Review
Biochemistry & Molecular Biology
Linh T. T. Le, Chan X. T. Nhu
Summary: This review examines the relationship and function of lncRNA in different cardiovascular diseases, highlighting their potential applications in clinical diagnosis, prognosis, and treatment. A deeper understanding of cardiovascular diseases will be achieved, leading to improvements in related techniques.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cardiac & Cardiovascular Systems
Jiawen Li, Yulin Zhang, Donghui Zhang, Yifei Li
Summary: Sepsis-induced cardiac dysfunction (SICD) is a major cause of death in septic cases. Long non-coding RNAs (lncRNAs) have been identified as a novel opportunity to explore the mechanisms and development of SICD.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Cell Biology
Jihui Lee, Hara Kang
Summary: Sarcopenia is an age-related disease that can be regulated by alterations in the expression levels of non-coding RNAs, leading to muscle atrophy and dysfunction. Exercise can affect the expression patterns of non-coding RNAs involved in sarcopenia.
Article
Veterinary Sciences
Zhaobo Zhang, Sishi Zhang, Guoshuai Wang, Siyu Feng, Kexin Han, Limei Han, Liping Han
Summary: Marek's disease virus (MDV) causes Marek's disease (MD), which involves highly infectious tumor lesions. Noncoding RNAs play a significant role in the pathogenesis of MD, with specific miRNAs and lncRNAs participating in various cellular processes.
RESEARCH IN VETERINARY SCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Anshika Goenka, Deanna Marie Tiek, Xiao Song, Rebeca Piatniczka Iglesia, Minghui Lu, Bo Hu, Shi-Yuan Cheng
Summary: Research in cancer biology has predominantly focused on protein-coding genes, but the discovery of non-coding RNAs (ncRNAs) has shed light on their crucial role in various biological processes and human diseases including cancer. Dysregulated ncRNA expression affects cancer initiation, progression, and therapy resistance. This review emphasizes the recent developments and advances in ncRNA biology relevant to glioma tumorigenesis and therapy response, highlighting the potential of ncRNAs as biomarkers and therapeutic agents in glioma.
Review
Endocrinology & Metabolism
Vinay Singh Tanwar, Marpadga A. Reddy, Rama Natarajan
Summary: Chronic metabolic disorders like obesity and diabetes are associated with accelerated vascular complications, and long non-coding RNAs play a crucial role in regulating gene expression in these diseases. Understanding the characteristics and mechanisms of lncRNAs can provide insights for the development of new therapeutic approaches to manage these disorders effectively.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Medicine, Research & Experimental
Mingxing Li, Xiao Yu, Qingyuan Zheng, Qiyao Zhang, Yuting He, Wenzhi Guo
Summary: Long non-coding RNAs (lncRNAs) are a newly identified class of RNA molecules at least 200 nucleotides in length that are not translated into proteins. The lncRNA prostate cancer-associated transcript 6 (PCAT6) is upregulated in various human malignancies and is closely correlated with aggressive clinicopathological characteristics and poor prognosis in cancer patients, indicating it is an oncogenic lncRNA that could serve as a new prognostic biomarker and therapeutic target for malignancies. The molecular mechanisms, regulatory functions, and potential clinical applications of PCAT6 in cancer are discussed.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Neurosciences
Yu-Shen Yang, Shi-Ling He, Wei-Can Chen, Cong-Mei Wang, Qiao-Mei Huang, Yan-Chuan Shi, Shu Lin, He-fan He
Summary: This article focuses on the role of non-coding RNA in postoperative cognitive dysfunction (POCD), emphasizing their importance in the pathogenesis, diagnosis, and treatment of POCD.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Review
Medicine, Research & Experimental
Hongxu Li, Jie Gao, Long Liu, Shuijun Zhang
