Oncogenic pathways and the electron transport chain: a dangeROS liaison

Mechanisms of apoptosis modulation by curcumin: Implications for cancer therapy

(2019) Keywan Mortezaee et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Ubiquinol-cytochrome C reductase core protein II promotes tumorigenesis by facilitating p53 degradation

(2019) Yingyan Han et al.   EBioMedicine

Elucidating cancer metabolic plasticity by coupling gene regulation with metabolic pathways

(2019) Dongya Jia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitohormesis Primes Tumor Invasion and Metastasis

(2019) Timothy C. Kenny et al.   Cell Reports

The Diverse Functions of Non-Essential Amino Acids in Cancer

(2019) Bo-Hyun Choi et al.   Cancers

Mutations in the ND2 Subunit of Mitochondrial Complex I Are Sufficient to Confer Increased Tumorigenic and Metastatic Potential to Cancer Cells

(2019) Joaquín Marco-Brualla et al.   Cancers

Current overview on the clinical update of Bcl-2 anti-apoptotic inhibitors for cancer therapy

(2019) Vasanti Suvarna et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Electron transport chain complex II sustains high mitochondrial membrane potential in hematopoietic stem and progenitor cells

(2019) Claudia Morganti et al.   Stem Cell Research

Structure of the intact 14-subunit human cytochrome c oxidase

(2018) Shuai Zong et al.   CELL RESEARCH

The prognostic value of PI3K mutational status in breast cancer: A meta-analysis

(2018) Navid Sobhani et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Targeting BCL-2 regulated apoptosis in cancer

(2018) Kirsteen J. Campbell et al.   Open Biology

Mitochondrial Proteins Coded by Human Tumor Viruses

(2018) Ilaria Cavallari et al.   Frontiers in Microbiology

Involvement of NADPH Oxidase 1 in Liver Kinase B1-Mediated Effects on Tumor Angiogenesis and Growth

(2018) Elisabetta Zulato et al.   Frontiers in Oncology

OUP accepted manuscript

(2018)   AMERICAN JOURNAL OF CLINICAL NUTRITION

LKB1 loss is associated with glutathione deficiency under oxidative stress and sensitivity of cancer cells to cytotoxic drugs and γ-irradiation

(2018) E. Zulato et al.   BIOCHEMICAL PHARMACOLOGY

Tuberous sclerosis complex is required for tumor maintenance in MYC‐driven Burkitt's lymphoma

(2018) Götz Hartleben et al.   EMBO JOURNAL

Tissue-specific expression and post-transcriptional regulation of the ATPase inhibitory factor 1 (IF1) in human and mouse tissues

(2018) Pau B. Esparza-Moltó et al.   FASEB JOURNAL

Mitochondria-targeted drugs stimulate mitophagy and abrogate colon cancer cell proliferation

(2018) Kathleen A. Boyle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Overexpression of UQCRC2 is correlated with tumor progression and poor prognosis in colorectal cancer

(2018) Yuanyuan Shang et al.   PATHOLOGY RESEARCH AND PRACTICE

Selective killing of human T-ALL cells: an integrated approach targeting redox homeostasis and the OMA1/OPA1 axis

(2018) Micol Silic-Benussi et al.   Cell Death & Disease

KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism

(2018) Angelina V. Vaseva et al.   CANCER CELL

Reactive Oxygen and Nitrogen Species–Induced Protein Modifications: Implication in Carcinogenesis and Anticancer Therapy

(2018) Nurbubu T. Moldogazieva et al.   CANCER RESEARCH

Akt‐mediated phosphorylation of MICU1 regulates mitochondrial Ca2+ levels and tumor growth

(2018) Saverio Marchi et al.   EMBO JOURNAL

The emergence of dihydroorotate dehydrogenase (DHODH) as a therapeutic target in acute myeloid leukemia

