Genome-Wide Association Study with Targeted and Non-targeted NMR Metabolomics Identifies 15 Novel Loci of Urinary Human Metabolic Individuality

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

Insight in Genome-Wide Association of Metabolite Quantitative Traits by Exome Sequence Analyses

(2015) Ayşe Demirkan et al.   PLoS Genetics

NMR Spectroscopy for Metabolomics and Metabolic Profiling

(2014) Cynthia K. Larive et al.   ANALYTICAL CHEMISTRY

SNiPA: an interactive, genetic variant-centered annotation browser

(2014) Matthias Arnold et al.   BIOINFORMATICS

Metabolomics approach reveals effects of antihypertensives and lipid-lowering drugs on the human metabolism

(2014) Elisabeth Altmaier et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

Lysine 2-hydroxyisobutyrylation is a widely distributed active histone mark

(2014) Lunzhi Dai et al.   Nature Chemical Biology

An atlas of genetic influences on human blood metabolites

(2014) So-Youn Shin et al.   NATURE GENETICS

Alanine-glyoxylate aminotransferase 2 (AGXT2) Polymorphisms Have Considerable Impact on Methylarginine and β-aminoisobutyrate Metabolism in Healthy Volunteers

(2014) Anja Kittel et al.   PLoS One

Genome-Wide Association Study of Metabolic Traits Reveals Novel Gene-Metabolite-Disease Links

(2014) Rico Rueedi et al.   PLoS Genetics

Genetic Determinants Influencing Human Serum Metabolome among African Americans

(2014) Bing Yu et al.   PLoS Genetics

Focus: A Robust Workflow for One-Dimensional NMR Spectral Analysis

(2013) Arnald Alonso et al.   ANALYTICAL CHEMISTRY

A Genome-wide Association Study of the Human Metabolome in a Community-Based Cohort

(2013) Eugene P. Rhee et al.   Cell Metabolism

Multiethnic Meta-Analysis of Genome-Wide Association Studies in >100 000 Subjects Identifies 23 Fibrinogen-Associated Loci but No Strong Evidence of a Causal Association Between Circulating Fibrinogen and Cardiovascular Disease

(2013) Maria Sabater-Lleal et al.   CIRCULATION

Genome-Wide Association Study Identifies 3 Genomic Loci Significantly Associated With Serum Levels of Homoarginine

(2013) Marcus E. Kleber et al.   Circulation-Cardiovascular Genetics

Genetic Variants Associated With Glycine Metabolism and Their Role in Insulin Sensitivity and Type 2 Diabetes

(2013) W. Xie et al.   DIABETES

Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality

(2013) Ilkka Seppälä et al.   EUROPEAN HEART JOURNAL

The Human Gene Mutation Database: building a comprehensive mutation repository for clinical and molecular genetics, diagnostic testing and personalized genomic medicine

(2013) Peter D. Stenson et al.   HUMAN GENETICS

Genome-wide association study identifies multiple loci associated with bladder cancer risk

(2013) Jonine D. Figueroa et al.   HUMAN MOLECULAR GENETICS

Genome-wide association study identifies loci affecting blood copper, selenium and zinc

(2013) David M. Evans et al.   HUMAN MOLECULAR GENETICS

Using multiple measures for quantitative trait association analyses: application to estimated glomerular filtration rate

(2013) Adrienne Tin et al.   JOURNAL OF HUMAN GENETICS

Stroke in Primary Hyperoxaluria Type I

(2013) Neal M. Rao et al.   JOURNAL OF NEUROIMAGING

Two Novel Susceptibility SNPs for Ischemic Stroke Using Exome Sequencing in Chinese Han Population

(2013) Yanwei Zhang et al.   MOLECULAR NEUROBIOLOGY

Genetics of rheumatoid arthritis contributes to biology and drug discovery

(2013) Yukinori Okada et al.   NATURE

Discovery and refinement of loci associated with lipid levels

(2013) Cristen J Willer et al.   NATURE GENETICS

ClinVar: public archive of relationships among sequence variation and human phenotype

(2013) Melissa J. Landrum et al.   NUCLEIC ACIDS RESEARCH

The NHGRI GWAS Catalog, a curated resource of SNP-trait associations

(2013) Danielle Welter et al.   NUCLEIC ACIDS RESEARCH

The Human Urine Metabolome

(2013) Souhaila Bouatra et al.   PLoS One

Identification and MS-assisted interpretation of genetically influenced NMR signals in human plasma

(2013) Johannes Raffler et al.   Genome Medicine

On the hypothesis-free testing of metabolite ratios in genome-wide and metabolome-wide association studies

