Importance of Long Non-coding RNAs in the Development and Disease of Skeletal Muscle and Cardiovascular Lineages

lncRNA H19 prevents endothelial–mesenchymal transition in diabetic retinopathy

(2019) Anu A. Thomas et al.   DIABETOLOGIA

Myogenin promoter‐associated lncRNA Myoparr is essential for myogenic differentiation

(2019) Keisuke Hitachi et al.   EMBO REPORTS

Long non-coding RNA Irm enhances myogenic differentiation by interacting with MEF2D

(2019) Yutong Sui et al.   Cell Death & Disease

Paraxial Mesoderm Is the Major Source of Lymphatic Endothelium

(2019) Oliver A. Stone et al.   DEVELOPMENTAL CELL

MicroRNA therapy stimulates uncontrolled cardiac repair after myocardial infarction in pigs

(2019) Khatia Gabisonia et al.   NATURE

Long noncoding RNAs in vascular smooth muscle cells regulate vascular calcification

(2019) Geon Jeong et al.   Scientific Reports

The Human- and Smooth Muscle Cell-Enriched lncRNA SMILR Promotes Proliferation by Regulating Mitotic CENPF mRNA and Drives Cell-Cycle Progression Which Can Be Targeted to Limit Vascular Remodeling

(2019) Amira D Mahmoud et al.   CIRCULATION RESEARCH

The lncRNA Hand2os1/Uph locus orchestrates heart development through regulation of precise expression of Hand2

(2019) Xue Han et al.   DEVELOPMENT

RNA-based diagnostic and therapeutic strategies for cardiovascular disease

(2019) Dongchao Lu et al.   Nature Reviews Cardiology

LncRNA-Ang362 Promotes Pulmonary Arterial Hypertension by Regulating miR-221 and miR-222

(2019) Han Wang et al.   SHOCK

The lncRNA Locus Handsdown Regulates Cardiac Gene Programs and Is Essential for Early Mouse Development

(2019) Nicole Ritter et al.   DEVELOPMENTAL CELL

Long noncoding RNA H19-derived miR-675 aggravates restenosis by targeting PTEN

(2018) Junyuan Lv et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Long noncoding RNA FTX regulates cardiomyocyte apoptosis by targeting miR-29b-1-5p and Bcl2l2

(2018) Bo Long et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Down-regulation of lncRNA MEG3 promotes hypoxia-induced human pulmonary artery smooth muscle cell proliferation and migration via repressing PTEN by sponging miR-21

(2018) Boqian Zhu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

LncRNA myocardial infarction-associated transcript (MIAT) contributed to cardiac hypertrophy by regulating TLR4 via miR-93

(2018) Yunwei Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

lncRNA AK017368 promotes proliferation and suppresses differentiation of myoblasts in skeletal muscle development by attenuating the function of miR-30c

(2018) Tingting Liang et al.   FASEB JOURNAL

The lncRNA GATA6-AS epigenetically regulates endothelial gene expression via interaction with LOXL2

(2018) Philipp Neumann et al.   Nature Communications

Enhancer-associated long non-coding RNA LEENE regulates endothelial nitric oxide synthase and endothelial function

(2018) Yifei Miao et al.   Nature Communications

Long non-coding RNA profiling reveals an abundant MDNCR that promotes differentiation of myoblasts via sponging miR-133a

(2018) Hui Li et al.   Molecular Therapy-Nucleic Acids

The lncRNA Plscr4 Controls Cardiac Hypertrophy by Regulating miR-214

(2018) Lifang Lv et al.   Molecular Therapy-Nucleic Acids

Long non-coding RNA H19 regulates endothelial cell aging via inhibition of STAT3 signalling

(2018) Patrick Hofmann et al.   CARDIOVASCULAR RESEARCH

Deficiency in the nuclear long noncoding RNA Charme causes myogenic defects and heart remodeling in mice

(2018) Monica Ballarino et al.   EMBO JOURNAL

Long-noncoding RNA Atrolnc-1 promotes muscle wasting in mice with chronic kidney disease