(2018) David B. Sykes   EXPERT OPINION ON THERAPEUTIC TARGETS

Regulation of Mitochondrial Electron Transport Chain Assembly

(2018) Sara Cogliati et al.   JOURNAL OF MOLECULAR BIOLOGY

Revisiting the role of dihydroorotate dehydrogenase as a therapeutic target for cancer

(2018) Joseph T. Madak et al.   PHARMACOLOGY & THERAPEUTICS

Proline dehydrogenase promotes senescence through the generation of reactive oxygen species

(2017) Taiki Nagano et al.   JOURNAL OF CELL SCIENCE

Reactive Oxygen and Nitrogen Species in Carcinogenesis: Implications of Oxidative Stress on the Progression and Development of Several Cancer Types

(2017) Joanna Kruk et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Effect of mitochondrially targeted carboxy proxyl nitroxide on Akt-mediated survival in Daudi cells: Significance of a dual mode of action

(2017) Gokul Variar et al.   PLoS One

Mitochondrial Complex II: At the Crossroads

(2017) Ayenachew Bezawork-Geleta et al.   TRENDS IN BIOCHEMICAL SCIENCES

Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells

(2017) Ilaria Elia et al.   Nature Communications

The mitochondrial hinge protein, UQCRH, is a novel prognostic factor for hepatocellular carcinoma

(2017) Eun-Ran Park et al.   Cancer Medicine

Role of Mitochondrial Reverse Electron Transport in ROS Signaling: Potential Roles in Health and Disease

(2017) Filippo Scialò et al.   Frontiers in Physiology

MYC Deregulation in Primary Human Cancers

(2017) Manpreet Kalkat et al.   Genes

Escaping Death: Mitochondrial Redox Homeostasis in Cancer Cells

(2017) Francesco Ciccarese et al.   Frontiers in Oncology

Synthetic Lethality of a Novel Small Molecule Against Mutant KRAS-Expressing Cancer Cells Involves AKT-Dependent ROS Production

(2016) Kartini Iskandar et al.   ANTIOXIDANTS & REDOX SIGNALING

The ATPase Inhibitory Factor 1 (IF1): A master regulator of energy metabolism and of cell survival

(2016) Javier García-Bermúdez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Complex I function in mitochondrial supercomplexes

(2016) Giorgio Lenaz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

MYC functions are specific in biological subtypes of breast cancer and confers resistance to endocrine therapy in luminal tumours

(2016) Andrew R Green et al.   BRITISH JOURNAL OF CANCER

Serine Synthesis Helps Hypoxic Cancer Stem Cells Regulate Redox

(2016) Debangshu Samanta et al.   CANCER RESEARCH

Suppressors of Superoxide-H 2 O 2 Production at Site I Q of Mitochondrial Complex I Protect against Stem Cell Hyperplasia and Ischemia-Reperfusion Injury

(2016) Martin D. Brand et al.   Cell Metabolism

Mitochondrial ROS Produced via Reverse Electron Transport Extend Animal Lifespan

(2016) Filippo Scialò et al.   Cell Metabolism

Mutant KRas-Induced Mitochondrial Oxidative Stress in Acinar Cells Upregulates EGFR Signaling to Drive Formation of Pancreatic Precancerous Lesions

(2016) Geou-Yarh Liou et al.   Cell Reports

Identification of ubiquinol cytochromecreductase hinge (UQCRH) as a potential diagnostic biomarker for lung adenocarcinoma

(2016) Feng Gao et al.   Open Biology

Landscape of Phosphatidylinositol-3-Kinase Pathway Alterations Across 19 784 Diverse Solid Tumors

(2016) Sherri Z. Millis et al.   JAMA Oncology

Co-regulation of mitochondrial respiration by proline dehydrogenase/oxidase and succinate

(2015) Chad N. Hancock et al.   AMINO ACIDS

ATPase inhibitory factor 1 is a prognostic marker and contributes to proliferation and invasion of human gastric cancer cells

(2015) Tao Yin et al.   BIOMEDICINE & PHARMACOTHERAPY

Glutathione and Thioredoxin Antioxidant Pathways Synergize to Drive Cancer Initiation and Progression

