Genetics of Hyperuricemia and Gout: Implications for the Present and Future

Genome-Wide Association of Serum Uric Acid Concentration: Replication of Sequence Variants in an Island Population of the Adriatic Coast of Croatia

(2012) Rebekah Karns et al.   ANNALS OF HUMAN GENETICS

Absence of SLC22A12/URAT1 Gene Mutations in Patients with Primary Gout

(2012) R. J. TORRES et al.   JOURNAL OF RHEUMATOLOGY

Urate Transporter Gene SLC22A12 Polymorphisms Associated with Obesity and Metabolic Syndrome in Caucasians with Hypertension

(2012) Mohamed Shafiu et al.   KIDNEY & BLOOD PRESSURE RESEARCH

2012 American College of Rheumatology guidelines for management of gout. Part 1: Systematic nonpharmacologic and pharmacologic therapeutic approaches to hyperuricemia

(2012) Dinesh Khanna et al.   ARTHRITIS CARE & RESEARCH

Decreased extra-renal urate excretion is a common cause of hyperuricemia

(2012) Kimiyoshi Ichida et al.   Nature Communications

Prevalence of gout and hyperuricemia in the US general population: The National Health and Nutrition Examination Survey 2007-2008

(2011) Yanyan Zhu et al.   ARTHRITIS AND RHEUMATISM

A genome-wide association study of serum uric acid in African Americans

(2011) Bashira A Charles et al.   BMC Medical Genomics

Recent advances in renal urate transport: characterization of candidate transporters indicated by genome-wide association studies

(2011) Naohiko Anzai et al.   Clinical and Experimental Nephrology

Genome-wide association study for serum urate concentrations and gout among African Americans identifies genomic risk loci and a novel URAT1 loss-of-function allele

(2011) Adrienne Tin et al.   HUMAN MOLECULAR GENETICS

Genotype-based changes in serum uric acid affect blood pressure

(2011) Afshin Parsa et al.   KIDNEY INTERNATIONAL

Identification of low-frequency variants associated with gout and serum uric acid levels

(2011) Patrick Sulem et al.   NATURE GENETICS

Diagnostic Tests for Primary Renal Hypouricemia

(2011) Ivan Sebesta et al.   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

Mutational Analysis of Threonine 402 Adjacent to the GXXXG Dimerization Motif in Transmembrane Segment 1 of ABCG2

(2010) Orsolya Polgar et al.   BIOCHEMISTRY

Multiple Genetic Loci Influence Serum Urate Levels and Their Relationship With Gout and Cardiovascular Disease Risk Factors

(2010) Qiong Yang et al.   Circulation-Cardiovascular Genetics

A strong role for the ABCG2 gene in susceptibility to gout in New Zealand Pacific Island and Caucasian, but not Māori, case and control sample sets

(2010) Amanda J. Phipps-Green et al.   HUMAN MOLECULAR GENETICS

Bayesian methods for instrumental variable analysis with genetic instruments (‘Mendelian randomization’): example with urate transporter SLC2A9 as an instrumental variable for effect of urate levels on metabolic syndrome

(2010) Paul M McKeigue et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

The genetic basis of hyperuricaemia and gout

(2010) Tony R. Merriman et al.   JOINT BONE SPINE

Uric acid transport and disease

(2010) Alexander So et al.   JOURNAL OF CLINICAL INVESTIGATION

Gout therapeutics: new drugs for an old disease

(2010) Christopher M Burns et al.   LANCET

URAT1 mutations cause renal hypouricemia type 1 in Iraqi Jews

(2010) D. Dinour et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

The rs2231142 variant of the ABCG2 gene is associated with uric acid levels and gout among Japanese people

(2010) K. Yamagishi et al.   RHEUMATOLOGY

Hereditary Interstitial Kidney Disease

(2010) Anthony J. Bleyer et al.   SEMINARS IN NEPHROLOGY

Gout, Hyperuricemia, and the Risk of Cardiovascular Disease: Cause and Effect?