(2018) Lijing Sun et al.   Journal of Cachexia Sarcopenia and Muscle

yylncT Defines a Class of Divergently Transcribed lncRNAs and Safeguards the T-mediated Mesodermal Commitment of Human PSCs

(2018) Stefan Frank et al.   Cell Stem Cell

Long Noncoding RNA lncMUMA Reverses Established Skeletal Muscle Atrophy following Mechanical Unloading

(2018) Zong-Kang Zhang et al.   MOLECULAR THERAPY

SENCR stabilizes vascular endothelial cell adherens junctions through interaction with CKAP4

(2018) Qing Lyu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Long noncoding RNA SYISL regulates myogenesis by interacting with polycomb repressive complex 2

(2018) Jian Jun Jin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein sequestration as a normal function of long noncoding RNAs and a pathogenic mechanism of RNAs containing nucleotide repeat expansions

(2017) Ginny R. Morriss et al.   HUMAN GENETICS

lncRNA Chronos is an aging-induced inhibitor of muscle hypertrophy

(2017) Ronald L Neppl et al.   JOURNAL OF CELL BIOLOGY

The long noncoding RNA Wisper controls cardiac fibrosis and remodeling

(2017) Rudi Micheletti et al.   Science Translational Medicine

Lnc-mg is a long non-coding RNA that promotes myogenesis

(2017) Mu Zhu et al.   Nature Communications

Long non-coding RNA Linc-RAM enhances myogenic differentiation by interacting with MyoD

(2017) Xiaohua Yu et al.   Nature Communications

LncRNA MALAT1 regulates smooth muscle cell phenotype switch via activation of autophagy

(2017) Tie-Feng Song et al.   Oncotarget

Plasma Long Non-Coding RNA (lncRNA) GAS5 is a New Biomarker for Coronary Artery Disease

(2017) Qiong Yin et al.   MEDICAL SCIENCE MONITOR

The Function and Therapeutic Potential of Long Non-coding RNAs in Cardiovascular Development and Disease

(2017) Clarissa P.C. Gomes et al.   Molecular Therapy-Nucleic Acids

Malat1 regulates myogenic differentiation and muscle regeneration through modulating MyoD transcriptional activity

(2017) Xiaona Chen et al.   Cell Discovery

Identification of MyoD-Responsive Transcripts Reveals a Novel Long Non-coding RNA (lncRNA-AK143003) that Negatively Regulates Myoblast Differentiation

(2017) Yiwen Guo et al.   Scientific Reports

MYOSLIDIs a Novel Serum Response Factor–Dependent Long Noncoding RNA That Amplifies the Vascular Smooth Muscle Differentiation ProgramHighlights

(2016) Jinjing Zhao et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Divergent lncRNAs Regulate Gene Expression and Lineage Differentiation in Pluripotent Cells

(2016) Sai Luo et al.   Cell Stem Cell

Smooth Muscle Enriched Long Noncoding RNA (SMILR) Regulates Cell ProliferationCLINICAL PERSPECTIVE

(2016) Margaret D. Ballantyne et al.   CIRCULATION

PANCR, thePITX2Adjacent Noncoding RNA, Is Expressed in Human Left Atria and Regulates PITX2c Expression

(2016) Shamone R. Gore-Panter et al.   Circulation-Arrhythmia and Electrophysiology

Cell fate control by pioneer transcription factors

(2016) Makiko Iwafuchi-Doi et al.   DEVELOPMENT

RNA polymerase II promoter-proximal pausing in mammalian long non-coding genes

(2016) Heeyoun Bunch et al.   GENOMICS

A Role for the Long Noncoding RNA SENCR in Commitment and Function of Endothelial Cells

(2016) Mounia Boulberdaa et al.   MOLECULAR THERAPY

Transcription of the non-coding RNA upperhand controls Hand2 expression and heart development

