Hepatic macrophages in homeostasis and liver diseases: from pathogenesis to novel therapeutic strategies

Macrophages: Development and Tissue Specialization

(2015) Chen Varol et al.   Annual Review of Immunology

Fluorescent cell-traceable dexamethasone-loaded liposomes for the treatment of inflammatory liver diseases

(2015) Matthias Bartneck et al.   BIOMATERIALS

Commensal microbiota is hepatoprotective and prevents liver fibrosis in mice

(2015) Magdalena Mazagova et al.   FASEB JOURNAL

CSF1 Restores Innate Immunity After Liver Injury in Mice and Serum Levels Indicate Outcomes of Patients With Acute Liver Failure

(2015) Benjamin M. Stutchfield et al.   GASTROENTEROLOGY

Combination of Granulocyte Colony-Stimulating Factor and Erythropoietin Improves Outcomes of Patients With Decompensated Cirrhosis

(2015) Chandan Kumar Kedarisetty et al.   GASTROENTEROLOGY

Kupffer cell-monocyte communication is essential for initiating murine liver progenitor cell-mediated liver regeneration

(2015) Caryn L. Elsegood et al.   HEPATOLOGY

Liver inflammation abrogates immunological tolerance induced by Kupffer cells

(2015) Felix Heymann et al.   HEPATOLOGY

A dynamic spectrum of monocytes arising from the in situ reprogramming of CCR2+monocytes at a site of sterile injury

(2015) Daniela Dal-Secco et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mechanisms of liver fibrosis resolution

(2015) Frank Tacke et al.   JOURNAL OF HEPATOLOGY

Monocyte-endothelial cell interactions in the regulation of vascular sprouting and liver regeneration in mouse

(2015) Pedro Melgar-Lesmes et al.   JOURNAL OF HEPATOLOGY

Heterogeneity in the Locomotory Behavior of Human Monocyte Subsets over Human Vascular Endothelium In Vitro

(2015) Joanna L. Collison et al.   JOURNAL OF IMMUNOLOGY

CD163L1 and CLEC5A discriminate subsets of human resident and inflammatory macrophages in vivo

(2015) E. Gonzalez-Dominguez et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Inflammatory Monocytes Recruited to the Liver within 24 Hours after Virus-Induced Inflammation Resemble Kupffer Cells but Are Functionally Distinct

(2015) Dowty Movita et al.   JOURNAL OF VIROLOGY

REpeated AutoLogous Infusions of STem cells In Cirrhosis (REALISTIC): a multicentre, phase II, open-label, randomised controlled trial of repeated autologous infusions of granulocyte colony-stimulating factor (GCSF) mobilised CD133+ bone marrow stem cells in patients with cirrhosis. A study protocol for a randomised controlled trial

(2015) A. King et al.   BMJ Open

Ly6C- Monocytes Regulate Parasite-Induced Liver Inflammation by Inducing the Differentiation of Pathogenic Ly6C+ Monocytes into Macrophages

(2015) Yannick Morias et al.   PLoS Pathogens

Japanese phase I study of GC33, a humanized antibody against glypican-3 for advanced hepatocellular carcinoma

(2014) Masafumi Ikeda et al.   CANCER SCIENCE

Tissue-Resident Macrophage Enhancer Landscapes Are Shaped by the Local Microenvironment

(2014) Yonit Lavin et al.   CELL

Tumor-Associated Macrophages Produce Interleukin 6 and Signal via STAT3 to Promote Expansion of Human Hepatocellular Carcinoma Stem Cells

(2014) Shanshan Wan et al.   GASTROENTEROLOGY

Roles for Chemokines in Liver Disease

(2014) Fabio Marra et al.   GASTROENTEROLOGY

Identifying Molecular Factors That Contribute to Resolution of Liver Fibrosis

(2014) John P. Iredale et al.   GASTROENTEROLOGY

Interactions Between the Intestinal Microbiome and Liver Diseases

(2014) Bernd Schnabl et al.   GASTROENTEROLOGY

CCL2-dependent infiltrating macrophages promote angiogenesis in progressive liver fibrosis

