Genetic programming of macrophages to perform anti-tumor functions using targeted mRNA nanocarriers

Targeting Protumoral Tumor-Associated Macrophages with Nanobody-Functionalized Nanogels through Strain Promoted Azide Alkyne Cycloaddition Ligation

(2018) Lutz Nuhn et al.   BIOCONJUGATE CHEMISTRY

Emergence of synthetic mRNA: In vitro synthesis of mRNA and its applications in regenerative medicine

(2018) Hyokyoung Kwon et al.   BIOMATERIALS

The impact of interferon-regulatory factors to macrophage differentiation and polarization into M1 and M2

(2018) Dimitry A. Chistiakov et al.   IMMUNOBIOLOGY

Nucleoside-modified mRNA vaccines induce potent T follicular helper and germinal center B cell responses

(2018) Norbert Pardi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

mRNA vaccines — a new era in vaccinology

(2018) Norbert Pardi et al.   NATURE REVIEWS DRUG DISCOVERY

M1-like macrophages change tumor blood vessels and microenvironment in murine melanoma

(2018) Magdalena Jarosz-Biej et al.   PLoS One

Advances in Radiotherapy for Glioblastoma

(2018) Justin Mann et al.   Frontiers in Neurology

An RNA toolbox for cancer immunotherapy

(2018) Fernando Pastor et al.   NATURE REVIEWS DRUG DISCOVERY

Tumor-associated macrophages: from basic research to clinical application

(2017) Li Yang et al.   Journal of Hematology & Oncology

Immune modulation of some autoimmune diseases: the critical role of macrophages and neutrophils in the innate and adaptive immunity

(2017) Kely Campos Navegantes et al.   Journal of Translational Medicine

Macrophages as Key Drivers of Cancer Progression and Metastasis

(2017) Sebastian R. Nielsen et al.   MEDIATORS OF INFLAMMATION

In situ programming of leukaemia-specific T cells using synthetic DNA nanocarriers

(2017) Tyrel T. Smith et al.   Nature Nanotechnology

Multidimensional pooled shRNA screens in human THP-1 cells identify candidate modulators of macrophage polarization

(2017) Ewa Surdziel et al.   PLoS One

CXCR3+ monocytes/macrophages are required for establishment of pulmonary metastases

(2017) Kiah L. Butler et al.   Scientific Reports

Combination of CD40 Agonism and CSF-1R Blockade Reconditions Tumor-Associated Macrophages and Drives Potent Antitumor Immunity

(2017) Karla R. Wiehagen et al.   Cancer Immunology Research

Homology-Directed Recombination for Enhanced Engineering of Chimeric Antigen Receptor T Cells

(2017) Malika Hale et al.   Molecular Therapy-Methods & Clinical Development

Correction to Bioconjugated Manganese Dioxide Nanoparticles Enhance Chemotherapy Response by Priming Tumor-Associated Macrophages toward M1-like Phenotype and Attenuating Tumor Hypoxia

(2016) Manli Song et al.   ACS Nano

A Milestone Review on How Macrophages Affect Tumor Growth

(2016) Christophe Caux et al.   CANCER RESEARCH

Hepatic macrophages in homeostasis and liver diseases: from pathogenesis to novel therapeutic strategies

(2016) Cynthia Ju et al.   Cellular & Molecular Immunology

Multiplex Genome Editing to Generate Universal CAR T Cells Resistant to PD1 Inhibition

(2016) Jiangtao Ren et al.   CLINICAL CANCER RESEARCH

Targeting tumour-associated macrophages with CCR2 inhibition in combination with FOLFIRINOX in patients with borderline resectable and locally advanced pancreatic cancer: a single-centre, open-label, dose-finding, non-randomised, phase 1b trial

(2016) Timothy M Nywening et al.   LANCET ONCOLOGY

The role of microglia and macrophages in glioma maintenance and progression

(2016) Dolores Hambardzumyan et al.   NATURE NEUROSCIENCE

A general method for rapid and cost-efficient large-scale production of 5′ capped RNA

(2016) Anna-Lisa Fuchs et al.   RNA

The tumor microenvironment underlies acquired resistance to CSF-1R inhibition in gliomas

(2016) D. F. Quail et al.   SCIENCE

Concise Review: Application of In Vitro Transcribed Messenger RNA for Cellular Engineering and Reprogramming: Progress and Challenges

(2016) Heidrun Steinle et al.   STEM CELLS

Bioelectric modulation of macrophage polarization

(2016) Chunmei Li et al.   Scientific Reports

Polymeric Nanoparticles for Nonviral Gene Therapy Extend Brain Tumor Survival in Vivo