(2015) Isaac S. Harris et al.   CANCER CELL

Hydrogen peroxide – production, fate and role in redox signaling of tumor cells

(2015) Claudia Lennicke et al.   Cell Communication and Signaling

Cancer metabolism and the Warburg effect: the role of HIF-1 and PI3K

(2015) Rupert Courtnay et al.   MOLECULAR BIOLOGY REPORTS

Oxidative stress inhibits distant metastasis by human melanoma cells

(2015) Elena Piskounova et al.   NATURE

ATPase inhibitory factor 1 is a potential prognostic marker for the migration and invasion of glioma

(2015) JIANHENG WU et al.   Oncology Letters

Metalloprotease OMA1 Fine-tunes Mitochondrial Bioenergetic Function and Respiratory Supercomplex Stability

(2015) Iryna Bohovych et al.   Scientific Reports

PKA Phosphorylates the ATPase Inhibitory Factor 1 and Inactivates Its Capacity to Bind and Inhibit the Mitochondrial H+-ATP Synthase

(2015) Javier García-Bermúdez et al.   Cell Reports

Structure and conformational states of the bovine mitochondrial ATP synthase by cryo-EM

(2015) Anna Zhou et al.   eLife

Teriflunomide (Leflunomide) Promotes Cytostatic, Antioxidant, and Apoptotic Effects in Transformed Prostate Epithelial Cells: Evidence Supporting a Role for Teriflunomide in Prostate Cancer Chemoprevention

(2015) Numsen Hail et al.   NEOPLASIA

Role of the N-Terminus of Subunit III in Proton Uptake in Cytochrome c Oxidase of Rhodobacter sphaeroides

(2014) Khadijeh S. Alnajjar et al.   BIOCHEMISTRY

Ser70 phosphorylation of Bcl-2 by selective tyrosine nitration of PP2A-B56  stabilizes its antiapoptotic activity

(2014) I. C. C. Low et al.   BLOOD

VEGF-Targeted Therapy Stably Modulates the Glycolytic Phenotype of Tumor Cells

(2014) M. Curtarello et al.   CANCER RESEARCH

Oncogene-induced reactive oxygen species fuel hyperproliferation and DNA damage response activation

(2014) M Ogrunc et al.   CELL DEATH AND DIFFERENTIATION

Production of superoxide/H2O2 by dihydroorotate dehydrogenase in rat skeletal muscle mitochondria

(2014) Martin Hey-Mogensen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Reciprocal activation between ATPase inhibitory factor 1 and NF-κB drives hepatocellular carcinoma angiogenesis and metastasis

(2014) Ruipeng Song et al.   HEPATOLOGY

The mechanism of coupling between electron transfer and proton translocation in respiratory complex I

(2014) Leonid A. Sazanov   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR

(2014) Randall M. Chin et al.   NATURE

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS

(2014) Edward T. Chouchani et al.   NATURE

Antioxidants Accelerate Lung Cancer Progression in Mice

(2014) V. I. Sayin et al.   Science Translational Medicine

A Mitochondrial Switch Promotes Tumor Metastasis

(2014) Paolo E. Porporato et al.   Cell Reports

Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis

(2014) William W Wheaton et al.   eLife

Sources of superoxide/H2O2 during mitochondrial proline oxidation

(2014) Renata L.S. Goncalves et al.   Redox Biology

The identification of mitochondrial DNA variants in glioblastoma multiforme

(2014) Ka Yu Yeung et al.   Acta Neuropathologica Communications

Does Scavenging of Mitochondrial Superoxide Attenuate Cancer Prosurvival Signaling Pathways?