(2014) Josef Ehling et al.   GUT

IL-34 and macrophage colony-stimulating factor are overexpressed in hepatitis C virus fibrosis and induce profibrotic macrophages that promote collagen synthesis by hepatic stellate cells

(2014) Laurence Preisser et al.   HEPATOLOGY

Pharmacological inhibition of the chemokine C-C motif chemokine ligand 2 (monocyte chemoattractant protein 1) accelerates liver fibrosis regression by suppressing Ly-6C+macrophage infiltration in mice

(2014) Christer Baeck et al.   HEPATOLOGY

Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation

(2014) Jia Xue et al.   IMMUNITY

Origin and Functions of Tissue Macrophages

(2014) Slava Epelman et al.   IMMUNITY

The role of Kupffer cells in hepatitis B and hepatitis C virus infections

(2014) Arjan Boltjes et al.   JOURNAL OF HEPATOLOGY

Macrophage heterogeneity in liver injury and fibrosis

(2014) Frank Tacke et al.   JOURNAL OF HEPATOLOGY

Infiltrating Monocyte-Derived Macrophages and Resident Kupffer Cells Display Different Ontogeny and Functions in Acute Liver Injury

(2014) E. Zigmond et al.   JOURNAL OF IMMUNOLOGY

Chronic alcohol ingestion modulates hepatic macrophage populations and functions in mice

(2014) Meng Wang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Liposomal encapsulation of dexamethasone modulates cytotoxicity, inflammatory cytokine response, and migratory properties of primary human macrophages

(2014) Matthias Bartneck et al.   Nanomedicine-Nanotechnology Biology and Medicine

Alterations of the human gut microbiome in liver cirrhosis

(2014) Nan Qin et al.   NATURE

Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors

(2014) Elisa Gomez Perdiguero et al.   NATURE

Role of hepatic resident and infiltrating macrophages in liver repair after acute injury

(2013) Qiang You et al.   BIOCHEMICAL PHARMACOLOGY

Multifunctional polymeric nanoparticles for oral delivery of TNF-α siRNA to macrophages

(2013) Chunbai He et al.   BIOMATERIALS

Nr4a1-Dependent Ly6Clow Monocytes Monitor Endothelial Cells and Orchestrate Their Disposal

(2013) Leo M. Carlin et al.   CELL

First-in-Man Phase I Study of GC33, a Novel Recombinant Humanized Antibody Against Glypican-3, in Patients with Advanced Hepatocellular Carcinoma

(2013) A. X. Zhu et al.   CLINICAL CANCER RESEARCH

The liver is populated by a broad spectrum of markers for macrophages. In alcoholic hepatitis the macrophages are M1 and M2

(2013) James Lee et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Hepatic macrophages but not dendritic cells contribute to liver fibrosis by promoting the survival of activated hepatic stellate cells in mice

(2013) Jean-Philippe Pradere et al.   HEPATOLOGY

Hepatitis C Virus Induces Interleukin-1  (IL-1 )/IL-18 in Circulatory and Resident Liver Macrophages

(2013) S. Shrivastava et al.   JOURNAL OF VIROLOGY

Immune surveillance by the liver

(2013) Craig N Jenne et al.   NATURE IMMUNOLOGY

Therapy of Experimental NASH and Fibrosis with Galectin Inhibitors

(2013) Peter G. Traber et al.   PLoS One

Regression of Fibrosis and Reversal of Cirrhosis in Rats by Galectin Inhibitors in Thioacetamide-Induced Liver Disease

(2013) Peter G. Traber et al.   PLoS One

Macrophages as potential targets for zoledronic acid outside the skeleton—evidence from in vitro and in vivo models

(2013) T. L. Rogers et al.   CELLULAR ONCOLOGY

TNFα-Mediated Liver Destruction by Kupffer Cells and Ly6Chi Monocytes during Entamoeba histolytica Infection

