NQO1 potentiates apoptosis evasion and upregulates XIAP via inhibiting proteasome-mediated degradation SIRT6 in hepatocellular carcinoma

NAD(P)H: Quinone oxidoreductase 1 overexpression in hepatocellular carcinoma potentiates apoptosis evasion through regulating stabilization of X-linked inhibitor of apoptosis protein

(2019) Wan-Yu Li et al.   CANCER LETTERS

Phosphorylation of XIAP at threonine 180 controls its activity in Wnt signaling

(2018) Victoria H. Ng et al.   JOURNAL OF CELL SCIENCE

Redox modulation of NQO1

(2018) David Siegel et al.   PLoS One

Reduced CD160 expression contributes to impaired NK cell function and poor clinical outcomes in patients with HCC

(2018) Haoyu Sun et al.   CANCER RESEARCH

SIRT6 deficiency results in developmental retardation in cynomolgus monkeys

(2018) Weiqi Zhang et al.   NATURE

Role for the longevity protein SIRT6 in primate development

(2018) Shoshana Naiman et al.   NATURE

Roles for the IKK-Related Kinases TBK1 and IKKε in Cancer

(2018) Joel Durand et al.   Cells

The role of SIRT6 in tumors

(2017) Vanessa Desantis et al.   HAEMATOLOGICA

The NQO1 bioactivatable drug, β-lapachone, alters the redox state of NQO1+ pancreatic cancer cells, causing perturbation in central carbon metabolism

(2017) Molly A. Silvers et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteasome inhibitor MG132 enhances cisplatin-induced apoptosis in osteosarcoma cells and inhibits tumor growth

(2017) Farui Sun et al.   ONCOLOGY RESEARCH

SIRT6 Suppresses Cancer Stem-like Capacity in Tumors with PI3K Activation Independently of Its Deacetylase Activity

(2017) Rafael M. Ioris et al.   Cell Reports

Regulation of Serine-Threonine Kinase Akt Activation by NAD + -Dependent Deacetylase SIRT7

(2017) Jia Yu et al.   Cell Reports

The role of SIRT6 in tumors

(2017) Vanessa Desantis et al.   HAEMATOLOGICA

Leveraging an NQO1 Bioactivatable Drug for Tumor-Selective Use of Poly(ADP-ribose) Polymerase Inhibitors

(2016) Xiumei Huang et al.   CANCER CELL

SIRT6 Overexpression Potentiates Apoptosis Evasion in Hepatocellular Carcinoma via BCL2-Associated X Protein-Dependent Apoptotic Pathway

(2016) L.-K. Ran et al.   CLINICAL CANCER RESEARCH

Phosphorylation of XIAP by CDK1–cyclin-B1 controls mitotic cell death

(2016) Ying Hou et al.   JOURNAL OF CELL SCIENCE

DNA damage signalling barrier, oxidative stress and treatment-relevant DNA repair factor alterations during progression of human prostate cancer

(2016) Daniela Kurfurstova et al.   Molecular Oncology

NQO1 inhibits proteasome-mediated degradation of HIF-1α

(2016) Eun-Taex Oh et al.   Nature Communications

Reciprocal Regulation between SIRT6 and miR-122 Controls Liver Metabolism and Predicts Hepatocarcinoma Prognosis

(2016) Sivan Elhanati et al.   Cell Reports

Evidence for a role of the histone deacetylase SIRT6 in DNA damage response of multiple myeloma cells

(2015) Michele Cea et al.   BLOOD

Implications of NQO1 in cancer therapy

(2015) Eun-Taex Oh et al.   BMB Reports

NQO1 protein expression predicts poor prognosis of non-small cell lung cancers

(2015) Zhenling Li et al.   BMC CANCER

The complex role of SIRT6 in carcinogenesis

(2015) Batia Lerrer et al.   CARCINOGENESIS

Cyclic AMP Signaling Reduces Sirtuin 6 Expression in Non-small Cell Lung Cancer Cells by Promoting Ubiquitin-Proteasomal Degradation via Inhibition of the Raf-MEK-ERK (Raf/Mitogen-activated Extracellular Signal-regulated Kinase/Extracellular Signal-regulated Kinase) Pathway