(2016) Kelly M. Anderson et al.   NATURE

mTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide

(2016) Akinobu Matsumoto et al.   NATURE

The long noncoding RNA Chaer defines an epigenetic checkpoint in cardiac hypertrophy

(2016) Zhihua Wang et al.   NATURE MEDICINE

A peptide encoded by a transcript annotated as long noncoding RNA enhances SERCA activity in muscle

(2016) B. R. Nelson et al.   SCIENCE

Long noncoding RNA Chast promotes cardiac remodeling

(2016) Janika Viereck et al.   Science Translational Medicine

Role of long non-coding RNA-RNCR3 in atherosclerosis-related vascular dysfunction

(2016) K Shan et al.   Cell Death & Disease

Reciprocal Changes of Circulating Long Non-Coding RNAs ZFAS1 and CDR1AS Predict Acute Myocardial Infarction

(2016) Ying Zhang et al.   Scientific Reports

Downregulation of long non-coding RNA H19 promotes P19CL6 cells proliferation and inhibits apoptosis during late-stage cardiac differentiation via miR-19b-modulated Sox6

(2016) Yu Han et al.   Cell and Bioscience

HoxBlinc RNA Recruits Set1/MLL Complexes to Activate Hox Gene Expression Patterns and Mesoderm Lineage Development

(2016) Changwang Deng et al.   Cell Reports

Long Non-Coding RNA-ROR Mediates the Reprogramming in Cardiac Hypertrophy

(2016) Feng Jiang et al.   PLoS One

Sirt1 AS lncRNA interacts with its mRNA to inhibit muscle formation by attenuating function of miR-34a

(2016) Guo-qiang Wang et al.   Scientific Reports

Assessment of Circulating LncRNAs Under Physiologic and Pathologic Conditions in Humans Reveals Potential Limitations as Biomarkers

(2016) Kenny Schlosser et al.   Scientific Reports

DECKO: Single-oligo, dual-CRISPR deletion of genomic elements including long non-coding RNAs

(2015) Estel Aparicio-Prat et al.   BMC GENOMICS

A Micropeptide Encoded by a Putative Long Noncoding RNA Regulates Muscle Performance

(2015) Douglas M. Anderson et al.   CELL

LncRNA Dum interacts with Dnmts to regulate Dppa2 expression during myogenic differentiation and muscle regeneration

(2015) Lijun Wang et al.   CELL RESEARCH

Identification of Novel Long Noncoding RNAs Underlying Vertebrate Cardiovascular Development

(2015) L. Kurian et al.   CIRCULATION

Plasma long non-coding RNA, CoroMarker, a novel biomarker for diagnosis of coronary artery disease

(2015) Yujia Yang et al.   CLINICAL SCIENCE

A Long Non-coding RNA, LncMyoD, Regulates Skeletal Muscle Differentiation by Blocking IMP2-Mediated mRNA Translation

(2015) Chenguang Gong et al.   DEVELOPMENTAL CELL

Malat1 regulates serum response factor through miR-133 as a competing endogenous RNA in myogenesis

(2015) Xiaorui Han et al.   FASEB JOURNAL

CARMEN, a human super enhancer-associated long noncoding RNA controlling cardiac specification, differentiation and homeostasis

(2015) Samir Ounzain et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Development of Long Noncoding RNA-Based Strategies to Modulate Tissue Vascularization

(2015) Jan Fiedler et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Cellular localization of long non-coding RNAs affects silencing by RNAi more than by antisense oligonucleotides

(2015) Kim A. Lennox et al.   NUCLEIC ACIDS RESEARCH

Linc-YY1 promotes myogenic differentiation and muscle regeneration through an interaction with the transcription factor YY1

(2015) Liang Zhou et al.   Nature Communications

APF lncRNA regulates autophagy and myocardial infarction by targeting miR-188-3p

(2015) Kun Wang et al.   Nature Communications

Low Expression of lncRNA-GAS5 Is Implicated in Human Primary Varicose Great Saphenous Veins