(2013) Elena Helk et al.   PLoS Pathogens

Peptide-Functionalized Gold Nanorods Increase Liver Injury in Hepatitis

(2012) Matthias Bartneck et al.   ACS Nano

The peritoneal macrophage inflammatory profile in cirrhosis depends on the alcoholic or hepatitis C viral etiology and is related to ERK phosphorylation

(2012) Ana Tapia-Abellán et al.   BMC IMMUNOLOGY

Promotion of Hepatocellular Carcinoma by the Intestinal Microbiota and TLR4

(2012) Dianne H. Dapito et al.   CANCER CELL

The Proinflammatory Myeloid Cell Receptor TREM-1 Controls Kupffer Cell Activation and Development of Hepatocellular Carcinoma

(2012) Juan Wu et al.   CANCER RESEARCH

Source and characterization of hepatic macrophages in acetaminophen-induced acute liver failure in humans

(2012) Charalambos Gustav Antoniades et al.   HEPATOLOGY

Monocyte subsets in human liver disease show distinct phenotypic and functional characteristics

(2012) Evaggelia Liaskou et al.   HEPATOLOGY

Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis

(2012) Simon Yona et al.   IMMUNITY

IL-1 receptor antagonist ameliorates inflammasome-dependent alcoholic steatohepatitis in mice

(2012) Jan Petrasek et al.   JOURNAL OF CLINICAL INVESTIGATION

Upregulation of the Tim-3/Galectin-9 Pathway of T Cell Exhaustion in Chronic Hepatitis B Virus Infection

(2012) Gaia Nebbia et al.   PLoS One

Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis

(2012) P. Ramachandran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

(2012) C. Schulz et al.   SCIENCE

The Inflammatory Microenvironment in Hepatocellular Carcinoma: A Pivotal Role for Tumor-Associated Macrophages

(2012) Daria Capece et al.   Biomed Research International

Liver Ischemia and Reperfusion Injury: New Insights into Mechanisms of Innate-Adaptive Immune-Mediated Tissue Inflammation

(2011) Y. Zhai et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Pathological mechanisms of liver injury caused by continuous intraperitoneal injection of silica nanoparticles

(2011) Tianlong Liu et al.   BIOMATERIALS

Endogenous Interleukin-4 Regulates Glutathione Synthesis Following Acetaminophen-Induced Liver Injury in Mice

(2011) Pauline M. Ryan et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Hepatitis B virus particles preferably induce Kupffer cells to produce TGF-β1 over pro-inflammatory cytokines

(2011) Hai Li et al.   DIGESTIVE AND LIVER DISEASE

Host Response to Translocated Microbial Products Predicts Outcomes of Patients With HBV or HCV Infection

(2011) Netanya G. Sandler et al.   GASTROENTEROLOGY

Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury

(2011) Christer Baeck et al.   GUT

Kupffer cells contribute to concanavalin A-induced hepatic injury through a Th1 but not Th17 type response-dependent pathway in mice

(2011) Lin Chen et al.   Hepatobiliary & Pancreatic Diseases International

Macrophage therapy for murine liver fibrosis recruits host effector cells improving fibrosis, regeneration, and function

(2011) James A. Thomas et al.   HEPATOLOGY

An essential role for monocyte chemoattractant protein-1 in alcoholic liver injury: Regulation of proinflammatory cytokines and hepatic steatosis in mice

(2011) Pranoti Mandrekar et al.   HEPATOLOGY

Elastin accumulation is regulated at the level of degradation by macrophage metalloelastase (MMP-12) during experimental liver fibrosis

(2011) Antonella Pellicoro et al.   HEPATOLOGY

Hepatic macrophage migration and differentiation critical for liver fibrosis is mediated by the chemokine receptor C-C motif chemokine receptor 8 in mice

