HLA Heterozygote Advantage against HIV-1 Is Driven by Quantitative and Qualitative Differences in HLA Allele-Specific Peptide Presentation

HIV peptidome-wide association study reveals patient-specific epitope repertoires associated with HIV control

(2019) Jatin Arora et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathogen diversity drives the evolution of generalist MHC-II alleles in human populations

(2019) Máté Manczinger et al.   PLOS BIOLOGY

Divergent Allele Advantage at Human MHC Genes: Signatures of Past and Ongoing Selection

(2018) Federica Pierini et al.   MOLECULAR BIOLOGY AND EVOLUTION

Adaptive value of novel MHC immune gene variants

(2018) Tobias L. Lenz   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A genomic perspective on HLA evolution

(2017) Diogo Meyer et al.   IMMUNOGENETICS

NetMHCpan-4.0: Improved Peptide–MHC Class I Interaction Predictions Integrating Eluted Ligand and Peptide Binding Affinity Data

(2017) Vanessa Jurtz et al.   JOURNAL OF IMMUNOLOGY

Natural selection on MHC IIβ in parapatric lake and stream stickleback: Balancing, divergent, both or neither?

(2017) William E. Stutz et al.   MOLECULAR ECOLOGY

Distinguishing functional polymorphism from random variation in the sequences of >10,000 HLA-A, -B and -C alleles

(2017) James Robinson et al.   PLoS Genetics

HLA class I molecular variation and peptide-binding properties suggest a model of joint divergent asymmetric selection

(2016) Stéphane Buhler et al.   IMMUNOGENETICS

The Ensembl gene annotation system

(2016) Bronwen L. Aken et al.   Database-The Journal of Biological Databases and Curation

HLA supertype variation across populations: new insights into the role of natural selection in the evolution of HLA-A and HLA-B polymorphisms

(2015) Rodrigo dos Santos Francisco et al.   IMMUNOGENETICS

Polymorphic HLA-C Receptors Balance the Functional Characteristics ofKIRHaplotypes

(2015) Hugo G. Hilton et al.   JOURNAL OF IMMUNOLOGY

Polymorphisms of large effect explain the majority of the host genetic contribution to variation of HIV-1 virus load

(2015) Paul J. McLaren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Red Queen Processes Drive Positive Selection on Major Histocompatibility Complex (MHC) Genes

(2015) Maciej Jan Ejsmond et al.   PLoS Computational Biology

Expression levels of MHC class I molecules are inversely correlated with promiscuity of peptide binding

(2015) Paul E Chappell et al.   eLife

HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes

(2014) F. Pereyra et al.   JOURNAL OF VIROLOGY

The IPD and IMGT/HLA database: allele variant databases

(2014) James Robinson et al.   NUCLEIC ACIDS RESEARCH

HIV escape mutations occur preferentially at HLA-binding sites of CD8 T-cell epitopes

(2013) Corine Bronke et al.   AIDS

Major Histocompatibility Complex Genomics and Human Disease

(2013) John Trowsdale et al.   Annual Review of Genomics and Human Genetics

Balancing selection and heterozygote advantage in major histocompatibility complex loci of the bottlenecked Finnish wolf population

(2013) A. K. Niskanen et al.   MOLECULAR ECOLOGY

A peptide's perspective on antigen presentation to the immune system

(2013) Jacques Neefjes et al.   Nature Chemical Biology

Divergent allele advantage at MHC-DRB through direct and maternal genotypic effects and its consequences for allele pool composition and mating

(2013) T. L. Lenz et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

CD8+ T cells from HLA-B*57 elite suppressors effectively suppress replication of HIV-1 escape mutants

(2013) Christopher W Pohlmeyer et al.   Retrovirology

Human-specific evolution of killer cell immunoglobulin-like receptor recognition of major histocompatibility complex class I molecules

(2012) P. Parham et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

HLA-C and HIV-1: friends or foes?

(2012) Donato Zipeto et al.   Retrovirology

COMPUTATIONAL PREDICTION OF MHC II-ANTIGEN BINDING SUPPORTS DIVERGENT ALLELE ADVANTAGE AND EXPLAINS TRANS-SPECIES POLYMORPHISM

(2011) Tobias L. Lenz   EVOLUTION

HLA class I allele promiscuity revisited

(2011) Xiangyu Rao et al.   IMMUNOGENETICS

The MHC, disease and selection

(2011) John Trowsdale   IMMUNOLOGY LETTERS

Differential microRNA regulation of HLA-C expression and its association with HIV control

(2011) Smita Kulkarni et al.   NATURE

Are there Ubiquitous Parasite-driven Major Histocompatibility Complex Selection Mechanisms in Gray Mouse Lemurs?

(2010) Nina Schwensow et al.   INTERNATIONAL JOURNAL OF PRIMATOLOGY

Major histocompatibility complex polymorphism: dynamics and consequences of parasite-mediated local adaptation in fishes

(2010) C. Eizaguirre et al.   JOURNAL OF FISH BIOLOGY

How pathogens drive genetic diversity: MHC, mechanisms and misunderstandings

(2010) L. G. Spurgin et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Diverse MHC IIB allele repertoire increases parasite resistance and body condition in the Long-tailed giant rat (Leopoldamys sabanus)

(2009) Tobias L Lenz et al.   BMC EVOLUTIONARY BIOLOGY

HLA and Infectious Diseases

(2009) J. M. Blackwell et al.   CLINICAL MICROBIOLOGY REVIEWS

Major histocompatibility complex heterozygote advantage and widespread bacterial infections in populations of Chinook salmon (Oncorhynchus tshawytscha)

(2009) MELISSA L. EVANS et al.   MOLECULAR ECOLOGY

Balancing selection and heterogeneity across the classical human leukocyte antigen loci: A meta-analytic review of 497 population studies

(2008) Owen D. Solberg et al.   HUMAN IMMUNOLOGY

Evidence for cattle major histocompatibility complex (BoLA) class IIDQA1gene heterozygote advantage against clinical mastitis caused byStreptococciandEscherichiaspecies

(2008) S. Takeshima et al.   TISSUE ANTIGENS