(2015) Li Li et al.   PLoS One

Identification and Initial Functional Characterization of a Human Vascular Cell–Enriched Long Noncoding RNA

(2014) Robert D. Bell et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

LincRNA-p21 Regulates Neointima Formation, Vascular Smooth Muscle Cell Proliferation, Apoptosis, and Atherosclerosis by Enhancing p53 Activity

(2014) Gengze Wu et al.   CIRCULATION

The Long Noncoding RNA CHRF Regulates Cardiac Hypertrophy by Targeting miR-489

(2014) Kun Wang et al.   CIRCULATION RESEARCH

Circulating Long Noncoding RNA, LIPCAR, Predicts Survival in Patients With Heart Failure

(2014) Regalla Kumarswamy et al.   CIRCULATION RESEARCH

Long Noncoding RNA MALAT1 Regulates Endothelial Cell Function and Vessel Growth

(2014) Katharina M. Michalik et al.   CIRCULATION RESEARCH

The H19 long noncoding RNA gives rise to microRNAs miR-675-3p and miR-675-5p to promote skeletal muscle differentiation and regeneration

(2014) B. K. Dey et al.   GENES & DEVELOPMENT

Functional importance of cardiac enhancer-associated noncoding RNAs in heart development and disease

(2014) Samir Ounzain et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Novel Long Noncoding RNAs (lncRNAs) in Myogenesis: amiR-31Overlapping lncRNA Transcript Controls Myoblast Differentiation

(2014) Monica Ballarino et al.   MOLECULAR AND CELLULAR BIOLOGY

MUNC, a Long Noncoding RNA That Facilitates the Function of MyoD in Skeletal Myogenesis

(2014) Adam C. Mueller et al.   MOLECULAR AND CELLULAR BIOLOGY

A Feedforward Regulatory Loop between HuR and the Long Noncoding RNA linc-MD1 Controls Early Phases of Myogenesis

(2014) Ivano Legnini et al.   MOLECULAR CELL

A long noncoding RNA protects the heart from pathological hypertrophy

(2014) Pei Han et al.   NATURE

CARL lncRNA inhibits anoxia-induced mitochondrial fission and apoptosis in cardiomyocytes by impairing miR-539-dependent PHB2 downregulation

(2014) Kun Wang et al.   Nature Communications

MDRL lncRNA Regulates the Processing of miR-484 Primary Transcript by Targeting miR-361

(2014) Kun Wang et al.   PLoS Genetics

Myostatin-induced inhibition of the long noncoding RNA Malat1 is associated with decreased myogenesis

(2013) Rani Watts et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

lincRNAs: Genomics, Evolution, and Mechanisms

(2013) Igor Ulitsky et al.   CELL

Braveheart, a Long Noncoding RNA Required for Cardiovascular Lineage Commitment

(2013) Carla A. Klattenhoff et al.   CELL

Novel Long Noncoding RNAs Are Regulated by Angiotensin II in Vascular Smooth Muscle Cells

(2013) Amy Leung et al.   CIRCULATION RESEARCH

Myod and H19-Igf2 locus interactions are required for diaphragm formation in the mouse

(2013) M. Borensztein et al.   DEVELOPMENT

The Tissue-Specific lncRNA Fendrr Is an Essential Regulator of Heart and Body Wall Development in the Mouse

(2013) Phillip Grote et al.   DEVELOPMENTAL CELL

The Yin and Yang of enhancer-like RNAs

(2013) Ramin Shiekhattar   EMBO JOURNAL

Genome-wide survey by ChIP-seq reveals YY1 regulation of lincRNAs in skeletal myogenesis

(2013) Leina Lu et al.   EMBO JOURNAL

The large non-coding RNA ANRIL, which is associated with atherosclerosis, periodontitis and several forms of cancer, regulates ADIPOR1, VAMP3 and C11ORF10

