标题
Pharmacologic inhibition of STAT5 in acute myeloid leukemia
作者
关键词
-
出版物
LEUKEMIA
Volume 32, Issue 5, Pages 1135-1146
出版商
Springer Nature
发表日期
2018-02-02
DOI
10.1038/s41375-017-0005-9
参考文献
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Rational development of Stafib-2: a selective, nanomolar inhibitor of the transcription factor STAT5b
- (2017) Nagarajan Elumalai et al. Scientific Reports
- Disarming an Electrophilic Warhead: Retaining Potency in Tyrosine Kinase Inhibitor (TKI)-Resistant CML Lines While Circumventing Pharmacokinetic Liabilities
- (2016) Ahmed M. Ali et al. ChemMedChem
- Impact of FLT3-ITD diversity on response to induction chemotherapy in patients with acute myeloid leukemia
- (2016) Mike Fischer et al. HAEMATOLOGICA
- Genomic Classification and Prognosis in Acute Myeloid Leukemia
- (2016) Elli Papaemmanuil et al. NEW ENGLAND JOURNAL OF MEDICINE
- Impact of FLT3-ITD diversity on response to induction chemotherapy in patients with acute myeloid leukemia
- (2016) Mike Fischer et al. HAEMATOLOGICA
- Intramolecular hydrophobic interactions are critical mediators of STAT5 dimerization
- (2016) Dirk Fahrenkamp et al. Scientific Reports
- Cytokine‐induced megakaryocytic differentiation is regulated by genome‐wide loss of a uSTAT transcriptional program
- (2015) Hyun Jung Park et al. EMBO JOURNAL
- Hydrogen Sulfide Promotes Tet1- and Tet2-Mediated Foxp3 Demethylation to Drive Regulatory T Cell Differentiation and Maintain Immune Homeostasis
- (2015) Ruili Yang et al. IMMUNITY
- Activating mutations of STAT5B and STAT3 in lymphomas derived from γδ-T or NK cells
- (2015) Can Küçük et al. Nature Communications
- Uncovering the pathogenesis of large granular lymphocytic leukemia—novelSTAT3andSTAT5bmutations
- (2014) Hanna L. M. Rajala et al. ANNALS OF MEDICINE
- Role of altered growth factor receptor-mediated JAK2 signaling in growth and maintenance of human acute myeloid leukemia stem cells
- (2014) A. M. Cook et al. BLOOD
- Nanomolar-Potency Small Molecule Inhibitor of STAT5 Protein
- (2014) Abbarna A. Cumaraswamy et al. ACS Medicinal Chemistry Letters
- Identification and targeting leukemia stem cells: The path to the cure for acute myeloid leukemia
- (2014) Jianbiao Zhou World Journal of Stem Cells
- Inhibiting Aberrant Signal Transducer and Activator of Transcription Protein Activation with Tetrapodal, Small Molecule Src Homology 2 Domain Binders: Promising Agents against Multiple Myeloma
- (2013) Brent D. G. Page et al. JOURNAL OF MEDICINAL CHEMISTRY
- Therapeutic modulators of STAT signalling for human diseases
- (2013) Gabriella Miklossy et al. NATURE REVIEWS DRUG DISCOVERY
- Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia
- (2013) NEW ENGLAND JOURNAL OF MEDICINE
- Potent Targeting of the STAT3 Protein in Brain Cancer Stem Cells: A Promising Route for Treating Glioblastoma
- (2013) Sina Haftchenary et al. ACS Medicinal Chemistry Letters
- Essential role for Stat5a/b in myeloproliferative neoplasms induced by BCR-ABL1 and JAK2V617F in mice
- (2012) C. Walz et al. BLOOD
- JAK2/STAT5 Inhibition Circumvents Resistance to PI3K/mTOR Blockade: A Rationale for Cotargeting These Pathways in Metastatic Breast Cancer
- (2012) Adrian Britschgi et al. CANCER CELL
- Indirubin derivatives induce apoptosis of chronic myelogenous leukemia cells involving inhibition of Stat5 signaling
- (2012) Sangkil Nam et al. Molecular Oncology
- JAK/STAT signaling in hematological malignancies
- (2012) W Vainchenker et al. ONCOGENE
- Critical requirement for Stat5 in a mouse model of polycythemia vera
- (2011) D. Yan et al. BLOOD
- High STAT5 levels mediate imatinib resistance and indicate disease progression in chronic myeloid leukemia
- (2011) W. Warsch et al. BLOOD
- The STAT5 inhibitor pimozide decreases survival of chronic myelogenous leukemia cells resistant to kinase inhibitors
- (2011) E. A. Nelson et al. BLOOD
- The clinical development of FLT3 inhibitors in acute myeloid leukemia
- (2011) Steven Knapper EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Small Molecule STAT5-SH2 Domain Inhibitors Exhibit Potent Antileukemia Activity
- (2011) Brent D. G. Page et al. JOURNAL OF MEDICINAL CHEMISTRY
- Epigenetic repression of the Igk locus by STAT5-mediated recruitment of the histone methyltransferase Ezh2
- (2011) Malay Mandal et al. NATURE IMMUNOLOGY
- Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method
- (2010) T.-C. Chou CANCER RESEARCH
- Stat5 is indispensable for the maintenance ofbcr/abl-positive leukaemia
- (2010) Andrea Hoelbl et al. EMBO Molecular Medicine
- Acetylation modulates prolactin receptor dimerization
- (2010) L. Ma et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- FLT3-ITD up-regulates MCL-1 to promote survival of stem cells in acute myeloid leukemia via FLT3-ITD-specific STAT5 activation
- (2009) G. Yoshimoto et al. BLOOD
- Single-Cell Profiling Identifies Aberrant STAT5 Activation in Myeloid Malignancies with Specific Clinical and Biologic Correlates
- (2008) Nikesh Kotecha et al. CANCER CELL
- Discovery of Chromone-Based Inhibitors of the Transcription Factor STAT5
- (2008) Judith Müller et al. CHEMBIOCHEM
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