The developmental Wnt signaling pathway effector β-catenin/TCF mediates hepatic functions of the sex hormone estradiol in regulating lipid metabolism

Wnt/Beta-Catenin Signaling Regulation and a Role for Biomolecular Condensates

(2019) Kristina N. Schaefer et al.   DEVELOPMENTAL CELL

The LIM homeodomain protein ISL1 mediates the function of TCF7L2 in pancreatic beta cells

(2018) Weijuan Shao et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Roles of G protein-coupled estrogen receptor GPER in metabolic regulation

(2018) Geetanjali Sharma et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

TAp63 contributes to sexual dimorphism in POMC neuron functions and energy homeostasis

(2018) Chunmei Wang et al.   Nature Communications

Menopausal Hormone Therapy and Type 2 Diabetes Prevention: Evidence, Mechanisms, and Clinical Implications

(2017) Franck Mauvais-Jarvis et al.   ENDOCRINE REVIEWS

Sex Hormones and Cardiometabolic Health: Role of Estrogen and Estrogen Receptors

(2017) Deborah Clegg et al.   ENDOCRINOLOGY

Curcumin represses mouse 3T3-L1 cell adipogenic differentiation via inhibiting miR-17-5p and stimulating the Wnt signalling pathway effector Tcf7l2

(2017) Lili Tian et al.   Cell Death & Disease

Extranuclear Actions of the Androgen Receptor Enhance Glucose-Stimulated Insulin Secretion in the Male

(2016) Guadalupe Navarro et al.   Cell Metabolism

The type 2 diabetes presumed causal variant within TCF7L2 resides in an element that controls the expression of ACSL5

(2016) Qianghua Xia et al.   DIABETOLOGIA

Sex and Gender Differences in Risk, Pathophysiology and Complications of Type 2 Diabetes Mellitus

(2016) Alexandra Kautzky-Willer et al.   ENDOCRINE REVIEWS

Current Understanding on Role of the Wnt Signaling Pathway Effector TCF7L2 in Glucose Homeostasis

(2016) Tianru Jin   ENDOCRINE REVIEWS

Alternative Wnt Signaling Activates YAP/TAZ

(2015) Hyun Woo Park et al.   CELL

Acute Wnt pathway activation positively regulates leptin gene expression in mature adipocytes

(2015) Zong-Lan Chen et al.   CELLULAR SIGNALLING

Liver-Specific Expression of Dominant-Negative Transcription Factor 7-Like 2 Causes Progressive Impairment in Glucose Homeostasis

(2015) Wilfred Ip et al.   DIABETES

Estrogen Enhances Activity of Wnt Signaling During Osteogenesis by Inducing Fhl1 Expression

(2015) Shao-Min Wu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The expression of dominant negative TCF7L2 in pancreatic beta cells during the embryonic stage causes impaired glucose homeostasis

(2015) Weijuan Shao et al.   Molecular Metabolism

The Combined Hyperlipidemia Caused by Impaired Wnt-LRP6 Signaling Is Reversed by Wnt3a Rescue

(2014) Gwang-woong Go et al.   Cell Metabolism

Alternative human liver transcripts of TCF7L2 bind to the gluconeogenesis regulator HNF4α at the protein level

(2014) Bernadette Neve et al.   DIABETOLOGIA

Estradiol Prevents Fat Accumulation and Overcomes Leptin Resistance in Female High-Fat Diet Mice

(2014) Sara A. Litwak et al.   ENDOCRINOLOGY

Selective disruption of Tcf7l2 in the pancreatic β cell impairs secretory function and lowers β cell mass

(2014) Ryan K. Mitchell et al.   HUMAN MOLECULAR GENETICS

The mechanisms of genome-wide target gene regulation by TCF7L2 in liver cells

(2014) Luke Norton et al.   NUCLEIC ACIDS RESEARCH

Regulation of Wnt/β-catenin signaling by posttranslational modifications

(2014) Chenxi Gao et al.   Cell and Bioscience

GLP-1(28–36) improves β-cell mass and glucose disposal in streptozotocin-induced diabetic mice and activates cAMP/PKA/β-catenin signaling in β-cells in vitro

(2013) Weijuan Shao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

p21-Activated protein kinases and their emerging roles in glucose homeostasis

(2013) Yu-ting Alex Chiang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

LRP6 Enhances Glucose Metabolism by Promoting TCF7L2-Dependent Insulin Receptor Expression and IGF Receptor Stabilization in Humans