(2010) Ankoor Shah et al.   Current Rheumatology Reports

Dominant Renin Gene Mutations Associated with Early-Onset Hyperuricemia, Anemia, and Chronic Kidney Failure

(2009) Martina Živná et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Facilitative glucose transporter 9, a unique hexose and urate transporter

(2009) Manuel Doblado et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Sodium-dependent phosphate cotransporter type 1 sequence polymorphisms in male patients with gout

(2009) W. Urano et al.   ANNALS OF THE RHEUMATIC DISEASES

The SLC22A12 gene is associated with gout in Han Chinese and Solomon Islanders

(2009) H.-P. Tu et al.   ANNALS OF THE RHEUMATIC DISEASES

Role of the urate transporterSLC2A9gene in susceptibility to gout in New Zealand Māori, Pacific Island, and Caucasian case-control sample sets

(2009) Jade E. Hollis-Moffatt et al.   ARTHRITIS AND RHEUMATISM

Genetic analysis of ABCG2 gene C421A polymorphism with gout disease in Chinese Han male population

(2009) Binbin Wang et al.   HUMAN GENETICS

Replication of the five novel loci for uric acid concentrations and potential mediating mechanisms

(2009) P. van der Harst et al.   HUMAN MOLECULAR GENETICS

Multiple single nucleotide polymorphisms in the human urate transporter 1 (hURAT1) gene are associated with hyperuricaemia in Han Chinese

(2009) C. Li et al.   JOURNAL OF MEDICAL GENETICS

Strong association between HLA-B*5801 and allopurinol-induced Stevens–Johnson syndrome and toxic epidermal necrolysis in a Thai population

(2009) Wichittra Tassaneeyakul et al.   Pharmacogenetics and Genomics

Common Polymorphisms Influencing Serum Uric Acid Levels Contribute to Susceptibility to Gout, but Not to Coronary Artery Disease

(2009) Klaus Stark et al.   PLoS One

Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout

(2009) O. M. Woodward et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High‐resolution melting analysis for the rapid detection of an intronic single nucleotide polymorphism in SLC22A12 in male patients with primary gout in China

(2009) M. Guan et al.   SCANDINAVIAN JOURNAL OF RHEUMATOLOGY

Common Defects of ABCG2, a High-Capacity Urate Exporter, Cause Gout: A Function-Based Genetic Analysis in a Japanese Population

(2009) H. Matsuo et al.   Science Translational Medicine

Gout. Novel therapies for treatment of gout and hyperuricemia

(2009) Robert Terkeltaub   ARTHRITIS RESEARCH & THERAPY

Meta-Analysis of 28,141 Individuals Identifies Common Variants within Five New Loci That Influence Uric Acid Concentrations

(2009) Melanie Kolz et al.   PLoS Genetics

Genome-wide Association Study Identifies Genes for Biomarkers of Cardiovascular Disease: Serum Urate and Dyslipidemia

(2008) Chris Wallace et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Association of a common nonsynonymous variant in GLUT9 with serum uric acid levels in old order amish

(2008) Patrick F. McArdle et al.   ARTHRITIS AND RHEUMATISM

T6092C polymorphism of SLC22A12 gene is associated with serum uric acid concentrations in Korean male subjects

(2008) Won Cheoul Jang et al.   CLINICA CHIMICA ACTA

Sex-Specific Association of the Putative Fructose Transporter SLC2A9 Variants With Uric Acid Levels Is Modified by BMI

(2008) A. Brandstatter et al.   DIABETES CARE

Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study

(2008) Abbas Dehghan et al.   LANCET

SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout

(2008) Veronique Vitart et al.   NATURE GENETICS

SLC2A9 influences uric acid concentrations with pronounced sex-specific effects

(2008) Angela Döring et al.   NATURE GENETICS

Urate Transport Across the Apical Membrane of Renal Proximal Tubules

(2008) Hitoshi Endou et al.   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

A European study of HLA-B in Stevens???Johnson syndrome and toxic epidermal necrolysis related to five high-risk drugs

(2008) Christine Lonjou et al.   Pharmacogenetics and Genomics

Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study

(2008) Klaus Stark et al.   PLoS One

SLC2A9 Is a High-Capacity Urate Transporter in Humans

(2008) Mark J Caulfield et al.   PLOS MEDICINE