No causal effects of serum urate levels on the risk of chronic kidney disease: A Mendelian randomization study

Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases

(2018) Marie Verbanck et al.   NATURE GENETICS

Analysis of the Global Burden of Disease study highlights the global, regional, and national trends of chronic kidney disease epidemiology from 1990 to 2016

(2018) Yan Xie et al.   KIDNEY INTERNATIONAL

Association of Chronic Kidney Disease With Allopurinol Use in Gout Treatment

(2018) Ana Beatriz Vargas-Santos et al.   JAMA Internal Medicine

Sensitivity Analyses for Robust Causal Inference from Mendelian Randomization Analyses with Multiple Genetic Variants

(2017) Stephen Burgess et al.   EPIDEMIOLOGY

Semiparametric methods for estimation of a nonlinear exposure-outcome relationship using instrumental variables with application to Mendelian randomization

(2017) James R. Staley et al.   GENETIC EPIDEMIOLOGY

Mendelian randomization analysis indicates serum urate has a causal effect on renal function in Chinese women

(2017) Jing Liu et al.   INTERNATIONAL UROLOGY AND NEPHROLOGY

Time to target uric acid to retard CKD progression

(2016) Takanori Kumagai et al.   Clinical and Experimental Nephrology

Bias due to participant overlap in two-sample Mendelian randomization

(2016) Stephen Burgess et al.   GENETIC EPIDEMIOLOGY

Causal Assessment of Serum Urate Levels in Cardiometabolic Diseases Through a Mendelian Randomization Study

(2016) Tanya Keenan et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The genetics of drug efficacy: opportunities and challenges

(2016) Matthew R. Nelson et al.   NATURE REVIEWS GENETICS

Insight into rheumatological cause and effect through the use of Mendelian randomization

(2016) Philip C. Robinson et al.   Nature Reviews Rheumatology

Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

(2016) Cristian Pattaro et al.   Nature Communications

Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression

(2015) J. Bowden et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Urate lowering therapy to improve renal outcomes in patients with chronic kidney disease: systematic review and meta-analysis

(2015) Tahir Kanji et al.   BMC Nephrology

Allopurinol for the treatment of chronic kidney disease: asystematic review

(2014) Nigel Fleeman et al.   HEALTH TECHNOLOGY ASSESSMENT

The effect of febuxostat to prevent a further reduction in renal function of patients with hyperuricemia who have never had gout and are complicated by chronic kidney disease stage 3: study protocol for a multicenter randomized controlled study

(2014) Tatsuo Hosoya et al.   Trials

Mendelian Randomization Analysis With Multiple Genetic Variants Using Summarized Data

(2013) Stephen Burgess et al.   GENETIC EPIDEMIOLOGY

Calculating statistical power in Mendelian randomization studies

(2013) Marie-Jo A Brion et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Mendelian randomization analysis associates increased serum urate, due to genetic variation in uric acid transporters, with improved renal function

(2013) Kim Hughes et al.   KIDNEY INTERNATIONAL

The Framingham Heart Study and the epidemiology of cardiovascular disease: a historical perspective

(2013) Syed S Mahmood et al.   LANCET

Uric Acid Reduction Rectifies Prehypertension in Obese Adolescents

(2012) Beth Soletsky et al.   HYPERTENSION

Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study

(2012) Benjamin F Voight et al.   LANCET

Genome-wide association analyses identify 18 new loci associated with serum urate concentrations

(2012) Anna Köttgen et al.   NATURE GENETICS

Multiple Genetic Loci Influence Serum Urate Levels and Their Relationship With Gout and Cardiovascular Disease Risk Factors

(2010) Qiong Yang et al.   Circulation-Cardiovascular Genetics

Conceptual Model of CKD: Applications and Implications

(2009) Andrew S. Levey et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Effect of Allopurinol on Blood Pressure of Adolescents With Newly Diagnosed Essential Hypertension

(2008) Daniel I. Feig et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Uric Acid and Incident Kidney Disease in the Community

(2008) D. E. Weiner et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY