Article
Multidisciplinary Sciences
Egle Kvedaraite, Laura Hertwig, Indranil Sinha, Andrea Ponzetta, Ida Hed Myrberg, Magda Lourda, Majda Dzidic, Mira Akber, Jonas Klingstrom, Elin Folkesson, Jagadeeswara Rao Muvva, Puran Chen, Sara Gredmark-Russ, Susanna Brighenti, Anna Norrby-Teglund, Lars Eriksson, Olav Rooyackers, Soo Aleman, Kristoffer Stralin, Hans-Gustaf Ljunggren, Florent Ginhoux, Niklas K. Bjorkstrom, Jan-Inge Henter, Mattias Svensson
Summary: This study found that COVID-19 patients experience a redistribution of monocyte subsets towards intermediate monocytes and a general decrease in circulating dendritic cells. Severe disease is associated with the appearance of monocytic myeloid-derived suppressor cell-like cells and a higher frequency of pre-DC2. The phenotypic alterations in mononuclear phagocytes are cell-lineage-specific and linked to the response against SARS-CoV-2 or COVID-19 severity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Hematology
Danying Liao, Jesse Sundlov, Jieqing Zhu, Heng Mei, Yu Hu, Debra K. Newman, Peter J. Newman
Summary: This study investigated the impact of amino acid substitutions at interfaces between PECAM-1 molecules on homophilic binding and endothelial cell function. It was found that substitutions at key residues within the IgD1-IgD1 and IgD1-IgD2 interfaces disrupted PECAM-1 homophilic binding and downstream effector functions.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Zhao Yang, C. Mary Schooling, Man Ki Kwok
Summary: The role of IL-1 family members/receptors in lung cancer remains uncertain, with no significant associations found in this study, although suggestive total effects were noted for certain IL-1 family members/receptors with lung cancer and its subtypes.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Ana Bocanegra, Gonzalo Fernandez-Hinojal, Daniel Ajona, Ester Blanco, Miren Zuazo, Maider Garnica, Luisa Chocarro, Elvira Alfaro-Arnedo, Sergio Pineiro-Hermida, Pilar Morente, Leticia Fernandez, Ana Remirez, Miriam Echaide, Maite Martinez-Aguillo, Idoia Morilla, Beatriz Tavira, Alejandra Roncero, Carolina Gotera, Alfonso Ventura, Nerea Recalde, Jose G. Pichel, Juan Jose Lasarte, Luis Montuenga, Ruth Vera, Ruben Pio, David Escors, Grazyna Kochan
Summary: Recent studies show that baseline functional immunity is crucial for the success of immune checkpoint blockade therapies. In this study, high-dimensional systemic immune profiling was performed on non-small-cell lung cancer patients undergoing PD-L1/PD-1 blockade immunotherapy. Responders had a higher diversity of myeloid phenotypes in their peripheral blood. A diversity index was defined as a potential biomarker of response. Fractalkine (FKN), a chemokine linked to immune chemotaxis and adhesion, was identified as a biomarker of response and correlated with myeloid cell diversity. FKN inhibited lung adenocarcinoma growth in both human and mouse models through the involvement of systemic effector NK cells and increased tumor immune infiltration. FKN also sensitized mouse lung cancer models resistant to anti-PD-1 treatment to immunotherapy, indicating its potential therapeutic use in combination with immunotherapy.
Article
Cell Biology
Sophia J. Wiedemann, Kelly Trimigliozzi, Erez Dror, Daniel T. Meier, Jose Alberto Molina-Tijeras, Leila Rachid, Christelle Le Foll, Christophe Magnan, Friederike Schulze, Marc Stawiski, Stephanie P. Haeuselmann, Helene Mereau, Marianne Boeni-Schnetzler, Marc Y. Donath
Summary: This study reveals that the initial cephalic phase of insulin secretion is mediated through the vagus nerve and IL-10 is involved in this process. IL-10 stimulates postprandial insulin secretion through neuronal transmission and is produced by microglia. It activates the vagus nerve and regulates hypothalamic activity. Impaired IL-10 signaling contributes to the dysregulation of cephalic phase insulin release in obesity.
Article
Immunology
Abi G. Yates, Trisha Jogia, Ellen R. Gillespie, Yvonne Couch, Marc J. Ruitenberg, Daniel C. Anthony
Summary: The study found that exogenous administration of IL-1RA can attenuate the acute phase response (APR) in traumatic spinal cord injury, reducing immune cell infiltration at the spinal cord lesion site.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Immunology
Sandy ElSayed, Gregory D. Jay, Ralph Cabezas, Marwa Qadri, Tannin A. Schmidt, Khaled A. Elsaid
Summary: The study revealed that monocytes from acute gout patients exhibited higher phagocytic activation and ROS generation under basal conditions, as well as increased IL-1 beta secretion upon MSU stimulation. rhPRG4 showed better inhibition of phagocytic activation in monocytes from both normal and gout patients compared to IL-1RA, and both treatments effectively reduced IL-1 beta secretion.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Nicolaas C. Budhiparama, Imelda Lumban-Gaol, Herawati Sudoyo, Rahadyan Magetsari, Tri Wibawa
Summary: This study aimed to evaluate the association of SNPs of the IL-1 family with the clinical severity of knee OA. Three SNPs of IL-1R1, rs871659, rs3771202, and rs3917238, were associated with primary knee OA. No correlation was found between SNPs of IL-1R1 and IL-1RN and clinical or radiologic severity or serum concentrations of IL-1R1 and IL-1Ra. BMI and IL-1R1 rs3917238 genotype C/C were correlated with moderate-severe VAS scores.
SCIENTIFIC REPORTS
(2023)
Article
Cell Biology
Mariasilvia Colantuoni, Raisa Jofra Hernandez, Emanuela Pettinato, Luca Basso-Ricci, Laura Magnani, Grazia Andolfi, Chiara Rigamonti, Annamaria Finardi, Valentina Romeo, Monica Soldi, Lucia Sergi Sergi, Martina Rocchi, Serena Scala, Hal M. Hoffman, Silvia Gregori, Anna Kajaste-Rudnitski, Francesca Sanvito, Luca Muzio, Luigi Naldini, Alessandro Aiuti, Alessandra Mortellaro
Summary: We developed a gene transfer strategy using transplanted autologous hematopoietic stem/progenitor cells (HSPCs) as a source of IL-1 receptor antagonist (IL-1RA) for systemic delivery to tissues and organs. Our findings demonstrate the potential of HSPC-mediated IL-1RA delivery as a therapeutic modality for suppressing tissue and organ inflammation in diverse immune-related diseases involving IL-1-driven inflammation.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Cell Biology
Mariasilvia Colantuoni, Raisa Jofra Hernandez, Emanuela Pettinato, Luca Basso-Ricci, Laura Magnani, Grazia Andolfi, Chiara Rigamonti, Annamaria Finardi, Valentina Romeo, Monica Soldi, Lucia Sergi Sergi, Martina Rocchi, Serena Scala, Hal M. Hoffman, Silvia Gregori, Anna Kajaste-Rudnitski, Francesca Sanvito, Luca Muzio, Luigi Naldini, Alessandro Aiuti, Alessandra Mortellaro
Summary: This study developed a lentivirus-mediated gene transfer strategy using transplanted autologous hematopoietic stem/progenitor cells (HSPCs) as a source of IL-1 receptor antagonist (IL-1RA) for systemic delivery to tissues and organs. The HSPC-mediated IL-1RA delivery showed therapeutic efficacy in various IL-1-driven inflammation models.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Immunology
Jiarui Mi, Zhengye Liu, Shengduo Pei, Xia Wu, Nan Zhao, Lingjuan Jiang, Zhenjie Zhang, Xiaoyin Bai
Summary: This study using Mendelian randomization found that IL-18 is causally associated with an increased risk of IBD, while IL-1Ra is inversely associated with the risk of IBD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Catiule de Oliveira Santos, Sidnei Ferro Costa, Fabiana Santana Souza, Jessica Mariane Ferreira Mendes, Cristiane Garboggini Melo de Pinheiro, Diogo Rodrigo de Magalhaes Moreira, Luciano Kalabric Silva, Valeria Marcal Felix de Lima, Geraldo Gileno de Sa Oliveira
Summary: IL-10 plays a crucial role in regulating inflammatory and immune responses, but its restriction can also lead to chronic infections. Blocking IL-10 signaling may be beneficial for treating CanL, as it can prevent exhaustion of T lymphocytes and promote appropriate immune responses.
Article
Respiratory System
Yaping Liu, Xinxin Zhang, Jing Wang, Fuhuang Yang, Wei Luo, Jie Huang, Mengling Chen, Sha Wang, Caolong Li, Wei Zhang, Jie Chao
Summary: This study investigated the role of monocytes in silicosis and found that infiltrating monocytes can inhibit fibroblast function in early inflammation by regulating IL-10. The protein ZC3H4 was identified as a key player in this process, as it downregulated IL-10 through autophagy signaling. These findings provide new insights into the clinical treatment of silicosis.
RESPIRATORY RESEARCH
(2022)
Article
Microbiology
Gongguan Liu, Osama Abas, Yong Fu, Yanli Chen, Ashley B. Strickland, Donglei Sun, Meiqing Shi
Summary: Tip-DCs are key immune effector cells involved in fighting off various infections, but their excessive development can lead to tissue damage. This study reveals that IL-27 plays a crucial role in inhibiting Tip-DC development during parasitic infections by interfering with the CD4(+) T cell-IFN-gamma axis and preserving the balance between Ly6C(-) and Ly6C(+) monocytes. Targeting IL-27 signaling may offer a promising approach for therapeutic intervention to control Tip-DC development.
Article
Pediatrics
Roberta Caorsi, Antonella Insalaco, Francesca Bovis, Giorgia Martini, Marco Cattalini, Marcello Chinali, Alessandro Rimini, Chiara Longo, Silvia Federici, Camilla Celani, Giovanni Filocamo, Rita Consolini, Maria Cristina Maggio, Gloria Fadanelli, Francesco Licciardi, Micol Romano, Barbara Lia Teruzzi, Andrea Taddio, Angela Miniaci, Francesco La Torre, Alessandro De Fanti, Giulio Cavalli, Barbara Bigucci, Romina Gallizzi, Matteo Chinello, Massimo Imazio, Antonio Brucato, Rolando Cimaz, Fabrizio De Benedetti, Marco Gattorno
Summary: This study analyzed the treatment of pediatric patients with recurrent pericarditis using anti-IL-1 therapy. The study found that most patients received inadequate first-line treatment and only a few achieved drug-free remission. The effectiveness of anakinra was supported, but the different response rates to anakinra and canakinumab may suggest a role of IL-1 alpha in the pathogenesis of recurrent pericarditis.
JOURNAL OF PEDIATRICS
(2023)
Article
Oncology
F. Saettini, S. Radaelli, L. Ocello, G. M. Ferrari, P. Corti, F. Dell'Acqua, D. Ippolito, S. Foresti, C. Gervasini, R. Badolato, A. Biondi
Summary: Rubinstein-Taybi syndrome is an autosomal dominant disorder caused by variants in CREBBP or EP300, characterized by distinctive features, intellectual disability, and immunodeficiency. The clinical presentation is expanding to include complications such as autoinflammatory, autoimmune, and infectious conditions, and prompt treatment can reduce mortality rates.
PEDIATRIC HEMATOLOGY AND ONCOLOGY
(2022)
Article
Infectious Diseases
Elena Chiappini, Catiuscia Lisi, Vania Giacomet, Paola Erba, Stefania Bernardi, Paola Zangari, Antonio Di Biagio, Lucia Taramasso, Carlo Giaquinto, Osvalda Rampon, Clara Gabiano, Silvia Garazzino, Claudia Tagliabue, Susanna Esposito, Eugenia Bruzzese, Raffaele Badolato, Domenico Zanaboni, Monica Cellini, Maurizio Dedoni, Antonio Mazza, Andrea Pession, Anna Maria Giannini, Filippo Salvini, Icilio Dodi, Ines Carloni, Salvatore Cazzato, Pier Angelo Tovo, Maurizio de Martino, Luisa Galli
Summary: Early initiation of HAART is crucial to prevent immunological and clinical deterioration in perinatally HIV-1 infected children. However, due to the lack of adequate pediatric clinical studies, only a small number of antiretroviral drugs are licensed for use in children.
BMC INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Elizabeth Chappell, Malte Kohns Vasconcelos, Ruth L. Goodall, Luisa Galli, Tessa Goetghebuer, Antoni Noguera-Julian, Laura C. Rodrigues, Henriette Scherpbier, Colette Smit, Alasdair Bamford, Siobhan Crichton, Marissa Luisa Navarro, Jose T. Ramos, Josiane Warszawski, Vana Spolou, Elena Chiappini, Elisabetta Venturini, Filipa Prata, Christian Kahlert, Magdalena Marczynska, Laura Marques, Lars Naver, Claire Thorne, Diana M. Gibb, Carlo Giaquinto, Ali Judd, Intira Jeannie Collins
Summary: In Europe, migrant children have virological and immunological outcomes at 1 year of ART that are comparable to domestic-born children, indicating potential equity in access to healthcare. However, there is some evidence of a difference in AIDS-free survival among migrant children, which needs further monitoring.
Article
Infectious Diseases
Carla Colombo, Marco Cipolli, Valeria Dacco, Paola Medino, Federico Alghisi, Maura Ambroni, Raffaele Badolato, Fiorella Battistini, Elisabetta Bignamini, Rosaria Casciaro, Fabiana Ciciriello, Mirella Collura, Isabella Comello, Michela Francalanci, Francesca Ficili, Anna Folino, Salvatore Leonardi, Giuseppina Leonetti, Maria Cristina Lucanto, Francesca Lucca, Massimo Maschio, Valeria Mencarini, Barbara Messore, Giovanna Pisi, Giovanna Pizzamiglio, Piercarlo Poli, Valeria Raia, Luca Riberi, Mirco Ros, Novella Rotolo, Angela Sepe, Giovanni Taccetti, Pamela Vitullo, Gianfranco Alicandro
Summary: This study aimed to describe the clinical course of COVID-19 in cystic fibrosis patients and identify risk factors for severe COVID-19. The study found that certain clinical features were associated with an increased risk of COVID-19 hospitalization.
Article
Immunology
Manuela Baronio, Francesco Saettini, Luisa Gazzurelli, Stefano Rossi, Antonio Marzollo, Silvia Ricci, Daniele Zama, Boaz Palterer, Canessa Clementina, Lodi Lorenzo, Marco Chiarini, Alessandra Sottini, Luisa Imberti, Chiara Gorio, Linda Rossini, Raffaele Badolato, Alessandro Plebani, Daniele Moratto, Vassilios Lougaris
Summary: Our study found that patients with JS may experience significant numerical and maturational alterations in the T-, B-, and NK-cell compartments. These findings suggest that JS patients should be regularly monitored from an immunological point of view.
JOURNAL OF CLINICAL IMMUNOLOGY
(2022)
Article
Urology & Nephrology
Federico Alberici, Stefania Affatato, Daniele Moratto, Federica Mescia, Elisa Delbarba, Alice Guerini, Martina Tedesco, Peter D. Burbelo, Roberta Zani, Ilaria Castagna, Agnese Gallico, Mattia Tonoli, Margherita Venturini, Aldo M. Roccaro, Mauro Giacomelli, Jeffrey Cohen, Viviana Giustini, Kerry Dobbs, Helen C. Su, Chiara Fiorini, Virginia Quaresima, Fabio Battista Viola, Valerio Vizzardi, Mario Gaggiotti, Nicola Bossini, Paola Gaggia, Raffaele Badolato, Luigi D. Notarangelo, Marco Chiarini, Francesco Scolari
Summary: Dialysis and kidney transplant patients with COVID-19 exhibit immunophenotype abnormalities, with kidney transplant recipients showing more profound alterations of the innate immune system and lower anti-spike antibody response.
JOURNAL OF NEPHROLOGY
(2022)
Article
Immunology
Emilia Cirillo, Agata Polizzi, Annarosa Soresina, Rosaria Prencipe, Giuliana Giardino, Caterina Cancrini, Andrea Finocchi, Beatrice Rivalta, Rosa M. Dellepiane, Lucia A. Baselli, Davide Montin, Antonino Trizzino, Rita Consolini, Chiara Azzari, Silvia Ricci, Lorenzo Lodi, Isabella Quinti, Cinzia Milito, Lucia Leonardi, Marzia Duse, Maria Carrabba, Giovanna Fabio, Patrizia Bertolini, Paola Coccia, Irene D'Alba, Andrea Pession, Francesca Conti, Marco Zecca, Claudio Lunardi, Manuela Lo Bianco, Santiago Presti, Laura Sciuto, Roberto Micheli, Dario Bruzzese, Vassilios Lougaris, Raffaele Badolato, Alessandro Plebani, Luciana Chessa, Claudio Pignata
Summary: This study investigated the disease characteristics and genotype-phenotype correlation in an Italian cohort of AT patients and found that lymphopenia and specific genotypes are associated with poorer clinical outcomes.
JOURNAL OF CLINICAL IMMUNOLOGY
(2022)
Review
Immunology
Manuela Cortesi, Annarosa Soresina, Laura Dotta, Chiara Gorio, Marco Cattalini, Vassilios Lougaris, Fulvio Porta, Raffaele Badolato
Summary: Autoimmune cytopenias in IEI typically have a more severe and chronic course, and genetic characterization is crucial for early diagnosis and targeted therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Federica Calzetti, Giulia Finotti, Marco A. Cassatella
Summary: Neutrophils are not a homogeneous population and exhibit phenotypic heterogeneity and functional versatility. The exact role of neutrophils in inflammation, immune response, and pathophysiological processes needs further evaluation. Recent studies have uncovered new information about the early precursors of human neutrophils, bringing new perspectives to our understanding of human neutropoiesis.
IMMUNOLOGICAL REVIEWS
(2023)
Editorial Material
Immunology
Marco A. Cassatella, William M. Nauseef
IMMUNOLOGICAL REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Oliviero Olivieri, Sara Gasperini, Federica Calzetti, Elisa Gardiman, Annalisa Castagna, Nicola Martinelli, Nicola Tamassia, Marco A. Cassatella
Summary: ApoCIII can activate CD14(+) monocytes to express tissue factor (TF), linking inflammation and atherothrombosis-related processes to cardiovascular risk.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Elisa Gardiman, Francisco Bianchetto-Aguilera, Sara Gasperini, Laura Tiberio, Matteo Scandola, Virginia Lotti, Davide Gibellini, Valentina Salvi, Daniela Bosisio, Marco A. A. Cassatella, Nicola Tamassia
Summary: COVID-19 disease is characterized by dysregulation of the innate immune system. This study demonstrates that single-strand RNAs from the SARS-CoV-2 genome can activate human neutrophils via the TLR8 pathway, potentially contributing to the pathogenesis of severe COVID-19.
Editorial Material
Immunology
Nicola Tamassia, Sebastien Jaillon
FRONTIERS IN IMMUNOLOGY
(2023)
Meeting Abstract
Immunology
F. Pettinella, B. Mariotti, K. Bruderek, M. Donini, S. Costa, O. Marini, G. Iannoto, S. Gasperini, E. Caveggion, M. Castellucci, F. Calzetti, F. Bianchetto-Aguilera, E. Gardiman, C. Lattanzi, S. Dusi, M. Cantini, A. Vassanelli, D. Pavone, M. Milella, S. Pilotto, P. Biondani, B. Hoeing, M. C. Schleupner, T. Hussain, B. Hadaschik, C. Kaspar, C. Visco, C. Tecchio, L. Koenderman, F. Bazzoni, N. Tamassia, S. Brandau, M. A. Cassatella, P. Scapini
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Article
Pediatrics
Chiara Mameli, Marina Picca, Roberto Buzzetti, Maria Elisabetta Pace, Raffaele Badolato, Claudio Cravidi, Gian Vincenzo Zuccotti, Paola Marchisio
Summary: This study aimed to estimate the incidence of acute respiratory tract infections (ARTIs) in children aged 0-5 years in an outpatient setting. The results showed that infants aged 1-12 months had the highest incidence rate. The COVID-19 pandemic significantly reduced the incidence of ARTIs.
ITALIAN JOURNAL OF PEDIATRICS
(2022)