(2015) Antonella Mangraviti et al.   ACS Nano

N 1 -methylpseudouridine-incorporated mRNA outperforms pseudouridine-incorporated mRNA by providing enhanced protein expression and reduced immunogenicity in mammalian cell lines and mice

(2015) Oliwia Andries et al.   JOURNAL OF CONTROLLED RELEASE

Orally administered colony stimulating factor 1 receptor inhibitor PLX3397 in recurrent glioblastoma: an Ivy Foundation Early Phase Clinical Trials Consortium phase II study

(2015) Nicholas Butowski et al.   NEURO-ONCOLOGY

Synthetic mRNAs for manipulating cellular phenotypes: an overview

(2015) Elgar Susanne Quabius et al.   New Biotechnology

Structure-Guided Blockade of CSF1R Kinase in Tenosynovial Giant-Cell Tumor

(2015) William D. Tap et al.   NEW ENGLAND JOURNAL OF MEDICINE

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

Pleiotropic effects of extended blockade of CSF1R signaling in adult mice

(2014) K. A. Sauter et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Expression of Porcine Fusion Protein IRF7/3(5D) Efficiently Controls Foot-and-Mouth Disease Virus Replication

(2014) L. Ramirez-Carvajal et al.   JOURNAL OF VIROLOGY

IKKβ is an IRF5 kinase that instigates inflammation

(2014) Junyao Ren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modeling Adult Gliomas Using RCAS/t-va Technology

(2014) Dolores Hambardzumyan et al.   Translational Oncology

Depletion of Tumor-Associated Macrophages Slows the Growth of Chemically Induced Mouse Lung Adenocarcinomas

(2014) Jason M. Fritz et al.   Frontiers in Immunology

IRF5 Is a Specific Marker of Inflammatory MacrophagesIn Vivo

(2013) Miriam Weiss et al.   MEDIATORS OF INFLAMMATION

Targeting of Tumor-Associated Macrophages Made Possible by PEG-Sheddable, Mannose-Modified Nanoparticles

(2013) Saijie Zhu et al.   MOLECULAR PHARMACEUTICS

CSF-1R inhibition alters macrophage polarization and blocks glioma progression

(2013) Stephanie M Pyonteck et al.   NATURE MEDICINE

Phase I study of the CD40 agonist antibody CP-870,893 combined with carboplatin and paclitaxel in patients with advanced solid tumors

(2013) Robert H. Vonderheide et al.   OncoImmunology

Nanoparticulate Nonviral Agent for the Effective Delivery of pDNA and siRNA to Differentiated Cells and Primary Human T Lymphocytes

(2012) Anja Schallon et al.   BIOMACROMOLECULES

The CD47–SIRPα pathway in cancer immune evasion and potential therapeutic implications

(2012) Mark P Chao et al.   CURRENT OPINION IN IMMUNOLOGY

The Small Ubiquitin-like Modifier-Deconjugating Enzyme Sentrin-Specific Peptidase 1 Switches IFN Regulatory Factor 8 from a Repressor to an Activator during Macrophage Activation

(2012) T.-H. Chang et al.   JOURNAL OF IMMUNOLOGY

Targeting the ANG2/TIE2 Axis Inhibits Tumor Growth and Metastasis by Impairing Angiogenesis and Disabling Rebounds of Proangiogenic Myeloid Cells

(2011) Roberta Mazzieri et al.   CANCER CELL

Macrophages limit chemotherapy

(2011) Michele De Palma et al.   NATURE

Expression of therapeutic proteins after delivery of chemically modified mRNA in mice

(2011) Michael S D Kormann et al.   NATURE BIOTECHNOLOGY

IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses

(2011) Thomas Krausgruber et al.   NATURE IMMUNOLOGY

Incorporation of pseudouridine into mRNA enhances translation by diminishing PKR activation

(2010) Bart R. Anderson et al.   NUCLEIC ACIDS RESEARCH

Blood Cytokines as Biomarkers of In Vivo Toxicity in Preclinical Safety Assessment: Considerations for Their Use

(2010) Jacqueline M. Tarrant   TOXICOLOGICAL SCIENCES

MRI-visible polymeric vector bearing CD3 single chain antibody for gene delivery to T cells for immunosuppression

(2009) Guihua Chen et al.   BIOMATERIALS

Porous Nanoparticle Supported Lipid Bilayers (Protocells) as Delivery Vehicles

(2009) Juewen Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Incorporation of Pseudouridine Into mRNA Yields Superior Nonimmunogenic Vector With Increased Translational Capacity and Biological Stability

(2008) Katalin Karikó et al.   MOLECULAR THERAPY