Summary: LINC00958, a long non-coding RNA highly expressed in various malignancies, plays a role in enhancing tumor cells' resistance to radiotherapy and chemotherapy, inducing lymphangiogenesis, and facilitating tumor glycolytic metabolism. Additionally, LINC00958 acts as a ceRNA and regulates the malignant behavior of tumor cells through the miRNA-mRNA axis, showcasing potential as a novel biomarker and therapeutic target in cancer diagnosis and treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Endocrinology & Metabolism
Guanqing Zhou, Mimi Zhang, Jingzhi Zhang, Yaofeng Feng, Zhishen Xie, Siyi Liu, Detu Zhu, Yumei Luo
Summary: Non-coding RNAs play important roles in cell differentiation, proliferation, apoptosis, and the pathogenesis of various diseases. Especially in non-obstructive azoospermia, the expression of non-coding RNAs is associated with pathological conditions.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Cell Biology
Toshihiko Takeiwa, Kazuhiro Ikeda, Kuniko Horie-Inoue, Satoshi Inoue
Summary: Ovarian cancer is a health-threatening malignancy of the ovary in the female reproductive system, often diagnosed at advanced stages with poor prognosis. Recent studies have shown that some lncRNAs play roles in apoptosis of ovarian cancer cells, potentially serving as promising new targets in therapy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Qianqin Li, Zezhou Xiao, Yongsheng Wang, Ximao Liu, Hao Liu, Zhiwen Luo, Shaoyi Zheng
Summary: In this study, RNA sequencing was used to identify various lncRNAs and mRNAs associated with vascular aging in the thoracic aortas of young and old rats. Differentially expressed mRNAs were found to be enriched in biological processes and signaling pathways related to angiogenesis. Specific lncRNAs and mRNAs, as well as signaling pathways, were identified as potential targets for improving vascular aging.
Article
Plant Sciences
Gyanendra K. Patra, Divya Gupta, Gyana Ranjan Rout, Sanjib Kumar Panda
Summary: Recent advancements in high-throughput sequencing and NGS techniques have allowed us to study the important functions of long non-coding RNAs (lncRNAs) in plants. LncRNAs play crucial roles in plant growth, development, and response to environmental stresses, although our understanding of them is still limited.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Review
Pathology
Soudeh Ghafouri-Fard, Tayyebeh Khoshbakht, Mohammad Taheri, Mohammadreza Hajiesmaeili
Summary: Long intergenic non-coding RNAs (lincRNAs) are a group of long non-coding RNAs that do not overlap with protein-coding genes, playing roles in chromatin configurations and cancer pathoetiology. LINC00460, a member of this group, acts as a sponge for tumor suppressor miRNAs, increasing oncogenic targets expression and affecting chemotherapeutic agents sensitivity of cancer cells.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Review
Biochemistry & Molecular Biology
Janusz Blasiak, Juha M. T. Hyttinen, Joanna Szczepanska, Elzbieta Pawlowska, Kai Kaarniranta
Summary: AMD is the leading cause of visual impairment in the aging population, with age and family history as the strongest risk factors. Long non-coding RNAs play a significant role in the pathogenesis of AMD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Yangyang Zhang, Xianting Ke, Jingjing Liu, Xiue Ma, Yi Liu, Dandan Liang, Luxin Wang, Changfa Guo, Yiwei Luo
MOLECULAR MEDICINE REPORTS
(2019)
Article
Health Care Sciences & Services
Zhi Li, Wen Ge, Chunyan Han, Mengwei Lv, Yanzhong He, Juntao Su, Ban Liu, Yangyang Zhang
THERAPEUTICS AND CLINICAL RISK MANAGEMENT
(2020)
Article
Biotechnology & Applied Microbiology
Ban Liu, Xin Shi, Keke Ding, Mengwei Lv, Yongjun Qian, Shijie Zhu, Changfa Guo, Yangyang Zhang
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Xin Shi, Xuelian Shao, Ban Liu, Mengwei Lv, Pratik Pandey, Changfa Guo, Ruilin Zhang, Yangyang Zhang
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2020)
Article
Cardiac & Cardiovascular Systems
Mengwei Lv, Bo Hu, Wen Ge, Zhi Li, Qi Wang, Chunyan Han, Ban Liu, Yangyang Zhang
Summary: Occult renal dysfunction is a significant risk factor for postoperative acute kidney injury and in-hospital mortality in patients undergoing OPCABG surgery. Patients with occult renal dysfunction have higher risks for complications and adverse outcomes following surgery.
