Growth hormone-STAT5 regulation of growth, hepatocellular carcinoma, and liver metabolism

GH-Dependent STAT5 Signaling Plays an Important Role in Hepatic Lipid Metabolism

(2010) Johanna L. Barclay et al.   ENDOCRINOLOGY

The transcription factors signal transducer and activator of transcription 5A (STAT5A) and STAT5B negatively regulate cell proliferation through the activation of cyclin-dependent kinase inhibitor 2b (Cdkn2b) and Cdkn1a expression

(2010) Ji Hoon Yu et al.   HEPATOLOGY

Dispersed Chromosomal Stat5b-binding Elements Mediate Growth Hormone-activated Insulin-like Growth Factor-I Gene Transcription

(2010) Dennis J. Chia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Organic anion transporting polypeptide 1a/1b–knockout mice provide insights into hepatic handling of bilirubin, bile acids, and drugs

(2010) Evita van de Steeg et al.   JOURNAL OF CLINICAL INVESTIGATION

Distinct Alterations in Chromatin Organization of the Two IGF-I Promoters Precede Growth Hormone-Induced Activation of IGF-I Gene Transcription

(2010) Dennis J. Chia et al.   MOLECULAR ENDOCRINOLOGY

Mechanisms of gender-specific regulation of mouse sulfotransferases (Sults)

(2010) Yazen Alnouti et al.   XENOBIOTICA

Impact of OATP transporters on pharmacokinetics

(2009) A Kalliokoski et al.   BRITISH JOURNAL OF PHARMACOLOGY

Skeletal muscle growth and fiber composition in mice are regulated through the transcription factors STAT5a/b: linking growth hormone to the androgen receptor

(2009) Peter Klover et al.   FASEB JOURNAL

Disruption of the growth hormone-Signal transducer and activator of transcription 5-Insulinlike growth factor 1 axis severely aggravates liver fibrosis in a mouse model of cholestasis

(2009) Leander Blaas et al.   HEPATOLOGY

Liver-specific Deletion of the Growth Hormone Receptor Reveals Essential Role of Growth Hormone Signaling in Hepatic Lipid Metabolism

(2009) Yong Fan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of STAT5 causes liver fibrosis and cancer development through increased TGF-β and STAT3 activation

(2009) Atsushi Hosui et al.   JOURNAL OF EXPERIMENTAL MEDICINE

SOCS1 Links Cytokine Signaling to p53 and Senescence

(2009) Viviane Calabrese et al.   MOLECULAR CELL

Growth Hormone-Activated STAT5 May Indirectly Stimulate IGF-I Gene Transcription through HNF-3γ

(2009) Satyanarayana Eleswarapu et al.   MOLECULAR ENDOCRINOLOGY

Dynamicin VivoBinding of STAT5 to Growth Hormone-Regulated Genes in Intact Rat Liver. Sex-Specific Binding at Low- But Not High-Affinity STAT5 Sites

(2009) Ekaterina V. Laz et al.   MOLECULAR ENDOCRINOLOGY

Male-Specific Hepatic Bcl6: Growth Hormone-Induced Block of Transcription Elongation in Females and Binding to Target Genes Inversely Coordinated with STAT5

(2009) Rosana D. Meyer et al.   MOLECULAR ENDOCRINOLOGY

Regulator of sex-limitation KRAB zinc finger proteins modulate sex-dependent and -independent liver metabolism

(2009) Christopher J. Krebs et al.   PHYSIOLOGICAL GENOMICS

Cytochrome P450 omega hydroxylase (CYP4) function in fatty acid metabolism and metabolic diseases

(2008) James P. Hardwick   BIOCHEMICAL PHARMACOLOGY

Steroid Hormones Control CircadianElovl3Expression in Mouse Liver

(2008) Annelie Brolinson et al.   ENDOCRINOLOGY

Sex-Specific Early Growth Hormone Response Genes in Rat Liver

(2008) Valerie Wauthier et al.   MOLECULAR ENDOCRINOLOGY

Increased SULT1E1 activity in HepG2 hepatocytes decreases growth hormone stimulation of STAT5b phosphorylation

(2008) Li Li et al.   STEROIDS