Cytochrome P450s in the synthesis of cholesterol and bile acids - from mouse models to human diseases

Regulation of Hepatic Cytochromes P450 by Lipids and Cholesterol

(2011) Mateja Hafner et al.   CURRENT DRUG METABOLISM

Defects in cholesterol synthesis genes in mouse and in humans: lessons for drug development and safer treatments

(2011) Simon Horvat et al.   DRUG METABOLISM REVIEWS

Nuclear Receptors CAR and PXR; therapeutic targets for cholestatic liver disease

(2011) Satoru Kakizaki   Frontiers in Bioscience-Landmark

Use and indications of cholestyramine and bile acid sequestrants

(2011) Franco Scaldaferri et al.   Internal and Emergency Medicine

Mouse Knockout of the Cholesterogenic Cytochrome P450 Lanosterol 14α-Demethylase (Cyp51) Resembles Antley-Bixler Syndrome

(2011) Rok Keber et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enhanced production of 24S-hydroxycholesterol is not sufficient to drive liver X receptor target genes in vivo

(2011) M. Shafaati et al.   JOURNAL OF INTERNAL MEDICINE

Novel mutations in theCYP7B1gene cause hereditary spastic paraplegia

(2011) Li Cao et al.   MOVEMENT DISORDERS

27-Hydroxycholesterol: the first identified endogenous SERM

(2011) Michihisa Umetani et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Cerebrotendinous xanthomatosis: An inborn error in bile acid synthesis with defined mutations but still a challenge

(2010) Ingemar Björkhem et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Promoter variant −204A > C of the cholesterol 7α-hydroxylase gene: Association with response to plant sterols in humans and increased transcriptional activity in transfected HepG2 cells

(2010) Isabel De Castro-Orós et al.   CLINICAL NUTRITION

Transgenic expression of cholesterol 7α-hydroxylase in the liver prevents high-fat diet-induced obesity and insulin resistance in mice

(2010) Tiangang Li et al.   HEPATOLOGY

Overexpression of cholesterol 7α-hydroxylase promotes hepatic bile acid synthesis and secretion and maintains cholesterol homeostasis

(2010) Tiangang Li et al.   HEPATOLOGY

On the mechanism of accumulation of cholestanol in the brain of mice with a disruption of sterol 27-hydroxylase

(2010) Ann Båvner et al.   JOURNAL OF LIPID RESEARCH

Malformation syndromes caused by disorders of cholesterol synthesis

(2010) Forbes D. Porter et al.   JOURNAL OF LIPID RESEARCH

Abolished synthesis of cholic acid reduces atherosclerotic development in apolipoprotein E knockout mice

(2010) Katharina Slätis et al.   JOURNAL OF LIPID RESEARCH

Perspectives of the non-statin hypolipidemic agents

(2010) Damjana Rozman et al.   PHARMACOLOGY & THERAPEUTICS

CYP46A1 variants influence Alzheimer's disease risk and brain cholesterol metabolism

(2009) Heike Kölsch et al.   EUROPEAN PSYCHIATRY

Leptin Is Associated With Blood Pressure and Hypertension in Women From the National Heart, Lung, and Blood Institute Family Heart Study

(2009) Duanduan Ma et al.   HYPERTENSION

Cholesterol 24-hydroxylase (CYP46A1) polymorphisms are associated with faster cognitive deterioration in Chinese older persons: a two-year follow up study

(2009) Brenda Yan Fu et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

CYP7B1: One Cytochrome P450, Two Human Genetic Diseases, and Multiple Physiological Functions

(2009) Ashlee R. Stiles et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cyp46 Polymorphisms in Alzheimer’s Disease: A Review

(2009) Anália Nusya Medeiros Garcia et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Neonatal Cholestatic Liver Disease in an Asian Patient With a Homozygous Mutation in the Oxysterol 7α-hydroxylase Gene

(2009) Isao Ueki et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Cholesterol Metabolism: the Main Pathway Acting Downstream of Cytochrome P450 Oxidoreductase in Skeletal Development of the Limb

(2009) K. Schmidt et al.   MOLECULAR AND CELLULAR BIOLOGY

Common CYP7A1 promoter polymorphism associated with risk of neuromyelitis optica

(2009) Ho Jin Kim et al.   NEUROBIOLOGY OF DISEASE

Role of Bile Acids and Bile Acid Receptors in Metabolic Regulation

(2009) Philippe Lefebvre et al.   PHYSIOLOGICAL REVIEWS

Reduction of cholesterol synthesis in the mouse brain does not affect amyloid formation in Alzheimer's disease, but does extend lifespan

(2009) R. W. Halford et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

25-Hydroxycholesterol secreted by macrophages in response to Toll-like receptor activation suppresses immunoglobulin A production

(2009) D. R. Bauman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bile acids: Chemistry, physiology, and pathophysiology

(2009) Maria J Monte et al.   WORLD JOURNAL OF GASTROENTEROLOGY

CREM modulates the circadian expression of CYP51, HMGCR and cholesterogenesis in the liver

(2008) Jure Acimovic et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

CYP7B1-mediated metabolism of dehydroepiandrosterone and 5α-androstane-3β,17β-diol - potential role(s) for estrogen signaling

(2008) Hanna Pettersson et al.   FEBS Journal

Neuronal expression and subcellular localization of cholesterol 24-hydroxylase in the mouse brain

(2008) Denise M.O. Ramirez et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Hereditary spastic paraplegia: clinical features and pathogenetic mechanisms

(2008) Sara Salinas et al.   LANCET NEUROLOGY

27-Hydroxycholesterol Is an Endogenous Selective Estrogen Receptor Modulator

(2007) Carolyn D. DuSell et al.   MOLECULAR ENDOCRINOLOGY