(2012) Ann-Kristin Petersen et al.   BMC BIOINFORMATICS

Current status on genome–metabolome-wide associations: an opportunity in nutrition research

(2012) Ivan Montoliu et al.   Genes and Nutrition

A Genome-Wide Assessment of Variability in Human Serum Metabolism

(2012) Mun-Gwan Hong et al.   HUMAN MUTATION

Structure and Function of Human Xylulokinase, an Enzyme with Important Roles in Carbohydrate Metabolism

(2012) Richard D. Bunker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Identification of Hydroxylysine Kinase and of Ammoniophospholyases Acting on 5-Phosphohydroxy-l-lysine and Phosphoethanolamine

(2012) Maria Veiga-da-Cunha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An integrated map of genetic variation from 1,092 human genomes

(2012)   NATURE

Genome-wide association study identifies multiple loci influencing human serum metabolite levels

(2012) Johannes Kettunen et al.   NATURE GENETICS

Genetic variation in metabolic phenotypes: study designs and applications

(2012) Karsten Suhre et al.   NATURE REVIEWS GENETICS

HMDB 3.0—The Human Metabolome Database in 2013

(2012) David S. Wishart et al.   NUCLEIC ACIDS RESEARCH

Mining the Unknown: A Systems Approach to Metabolite Identification Combining Genetic and Metabolic Information

(2012) Jan Krumsiek et al.   PLoS Genetics

Human metabolic individuality in biomedical and pharmaceutical research

(2011) Karsten Suhre et al.   NATURE

A genome-wide association study of metabolic traits in human urine

(2011) Karsten Suhre et al.   NATURE GENETICS

A linear complexity phasing method for thousands of genomes

(2011) Olivier Delaneau et al.   NATURE METHODS

1 H-NMR-Based Metabolomics Study of Cerebral Infarction

(2011) Jee Youn Jung et al.   STROKE

A Genome-Wide Metabolic QTL Analysis in Europeans Implicates Two Loci Shaped by Recent Positive Selection

(2011) George Nicholson et al.   PLoS Genetics

Genome-wide association study of homocysteine levels in Filipinos provides evidence for CPS1 in women and a stronger MTHFR effect in young adults

(2010) Leslie A. Lange et al.   HUMAN MOLECULAR GENETICS

Understanding carbamoyl-phosphate synthetase I (CPS1) deficiency by using expression studies and structure-based analysis

(2010) Satu Pekkala et al.   HUMAN MUTATION

Cohort Profile: The Study of Health in Pomerania

(2010) H. Volzke et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Conserved regulatory motifs at phenylethanolamine N-methyltransferase (PNMT) are disrupted by common functional genetic variation: an integrated computational/experimental approach

(2010) Juan L. Rodríguez-Flores et al.   MAMMALIAN GENOME

Biological, clinical and population relevance of 95 loci for blood lipids

(2010) Tanya M. Teslovich et al.   NATURE

A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci

(2010) Nathaniel Rothman et al.   NATURE GENETICS

New loci associated with kidney function and chronic kidney disease

(2010) Anna Köttgen et al.   NATURE GENETICS

Genetic loci influencing kidney function and chronic kidney disease

(2010) John C Chambers et al.   NATURE GENETICS

A genome-wide perspective of genetic variation in human metabolism

(2009) Thomas Illig et al.   NATURE GENETICS

Genetic Determinants of Circulating Sphingolipid Concentrations in European Populations

(2009) Andrew A. Hicks et al.   PLoS Genetics

Genome-Wide Association Study of Plasma Polyunsaturated Fatty Acids in the InCHIANTI Study

(2009) Toshiko Tanaka et al.   PLoS Genetics

A Flexible and Accurate Genotype Imputation Method for the Next Generation of Genome-Wide Association Studies

(2009) Bryan N. Howie et al.   PLoS Genetics

Shared Gene Expression Alterations in Schizophrenia and Bipolar Disorder

(2008) Ling Shao et al.   BIOLOGICAL PSYCHIATRY

Iminoglycinuria and hyperglycinuria are discrete human phenotypes resulting from complex mutations in proline and glycine transporters

(2008) Stefan Bröer et al.   JOURNAL OF CLINICAL INVESTIGATION

Glycine cleavage system: reaction mechanism, physiological significance, and hyperglycinemia

(2008) Goro KIKUCHI et al.   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Symbiotic gut microbes modulate human metabolic phenotypes

(2008) M. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetics Meets Metabolomics: A Genome-Wide Association Study of Metabolite Profiles in Human Serum

(2008) Christian Gieger et al.   PLoS Genetics