenous MalformationsSignificance

(2016) Konstantinos Gkatzis et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Alk1 controls arterial endothelial cell migration in lumenized vessels

(2016) Elizabeth R. Rochon et al.   DEVELOPMENT

Defective fluid shear stress mechanotransduction mediates hereditary hemorrhagic telangiectasia

(2016) Nicolas Baeyens et al.   JOURNAL OF CELL BIOLOGY

PI3 kinase inhibition improves vascular malformations in mouse models of hereditary haemorrhagic telangiectasia

(2016) Roxana Ola et al.   Nature Communications

A mouse model of hereditary hemorrhagic telangiectasia generated by transmammary-delivered immunoblocking of BMP9 and BMP10

(2016) Santiago Ruiz et al.   Scientific Reports

Executive summary of the 11th HHT international scientific conference

(2015) Helen Arthur et al.   ANGIOGENESIS

Context-specific interactions between Notch and ALK1 cannot explain ALK1-associated arteriovenous malformations

(2015) Elizabeth R. Rochon et al.   CARDIOVASCULAR RESEARCH

VEGFR3 does not sustain retinal angiogenesis without VEGFR2

(2015) Georgia Zarkada et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Research on potential biomarkers in hereditary hemorrhagic telangiectasia

(2015) Luisa-María Botella et al.   Frontiers in Genetics

Hereditary hemorrhagic telangiectasia: genetics and molecular diagnostics in a new era

(2015) Jamie McDonald et al.   Frontiers in Genetics

VEGF neutralization can prevent and normalize arteriovenous malformations in an animal model for hereditary hemorrhagic telangiectasia 2

(2014) Chul Han et al.   ANGIOGENESIS

Deletion of Rbpj from postnatal endothelium leads to abnormal arteriovenous shunting in mice

(2014) C. M. Nielsen et al.   DEVELOPMENT

Imatinib inhibits VEGF-independent angiogenesis by targeting neuropilin 1–dependent ABL1 activation in endothelial cells

(2014) Claudio Raimondi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A comparative encyclopedia of DNA elements in the mouse genome

(2014) Feng Yue et al.   NATURE

Novel Brain Arteriovenous Malformation Mouse Models for Type 1 Hereditary Hemorrhagic Telangiectasia

(2014) Eun-Jung Choi et al.   PLoS One

Endothelial Depletion of Acvrl1 in Mice Leads to Arteriovenous Malformations Associated with Reduced Endoglin Expression

(2014) Simon Tual-Chalot et al.   PLoS One

Constitutively active Notch4 receptor elicits brain arteriovenous malformations through enlargement of capillary-like vessels

(2014) Patrick A. Murphy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuropilin-1 functions as a VEGFR2 co-receptor to guide developmental angiogenesis independent of ligand binding

(2014) Maria V Gelfand et al.   eLife

Endothelial signaling and the molecular basis of arteriovenous malformation

(2013) Deepak Atri et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Bevacizumab in the treatment of hereditary hemorrhagic telangiectasia

(2013) Theoni Kanellopoulou et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

The use of US health insurance data for surveillance of rare disorders: hereditary hemorrhagic telangiectasia

(2013) Scott D. Grosse et al.   GENETICS IN MEDICINE

ALK1 Signaling Inhibits Angiogenesis by Cooperating with the Notch Pathway

(2012) Bruno Larrivée et al.   DEVELOPMENTAL CELL

TGF-β signaling in development and disease

(2012) Joan Massagué   FEBS LETTERS

Bevacizumab in hereditary hemorrhagic telangiectasia-associated epistaxis: Effectiveness of an injection protocol based on the vascular anatomy of the nose

(2012) Sinan Dheyauldeen et al.   LARYNGOSCOPE

Bevacizumab Attenuates VEGF-Induced Angiogenesis and Vascular Malformations in the Adult Mouse Brain

(2012) Espen J. Walker et al.   STROKE

Interaction between alk1 and blood flow in the development of arteriovenous malformations

(2011) P. Corti et al.   DEVELOPMENT

Endothelial Smad4 Maintains Cerebrovascular Integrity by Activating N-Cadherin through Cooperation with Notch

(2011) Fangfei Li et al.   DEVELOPMENTAL CELL

Pericytes: Developmental, Physiological, and Pathological Perspectives, Problems, and Promises

(2011) Annika Armulik et al.   DEVELOPMENTAL CELL

Overlapping spectra ofSMAD4mutations in juvenile polyposis (JP) and JP-HHT syndrome

(2010) Carol Gallione et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Hereditary haemorrhagic telangiectasia: Pathophysiology, diagnosis and treatment

(2010) Claire L. Shovlin   BLOOD REVIEWS

Pathogenesis of Arteriovenous Malformations in the Absence of Endoglin

(2010) Marwa Mahmoud et al.   CIRCULATION RESEARCH

Notch1activation in mice causes arteriovenous malformations phenocopied by ephrinB2 and EphB4 mutants

(2010) Luke T. Krebs et al.   GENESIS

Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis

(2010) Yingdi Wang et al.   NATURE

Isolation and Culture of Pulmonary Endothelial Cells from Neonatal Mice

(2010) Magdalena Sobczak et al.   Jove-Journal of Visualized Experiments

Hereditary haemorrhagic telangiectasia: a clinical and scientific review

(2009) Fatima S Govani et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Real-time imaging of de novo arteriovenous malformation in a mouse model of hereditary hemorrhagic telangiectasia

(2009) Sung Ok Park et al.   JOURNAL OF CLINICAL INVESTIGATION

Alternatively spliced vascular endothelial growth factor receptor-2 is an essential endogenous inhibitor of lymphatic vessel growth

(2009) Romulo J C Albuquerque et al.   NATURE MEDICINE

Bevacizumab in Hereditary Hemorrhagic Telangiectasia

(2009) Prithviraj Bose et al.   NEW ENGLAND JOURNAL OF MEDICINE