(2015) Eui-Jun Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HIV-1 Rev downregulates Tat expression and viral replication via modulation of NAD(P)H:quinine oxidoreductase 1 (NQO1)

(2015) Sneh Lata et al.   Nature Communications

NQO1 overexpression is associated with poor prognosis in squamous cell carcinoma of the uterine cervix

(2014) Yue Ma et al.   BMC CANCER

NQO1 Suppresses NF- B-p300 Interaction to Regulate Inflammatory Mediators Associated with Prostate Tumorigenesis

(2014) D. Thapa et al.   CANCER RESEARCH

SIRT6 Promotes COX-2 Expression and Acts as an Oncogene in Skin Cancer

(2014) M. Ming et al.   CANCER RESEARCH

Proteasome inhibitor MG132 inhibits the proliferation and promotes the cisplatin-induced apoptosis of human esophageal squamous cell carcinoma cells

(2014) LIFENG DANG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Suppression of NAD(P)H-quinone oxidoreductase 1 enhanced the susceptibility of cholangiocarcinoma cells to chemotherapeutic agents

(2014) Ponsilp Zeekpudsa et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

SIRT6 modulates paclitaxel and epirubicin resistance and survival in breast cancer

(2013) Mattaka Khongkow et al.   CARCINOGENESIS

A miR-34a-SIRT6 axis in the squamous cell differentiation network

(2013) Karine Lefort et al.   EMBO JOURNAL

SIRT2 overexpression in hepatocellular carcinoma mediates epithelial to mesenchymal transition by protein kinase B/glycogen synthase kinase-3β/β-catenin signaling

(2013) Juan Chen et al.   HEPATOLOGY

Microenvironment mesenchymal cells protect ovarian cancer cell lines from apoptosis by inhibiting XIAP inactivation

(2013) M Castells et al.   Cell Death & Disease

MG132 inhibition of proteasome blocks high-dose UV irradiation-induced apoptosis

(2011) Ling Zhang et al.   CELL CYCLE

Protein kinase C stabilizes X-linked inhibitor of apoptosis protein (XIAP) through phosphorylation at Ser87 to suppress apoptotic cell death

(2011) Kiyoko KATO et al.   Psychogeriatrics

The Deacetylase SIRT1 Promotes Membrane Localization and Activation of Akt and PDK1 During Tumorigenesis and Cardiac Hypertrophy

(2011) N. R. Sundaresan et al.   Science Signaling

Inhibition of Renal NQO1 Activity by Dicoumarol Suppresses Nitroreduction of Aristolochic Acid I and Attenuates its Nephrotoxicity

(2011) Min Chen et al.   TOXICOLOGICAL SCIENCES

c-Fos Proteasomal Degradation Is Activated by a Default Mechanism, and Its Regulation by NAD(P)H:Quinone Oxidoreductase 1 Determines c-Fos Serum Response Kinetics

(2010) J. Adler et al.   MOLECULAR AND CELLULAR BIOLOGY

SIRT6 Links Histone H3 Lysine 9 Deacetylation to NF-κB-Dependent Gene Expression and Organismal Life Span

(2009) Tiara L.A. Kawahara et al.   CELL

NAD(P)H Quinone-Oxydoreductase 1 Protects Eukaryotic Translation Initiation Factor 4GI from Degradation by the Proteasome

(2009) A. Alard et al.   MOLECULAR AND CELLULAR BIOLOGY

NAD(P)H quinone oxidoreductase 1 inhibits the proteasomal degradation of the tumour suppressor p33ING1b

(2008) Marco Garate et al.   EMBO REPORTS

Overexpression of cFLIPs inhibits oxaliplatin-mediated apoptosis through enhanced XIAP stability and Akt activation in human renal cancer cells

(2008) Shin Kim et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin

(2008) Eriko Michishita et al.   NATURE