Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels

No causal effects of serum urate levels on the risk of chronic kidney disease: A Mendelian randomization study

(2019) Daniel M. Jordan et al.   PLOS MEDICINE

A catalog of genetic loci associated with kidney function from analyses of a million individuals

(2019) Matthias Wuttke et al.   NATURE GENETICS

Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases

(2018) Masahiro Kanai et al.   NATURE GENETICS

From genome-wide associations to candidate causal variants by statistical fine-mapping

(2018) Daniel J. Schaid et al.   NATURE REVIEWS GENETICS

An update on the genetics of hyperuricaemia and gout

(2018) Tanya J. Major et al.   Nature Reviews Rheumatology

OUP accepted manuscript

(2018)   NUCLEIC ACIDS RESEARCH

Heritability and Genome-Wide Association Analyses of Serum Uric Acid in Middle and Old-Aged Chinese Twins

(2018) Weijing Wang et al.   Frontiers in Endocrinology

An eQTL Landscape of Kidney Tissue in Human Nephrotic Syndrome

(2018) Christopher E. Gillies et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Distinguishing genetic correlation from causation across 52 diseases and complex traits

(2018) Luke J. O’Connor et al.   NATURE GENETICS

Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

(2018) Anubha Mahajan et al.   NATURE GENETICS

Sequential recruitment of study participants may inflate genetic heritability estimates

(2017) Damia Noce et al.   HUMAN GENETICS

Trans-ethnic meta-regression of genome-wide association studies accounting for ancestry increases power for discovery and improves fine-mapping resolution

(2017) Reedik Mägi et al.   HUMAN MOLECULAR GENETICS

JASPAR 2018: update of the open-access database of transcription factor binding profiles and its web framework

(2017) Aziz Khan et al.   NUCLEIC ACIDS RESEARCH

Serum uric acid levels and multiple health outcomes: umbrella review of evidence from observational studies, randomised controlled trials, and Mendelian randomisation studies

(2017) Xue Li et al.   BMJ-British Medical Journal

Cell-Type-Specific Gene Programs of the Normal Human Nephron Define Kidney Cancer Subtypes

(2017) David Lindgren et al.   Cell Reports

Serum uric acid levels and multiple health outcomes: umbrella review of evidence from observational studies, randomised controlled trials, and Mendelian randomisation studies

(2017) Xue Li et al.   BMJ-British Medical Journal

RVTESTS: an efficient and comprehensive tool for rare variant association analysis using sequence data: Table 1.

(2016) Xiaowei Zhan et al.   BIOINFORMATICS

LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis

(2016) Jie Zheng et al.   BIOINFORMATICS

FINEMAP: efficient variable selection using summary data from genome-wide association studies

(2016) Christian Benner et al.   BIOINFORMATICS

Trends in Emergency Department Visits and Charges for Gout in the United States between 2006 and 2012

(2016) S. Jinno et al.   JOURNAL OF RHEUMATOLOGY

Causal Assessment of Serum Urate Levels in Cardiometabolic Diseases Through a Mendelian Randomization Study

(2016) Tanya Keenan et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

A reference panel of 64,976 haplotypes for genotype imputation

(2016)   NATURE GENETICS

Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

(2016) Cristian Pattaro et al.   Nature Communications

Plasma urate concentration and risk of coronary heart disease: a Mendelian randomisation analysis

(2016) Jon White et al.   Lancet Diabetes & Endocrinology

Functional cyclic AMP response element in the breast cancer resistance protein (BCRP/ABCG2) promoter modulates epidermal growth factor receptor pathway- or androgen withdrawal-mediated BCRP/ABCG2 transcription in human cancer cells

(2015) Yi Xie et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology

(2015) Sue Richards et al.   GENETICS IN MEDICINE

The Cooperative Health Research in South Tyrol (CHRIS) study: rationale, objectives, and preliminary results

(2015) Cristian Pattaro et al.   Journal of Translational Medicine

Integrative analysis of 111 reference human epigenomes

(2015) Anshul Kundaje et al.   NATURE

Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci

(2015) Kyle J Gaulton et al.   NATURE GENETICS

An atlas of genetic correlations across human diseases and traits

(2015) Brendan Bulik-Sullivan et al.   NATURE GENETICS

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

(2015) Brendan K Bulik-Sullivan et al.   NATURE GENETICS

Global epidemiology of gout: prevalence, incidence and risk factors

(2015) Chang-Fu Kuo et al.   Nature Reviews Rheumatology

Genome-Wide Association Study with Targeted and Non-targeted NMR Metabolomics Identifies 15 Novel Loci of Urinary Human Metabolic Individuality

(2015) Johannes Raffler et al.   PLoS Genetics

UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age

(2015) Cathie Sudlow et al.   PLOS MEDICINE

Second-generation PLINK: rising to the challenge of larger and richer datasets

(2015) Christopher C Chang et al.   GigaScience

Comparison and integration of deleteriousness prediction methods for nonsynonymous SNVs in whole exome sequencing studies

(2015) C. Dong et al.   HUMAN MOLECULAR GENETICS

MCMC Methods for Multi-Response Generalized Linear Mixed Models: TheMCMCglmmRPackage

(2015) Jarrod D. Hadfield   Journal of Statistical Software

Twenty-eight loci that influence serum urate levels: analysis of association with gout

(2014) A J Phipps-Green et al.   ANNALS OF THE RHEUMATIC DISEASES

SNiPA: an interactive, genetic variant-centered annotation browser

(2014) Matthias Arnold et al.   BIOINFORMATICS

LASAGNA-Search 2.0: integrated transcription factor binding site search and visualization in a browser

(2014) C. Lee et al.   BIOINFORMATICS

A general framework for estimating the relative pathogenicity of human genetic variants