(2013) Rajvir Singh et al.   Cell Metabolism

TCF7L2 in mouse pancreatic beta cells plays a crucial role in glucose homeostasis by regulating beta cell mass

(2013) Iseki Takamoto et al.   DIABETOLOGIA

G-protein-coupled receptor 30/adenylyl cyclase/protein kinase A pathway is involved in estradiol 17ß-d-glucuronide-induced cholestasis

(2013) Andrés E. Zucchetti et al.   HEPATOLOGY

Menopausal Hormone Therapy and Health Outcomes During the Intervention and Extended Poststopping Phases of the Women’s Health Initiative Randomized Trials

(2013) JoAnn E. Manson et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The Wnt signaling pathway effector TCF7L2 is upregulated by insulin and represses hepatic gluconeogenesis

(2012) Wilfred Ip et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Diabetes Risk Gene and Wnt Effector Tcf7l2/TCF4 Controls Hepatic Response to Perinatal and Adult Metabolic Demand

(2012) Sylvia F. Boj et al.   CELL

The Axin/TNKS complex interacts with KIF3A and is required for insulin-stimulated GLUT4 translocation

(2012) Hui-Ling Guo et al.   CELL RESEARCH

The Wnt Signaling Pathway Effector TCF7L2 Controls Gut and Brain Proglucagon Gene Expression and Glucose Homeostasis

(2012) W. Shao et al.   DIABETES

Abnormal glucose tolerance and insulin secretion in pancreas-specific Tcf7l2-null mice

(2012) G. da Silva Xavier et al.   DIABETOLOGIA

P21-Activated Protein Kinase 1 (Pak1) Mediates the Cross Talk between Insulin and β-Catenin on Proglucagon Gene Expression and Its Ablation Affects Glucose Homeostasis in Male C57BL/6 Mice

(2012) Yuting Alex Chiang et al.   ENDOCRINOLOGY

The involvement of the wnt signaling pathway and TCF7L2 in diabetes mellitus: The current understanding, dispute, and perspective

(2012) Wilfred Ip et al.   Cell and Bioscience

TCF7L2 Modulates Glucose Homeostasis by Regulating CREB- and FoxO1-Dependent Transcriptional Pathway in the Liver

(2012) Kyoung-Jin Oh et al.   PLoS Genetics

Chromatin occupancy of transcription factor 7-like 2 (TCF7L2) and its role in hepatic glucose metabolism

(2011) L. Norton et al.   DIABETOLOGIA

Alterations in TCF7L2 expression define its role as a key regulator of glucose metabolism

(2011) D. Savic et al.   GENOME RESEARCH

A Rac1/PAK1 cascade controls β-catenin activation in colon cancer cells

(2011) G Zhu et al.   ONCOGENE

β-Catenin Is a Positive Regulator of Estrogen Receptor-α Function in Breast Cancer Cells

(2011) Nibedita Gupta et al.   Cancers

Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis

(2010) Shijie Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Estrogen and androgen receptors: regulators of fuel homeostasis and emerging targets for diabetes and obesity

(2010) Franck Mauvais-Jarvis   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Impaired oxidative metabolism and inflammation are associated with insulin resistance in ERα-deficient mice

(2009) Vicent Ribas et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

(2009) Bryan T. MacDonald et al.   DEVELOPMENTAL CELL

WNT/β-catenin increases the production of incretins by entero-endocrine cells

(2009) J. M. García-Martínez et al.   DIABETOLOGIA

P-21-activated protein kinase-1 functions as a linker between insulin and Wnt signaling pathways in the intestine

(2009) J Sun et al.   ONCOGENE

Mechanisms of antidiabetogenic and body weight-lowering effects of estrogen in high-fat diet-fed mice

(2008) Galyna Bryzgalova et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Selective versus Total Insulin Resistance: A Pathogenic Paradox

(2008) Michael S. Brown et al.   Cell Metabolism

Wnt and beyond Wnt: Multiple mechanisms control the transcriptional property of β-catenin

(2008) Tianru Jin et al.   CELLULAR SIGNALLING

Glucagon-like Peptide-1 Activation of TCF7L2-dependent Wnt Signaling Enhances Pancreatic Beta Cell Proliferation

(2008) Zhengyu Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genome-Wide Identification of Estrogen Receptor α-Binding Sites in Mouse Liver

(2007) Hui Gao et al.   MOLECULAR ENDOCRINOLOGY