(2013) Rafal R. Nazarewicz et al.   ANTIOXIDANTS & REDOX SIGNALING

Repair of Oxidative DNA Damage and Cancer: Recent Progress in DNA Base Excision Repair

(2013) Timothy L. Scott et al.   ANTIOXIDANTS & REDOX SIGNALING

NADPH Oxidases: A Perspective on Reactive Oxygen Species Production in Tumor Biology

(2013) Jennifer L. Meitzler et al.   ANTIOXIDANTS & REDOX SIGNALING

Respiratory complex II: Role in cellular physiology and disease

(2013) Gary Cecchini   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

The role of mitochondrial electron transport in tumorigenesis and metastasis

(2013) An S. Tan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

mTORC1 Controls Mitochondrial Activity and Biogenesis through 4E-BP-Dependent Translational Regulation

(2013) Masahiro Morita et al.   Cell Metabolism

Molecular and Genetic Crosstalks between mTOR and ERRα Are Key Determinants of Rapamycin-Induced Nonalcoholic Fatty Liver

(2013) Cédric Chaveroux et al.   Cell Metabolism

Impact of c-MYC Protein Expression on Outcome of Patients with Early-Stage HER2+ Breast Cancer Treated with Adjuvant Trastuzumab NCCTG (Alliance) N9831

(2013) A. C. Dueck et al.   CLINICAL CANCER RESEARCH

Oxidant Sensing by Reversible Disulfide Bond Formation

(2013) Claudia M. Cremers et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

(2013) Jaekyoung Son et al.   NATURE

Mitochondrial Signaling: Forwards, Backwards, and In Between

(2013) Sean P. Whelan et al.   Oxidative Medicine and Cellular Longevity

Stimulation of de Novo Pyrimidine Synthesis by Growth Signaling Through mTOR and S6K1

(2013) I. Ben-Sahra et al.   SCIENCE

Expression, regulation and clinical relevance of the ATPase inhibitory factor 1 in human cancers

(2013) M Sánchez-Aragó et al.   Oncogenesis

Mitochondrial complex II, a novel target for anti-cancer agents

(2012) Katarina Kluckova et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

The role of complex II in disease

(2012) Attje S. Hoekstra et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

The function and the role of the mitochondrial glycerol-3-phosphate dehydrogenase in mammalian tissues

(2012) Tomáš Mráček et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Proline dehydrogenase (oxidase) in cancer

(2012) Wei Liu et al.   BIOFACTORS

Rac2-MRC-cIII-generated ROS cause genomic instability in chronic myeloid leukemia stem cells and primitive progenitors

(2012) M. Nieborowska-Skorska et al.   BLOOD

Proline Oxidase Promotes Tumor Cell Survival in Hypoxic Tumor Microenvironments

(2012) W. Liu et al.   CANCER RESEARCH

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Mitochondrial Complex I Plays an Essential Role in Human Respirasome Assembly

(2012) David Moreno-Lastres et al.   Cell Metabolism

Reactive oxygen species in apoptosis induced by cisplatin: review of physiopathological mechanisms in animal models

(2012) Celia Casares et al.   EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY

GSK3 inactivation is involved in mitochondrial complex IV defect in transforming growth factor (TGF) β1-induced senescence

(2012) Hae-Ok Byun et al.   EXPERIMENTAL CELL RESEARCH

Classification of mitocans, anti-cancer drugs acting on mitochondria

(2012) Jiri Neuzil et al.   MITOCHONDRION

The Mitochondrial ATPase Inhibitory Factor 1 Triggers a ROS-Mediated Retrograde Prosurvival and Proliferative Response

(2012) Laura Formentini et al.   MOLECULAR CELL

Physiological Roles of Mitochondrial Reactive Oxygen Species

(2012) Laura A. Sena et al.   MOLECULAR CELL

PTEN/Akt Signaling Controls Mitochondrial Respiratory Capacity through 4E-BP1

(2012) Chong Kiat Goo et al.   PLoS One

Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC

(2012) W. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A ROS rheostat for cell fate regulation

(2012) Maria Maryanovich et al.   TRENDS IN CELL BIOLOGY

Mitochondrial oxidative stress drives tumor progression and metastasis: should we use antioxidants as a key component of cancer treatment and prevention?