HEART LUNG AND CIRCULATION
(2021)
Article
Physiology
Ban Liu, Xiang Li, Cuimei Zhao, Yuliang Wang, Mengwei Lv, Xin Shi, Chunyan Han, Pratik Pandey, Chunhua Qian, Changfa Guo, Yangyang Zhang
FRONTIERS IN PHYSIOLOGY
(2020)
Article
Medicine, Research & Experimental
Mengwei Lv, Fei Gao, Ban Liu, Pratik Pandey, Yipeng Feng, Yingwei Wang, Yangyang Zhang, Zhi Li
Summary: The retrospective study involving 1471 patients undergoing coronary artery bypass graft (CABG) surgery in China found that obesity was associated with reduced 30-day postoperative mortality. There was an obesity paradox, with overweight patients having a protective effect against long-term mortality, especially in the off-pump CABG subgroup.
MEDICAL SCIENCE MONITOR
(2021)
Article
Genetics & Heredity
Cuimei Zhao, Jingjing Liu, Wen Ge, Zhi Li, Mengwei Lv, Yipeng Feng, Xuebo Liu, Ban Liu, Yangyang Zhang
Summary: Through analyzing the blood samples of AMI patients and normal controls, 142 differentially expressed circRNAs were identified. Functional characterization revealed that circRNAs were mainly involved in seven pathways, such as the Runt-related transcription factor-1 (RUNX1) expression and activity-related pathway.
FRONTIERS IN GENETICS
(2021)
Article
Cardiac & Cardiovascular Systems
Bo Hu, Fei Gao, Mengwei Lv, Ban Liu, Yu Shi, Xi Chen, Yipeng Feng, Xiaoqi Meng, Zhi Li, Yangyang Zhang
Summary: The study found that cTnT is a better indicator than CK-MB, and its peak value and peak occurrence are related to midterm mortality in patients undergoing OPCABG, with stronger predictive ability.
BMC CARDIOVASCULAR DISORDERS
(2021)
Article
Cell Biology
Jingjing Liu, Xianting Ke, Luxin Wang, Yangyang Zhang, Jian Yang
Summary: The study identified a critical role of CIRP in protecting against MCT-induced PAH by regulating the expression of CAV1 and CAVIN1, suggesting potential new therapeutic targets for PAH intervention.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Medicine, General & Internal
Yuying Gu, Lingtong Shan, Ban Liu, Mengwei Lv, Xi Chen, Tao Yan, Yu Shi, Jiapeng Chen, Zhi Li, Yangyang Zhang
Summary: In patients undergoing CABG, NYHA classification, CAD classification, valvular disease, IABP implantation, pulmonary hypertension, previous PCI, bypass graft number, cardiopulmonary bypass, and preoperative cTnT are independent risk factors of PMI.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Editorial Material
Medicine, Research & Experimental
Jin Yao, Xiao-Qun Wang, Yu-Jie Li, Kun Shan, Hong Yang, Yang-Ning-Zhi Wang, Mu-Di Yao, Chang Liu, Xiu-Miao Li, Yi Shen, Jing-Yu Liu, Hong Cheng, Jun Yuan, Yang-Yang Zhang, Qin Jiang, Biao Yan
EMBO MOLECULAR MEDICINE
(2022)
Article
Genetics & Heredity
Bo Hu, Wen Ge, Yuliang Wang, Xiaobin Zhang, Tao Li, Hui Cui, Yongjun Qian, Yangyang Zhang, Zhi Li
Summary: Atrial fibrillation (AF) is associated with an increased risk of heart failure, dementia, and stroke. Proteomics and metabolomics analyses revealed distinct metabolite and protein profiles between valvular and non-valvular AF patients, indicating potential different mechanisms underlying the two types of AF. The study identified specific biomarkers and metabolic pathways associated with each type of AF, providing insights for prognosis and potential treatment strategies.
FRONTIERS IN GENETICS
(2021)
Article
Medicine, General & Internal
Fei Gao, Lingtong Shan, Chong Wang, Xiaoqi Meng, Jiapeng Chen, Lixiang Han, Yangyang Zhang, Zhi Li
Summary: The study evaluated the performance of EuroSCORE II and STS score in predicting in-hospital and medium-term mortality of patients undergoing CABG. Both scoring systems showed good predictive power for in-hospital mortality, but their performance decreased over time.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Xiang Li, Lingtong Shan, Mengwei Lv, Zhi Li, Chunyan Han, Ban Liu, Wen Ge, Yangyang Zhang
BMC CARDIOVASCULAR DISORDERS
(2020)