(2011) Felix Heymann et al.   HEPATOLOGY

Local Macrophage Proliferation, Rather than Recruitment from the Blood, Is a Signature of TH2 Inflammation

(2011) S. J. Jenkins et al.   SCIENCE

Tolerance Induction in Response to Liver Inflammation

(2010) Annette Erhardt et al.   DIGESTIVE DISEASES

HCV-Related Proteins Activate Kupffer Cells Isolated from Human Liver Tissues

(2010) Naohiro Hosomura et al.   DIGESTIVE DISEASES AND SCIENCES

Conventional DCs reduce liver ischemia/reperfusion injury in mice via IL-10 secretion

(2010) Zubin M. Bamboat et al.   JOURNAL OF CLINICAL INVESTIGATION

Murine Kupffer Cells Are Protective in Total Hepatic Ischemia/Reperfusion Injury with Bowel Congestion through IL-10

(2010) J. D. Ellett et al.   JOURNAL OF IMMUNOLOGY

Liver ischemia/reperfusion injury: Processes in inflammatory networks-A review

(2010) Mahmoud Abu-Amara et al.   LIVER TRANSPLANTATION

A Crucial Role for Kupffer Cell-Derived Galectin-9 in Regulation of T Cell Immunity in Hepatitis C Infection

(2010) John A. Mengshol et al.   PLoS One

Functional Contribution of Elevated Circulating and Hepatic Non-Classical CD14+CD16+ Monocytes to Inflammation and Human Liver Fibrosis

(2010) Henning W. Zimmermann et al.   PLoS One

Heme oxygenase system in hepatic ischemia-reperfusion injury

(2010) James A Richards   WORLD JOURNAL OF GASTROENTEROLOGY

Inhibition of allogeneic T-cell response by Kupffer cells expressing indoleamine 2,3-dioxygenase

(2010) Mao-Lin Yan   WORLD JOURNAL OF GASTROENTEROLOGY

Comparison of gene expression profiles between human and mouse monocyte subsets

(2009) M. A. Ingersoll et al.   BLOOD

Kupffer Cell Suppression of CD8+ T Cells in Human Hepatocellular Carcinoma Is Mediated by B7-H1/Programmed Death-1 Interactions

(2009) K. Wu et al.   CANCER RESEARCH

Hepatitis C Virus Core Protein Subverts the Antiviral Activities of Human Kupffer Cells

(2009) Zhengkun Tu et al.   GASTROENTEROLOGY

Hepatic recruitment of the inflammatory Gr1+monocyte subset upon liver injury promotes hepatic fibrosis

(2009) Karlin Raja Karlmark et al.   HEPATOLOGY

Zoledronic acid repolarizes tumour-associated macrophages and inhibits mammary carcinogenesis by targeting the mevalonate pathway

(2009) Marta Coscia et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1

(2009) Dong-Ming Kuang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Hepatic Mrp4 induction following acetaminophen exposure is dependent on Kupffer cell function

(2008) Sarah N. Campion et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Liver fibrosis

(2008) Karen Wallace et al.   BIOCHEMICAL JOURNAL

Mechanism of T cell tolerance induction by murine hepatic Kupffer cells

(2008) Qiang You et al.   HEPATOLOGY

Inhibition of Kupffer cell-mediated early proinflammatory response with carbon monoxide in transplant-induced hepatic ischemia/reperfusion injury in rats

(2008) Koji Tomiyama et al.   HEPATOLOGY

High tumor-infiltrating macrophage density predicts poor prognosis in patients with primary hepatocellular carcinoma after resection

(2008) Tong Ding et al.   HUMAN PATHOLOGY

Toll-like receptor-stimulated non-parenchymal liver cells can regulate hepatitis C virus replication

(2008) Ruth Broering et al.   JOURNAL OF HEPATOLOGY

Identification and characterization of infiltrating macrophages in acetaminophen-induced liver injury

(2008) Michael P. Holt et al.   JOURNAL OF LEUKOCYTE BIOLOGY