(2014) Martin Kircher et al.   NATURE GENETICS

Epidemiology of Gout

(2014) Edward Roddy et al.   RHEUMATIC DISEASE CLINICS OF NORTH AMERICA

Bayesian Test for Colocalisation between Pairs of Genetic Association Studies Using Summary Statistics

(2014) Claudia Giambartolomei et al.   PLoS Genetics

Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease

(2013) Joyce BJ van Meurs et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

RegScan: a GWAS tool for quick estimation of allele effects on continuous traits and their combinations

(2013) T. Haller et al.   BRIEFINGS IN BIOINFORMATICS

Patterns of regulatory activity across diverse human cell types predict tissue identity, transcription factor binding, and long-range interactions

(2013) N. C. Sheffield et al.   GENOME RESEARCH

Multidomain integration in the structure of the HNF-4α nuclear receptor complex

(2013) Vikas Chandra et al.   NATURE

Mutations causing medullary cystic kidney disease type 1 lie in a large VNTR in MUC1 missed by massively parallel sequencing

(2013) Andrew Kirby et al.   NATURE GENETICS

The Genotype-Tissue Expression (GTEx) project

(2013) John Lonsdale et al.   NATURE GENETICS

Genetics of Hyperuricemia and Gout: Implications for the Present and Future

(2013) Ronald L. George et al.   Current Rheumatology Reports

Large-Scale Gene-Centric Meta-Analysis across 39 Studies Identifies Type 2 Diabetes Loci

(2012) Richa Saxena et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A Na+-phosphate cotransporter homologue (SLC17A4 protein) is an intestinal organic anion exporter

(2012) Natsuko Togawa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

An integrated map of genetic variation from 1,092 human genomes

(2012)   NATURE

Meta-analysis identifies multiple loci associated with kidney function–related traits in east Asian populations

(2012) Yukinori Okada et al.   NATURE GENETICS

Genome-wide association analyses identify 18 new loci associated with serum urate concentrations

(2012) Anna Köttgen et al.   NATURE GENETICS

Genome-wide efficient mixed-model analysis for association studies

(2012) Xiang Zhou et al.   NATURE GENETICS

Serum Uric Acid and Adiposity: Deciphering Causality Using a Bidirectional Mendelian Randomization Approach

(2012) Tanica Lyngdoh et al.   PLoS One

GWAtoolbox: an R package for fast quality control and handling of genome-wide association studies meta-analysis data

(2011) Christian Fuchsberger et al.   BIOINFORMATICS

APCluster: an R package for affinity propagation clustering

(2011) U. Bodenhofer et al.   BIOINFORMATICS

The death domain-containing protein Unc5CL is a novel MyD88-independent activator of the pro-inflammatory IRAK signaling cascade

(2011) L X Heinz et al.   CELL DEATH AND DIFFERENTIATION

Genome-wide association study for serum urate concentrations and gout among African Americans identifies genomic risk loci and a novel URAT1 loss-of-function allele

(2011) Adrienne Tin et al.   HUMAN MOLECULAR GENETICS

Two mutations in human BICC1 resulting in Wnt pathway hyperactivity associated with cystic renal dysplasia

(2011) Marine R.-C. Kraus et al.   HUMAN MUTATION

Identification of low-frequency variants associated with gout and serum uric acid levels

(2011) Patrick Sulem et al.   NATURE GENETICS

Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci

(2011) Jaspal S Kooner et al.   NATURE GENETICS

Population Heterogeneity in the Genetic Control of Serum Urate

(2011) Tony R. Merriman   SEMINARS IN NEPHROLOGY

Heritability of Measures of Kidney Disease Among Zuni Indians: The Zuni Kidney Project

(2010) Jean W. MacCluer et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

METAL: fast and efficient meta-analysis of genomewide association scans

(2010) C. J. Willer et al.   BIOINFORMATICS

ProbABEL package for genome-wide association analysis of imputed data

(2010) Yurii S Aulchenko et al.   BMC BIOINFORMATICS

Multiple Genetic Loci Influence Serum Urate Levels and Their Relationship With Gout and Cardiovascular Disease Risk Factors

(2010) Qiong Yang et al.   Circulation-Cardiovascular Genetics

MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes

(2010) Yun Li et al.   GENETIC EPIDEMIOLOGY

Proteomic Analysis of Native Hepatocyte Nuclear Factor-4α (HNF4α) Isoforms, Phosphorylation Status, and Interactive Cofactors

(2010) Kenji Daigo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genome-wide association study of hematological and biochemical traits in a Japanese population

(2010) Yoichiro Kamatani et al.   NATURE GENETICS

Genotype imputation for genome-wide association studies

(2010) Jonathan Marchini et al.   NATURE REVIEWS GENETICS

GWAF: an R package for genome-wide association analyses with family data

(2009) Ming-Huei Chen et al.   BIOINFORMATICS

The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver

(2009) Nicola L. Beer et al.   HUMAN MOLECULAR GENETICS

Genome-wide linkage analysis for uric acid in families enriched for hypertension

(2009) A. D. Rule et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout

(2009) O. M. Woodward et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Meta-Analysis of 28,141 Individuals Identifies Common Variants within Five New Loci That Influence Uric Acid Concentrations

(2009) Melanie Kolz et al.   PLoS Genetics

Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study

(2008) Abbas Dehghan et al.   LANCET

SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout

(2008) Veronique Vitart et al.   NATURE GENETICS

SLC2A9 influences uric acid concentrations with pronounced sex-specific effects

(2008) Angela Döring et al.   NATURE GENETICS

Uric Acid and Cardiovascular Risk

(2008) Daniel I. Feig et al.   NEW ENGLAND JOURNAL OF MEDICINE