(2013) Gregor Bochenek et al.   HUMAN MOLECULAR GENETICS

The Imprinted H19 LncRNA Antagonizes Let-7 MicroRNAs

(2013) Amanda N. Kallen et al.   MOLECULAR CELL

eRNAs Promote Transcription by Establishing Chromatin Accessibility at Defined Genomic Loci

(2013) Kambiz Mousavi et al.   MOLECULAR CELL

Tuberculosis

(2013) Alimuddin Zumla et al.   NEW ENGLAND JOURNAL OF MEDICINE

Signaling and Transcriptional Networks in Heart Development and Regeneration

(2013) B. G. Bruneau   Cold Spring Harbor Perspectives in Biology

Alu Elements in ANRIL Non-Coding RNA at Chromosome 9p21 Modulate Atherogenic Cell Functions through Trans-Regulation of Gene Networks

(2013) Lesca M. Holdt et al.   PLoS Genetics

A Long ncRNA Links Copy Number Variation to a Polycomb/Trithorax Epigenetic Switch in FSHD Muscular Dystrophy

(2012) Daphne S. Cabianca et al.   CELL

Functional screening identifies miRNAs inducing cardiac regeneration

(2012) Ana Eulalio et al.   NATURE

The DMD Locus Harbours Multiple Long Non-Coding RNAs Which Orchestrate and Control Transcription of Muscle Dystrophin mRNA Isoforms

(2012) Matteo Bovolenta et al.   PLoS One

Wnt signaling in myogenesis

(2012) Julia von Maltzahn et al.   TRENDS IN CELL BIOLOGY

Micromanaging Vascular Smooth Muscle Cell Differentiation and Phenotypic Modulation

(2011) Brandi N. Davis-Dusenbery et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

A Long Noncoding RNA Controls Muscle Differentiation by Functioning as a Competing Endogenous RNA

(2011) Marcella Cesana et al.   CELL

EVEN-SKIPPED HOMEOBOX 1 controls human ES cell differentiation by directly repressing GOOSECOID expression

(2011) Mark Kalisz et al.   DEVELOPMENTAL BIOLOGY

MiR-483-5p controls angiogenesis in vitro and targets serum response factor

(2011) Yu Qiao et al.   FEBS LETTERS

A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression

(2011) Kevin C. Wang et al.   NATURE

Transcriptional mechanisms regulating skeletal muscle differentiation, growth and homeostasis

(2011) Thomas Braun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Specific Gene Signatures and Pathways in Mesodermal Cells and Their Derivatives Derived from Embryonic Stem Cells

(2011) Michael Xavier Doss et al.   Stem Cell Reviews and Reports

Long noncoding RNA: unveiling hidden layer of gene regulatory networks

(2011) Eun-Deok Kim et al.   TRENDS IN PLANT SCIENCE

An Aptamer Targeting the Apical-Loop Domain Modulates pri-miRNA Processing

(2010) Christina E. Lünse et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

RNA Targeting Therapeutics: Molecular Mechanisms of Antisense Oligonucleotides as a Therapeutic Platform

(2010) C. Frank Bennett et al.   Annual Review of Pharmacology and Toxicology

Epithelial to mesenchymal transition during gastrulation: An embryological view

(2010) Yukiko Nakaya et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

Chromatin regulation by Brg1 underlies heart muscle development and disease

(2010) Calvin T. Hang et al.   NATURE

Large intergenic non-coding RNA-RoR modulates reprogramming of human induced pluripotent stem cells

(2010) Sabine Loewer et al.   NATURE GENETICS

Mapping the first stages of mesoderm commitment during differentiation of human embryonic stem cells

(2010) D. Evseenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Filling the gap in LNA antisense oligo gapmers: the effects of unlocked nucleic acid (UNA) and 4′-C-hydroxymethyl-DNA modifications on RNase H recruitment and efficacy of an LNA gapmer

(2009) Kees Fluiter et al.   Molecular BioSystems

Long non-coding RNAs: insights into functions

(2009) Tim R. Mercer et al.   NATURE REVIEWS GENETICS