(2011) Federica Sotgia et al.   BMC Medicine

K-rasG12V transformation leads to mitochondrial dysfunction and a metabolic switch from oxidative phosphorylation to glycolysis

(2011) Yumin Hu et al.   CELL RESEARCH

Arrangement of electron transport chain components in bovine mitochondrial supercomplex I1III2IV1

(2011) Thorsten Althoff et al.   EMBO JOURNAL

The Mechanism of Superoxide Production by the Antimycin-inhibited Mitochondrial Q-cycle

(2011) Casey L. Quinlan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Composition of Plant Mitochondrial Supercomplexes Changes with Oxygen Availability

(2011) Santiago J. Ramírez-Aguilar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

(2011) Gina M. DeNicola et al.   NATURE

Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

(2011) Christian M. Metallo et al.   NATURE

Selective killing of K-ras mutant cancer cells by small molecule inducers of oxidative stress

(2011) A. T. Shaw et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial fatty acid oxidation and oxidative stress: Lack of reverse electron transfer-associated production of reactive oxygen species

(2010) Peter Schönfeld et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

The electron transfer flavoprotein: Ubiquinone oxidoreductases

(2010) Nicholas J. Watmough et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Biographical Sketch: Otto Heinrich Warburg, PhD, MD

(2010) Richard A. Brand   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

ROS-mediated amplification of AKT/mTOR signalling pathway leads to myeloproliferative syndrome in Foxo3−/− mice

(2010) Safak Yalcin et al.   EMBO JOURNAL

The sites and topology of mitochondrial superoxide production

(2010) Martin D. Brand   EXPERIMENTAL GERONTOLOGY

The mitochondrial bioenergetic capacity of carcinomas

(2010) Laura Formentini et al.   IUBMB LIFE

Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

(2010) F. Weinberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial Complex I decrease is responsible for bioenergetic dysfunction in K-ras transformed cells

(2009) Alessandra Baracca et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Proline Oxidase Functions as a Mitochondrial Tumor Suppressor in Human Cancers

(2009) Y. Liu et al.   CANCER RESEARCH

Involvement of cytochrome c oxidase subunits Va and Vb in the regulation of cancer cell metabolism by Bcl-2

(2009) Z X Chen et al.   CELL DEATH AND DIFFERENTIATION

Novel Imaging Provides New Insights into Mechanisms of Oxygen Transport in Tumors

(2009) Matthew Hardee et al.   CURRENT MOLECULAR MEDICINE

Mitochondria and reactive oxygen species

(2009) Alicia J. Kowaltowski et al.   FREE RADICAL BIOLOGY AND MEDICINE

Role of peroxynitrite in the redox regulation of cell signal transduction pathways

(2009) Lucas Liaudet   Frontiers in Bioscience-Landmark

Structural and functional organization of the mitochondrial respiratory chain: A dynamic super-assembly

(2009) Giorgio Lenaz et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Association of reactive oxygen species levels and radioresistance in cancer stem cells

(2009) Maximilian Diehn et al.   NATURE

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

(2009) Dunyaporn Trachootham et al.   NATURE REVIEWS DRUG DISCOVERY

IF1: setting the pace of the F1Fo-ATP synthase

(2009) Michelangelo Campanella et al.   TRENDS IN BIOCHEMICAL SCIENCES

Lack of Cytochromecin Mouse Fibroblasts Disrupts Assembly/Stability of Respiratory Complexes I and IV

(2008) Uma D. Vempati et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Respiratory Active Mitochondrial Supercomplexes

(2008) Rebeca Acín-Pérez et al.   MOLECULAR CELL

Global Regulation of Nucleotide Biosynthetic Genes by c-Myc

(2008) Yen-Chun Liu et al.   PLoS One

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

(2008) D. R. Wise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ROS-Generating Mitochondrial DNA Mutations Can Regulate Tumor Cell Metastasis

(2008) K. Ishikawa et al.   SCIENCE